Clinical trials: Pyloric Stenosis
Infantile Hypertrophic Pyloric Stenosis, Pyloromyotomy
Per-oral Pyloromyotomy for Treating Infantile Hypertrophic Pyloric Stenosis
Infantile hypertrophic pyloric stenosis (IHPS) is the most common condition for surgical treatment in infant. Traditionally, laparoscopic or open pyloromyotomy are the standard treatments.
- Trial name
- NCT04148040
- Testing
- G-POEM
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Shanghai Zhongshan Hospital
Anaplastic Astrocytoma, Anaplastic Ependymoma
SJDAWN: St. Jude Children's Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies for Children and Young Adults With Recurrent Brain Tumors
Approximately 90% of children with malignant brain tumors that have recurred or relapsed after receiving conventional therapy will die of disease.
- Conditions
- Anaplastic Astrocytoma, Anaplastic Ependymoma, Anaplastic Ganglioglioma, Anaplastic Meningioma
- Trial name
- NCT03434262
- Testing
- Gemcitabine, ribociclib, sonidegib
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- St. Jude Children's Research Hospital
Cancer
Multiple Ascending Dose of BMS-911543
The purpose of this first in human study is to determine if BMS-911543 is safe and tolerable in subjects with symptomatic intermediate-1, intermediate-2 or high risk myelofibrosis to permit clinical testing at the Maximum…
- Trial name
- NCT01236352
- Testing
- BMS-911543
- Where
- 5 sites in United States, Australia
- Volunteers
- 98 people
- Sponsor
- Bristol-Myers Squibb
CNS Embryonal Tumor, CNS, Medulloblastoma
Pilot Study of IT Topotecan and Maintenance Chemotherapy for HR-EBTs in Children < 6 Years, Post Consolidation
Pilot study to determine feasibility of adding intrathecal chemotherapy and maintenance therapy after high dose chemotherapy for treatment of newly diagnosed HR-EBTs in patients less than 6 years of age.
- Conditions
- CNS Embryonal Tumor, CNS, Medulloblastoma, Atypical Teratoid Rhabdoid Tumor, Medulloblastoma, Childhood
- Trial name
- NCT06942039
- Testing
- Cytarabine IT, hydrocortisone, Cisplatin
- Where
- 13 sites in Canada
- Volunteers
- 15 people
- Sponsor
- C17 Council
Healthy, Hypertrophic Pyloric Stenosis
The Effect of Hypertrophic Pyloric Stenosis (HPS) on Sodium Intake in Childhood
The loss of sodium during infancy causes long term changes in sodium intake. Human research shows that the loss of maternal sodium during pregnancy and neonatal after birth causes an increase sodium intake during childhood.
- Trial name
- NCT01159509
- Testing
- sodium taste tests
- Volunteers
- 40 people
- Sponsor
- Sheba Medical Center
Pyloric Stenosis
Institutional Audit of the Use of Intravenous Acetaminophen in Infants Undergoing Pyloromyotomy
This is a retrospective chart review. The objective of the current study is to determine the analgesic efficacy and side effect profile of intravenous acetaminophen when administered to infants undergoing pyloromyotomy.
- Trial name
- NCT02359305
- Testing
- Acetaminophen
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- Arlyne Thung
Early T Acute Lymphoblastic Leukemia, T-Acute Lymphoblastic Leukemia
Venetoclax + Azacytidine for Newly Diagnosed ETP-like ALL and T-ALL With Myeloid Mutations
The goal of this clinical trial is to evaluate the efficacy and safety of venetoclax combined with azacitidine in treating newly diagnosed early T-cell precursor (ETP)-like acute lymphoblastic leukemia (ALL), T-ALL with myeloid…
- Conditions
- Early T Acute Lymphoblastic Leukemia, T-Acute Lymphoblastic Leukemia, Mixed Phenotype Acute Leukemia, T/Myeloid, Nos
- Trial name
- NCT07012447
- Testing
- Venetoclax, Azacitidine, Cytarabine
- Where
- China
- Volunteers
- 32 people
- Sponsor
- yuejun Liu
Glioblastoma Multiforme, Anaplastic Astrocytoma
INCB7839 in Treating Children With Recurrent/Progressive High-Grade Gliomas
This is a multicenter phase 1 trial of INCB7839 for children with recurrent or progressive high-grade gliomas, including, but not limited to, diffuse intrinsic pontine glioma (DIPG) and other diffuse midline gliomas (DMGs), after…
- Conditions
- Glioblastoma Multiforme, Anaplastic Astrocytoma, Anaplastic Oligodendroglioma, DIPG
- Trial name
- NCT04295759
- Testing
- INCB7839
- Where
- 11 sites in United States
- Volunteers
- 13 people
- Sponsor
- Pediatric Brain Tumor Consortium
Emesis
Different Feeding Methods After Pyloromyotomy
The objective of this study is to scientifically evaluate the ability to discharge patients based on feeding schedule comparing ad lib feeds to our current scheduled regimen.
- Trial name
- NCT01509417
- Testing
- ad lib feedings after pyloromyotomy, FLAP diet after pyloromyotomy
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Children's Mercy Hospital Kansas City
Hypertrophic Pyloric Stenosis, Spinal Anesthesia
Spinal Anesthesia and General Anesthesia for Pyloromyotomy - Surgical Outcomes a Comparison Retrospective Study
Background: The purpose of this retrospective study is to evaluate surgical outcomes of pyloromyotomy in infants performed under spinal anesthesia compares to general anesthesia.
- Conditions
- Hypertrophic Pyloric Stenosis, Spinal Anesthesia, General Anesthesia
- Trial name
- NCT03095144
- Testing
- Spinal anesthesia, General anesthesia
- Volunteers
- 100 people
- Sponsor
- Bnai Zion Medical Center
Intestinal Failure, Catheter-Related Bloodstream Infection (CRBSI) Nos
Catheter Salvage in Intestinal Failure Patients
This is an observational study evaluating a catheter salvage strategy in relation to catheter-related bloodstream infections in patients with chronic intestinal failure dependent on home parenteral support.
- Trial name
- NCT03222232
- Testing
- catheter salvage
- Where
- Denmark
- Volunteers
- 715 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Hypertrophic Pyloric Stenosis
Laparoscopic Versus Open Pyloromyotomy for Infants With Idiopathic Hypertrophic Pyloric Stenosis
Pyloric stenosis is a condition that develops in infants and that leads to an obstruction of the channel going out of the stomach.
- Trial name
- NCT00195949
- Testing
- Laparoscopic pyloromyotomy
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Children's Mercy Hospital Kansas City
Gastric Outlet Obstruction
Gastric Outlet Obstructions Tailored Covered Stents for GOO
gastric outlet obstruction tailored versus standard stents for malignant gastric outlet obstruction treatments
- Trial name
- NCT02299258
- Testing
- Standard stents MTN-CG-s-20/100, Tailored stents MTN-WE-20/100-A
- Where
- China
- Volunteers
- 63 people
- Sponsor
- The First People's Hospital of Yuhang District
Pyloric Stenosis
Open vs Laparoscopic Pyloromyotomy for Pyloric Stenosis
Comparison of open and laparoscopic pyloromyotomy
- Trial name
- NCT00144924
- Testing
- laparoscopy pyloromyotomy, open pyloromytomy
- Where
- United Kingdom
- Volunteers
- 180 people
- Sponsor
- Institute of Child Health
Achalasia, Gastric Outlet Obstruction
Endoscopic Surgery for Gastrointestinal Disorders: A Multicenter Registry Study
Currently, there is limited multi-center data on endoscopic surgery outcomes in western populations. Evaluation of these measurement would help the investigators compare them to conventional treatment modalities within current…
- Conditions
- Achalasia, Gastric Outlet Obstruction, Gastroparesis, GERD
- Trial name
- NCT05041608
- Testing
- Endoscopic Surgery
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- Advanced Endoscopy Research, Robert Wood Johnson Medical School Rutgers University
Diffuse Large B Cell Lymphoma (DLBCL), Transformed Indolent B-Cell Non-Hodgkin Lymphoma to Diffuse Large B-Cell Lymphoma
Axatilimab + CAR-T for High-Risk Lymphoma
Axatilimab + CAR-T in High-Risk Lymphoma
- Conditions
- Diffuse Large B Cell Lymphoma (DLBCL), Transformed Indolent B-Cell Non-Hodgkin Lymphoma to Diffuse Large B-Cell Lymphoma, High-grade B-cell Lymphoma (HGBCL), High-Grade B-Cell Lymphoma, Nos
- Trial name
- NCT07638982
- Testing
- Axatilimab
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Northside Hospital, Inc.
Embryonal Tumor With Multilayered Rosettes, Embryonal Tumor With Multilayered Rosettes, Nos
Embryonal Tumor With Multilayered Rosettes
This is an open-label, comprehensive, iterative investigation of evaluating the use of induction chemotherapy, high-dose chemotherapy, and focal radiation therapy in children with newly diagnosed Embryonal Tumor With Multilayered…
- Trial name
- PNOC031 (NCT06861244)
- Testing
- Radiotherapy (RT), Chemotherapy Drug, Cancer - Physician's Choice, Non-Investigational Surgical Resection
- Where
- 8 sites in United States
- Volunteers
- 70 people
- Sponsor
- University of California, San Francisco
Postoperative Pain
Post-operative Outcomes in the Pyloromyotomy Procedure Under Spinal Anesthesia
Infantile hypertrophic pyloric stenosis (HPS) is one of the most common gastrointestinal medical emergencies.This retrospective study will review the files of all infants with HPS, who were treated by open pyloromyotomy under…
- Trial name
- NCT02879292
- Testing
- Spinal anesthesia
- Volunteers
- 92 people
- Sponsor
- Bnai Zion Medical Center
Hypertrophic Pyloric Stenosis, Respiratory Complication
Gastric Tube in Pyloric Stenosis
Pyloric stenosis is a current condition in pediatric surgery. The medical management prior to surgery consists of ionic correction.
- Trial name
- SONPYL (NCT05068622)
- Where
- France
- Volunteers
- 87 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Pyloric Stenosis
Post-Operative Impact of Nasogastric Tubes on Rates of Emesis in Infants Diagnosed With Pyloric Stenosis
The overall objective of this research study is to determine the effect of a pre-operatively placed nasogastric tube compared to no nasogastric tube, on post-operative emesis rates and postoperative length of stay in infants with…
- Trial name
- POINTS (NCT01139853)
- Testing
- Nasogastric Tube
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Hamilton Health Sciences Corporation