Clinical trials: Prostaglandins
Healthy, Tooth Extraction
Prostanoid Levels After Medication to Prevent Pain Following Third Molar (Wisdom Tooth) Extraction
This study will evaluate how well different medications work to relieve pain following third molar (wisdom tooth) extraction. Scientists believe that hormone-like substances called prostanoids contribute to pain following oral…
- Trial name
- NCT00078104
- Testing
- Extraction of wisdom teeth
- Where
- United States
- Volunteers
- 148 people
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Dysmenorrhea
The Efficacy of Two Types of Acupuncture on Autonomic Nervous Activity and Quality of Life in Women With Dysmenorrhea.
Integrative medicine raises public's attention due to either mainstream or traditional medicine has its limitation. The topic "dysmenorrhea", with prevalence up to 50%, troubled many females with symptom as depression, reduced…
- Trial name
- NCT04178226
- Testing
- Manual Acupuncture, Laser Acupuncture
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Taipei City Hospital
Pyloric Stenosis;Acquired, Congenital Heart Disease
Effects of Prostaglandin E1 Treatment on Pyloric Wall in Newborns
Prostaglandin E1 (PGE1) has been used in the medical treatment of ductal dependent critical congenital heart disease in neonates.
- Trial name
- EOPTOPWT (NCT04496050)
- Testing
- Prostaglandin E1
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Hacettepe University
Pulmonary Arterial Hypertension (PAH), Pulmonary Hypertension (PH)
COMPERA / COMPERA-KIDS
In view of the manifold options for mono- and combination therapy that have now emerged for patients with pulmonary (arterial) hypertension (PH/PAH), controlled clinical trials can only provide part of the information needed for…
- Trial name
- COMPERA (NCT01347216)
- Where
- 7 sites in Belgium, Germany and 2 more
- Volunteers
- 14,000 people
- Sponsor
- Technische Universität Dresden
Healthy, Hypercapnia
Role of Prostaglandins in the Regulation of Brain Blood Flow
This study will use magnetic resonance imaging (MRI) to examine the role of prostaglandins-a type of fatty acid with hormone-like actions-in the regulation of brain blood flow.
- Trial name
- NCT00006318
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Facial Pain
Celebrex for Pain Relief After Oral Surgery
This study will evaluate the effects of the new anti-inflammatory drug, Celebrex, on relieving pain after oral surgery. It is also designed to assess the drug's selective inhibition of a chemical called cyclooxygenase-2 and not…
- Trial name
- NCT00006299
- Testing
- Celebrex
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Open Angle Glaucoma and Cataract
RCT to Investigate if Prostaglandin Analogue Drops Increase the Risk of Cystoid Macular Oedema After Cataract Surgery.
Post-operative cystoid macular oedema (CMO) is a common complication causing visual loss following routine cataract surgery. This complication is more prevalent in eyes with excessive inflammation as they heal from surgery.
- Trial name
- CMO (NCT03292796)
- Testing
- Prostaglandins
- Where
- United Kingdom
- Volunteers
- 56 people
- Sponsor
- Julie Dawson
Induction of Labor Affected Fetus / Newborn, Prostaglandins Causing Adverse Effects in Therapeutic Use
Induction of Labor in Term Pregnancies With Unfavourable Cervix
This is a prospective randomized trial comparing two prostaglandin E2 (dinoprostone) agents used for labor induction in pregnant women with term pregnancies and unfavorable cervix.
- Trial name
- RAND (NCT04280874)
- Testing
- Dinoprostone 0.5 MG, Dinoprostone 2 MG/2.5 ML Vaginal Gel/Jelly
- Where
- Croatia
- Volunteers
- 212 people, healthy volunteers welcome
- Sponsor
- Clinical Hospital Merkur
Alopecia Areata
Comparison of Topical Latanoprost vs Topical Corticosteroid in Treatment of Localized Alopecia Areata
Alopecia areata (AA) is an autoimmune disease that involves the hair follicles. Topical corticosteroids are the established agents for treating this disorder.
- Trial name
- COLA (NCT02350023)
- Testing
- Topical latanoprost 0.005%, Topical betamethasone 0.05%
- Where
- India
- Volunteers
- 50 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Prostate Cancer
Nerve-Sparing Radical Prostatectomy With or Without Nerve Grafting Followed by Standard Therapy for Erectile Dysfunction in Treating Patients With Localized Prostate Cancer
RATIONALE: Nerve-sparing radical prostatectomy with nerve grafting followed by standard therapies for erectile dysfunction may be effective in helping patients with prostate cancer improve sexual satisfaction and quality of life.
- Trial name
- NCT00080808
- Testing
- Alprostadil (E1), Papaverine, Phentolamine mesylate
- Where
- United States
- Volunteers
- 111 people
- Sponsor
- M.D. Anderson Cancer Center
Failed Induction of Labor
A Comparison of Transcervical Foley Catheter and Prostaglandins for Induction of Labor at Term
The purpose of this study is to assess the effectiveness and safety of transcervical foley catheter as compared to prostaglandins for preinduction cervical ripening and labor induction in term nulliparous women with unfavorable…
- Trial name
- NCT01317862
- Testing
- Transcervical foley catheter, Prostaglandins
- Where
- South Korea
- Volunteers
- 154 people
- Sponsor
- Seoul National University Hospital
Childhood Glaucoma
Efficacy and Safety of Topically Applied Medical Therapy for the Treatment of Pediatric Glaucoma
Objectives: The study will assess the ocular hypotensive effect of latanoprost and dorzolamide in a selected sample of patients affected by primary Pediatric Glaucoma (PG), refractory to surgical procedures.
- Trial name
- NCT01527682
- Testing
- Latanoprost, Dorzolamide
- Where
- 2 sites in Italy
- Volunteers
- 37 people
- Sponsor
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
Ovarian Cancer
Prostaglandin Metabolite in Urine Samples From Patients With Ovarian Cancer
RATIONALE: Measuring the amount of prostaglandin metabolite in urine samples and studying tissue samples in the laboratory from patients with ovarian cancer may help doctors identify and learn more about biomarkers related to…
- Trial name
- NCT00900523
- Testing
- protein expression analysis, immunohistochemistry
- Volunteers
- 7 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
Neonatal Prematurity, Patent Ductus Arteriosus in Preterm Infants
Relation Between Prostaglandin E2 Metabolite Levels and the Development of Hemodynamically Significant Patent Ductus Arteriosus in Preterm Neonates
prospective observational cohort study to explore the relationship between PGE2 metabolite levels and the development of hemodynamically significant PDA in preterm neonates.
- Conditions
- Neonatal Prematurity, Patent Ductus Arteriosus in Preterm Infants, Prostaglandins
- Trial name
- NCT07338370
- Testing
- Ibuprofen (Brufen®)
- Where
- Egypt
- Volunteers
- 34 people
- Sponsor
- Ain Shams University
Postpartum Hemorrhage
In Vitro Myometrial Contractions in Laboring and Non-laboring Women
The purpose of this study is to compare the ability of an isolated sample of uterine muscle tissue (in a tissue bath) to contract in the presence of various drugs.
- Trial name
- NCT01689311
- Testing
- Oxytocin, Ergonovine, Prostaglandin F2alpha
- Where
- Canada
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Primary Dysmenorrhea
Effect of Virtual Reality on Prostaglandin Levels in Adolescent Females With Primary Dysmenorrhea
This study will be conducted to study the effect of virtual reality therapy on prostaglandin levels in adolescent females with primary dysmenorrhea.
- Trial name
- NCT06987838
- Testing
- Pharmacological treatment, Virtual reality
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Benha National University
Pulmonary Arterial Hypertension
Study of Cicletanine for Pulmonary Arterial Hypertension (PAH)
This Phase 2, randomized, double-blind, placebo-controlled, multicenter, dose-ranging study will compare the efficacy, safety, and tolerability of cicletanine hydrochloride (HCl) to placebo in subjects with PAH.
- Trial name
- NCT00832507
- Testing
- Cicletanine
- Where
- 56 sites in United States, Australia and 8 more
- Volunteers
- 162 people
- Sponsor
- Gilead Sciences
Vitiligo, Excimer Laser
Effect Of Topical Prostaglandin F2α Analogs,Fractional CO2 Laser, Excimer Laser Or Their Combination In Treatment Of Vitiligo
Vitiligo is a chronic disease with an unpredictable clinical course, characterized by the appearance of white macules and patches on the skin and mucous membranes due to the disappearance of melanocytes in the affected area.
- Conditions
- Vitiligo, Excimer Laser, Fractional CO2 Laser
- Trial name
- NCT04577027
- Testing
- Topical travoprost 0.004% solution, Fractional CO2 laser, Excimer laser
- Volunteers
- 30 people
- Sponsor
- Assiut University
Induction of Labor
Methods of Labor Induction and Perinatal Outcomes
Since it is a frequent intervention in Obstetrics, labor induction is rarely evaluated from national population-based cohorts. The study aims to assess the frequency of different induction methods used in France from a…
- Trial name
- MEDIP (NCT02477085)
- Testing
- all women with an induced labor
- Where
- France
- Volunteers
- 3,049 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Induction Time, Apgar Score
The Balloon Project for Birth Induction
The use of prostaglandin E2 (PGE2) for induction of labour in women with unfavourable cervices is well-established1. There are, however, potential side effects to prostaglandins, in particular the risk of uterine hypertonicity…
- Conditions
- Induction Time, Apgar Score, Admission to Neonatal Unit, Vaginal Delivery
- Trial name
- NCT01255839
- Testing
- Double Balloon, Minprostin
- Where
- Denmark
- Volunteers
- 825 people
- Sponsor
- Glostrup University Hospital, Copenhagen