Clinical trials: Puberty Disorders
Early Puberty
the Association Between Obesity and Early Puberty
childhood obesity and early puberty are closely related, but existing reports usually focus on their relationship from the perspective of phenotype.
- Trial name
- NCT04317014
- Volunteers
- 628 people, healthy volunteers welcome
- Sponsor
- Shenzhen Center for Disease Control and Prevention
Puberty, Hyperandrogenism
Acute Progesterone Suppression of Wake vs. Sleep Luteinizing Hormone Pulse Frequency in Pubertal Girls With and Without Hyperandrogenism
The purpose of this study is two-fold. (1) We will determine if in mid- to late pubertal girls without hyperandrogenism (HA), progesterone (P4) acutely reduces waking luteinizing hormone (LH) frequency to a greater extent than…
- Trial name
- CRM003 (NCT00929006)
- Testing
- Micronized progesterone suspension
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Puberty, Precocious, McCune-Albright Syndrome
Faslodex in McCune-Albright Syndrome
The purpose of this study is to evaluate the safety, effectiveness and pharmacokinetics of a study drug called Faslodex (fulvestrant) in the treatment of progressive precocious puberty (PPP) (early puberty) in girls with…
- Trial name
- FMAS (NCT00278915)
- Testing
- Fulvestrant
- Where
- 16 sites in United States, France and 4 more
- Volunteers
- 30 people
- Sponsor
- AstraZeneca
Puberty and Body Composition
Association Between Soy Based Formula in Infancy and Puberty
Background: Children in industrialized and developing countries have a higher tendency to present earlier signs of puberty. One hypothesis includes the hormonal effects of phytoestrogens found in soy products.
- Trial name
- NCT02908971
- Testing
- soy based formula at infancy
- Where
- Israel
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Assaf-Harofeh Medical Center
Varicocele, Scrotal Disorder
Testicular Growth During Puberty in Boys With and Without a Left-sided Varicocele
Prospective observational study. A varicocele is defined as a dilatation of the veins in the plexus pampiniformis in the testicles. Varicoceles are a diagnostic dilemma and a therapeutic challenge.
- Trial name
- NCT03540056
- Testing
- Ultrasound
- Where
- Belgium
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Universiteit Antwerpen
Hypogonadism, Precocious Puberty
Study of Gonadotropin-Releasing Hormone Pulse Frequency in Sexual Maturation and in the Menstrual Cycle
OBJECTIVES: I. Evaluate the sleep-entrained patterns of gonadotropin-releasing hormone (GnRH) and sex steroid secretion in normal and hypogonadal children. II.
- Trial name
- NCT00004335
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Center for Research Resources (NCRR)
Precocious Puberty, Treatment
A Trial of Chinese Traditional Medicine Combining With Intradermal Acupuncture for Treating Precocious Puberty
A randomized controlled study will be conducted to evaluate the therapeutic effect of traditional Chinese medicine and acupoints stimulation on children with idiopathic precocious puberty.
- Conditions
- Precocious Puberty, Treatment, Alternative Medicine, Acupuncture
- Trial name
- NCT06510764
- Testing
- intradermal needles, Ziyinxiehuo Granules of traditional Chinese Medicine
- Where
- 2 sites in China
- Volunteers
- 170 people
- Sponsor
- Children's Hospital of Fudan University
Overweight/Obesity, Puberty
Improving Health Among Disadvantaged Girls to Slow Pubertal Onset and Reduce Long-term Health Risks
This study is testing whether improving health in girls during the prepubertal period may slow the onset of puberty. This study will focus on prepubertal girls who have a high weight status (at or above the 85th percentile for…
- Conditions
- Overweight/Obesity, Puberty, Health Behavior, Cardiometabolic Health
- Trial name
- NCT07460544
- Testing
- Family-Based Treatment (FBT)
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- University of Washington
Hyperandrogenism
Sleep-wake Changes of Luteinizing Hormone Frequency in Pubertal Girls With and Without High Testosterone
The purpose of this study is to determine whether sleep-wake changes of luteinizing hormone pulse frequency are different in early pubertal girls with high testosterone levels compared to early pubertal girls with normal…
- Trial name
- CRM005 (NCT00930007)
- Testing
- Blood sampling
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Central Precocious Puberty (CPP)
Idiopathic Central Precocious Puberty and Associated Neurodevelopmental Syndromes and Pathologies: Evaluation of Frequency and Comparison of Diagnostic and Developmental Characteristics
Observational, retrosopective, single-centre, non-profit study focused on the frequency of Central Precocious Puberty idiopathic, or associated to Neurodevelopmental Syndromes and Pathologies, and comparison of diagnostic and…
- Trial name
- NCT06720844
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Obesity, Insulin Resistance
The Health Influences of Puberty (HIP) Study
The Health Influences of Puberty (HIP) Study is designed to explore the relationships between puberty and the onset of type 2 diabetes in adolescents.
- Conditions
- Obesity, Insulin Resistance, Gonadal Dysfunction, Type 2 Diabetes
- Trial name
- HIP (NCT01775813)
- Testing
- Metformin
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- University of Colorado, Denver
Dermatologic Disease, Epidermolysis Bullosa
The State of Sexual Development in Children With Inherited Epidermolysis Bullosa
The aim of the study is to determine the state of sexual development in patients with inherited epidermolysis bullosa; the study is planned to include boys and girls aged 8 to 18 years with a diagnosis of epidermolysis bullosa…
- Conditions
- Dermatologic Disease, Epidermolysis Bullosa, Epidermolysis Bullosa Simplex, Epidermolysis Bullosa Dystrophica
- Trial name
- NCT05033574
- Testing
- Biochemical study of hormone levels, Ultrasound examination, Radiography of the hands
- Where
- Russia
- Volunteers
- 50 people
- Sponsor
- National Medical Research Center for Children's Health, Russian Federation
Thalassemia Intermedia, Thalassemia Major
Growth Evaluation, Health Promotion, and Clinical Management in Children and Adolescents With Thalassemia
There are nearly 300,000 patients with severe or intermediate thalassemia in China. Growth retardation is the most significant health issue for children and adolescents with transfusion-dependent thalassemia (TDT), placing a…
- Conditions
- Thalassemia Intermedia, Thalassemia Major, Growth Delay, Puberty, Delayed
- Trial name
- NCT06931912
- Testing
- MENBS clinical interventions
- Where
- China
- Volunteers
- 385 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
Acne Vulgaris, Gingivitis
Association of Acne Vulgaris With Oral Hygiene and Gingivitis
The goal of this observational study is to learn about in the relationship between acne vulgaris and oral hygiene and gingivitis.
- Conditions
- Acne Vulgaris, Gingivitis, Dental Plaque, Oral Hygiene
- Trial name
- NCT06237387
- Testing
- Periodontal examination
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Erzincan University
Anorexia Nervosa, Interruption of Growth
Severe Decrease of Growth Velocity in Children With Anorexia Nervosa.Therapeutic Trial of Growth Hormone
Anorexia nervosa may be responsible for a catch- down or even an interruption of growth, delayed puberty and osteopenia with failure of acquisition of bone mass.
- Conditions
- Anorexia Nervosa, Interruption of Growth, Delayed Puberty, Osteopenia With Failure of Acquisition of Bone Mass
- Trial name
- OREX (NCT01626833)
- Testing
- SOMATROPINE* : Norditropine® simplexx®
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Central Precocious Puberty
Histrelin Subcutaneous Implant in Children With Central Precocious Puberty
The purpose of this study is to follow and collect additional medical and developmental information on children after histrelin subcutaneous implant therapy is discontinued.
- Trial name
- NCT00779103
- Testing
- Histrelin Subcutaneous Implant
- Volunteers
- 36 people
- Sponsor
- Endo USA Inc., a Keenova Therapeutics Company
Type 1 Diabetes, Puberty: >Tanner 2 Breast Development or Testis >4ml
Rosiglitazone and Insulin in T1DM Adolescents
Type 1 Diabetes is the most common life-long disorder with onset in childhood. Patients need insulin injections, blood sugar monitoring several times each day, and adhere to a strict diet.
- Trial name
- NCT00372086
- Testing
- Rosiglitazone
- Where
- Australia
- Volunteers
- 32 people
- Sponsor
- The University of New South Wales
Pubertal Delay, Hypogonadism, Hypogonadotropic
Triptorelin for Early Diagnosis of Hypogonadotrophic Hypogonadism
The goal of this clinical trial is to learn if Triptorelin test works to early diagnose hypogonadotrophic hypogonadism in adolescents.
- Conditions
- Pubertal Delay, Hypogonadism, Hypogonadotropic, Constitutional Delay in Growth and Puberty (CDGP)
- Trial name
- NCT06691815
- Testing
- Triptorelin (GnRH agonists)
- Where
- Argentina
- Volunteers
- 48 people
- Sponsor
- Hospital de Niños R. Gutierrez de Buenos Aires
Transgenderism, Insulin Sensitivity/Resistance
Puberty Suppression and Cardiometabolic Health
This observational study will evaluate the effect of puberty suppression on insulin sensitivity, metabolic rate and vascular health among transgender female youth at baseline and 6 months after initiation of a gondoatropin…
- Conditions
- Transgenderism, Insulin Sensitivity/Resistance, Endothelial Dysfunction, Vascular Stiffness
- Trial name
- NCT04482374
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Colorado, Denver
Central Precocious Puberty
A Study to Assess the Efficacy, Safety, and Pharmacokinetics of Debio 4326 in Pediatric Participants With Central Precocious Puberty (LIBELULA™ Clinical Trial)
The primary objective of this study is to evaluate the efficacy of Debio 4326 in suppressing serum luteinizing hormone (LH) to prepubertal levels 52 weeks after the first Debio 4326 injection in pediatric participants with…
- Trial name
- NCT06129539
- Testing
- Debio 4326
- Where
- 17 sites in United States, Argentina and 3 more
- Volunteers
- 56 people
- Sponsor
- Debiopharm International SA