Clinical trials: Pulmonary Disorder
COVID-19
Relationship Between CT- Value With Prognosis in COVID-19 Patients
evaluate the relationship between cycle threshold number with final prognosis in COVID-19 patients
- Trial name
- NCT04902157
- Testing
- Cycle threshold
- Where
- 2 sites in Iran
- Volunteers
- 60 people
- Sponsor
- Shahid Beheshti University of Medical Sciences
Pulmonary Arterial Hypertension
Study to Evaluate Sotatercept (MK-7962) in Children With Pulmonary Arterial Hypertension (PAH) (MK-7962-008)
The primary objectives of the study are to evaluate the safety and tolerability, and pharmacokinetics (PK) of sotatercept over 24 weeks of treatment in children ≥1 to <18 years of age with PAH World Health Organization (WHO)…
- Trial name
- MOONBEAM (NCT05587712)
- Testing
- Sotatercept
- Where
- 35 sites in United States, Australia and 10 more
- Volunteers
- 42 people
- Sponsor
- Merck Sharp & Dohme LLC
COVID-19 Respiratory Infection, SARS-CoV-2 Infection
Benefit of Expanded Surveillance of Nursing Homes During the COVID-19 Pandemic
Residents in nursing homes for the senior citizens (NH) are at high risk for death from COVID-19. We investigated whether repeated non-mandatory RT-PCR SARS-CoV-2 surveillance of NH staff and visitors reduces COVID-19 incidence…
- Trial name
- NCT04933981
- Testing
- Nasopharyngeal swab for SARS-CoV-2
- Where
- Germany
- Volunteers
- 1,587 people, healthy volunteers welcome
- Sponsor
- University of Cologne
COPD, Pulmonary Hypertension
Prevalence of Pulmonary Hypertension in COPD Patients
The prevalence of an increased pulmonary blood pressure amongst patients with chronic obstructive pulmonary disease (COPD)is unclear. So is the impact of abnormal pulmonary blood pressure on symptoms.
- Trial name
- NCT00614900
- Where
- Denmark
- Volunteers
- 117 people
- Sponsor
- University of Aarhus
Cystic Fibrosis
A Study Evaluating the Efficacy and Safety of VX-445/Tezacaftor/Ivacaftor in Cystic Fibrosis Subjects, Homozygous for F508del
This study will evaluate the efficacy, safety, and pharmacodynamics of elexacaftor (ELX, VX-445) in triple combination (TC) with tezacaftor (TEZ) and ivacaftor (IVA) in subjects with cystic fibrosis (CF) who are homozygous for…
- Trial name
- NCT04105972
- Testing
- ELX/TEZ/IVA, TEZ/IVA, IVA
- Where
- 35 sites in Australia, Belgium and 2 more
- Volunteers
- 176 people
- Sponsor
- Vertex Pharmaceuticals Incorporated
Asthma, Medical Informatics
A Reminder System for Paper-Based Asthma Guidelines in the Pediatric Emergency Department
The primary idea is that the use of a computerized reminder system to help with the guideline implementation will increase utilization and adherence of guideline-driven care, leading to improved patient outcomes.
- Trial name
- NCT00699439
- Testing
- Paper-based asthma flow diagram
- Where
- United States
- Volunteers
- 1,102 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Asthma
Phosphodiesterase 4 Gene Variant and Salbutamol Response in Persistent Childhood Asthma
This study is designed to investigate whether the Phosphodiesterase 4 gene variability could be implicated in the salbutamol responsiveness in asthmatic children.
- Trial name
- PEGASE2 (NCT03592212)
- Testing
- Salbutamol
- Where
- France
- Volunteers
- 99 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pneumonia, Hematopoietic Stem Cell Transplantation
Mesenchymal Stem Cells for the Treatment of Pneumonia Post Haematopoietic Stem Cell Transplantation
The aim of this study is to determine whether mesenchymal stromal cell (MSC) treatment contribute to the good prognosis in patients with transplant-related complication, pneumonia post hematopoietic stem cell transplantation…
- Trial name
- MSCTPHSCT (NCT05131412)
- Where
- China
- Volunteers
- 107 people
- Sponsor
- Guangzhou Women and Children's Medical Center
Bronchiolitis
Nasal Irrigation in Infants With Bronchiolitis.
Bronchiolitis is a leading cause of acute illness and hospitalization in the first year of life. Most children with bronchiolitis have mild disease and are managed at home with support from primary care providers, while children…
- Trial name
- NCT02162745
- Testing
- Isotonic solution (NaCl 0.9%), Hypertonic solution (NaCl 3%)
- Where
- 2 sites in Italy
- Volunteers
- 133 people
- Sponsor
- IRCCS Burlo Garofolo
Prematurity, Respiratory Distress Syndrome
Curosurf and Survanta Treatment(CAST)of RDS in Very Premature Infants
Approval of surfactant by the FDA in 1989 for the treatment of Respiratory Distress Syndrome (RDS) in premature infants greatly improved survival rates.
- Conditions
- Prematurity, Respiratory Distress Syndrome, Patent Ductus Arteriosus
- Trial name
- CAST (NCT00767039)
- Testing
- Survanta (beractant), Curosurf (poractant)
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Alan Fujii
Asthma
Management of Asthma Patients Guided by Exhaled Nitric Oxide (eNO)
This study is designed to show that pharmacotherapy guided by eNO and clinical standard of care produces a superior outcome to trial-based therapy guided by clinical standard of care alone.
- Trial name
- Outcomes (NCT00739219)
- Testing
- Apieron Insight eNO monitor
- Where
- 12 sites in United States
- Volunteers
- 260 people
- Sponsor
- Apieron
COVID-19-Associated Encephalitis, Long COVID
Longterm Influence of Pediatric Long COVID Syndrome
We enroll pediatric patients who were diagnosed COVID-19 for main observation target. We will perform brain MRI and neuropsychiatric evaluation 4-6 months after COVID-19 diagnosed.
- Trial name
- NCT05566392
- Testing
- Brain MRI
- Where
- Taiwan
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Asthma
Magnesium Trial in Acute Asthma in Emergency Department
Despite optimal initial emergency department (ED) therapy, 50% of children with severe acute asthma have ongoing moderate-severe respiratory distress.
- Trial name
- MAGICIAN (NCT06785272)
- Testing
- magnesium sulfate, Normal Saline
- Where
- 6 sites in Canada
- Volunteers
- 192 people
- Sponsor
- Suzanne Schuh
Cystic Fibrosis
Cystic Fibrosis- Children and Adults Tai Chi Study
Cystic fibrosis (CF) is a progressive disease. Symptoms include coughing, poor lung ventilation, recurrent infections, poor weight gain, diarrhoea, malnutrition, stress, frustration, depression, irritability, worry, insomnia…
- Trial name
- CFCATS2 (NCT02054377)
- Testing
- Tai chi
- Where
- United Kingdom
- Volunteers
- 51 people
- Sponsor
- London South Bank University
Obesity
Postural Changes in Lung Volumes in Obesity
Postural changes are known to affect normal lung volumes. A reduction in sitting to supine functional residual capacity (FRC) is well-described in non-obese subjects adopting a supine position.
- Trial name
- NCT02207192
- Testing
- Postural change in lung volumes: sitting to Supine
- Where
- France
- Volunteers
- 12 people
- Sponsor
- Association pour la Formation du Personnel à la Medecine d'Urgence
COVID-19
Study to Evaluate the Safety and Antiviral Activity of Remdesivir (GS-5734™) in Participants With Severe Coronavirus Disease (COVID-19)
The primary objective of this study is to evaluate the efficacy of 2 remdesivir (RDV) regimens with respect to clinical status assessed by a 7-point ordinal scale on Day 14.
- Trial name
- NCT04292899
- Testing
- Remdesivir, Standard of Care
- Where
- 183 sites in United States, China and 13 more
- Volunteers
- 4,891 people
- Sponsor
- Gilead Sciences
Respiratory Syncytial Virus Infection, Bronchiolitis
Gut Microbiome and Immune Response in Severe RSV Infection in Vietnamese Infants
Respiratory syncytial virus (RSV) is a leading cause of severe lower respiratory tract infection in young children, and a substantial proportion of severe cases occur in previously healthy infants.
- Conditions
- Respiratory Syncytial Virus Infection, Bronchiolitis, Viral Lower Respiratory Tract Infection (LRTI)
- Trial name
- GUT-LUNG RSV (NCT07417657)
- Where
- Vietnam
- Volunteers
- 250 people
- Sponsor
- Phuc Huu Phan
Asthma
Pulmicort Respules on Relapse Rates After Treatment in the ED
The purpose of this study is to see if the addition of budesonide to oral corticosteroids will result in a decrease in relapse rates compared to oral corticosteroids alone in children who are discharged from the ED after an…
- Trial name
- Budesonide (NCT00584636)
- Testing
- pulmicort respules
- Where
- United States
- Sponsor
- Phoenix Children's Hospital
Sickle Cell Anemia, Sickle Cell Disease
Heart Arteries and Sickle Cell Disease / Coeur Artères DREpanocytose
The CADRE study is a multinational observational cohort of patients with sickle-cell disease (SCD) in five west and central sub-Saharan African countries.
- Trial name
- CADRE (NCT03114137)
- Where
- 13 sites in Cameroon, Côte d’Ivoire and 4 more
- Volunteers
- 4,500 people, healthy volunteers welcome
- Sponsor
- Cardiologie et Développement
Covid19, Convalescence
Convalescent Plasma Therapy in Severe COVID-19 Infection
As of March 18, 2020, COVID-19 cases were reported in approximately 195 countries. No specific therapeutic agents or vaccines for COVID-19 are available.
- Trial name
- NCT04403477
- Testing
- Convalescent plasma
- Where
- Bangladesh
- Volunteers
- 20 people
- Sponsor
- Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.