Clinical trials: Proton-therapy
Central Nervous System Sarcoma, Ependymoma
StrataXRT in Preventing Radiation Dermatitis in Pediatric Patients Undergoing Radiation Therapy to the Brain or Spinal Cord
This phase I trial studies the side effects of a silicone topical wound dressing (StrataXRT) and to see how well it works in preventing radiation dermatitis (skin burns and side effects caused by radiation) in pediatric patients…
- Conditions
- Central Nervous System Sarcoma, Ependymoma, Glioma, Malignant Intracranial Germ Cell Tumor
- Trial name
- NCT03990597
- Testing
- Questionnaire Administration, Wound Dressing Material
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Osteoporosis, Achlorhydria
Does Omeprazole Decrease Intestinal Calcium Absorption?
The purpose of this study is to measure the effect of omeprazole on intestinal calcium absorption in postmenopausal women.
- Conditions
- Osteoporosis, Achlorhydria, GERD, Hip Fracture
- Trial name
- NCT00582972
- Testing
- Omeprazole
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Assay Muscle, Liver Glutathione in Healthy Human
Non-invasive Quantification of Muscle and Liver Glutathione GSH-MRS
Glutathione (glutamyl-cysteinyl-glycine) is the main intracellular compound. It participates also in the detoxification of electrophiles molecules of which paracetamol.
- Trial name
- NCT02662816
- Testing
- Proton magnetic resonance spectroscopy (1H MRS), a protein rich breakfast at home, a protein rich lunch at the Clinical Investigation Center
- Where
- France
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Pediatric Obesity, NAFLD
Effect of Obesity on Proton Pump Inhibitors
This longitudinal study tests the hypothesis that obesity affects drug pharmacology of acid suppression medications in children.
- Conditions
- Pediatric Obesity, NAFLD, GERD
- Trial name
- LiverLabPPI (NCT04248335)
- Testing
- Lansoprazole, Pantoprazole, Midazolam
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Children's Mercy Hospital Kansas City
Bipolar Disorder, ADHD
Spectroscopy in Children and Adolescents With Bipolar Disorder
The primary aim of this study is to use proton magnetic resonance spectroscopy to look at myo-Inositol containing compounds (Ino) and creatine + phosphocreatine (Cr) in the anterior cingulate of 20 children with bipolar disorder…
- Trial name
- NCT00181831
- Testing
- Proton Magnetic Resonance Spectroscopy
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Multiple Sclerosis
Quantitative Imaging and Proton Spectroscopy in Multiple Sclerosis
The primary purpose of this study is to detect changes in the brain that may be associated with multiple sclerosis. Results will be compared to age matched controls.
- Trial name
- NCT01226654
- Testing
- Magnetic Resonance Imaging
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Gaucher
MR Spectroscopy and Disease Severity Score for Gaucher in Pediatric Population
The bone status in Gaucher disease is very difficult to monitor precisely in children. This is a major problem because lack of optimal treatment, especially enzyme replacement, may cause irreversible severe bone damage that will…
- Trial name
- MRS in Gaucher (NCT01397435)
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Prescription Pattern
Academic Detailing About Proton Pump Inhibitors
General practices in the Capital Region of Denmark are offered a short educational visit and are randomized to either proton pump inhibitor (intervention) or another topic (control).
- Trial name
- BRIEF-PI (NCT05443789)
- Testing
- Proton pump inhibitor education, Other education
- Where
- Denmark
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Jón Þór Trærup Andersen
Brain Tumor, Metastatic Brain Tumor
A Study of How Proton Beam Radiotherapy (PBRT) Affects Brain Function and Quality of Life in Children and Young Adults Undergoing Treatment for a Brain Tumor
The researchers are doing this study to find out if there are differences in the resting state brain networks of children and young adults (ages 6-25) after treatment with proton beam radiation therapy (PBRT).
- Trial name
- NCT05288439
- Testing
- Resting-state functional connectivity MRI, Neurocognitive battery with quality-of-life assessment
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Food Allergy
Integrated Approaches to Food Allergen and Allergy Risk Management
Patients with history of a food allergy to hazelnut, walnut or celeriac will undergo food provocation with a dose of the allergenic food to which 5% of the respective food allergic population (ED05) has been calculated to respond…
- Trial name
- iFAAM (NCT02295397)
- Testing
- food
- Where
- Switzerland
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Covid19
Rapid Diagnosis of COVID-19 by Chemical Analysis of Exhaled Air
Since the start of 2020, the new SARS-CoV-2 coronavirus is causing a real global health crisis. In France, nasopharyngeal swabs are used to obtain the sample needed for respiratory infection screening.
- Trial name
- COVIDAIR (NCT04706039)
- Testing
- Performance evaluation (sensitivity and specificity) for COVID-19 diagnosis of the Vocus PTR-TOF process
- Where
- France
- Volunteers
- 4,600 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
ADHD
Proton Magnetic Spectroscopy in Children and Adolescents With ADHD Before and After Treatment With OROS Methylphenidate
This will be an open label study using daily does of up to 126mg/day of Concerta in the treatment of children and adolescents, ages 12-17, who meet DSM-IV criteria for ADHD.
- Trial name
- NCT00593112
- Testing
- OROS methylphenidate, No intervention
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
H Pylori
Comparison of Omeprazole vs Vonoprazon in Treatment of H Pylori Infection
Current studies have primarily focused on comparing the advantages and disadvantages of P-CAB and PPI drugs, with little comparison between different P-CAB drugs or between regimens with varying drug combinations and treatment…
- Trial name
- NCT07040839
- Testing
- Clarithromycin 500 mg, Amoxicillin 1 g, Omeprazole 40 mg
- Where
- Pakistan
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Rehman Medical Institute - RMI
Muskuloskeletal Diseases, Healthy
Proton MRI of MSK Disorders
In this research study, the investigators want to learn about new ways to use MRI (Magnetic Resonance Imaging) to take clearer pictures of the lungs.
- Conditions
- Muskuloskeletal Diseases, Healthy, Respiratory
- Trial name
- NCT07845708
- Testing
- MRI
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Laura Walkup
Primary Brain Tumor
Neurocognitive Function After Proton Therapy in Children and Adolescents
Brain tumors are the second most frequent malignant diseases in children and adolescents. In the study the short and medium term consequences of proton therapy on cognitive processes in particular on executive functions in…
- Trial name
- ELBE-ProKids (NCT04066465)
- Where
- 3 sites in Germany
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Technische Universität Dresden