Clinical trials: RAD, open to volunteers
Sickle Cell Disease, Thalassemia
RADeep Multicenter European Epidemiological Platform for Patients Diagnosed With Rare Anemia Disorders (RADs)
Rare Anaemia Disorders (RADs) is a group of rare diseases characterized for presenting anaemia as the main clinical manifestation.
- Conditions
- Sickle Cell Disease, Thalassemia, Hemolytic; Anemia, Hereditary, Due to Enzyme Disorder, Anemia Due to Membrane Defect
- Trial name
- RADeep (NCT06213402)
- Testing
- Data collection from EHR.
- Where
- Spain
- Volunteers
- 32,564 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Chest X-ray for Clinical Evaluation
X-ray Assisted Diagnostic System
X-ray examination is one of the most commonly used imaging modalities, especially chest X-ray, which is routinely performed for hospitalized patients.
- Trial name
- NCT07497243
- Testing
- AI-assisted radiologist diagnostic group, Radiologist diagnostic group
- Where
- 4 sites in China
- Volunteers
- 16,000 people, healthy volunteers welcome
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Neonatal Pneumonia, Respiratory Distress Syndrome
Chest X-Ray Versus Lung Ultrasound in Neonatal Pneumonia
This prospective observational study aims to compare the diagnostic accuracy of chest X-ray versus lung ultrasound in the diagnosis of neonatal pneumonia among neonates admitted to the Neonatal Intensive Care Unit of Assiut…
- Conditions
- Neonatal Pneumonia, Respiratory Distress Syndrome, Pneumonia Neonatal
- Trial name
- NCT07807514
- Volunteers
- 100 people
- Sponsor
- Assiut University
Radiology, Internship and Residency
Measuring AI Reliance Among Intern Doctors in Palestine
This study aims to enroll intern doctors and have them sit one of three identical radiology exams. The only difference between them is an AI-assistant.
- Conditions
- Radiology, Internship and Residency, AI (Artificial Intelligence)
- Trial name
- AI-RP (NCT07558746)
- Testing
- AI prompt (Correct), AI prompt (Incorrect)
- Where
- Palestinian Territories
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- Al-Quds University
Radiation Dose Reduction
Multicenter Pediatric Low-Dose CT Protocol: Development and Clinical Verification
Children are sensitive to ionizing radiation, and there are significant regional variations in current pediatric CT radiation doses.
- Trial name
- NCT07199101
- Testing
- Low dose CT
- Where
- 20 sites in China
- Volunteers
- 2,650 people
- Sponsor
- Beijing Children's Hospital
Respiratory Distress Syndrome, Newborn, Neonatal Respiratory Distress
Chest Ultrasound as Diagnostic and Prognostic Tool in Neonatal RDS
This cross-sectional study aims to evaluate the diagnostic accuracy of chest ultrasound in neonatal respiratory distress syndrome and to assess its potential prognostic value compared with chest X-ray.
- Trial name
- NCT07857304
- Volunteers
- 82 people
- Sponsor
- Assiut University
Adult Pleomorphic Rhabdomyosarcoma, AJCC Grade 2 Sarcoma
Evaluation of Chest CT Versus Chest X-Ray for Lung Surveillance After Curative-Intent Resection of High-Risk Truncal-Extremity Soft Tissue Sarcoma
This phase III trial compares chest computed tomography (CT) to chest x-ray (CXR) for lung surveillance after curative-intent resection of high-risk truncal-extremity soft tissue sarcoma.
- Conditions
- Adult Pleomorphic Rhabdomyosarcoma, AJCC Grade 2 Sarcoma, AJCC Grade 3 Sarcoma, Alveolar Soft Part Sarcoma
- Trial name
- NCT06526897
- Testing
- Biopsy, Chest Computed Tomography, Chest Radiography
- Volunteers
- 1,582 people
- Sponsor
- ECOG-ACRIN Cancer Research Group
TB - Tuberculosis
Start Taking Action for Tuberculosis in Kids
Start4Kids: Evaluating the performance, feasibility, acceptability and cost effectiveness of computer-aided detection (CAD) of chest X-ray (CXR) and concurrent testing using novel diagnostics and non-sputum specimens for…
- Trial name
- Start4Kids (NCT07248423)
- Testing
- Xpert MTB/RIF Ultra, Truenat, MTB, Truenat MTB Plus
- Volunteers
- 7,920 people, healthy volunteers welcome
- Sponsor
- Liverpool School of Tropical Medicine
Cerebral Palsy
The BoDI (Bone Density Investigation) Study
Background: This study involves children with cerebral palsy, a lifelong condition caused by early damage to the developing brain.
- Trial name
- NCT06117124
- Testing
- Digital X-Ray Radiogrammetry, Quantitative Ultrasound (QUS)
- Volunteers
- 70 people
- Sponsor
- Sussex Community NHS Foundation Trust
Rectal Adenocarcinoma
Reporting of Tumour Deposits in Colorectal Cancer by Radiology and Pathology
Recent research shows that tumour deposits-small spots of cancer found near the main bowel tumour-may give doctors important information about how aggressive the cancer is and how likely it is to come back.
- Trial name
- RADAR (NCT07345273)
- Testing
- No Intervention: Observational Cohort
- Where
- 4 sites in United Kingdom
- Volunteers
- 225 people
- Sponsor
- Imperial College London
Inflammatory Bowel Disease, Crohn Disease
Skeletal Health and Bone Marrow Composition in Newly Diagnosed Adolescents With Crohn Disease
The investigators will be evaluating bone marrow composition via magnetic resonance imaging in newly diagnosed adolescents with Crohn disease (CD) compared to healthy, matched controls.
- Trial name
- NCT04508088
- Testing
- Coronal T1 weighted spin echo images, Spin-lattice relaxation (T1), Magnetic resonance spectroscopy
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Digestive Diseases, Radiology
AI-Driven Multimodal Imaging Integration for Diagnosis and Prognostication of Digestive System Diseases
The goal of this observational, retrospective and prospective study is to develop a noninvasive disease assessment system by leveraging artificial intelligence (AI) to comprehensively analyze multi-modal imaging features…
- Conditions
- Digestive Diseases, Radiology, AI (Artificial Intelligence), Imaging
- Trial name
- NCT07087418
- Testing
- Virtual endoscopy model-assisted diagnosis
- Where
- China
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Tuberculosis (TB)
Optimal Treatment Duration for Radiographically Apparent, Bacteriologically Unconfirmed TB, Identified Through Active Case Finding (RADIO-TB Trial)
People living in high TB burden communities who undergo active case finding for TB may have chest X-ray changes suggestive of TB but their sputum test can be negative for the TB bacteria or they are unable to provide a sputum…
- Trial name
- RADIO-TB (NCT07163143)
- Testing
- Isoniazid (H), Rifampicin (R), Pyrazinamide (Z)
- Where
- 4 sites in Pakistan, South Africa and 1 more
- Volunteers
- 784 people
- Sponsor
- University College, London
Acute Lymphocytic Leukemia, Acute Myeloid Leukemia
Pilot Imaging Study of Leukemia
This is a prospective pilot study, the primary aim of which is to determine whether the presence of 18F FLT imaging signal uptake abnormalities correlate with clinically validated evidence of hematopoietic malignant disease (e.g.
- Conditions
- Acute Lymphocytic Leukemia, Acute Myeloid Leukemia, Ambiguous Lineage Leukemia or Lymphoma, Myeloma
- Trial name
- REALIZE (NCT03633955)
- Testing
- FLT
- Where
- 3 sites in United States
- Volunteers
- 60 people
- Sponsor
- University of Oklahoma
Ovarian; Mastopathy
The Value of the O-RADS Radiological Classification in Predicting the Malignancy of Ovarian Masses in Children
When faced with an ovarian mass in a girl, conservative surgery (resection of the mass while preserving healthy ovarian tissue) via laparoscopy remains the most appropriate treatment option.
- Trial name
- MMO (NCT07313514)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Strasbourg, France
Cystic Fibrosis
Skeletal Health and Bone Marrow Composition in Adolescents With Cystic Fibrosis
The investigators will be evaluating bone marrow composition via magnetic resonance imaging in adolescents diagnosed with cystic fibrosis (CF) compared to healthy, matched controls.
- Trial name
- NCT06216704
- Testing
- Magnetic resonance relaxometry, Magnetic resonance spectroscopy, Blood Draw
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Gastric Cancer (Diagnosis)
Two-component Radiology-guided Autonomous Cascade Engine (TRACE)
This study employed a prospective, randomised crossover trial design to evaluate the clinical utility of the TRACE artificial intelligence system for gastric cancer T-staging.
- Trial name
- TRACE (NCT07651644)
- Testing
- Utilizing the TRACE model to assist radiologists in T-staging, washout period
- Where
- China
- Volunteers
- 54 people
- Sponsor
- Liaoning Cancer Hospital & Institute
Non Mass Breast Lesions
Diagnostic Accuracy of Multiparametric Dynamic Contrast Enhanced Magnetic Resonance Imaging in Improving Detection of Ultrasound Non-mass Breast Lesions According to ACR BI-RADS v2025
this study aims To evaluate the diagnostic performance of Ultrasound (US) in correlation with Dynamic Magnetic Resonance Imaging (MRI) for the assessment, characterization, and evaluation of non-mass breast lesions.
- Trial name
- NCT07679308
- Testing
- multiparametric DCE- MRI and US for all patients
- Volunteers
- 60 people
- Sponsor
- Sohag University
Sickle Cell Disease, Thalassaemia
Integrative Diagnosis for SCD and Other RADs
INTEGRA aims at enabling personalized medicine for RHADs patients by the establishment of an integrative diagnostic approach based on deep phenotypic and genetic characterization through combining new generation methodologies.
- Conditions
- Sickle Cell Disease, Thalassaemia, Congenital Dyserythropoietic Anemia (CDA), Enzyme Disorder; Anemia
- Trial name
- INTEGRA (NCT07206095)
- Testing
- Analysis of genetic modifiers, Disease phenotyping
- Where
- 9 sites in Spain
- Volunteers
- 200 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Heart Rate Determination, Patient Participation
Promoting Children's Participation in Conventional X-ray Examinations
The goal of this explorative observational study is to map the procedure and child centered approach in the examination for children that undergo conventional X-ray examinations.
- Trial name
- NCT06322264
- Testing
- Measurement of variation in heart rate
- Where
- Sweden
- Volunteers
- 220 people
- Sponsor
- Lund University