Clinical trials: Protein Metabolism
Nutritional Stunting, Nutritional Anemia
Association Between Intakes of Protein, Calcium and Milk With Gene Expression and Linear Growth of School Aged Children
Protein is one type of nutrients known as the cause of stunting in developing countries since the mid-1970s (1) but then less attention on protein intake with the assumption that protein intake is sufficient.
- Conditions
- Nutritional Stunting, Nutritional Anemia, Nutritional Deficiency, Nutrigenetic
- Trial name
- NCT03895151
- Testing
- Milk supplementation, Food Based Recommendation (FBR) nutrition education
- Where
- Indonesia
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- SEAMEO Regional Centre for Food and Nutrition
Body Mass Index Quantitative Trait Locus 5 Disorder, Tangier Disease
Effect of High Protein Diet on Adiponectin and Inflammation Among Overweight and Obese Children
The investigators aimed to determine the effects of HP diet on adiponectin and inflammatory factors among overweight and obese children.
- Trial name
- NCT01886495
- Testing
- nutrition intervention
- Where
- Iran
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Isfahan University of Medical Sciences
Accelerated Phase Chronic Myelogenous Leukemia, Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome
Fludarabine Phosphate, Melphalan, Total-Body Irradiation, Donor Stem Cell Transplant in Treating Patients With Hematologic Cancer or Bone Marrow Failure Disorders
This clinical trial is studying how well giving fludarabine phosphate and melphalan together with total-body irradiation followed by donor stem cell transplant works in treating patients with hematologic cancer or bone marrow…
- Conditions
- Accelerated Phase Chronic Myelogenous Leukemia, Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome, Adult Acute Lymphoblastic Leukemia in Remission, Adult Acute Myeloid Leukemia in Remission
- Trial name
- NCT00856388
- Testing
- fludarabine phosphate, melphalan, total-body irradiation
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Roswell Park Cancer Institute
Common Variable Immunodeficiency (CVID), Primary Immune Regulatory Disorder
Hematopoietic Stem Cell Transplantation (HSCT) for Common Variable Immunodeficiency (CVID) and Other Autoimmune Manifestations of Primary Immune Regulatory Disorders (PIRD)
This is a research protocol that will examine Hematopoietic Stem Cell Transplantation (HSCT) using a reduced conditioning regimen (RIC) with total body Irradiation (TBI) in those diagnosed with Common Variable Immunodeficiency…
- Conditions
- Common Variable Immunodeficiency (CVID), Primary Immune Regulatory Disorder, Immune Dysregulation, DiGeorge Syndrome
- Trial name
- CVID/PIRD (NCT07284641)
- Testing
- Hematopoietic stem cell transplant (HSCT)
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Paul Szabolcs
Hypoalbuminemia, Stunted Growth
Nutritional Parameters and Other Risk Factors Affecting Severity of Pneumonia in Children Under Five Years in Upper Egypt
Decrease mortality rate resulting from pneumonia
- Conditions
- Hypoalbuminemia, Stunted Growth, Anemia, Iron Deficiency
- Trial name
- NCT05050851
- Testing
- Measurement of nutritional parameters in children with pneumonia
- Volunteers
- 30 people
- Sponsor
- Assiut University
PKU, Phenylketonurias
Market Research - Acceptability Trial for a New PKU Amino Acid Based Protein Substitute
The aim of this study is to demonstrate that a new protein substitute is acceptable and well tolerated in children with PKU.
- Conditions
- PKU, Phenylketonurias, Inborn Errors of Metabolism, Metabolic Disease
- Trial name
- NCT04309331
- Testing
- Motion
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- Dr. Schär AG / SPA
Obesity, Metabolic Syndrome
Diet, Obesity and Genes (DiOGenes)
Study Title: Diogenes, A randomised controlled trial comparing the effect of reduced-fat diets varying in glycaemic index (high vs. low) and protein content (high vs.
- Conditions
- Obesity, Metabolic Syndrome, Type 2 Diabetes, Cardiovascular Disease
- Trial name
- DIOGENES (NCT00390637)
- Testing
- High or low Glycemic Index and high or low Protein Diet
- Where
- Denmark
- Volunteers
- 1,020 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Sickle Cell Disease, Thalassemia
Unrelated Hematopoietic Stem Cell Transplantation(HSCT) for Genetic Diseases of Blood Cells
This is a clinical trial of bone marrow transplantation for patients with the diagnosis of a genetic disease of blood cells that do not have an HLA-matched sibling donor.
- Conditions
- Sickle Cell Disease, Thalassemia, Anemia, Granuloma
- Trial name
- NCT00730314
- Testing
- Hematopoietic stem cell transplantation
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Children's Hospital Los Angeles
Malnutrition (Calorie), Protein-energy Malnutrition
Composite Flour Cookies for Improving Nutrition in Malnourished Children
Malnutrition is a major public health concern among children in developing countries, leading to impaired growth and increased risk of morbidity.
- Trial name
- CFC-MAL (NCT07504133)
- Testing
- Composite Flour Cookies
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Mairaj Noor
Tuberculosis Multi Drug Resistant Active, Rifampin-Resistant Pulmonary Tuberculosis
Oral Nutritional Supplementation and Weight Changes During Therapy in Malnourished Patients With Resistant Tuberculosis: A Clinical Trial
Tuberculosis increases energy demands and protein breakdown, leading to muscle wasting. Malnutrition and minimal weight gain less than 5% in first two months predict treatment failure.
- Conditions
- Tuberculosis Multi Drug Resistant Active, Rifampin-Resistant Pulmonary Tuberculosis, Pre-xdr tb
- Trial name
- NCT07058233
- Testing
- Oral nutritional supplementation
- Where
- Indonesia
- Volunteers
- 70 people
- Sponsor
- RSUP Persahabatan
Obesity
Developmental Adaptation to an Obesogenic Environment
The purpose of this study was to evaluate whether birth weight is related to the demand for dietary protein in adult survivors of severe acute malnutrition (Kwashiorkor and Marasmus), and that leveraging of protein intake is…
- Trial name
- NCT02257593
- Testing
- Dietary protein
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- The University of The West Indies
Obesity, Metabolic Syndrome
Milk Types and Fish Oil in 9- to 12-Month-Old Infants
The objective of this intervention study is to examine the effect of whole cow's milk versus infant formula as primary milk sources with or without supplements of n-3 LCPUFA for growth, nutritional status, development, risk…
- Conditions
- Obesity, Metabolic Syndrome, Growth, Blood Pressure
- Trial name
- NCT00379171
- Testing
- Cow's milk with fish oil, Cow's milk without fish oil, Formula with fish oil
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Appetitive Behavior, Pediatric Obesity
The Acute Effect of Protein or Carbohydrate Intake on Testosterone Levels and Food Intake in Children and Adolescent Boys
The purpose of this study was to determine the effect of acute protein and glucose intake on testosterone levels measured in adolescent boys and determine whether changes in testosterone levels are associated with alterations in…
- Trial name
- NCT03412136
- Testing
- Control, Glucose, Protein
- Where
- Canada
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Hypophosphatasia
Safety and Efficacy of Asfotase Alfa in Patients With Hypophosphatasia (HPP)
The aim of this study is to assess safety and efficacy of Asfotase Alfa (ALXN1215) in patients with hypophosphatasia
- Trial name
- NCT02456038
- Testing
- Asfotase Alfa (ALXN1215)
- Where
- 12 sites in Japan
- Volunteers
- 13 people
- Sponsor
- Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan
Accelerated Phase Chronic Myelogenous Leukemia, Acute Undifferentiated Leukemia
Massage Therapy Given by Caregiver in Treating Quality of Life of Young Patients Undergoing Treatment for Cancer
This clinical trial studies massage therapy given by caregiver in treating quality of life of young patients undergoing treatment for cancer.
- Conditions
- Accelerated Phase Chronic Myelogenous Leukemia, Acute Undifferentiated Leukemia, Angioimmunoblastic T-cell Lymphoma, Atypical Chronic Myeloid Leukemia, BCR-ABL1 Negative
- Trial name
- NCT01053494
- Testing
- massage therapy, questionnaire administration, quality-of-life assessment
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Wake Forest University Health Sciences
Healthy, Heart Disease
Family Research Study: Metabolism of Fats and Proteins in Specific Ethnic Groups
The purpose of this study is to determine whether lipoprotein(a), also called Lp(a), is a risk factor for cardiovascular (heart) disease. Lipoproteins are tiny particles that circulate in the blood.
- Trial name
- NCT00853775
- Testing
- No intervention, observational study
- Where
- United States
- Volunteers
- 325 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Protein-energy Malnutrition, Kwashiorkor
Study of Antioxidants and Oxidants in Malnourished Children
It is believed that the organs of severely malnourished children malfunction because harmful compounds called oxidants injure the tissues in these organs.
- Conditions
- Protein-energy Malnutrition, Kwashiorkor, Marasmus
- Trial name
- NCT00069134
- Testing
- sulfur amino acids
- Where
- Jamaica
- Volunteers
- 86 people
- Sponsor
- Baylor College of Medicine
Diabetes Mellitus, Type 2
Phenotypic and Genetic Correlates of Diabetes (Non-Type 1) in Young Non-Obese Asian Indians in North India and A Study to Evaluate the Efficacy of Sitagliptin (DPP-4 Inhibitor) in a Sub-group of the Study Population
This is a phase IV study of 3.5 years duration to evaluate the phenotypic and genetic correlates of diabetes (non-Type 1 in young non-obese Asian Indians in North India and pilot case control study to evaluate the efficacy of…
- Trial name
- NCT00964184
- Testing
- Metformin, Lifestyle modification
- Where
- India
- Volunteers
- 133 people
- Sponsor
- Diabetes Foundation, India
Crohn's Disease, Ulcerative Colitis
Protein Metabolism in Newly Diagnosed Pediatric Inflammatory Bowel Disease
Inflammatory bowel disease, which includes both Crohn's disease and ulcerative colitis, is a disease of the gastrointestinal tract leading to symptoms of abdominal pain, diarrhea, and growth disturbance.
- Conditions
- Crohn's Disease, Ulcerative Colitis, Protein Metabolism
- Trial name
- NCT00586352
- Testing
- stable isotope infusions
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Indiana University
Insulin Resistance, Hypermetabolism
Mechanisms of Improved Wound Healing and Protein Synthesis of Insulin and Metformin
Massive pediatric burns are associated with a persistent and sustained hypermetabolic response characterized by elevated levels of circulating catecholamine's, cortisol, and glucagon's, which can cause extreme muscle wasting…
- Conditions
- Insulin Resistance, Hypermetabolism, Hyperglycemia
- Trial name
- NCT01666665
- Testing
- Metformin, Sugar pill
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- The University of Texas Medical Branch, Galveston