Clinical trials: Puncture
Conscious Sedation, Simple Lacerations Less Than 4 cm
A Comparison of Intranasal Midazolam and Nitrous Oxide (N2O) Minimal Sedation for Minor Procedures in a Pediatric Emergency Department
The objective of this project is to compare the sedative effects of intranasal midazolam versus inhaled nitrous oxide (N2O) for minor procedures in the pediatric emergency department.
- Conditions
- Conscious Sedation, Simple Lacerations Less Than 4 cm, Lumbar Punctures, Minor Incision Drainage of Abscesses Not Requiring Extensive Debridement
- Trial name
- NCT03085563
- Testing
- Nitrous Oxide, Midazolam
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- University of Colorado, Denver
Traumatic Lumbar Puncture
The Effect of Bedside Ultrasound Assistance on the Proportion of Successful Infant Spinal Taps
The reported rate of unsuccessful spinal taps in children, especially young infants, is high. Our hypothesis is that ultrasound assistance can improve the success rate of spinal taps.
- Trial name
- NCT02133066
- Testing
- Bedside Ultrasound-Assisted Site Marking, Mindray M7 Ultrasound, Routine lumbar puncture
- Where
- United States
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Leukemia, Lymphoid Malignancies
Intrathecal Rituximab in Lymphoid Malignancies Involving Central Nervous System
The goal of this clinical research study is to learn about the safety and effectiveness of rituximab given by spinal tap in patients with lymphoid malignancies involving the central nervous system.
- Conditions
- Leukemia, Lymphoid Malignancies, Metastatic Malignant Neoplasm to the Leptomeninges
- Trial name
- NCT01596127
- Testing
- Intrathecal Rituximab
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- M.D. Anderson Cancer Center
Pain
Needle-Free Jet Injection of Lidocaine During Lumbar Puncture
Background: The J-Tip Device allows an intradermal needle-free jet injection of 1% buffered lidocaine. This study compares needle-free jet injection of lidocaine to saline in reducing pain prior to lumbar puncture in infants.
- Trial name
- NCT01224431
- Testing
- Buffered Lidocaine J-tip
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Phoenix Children's Hospital
Postdural Puncture Headache
Therapeutic Epidural Patch Versus Pain Block in the Midface for Headache
The purpose of this study is to compare a pain block in the midface, versus the traditional, more invasive, therapeutic epidural patch for the treatment of headaches
- Trial name
- NCT03112720
- Testing
- Epidural Blood Patch, Sphenopalatine Ganglion Block
- Where
- 2 sites in United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Accidental Puncture of Artery During Catheter Insertion
Ultrasound Guided Technique for Internal Jugular Central Venous Catheterization in Pediatric Cardiac Surgical Patients
The purpose of the study is to evaluate the success rate using ultrasound as guidance during central venous cannulation in pediatric cardiac surgical patients.
- Trial name
- NCT02687126
- Testing
- Central Venous Catheterization
- Where
- Nepal
- Volunteers
- 106 people
- Sponsor
- Shahid Gangalal National Heart Centre
Lumbar Puncture, Topical Analgesia
Jet Injection of 1% Buffered Lidocaine Versus Topical EMLA for Local Anesthesia Before Lumbar Puncture in Children
The purpose of this study is to evaluate the effectiveness of a needle-free jet-injection system with 1% buffered lidocaine for local anesthesia for lumbar punctures compared to a topical anesthetic agent.
- Trial name
- JTIP (NCT01628874)
- Testing
- J-Tip, EMLA, Lidocaine
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Spinal; Puncture, Complications
Ultrasound vs Palpation for Infant Lumbar Puncture
The purpose of this study is to determine if performing an ultrasound to identify the space to insert the needle before performing a lumbar puncture will improve success of the procedure and patient safety.
- Trial name
- NCT02373774
- Testing
- Ultrasound
- Where
- United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Columbia University
Pain
"Lidocaine 4% Cream (LMX4) vs Placebo for Pain Due to Lumbar Puncture in Infants 0-60 Days of Age."
The study's hypothesis is LMX4 cream, a topical anesthetic cream, will reduce the pain of infants undergoing Lumbar Puncture (spinal tap).
- Trial name
- NCT00533468
- Testing
- Lidocaine Cream 4%
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- State University of New York at Buffalo
Lumbar Puncture
The First Puncture Success Rate of a Novel Injeq IQ-Tip™ System in Pediatric Lumbar Punctures
The investigation aims to demonstrate the first puncture success rate, as proxy of clinical benefit and clinical performance, of bioimpedance spectroscopy based spinal needle guidance method among pediatric hemato-oncology…
- Trial name
- IQ-LP-03 (NCT04070144)
- Testing
- IQ-Tip(tm) system
- Where
- 3 sites in Finland
- Volunteers
- 50 people
- Sponsor
- Injeq Ltd
Malignant Neoplasm
Local Anesthetic Cream in Younger Patients Undergoing Lumbar Punctures
This randomized clinical trial studies local anesthetic (EMLA) cream in younger patients undergoing lumbar punctures (LP). A local anesthetic cream may be effective for numbing the skin and reducing movement when applied prior to…
- Trial name
- NCT01516684
- Testing
- EMLA, propofol, fentanyl citrate
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Wake Forest University Health Sciences
Hunter Syndrome
Collection and Study of Cerebrospinal Fluid in Patients With Hunter Syndrome
The purpose of the study is to collect data on CSF biomarkers in patients with Hunter Syndrome that would serve as reference data for comparison with cognitively impaired patients with Hunter syndrome, patients with other…
- Trial name
- NCT01449240
- Testing
- No treatment
- Where
- 7 sites in United States, United Kingdom
- Volunteers
- 10 people
- Sponsor
- Shire
Spinal Puncture
Co-administration of Propofol and Remifentanil for Lumbar Puncture in Children
The objective of this study is to compare intraoperative and recovery parameters in patients who receive two different dose combinations of propofol and remifentanil in patients undergoing a lumbar puncture.
- Trial name
- NCT00405522
- Testing
- Propofol 2.0 mg/kg + Remifentanil 1.5 ug/kg, Propofol 4.0 mg/kg + Remifentanil 0.5 ug/kg
- Where
- Canada
- Volunteers
- 34 people
- Sponsor
- The Hospital for Sick Children
Lumbar Puncture
Ultrasound Assisted Lumbar Puncture in the Neonate
Clinicians are often unable to successfully do a spinal tap. Ultrasound has been proposed as a method to improve success but it is not known if it helps. This study is designed to see if ultrasound improves the success rate.
- Trial name
- NCT02918149
- Testing
- Palpation Landmark Technique, Ultrasound-Assisted Technique LP
- Where
- United States
- Volunteers
- 91 people
- Sponsor
- Children's Hospital of Philadelphia
Hematologic Diseases, Neoplasms
A Dose Finding Study of Remifentanil and Propofol for Lumbar Punctures in Children
This study will examine whether the combination of two anaesthetic medications, propofol and remifentanil, is suitable for short duration surgical procedures, providing a shorter recovery time and fewer side effects than either…
- Trial name
- NCT00213239
- Testing
- Remifentanil
- Where
- Canada
- Volunteers
- 64 people
- Sponsor
- The Hospital for Sick Children
Immune System Diseases
Determination of the Sensitivity and Specificity of Prick Test Betula Verrucosa
The main objective is to evaluate the concentration of allergen extract of Betula verrucosa that elicit a papule equivalent to that produced by a solution of histamine dihydrochloride 10 mg / ml in size.
- Trial name
- T502 (NCT02527187)
- Testing
- 10 HEP/mL Betula verrucosa allergen extract, 25 HEP/mL Betula verrucosa allergen extract, 50 HEP/mL Betula verrucosa allergen extract
- Where
- Spain
- Volunteers
- 201 people
- Sponsor
- Inmunotek S.L.
Leukemia-Lymphoma
Pain Control in Pediatric Oncology: Utility of EMLA Cream vs Lidocaine Injection in Lumbar Punctures
A common procedure in children with cancer is the spinal tap, or lumbar puncture (LP), in which a needle is inserted into the spinal canal.
- Trial name
- NCT04003012
- Testing
- EMLA, Lidocaine
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- CAMC Health System
Infant, Newborn, Infant, Premature
Effect of a Vibratory Stimulus on Mitigating Nociception-specific Responses to Skin Puncture in Neonates
The assessment and treatment of pain in neonates remains a challenge. In an effort to improve the quality of care while limiting opioid-related adverse effects, this study aims to determine the efficacy of a non-pharmacological…
- Conditions
- Infant, Newborn, Infant, Premature, Pain Perception, Pain Measurement
- Trial name
- NCT04050384
- Testing
- Baby GentleStick
- Where
- United States
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- Lance M Relland, MD, PhD
Meningitis
Lumbar Punctures in Neonates: Improving Success Rates and Minimizing Pain
The purpose of this study is to compare two medications used to numb an infant's back when performing a lumbar puncture. A lumbar puncture (LP) is often needed in newborns to obtain cerebrospinal fluid (CSF).
- Trial name
- NCT01606150
- Testing
- 1% lidocaine, topical lidocaine
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Georgetown University