Clinical trials: Randomized Controlled Trial (RCT)
Juvenile Idiopathic Arthritis
Virtual Peer-to-Peer (VP2P) Support Mentoring for Juvenile Idiopathic Arthritis (JIA): A Pilot RCT
Study Hypothesis: A virtual peer-to-peer support intervention will improve health outcomes and quality of life in adolescents with Juvenile Idiopathic Arthritis
- Trial name
- NCT01986400
- Testing
- Virtual Peer-to-Peer Support Mentoring
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- The Hospital for Sick Children
To Compare Efficacy Intrauterine vs Sublingual MISOPROSTOL in Addition to Oxytocin in Reducing Blood Loss of Post-cesarean Section in High Risk Women
Sublingual vs Intrauterine MISOPROSTOL Plus Oxytocin Infusion for Prevention of Post-cesarean Hemorrhage in High Risk Pregnant Women: A Double-blind Placebo RCT
Research Objective: Primary outcome -To compare efficacy Intrauterine vs Sublingual MISOPROSTOL in addition to Oxytocin in reducing blood loss of post-cesarean section in high risk women Secondary outcome -To study…
- Trial name
- NCT04560218
- Testing
- sublingual Misoprostol, Intrauterine Misoprostol
- Where
- Thailand
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Department of Medical Services Ministry of Public Health of Thailand
Bell's Palsy
Randomized Controlled Trial of Acupuncture to Treat Bell's Palsy According to Different Stages
The purpose of this trial will certify the efficacy of using staging acupuncture and moxibustion to treat Bell's Palsy
- Trial name
- NCT00608660
- Testing
- acupuncture, acupuncture and moxibustion, electroacupuncture
- Where
- China
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Chengdu University of Traditional Chinese Medicine
Adolescents With Type 2 Diabetes
Situational Problem Solving in Adolescents With Type 2 Diabetes: Enhancing a Randomized Controlled Trial (RCT)
The proposed research will test a new comprehensive disease management intervention with adolescents who have type 2 diabetes using a randomized controlled trial (RCT).
- Trial name
- NCT00889785
- Testing
- Comprehensive intervention (disease management program), Usual Care
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Vanderbilt University
Adolescent Suicide, Suicidal Ideation
Shame-Focused Cognitive Behavioral Therapy For Reducing Suicide Risk In Adolescent Psychiatric Inpatients (SF-CBT)
This pilot randomized controlled trial (RCT) aims to evaluate the feasibility, acceptability, and preliminary efficacy of Shame-Focused Cognitive Behavioral Therapy (SF-CBT) among high-risk psychiatric inpatient adolescents.
- Conditions
- Adolescent Suicide, Suicidal Ideation, Suicidal Behavior, Shame
- Trial name
- SF-CBT (NCT07294001)
- Testing
- Supportive Therapy (ST)
- Where
- China
- Volunteers
- 42 people
- Sponsor
- Peking University
Patent Ductus Arteriosus After Premature Birth
Selective Early Medical Treatment of Patent Ductus Arteriosus in Extremely Low Gestational Age Infants: A Pilot RCT
Background: Among preterm infants, those born at a gestational age less than 26 weeks are considered the most vulnerable with a high risk of short- and long-term health problems that include chronic lung disease, brain bleeds…
- Trial name
- SMART-PDA (NCT05011149)
- Testing
- Ibuprofen
- Where
- 9 sites in United States, Canada
- Volunteers
- 100 people
- Sponsor
- IWK Health Centre
Acute Malnutrition in Infancy, Acute Malnutrition in Childhood
ComPAS Low-WAZ RCT Mali
Admissions criteria which treat children with only low mid-upper arm circumference (MUAC) or children with low weight-for-height z-score (WHZ) are not aligned with the evidence on which children are at risk of mortality.
- Conditions
- Acute Malnutrition in Infancy, Acute Malnutrition in Childhood, Underweight
- Trial name
- NCT05248516
- Testing
- Simplified dose of ready-to-use therapeutic food (RUTF), Standard dose of ready-to-use therapeutic food (RUTF), No nutritional treatment
- Where
- 11 sites in Mali
- Volunteers
- 1,500 people
- Sponsor
- International Rescue Committee
Community Acquired Pneumonia, Childhood Pneumonia
3 vs. 5 Days of Amoxicillin for Childhood Pneumonia: An RCT
Pneumonia is the most common infection in children and leading to most common cause of mortality and morbidity in in children globally. Bacterial cause is mostly streptococcus pneumonia in children of 3 months to 5 years of age.
- Trial name
- Pnemonia (NCT07647835)
- Testing
- Amoxicillin
- Where
- Pakistan
- Volunteers
- 250 people
- Sponsor
- Khyber Teaching Hospital
Long COVID
A Practical RCT of TCM in the Treatment of LCOVID and Analysis of Syndrome Types and Medication Characteristics.
This is a multi-center, outcome assessor-blinded, practical randomized controlled trial, aiming to compare the actual clinical effectiveness of individualized traditional Chinese medicine and conventional Western medicine in the…
- Trial name
- NCT06095258
- Testing
- Traditional Chinese medicine treatment, Western medicine treatment
- Volunteers
- 162 people
- Sponsor
- Chinese University of Hong Kong
B ALL, Allogenetic Hematopoietic Stem Cell Transplantation
CD19 CAR-T vs DLI for Post-HSCT MRD in Ph- ALL: A RCT
This prospective, open-label randomized controlled trial compares CD19 CAR-T therapy with chemotherapy plus donor lymphocyte infusion (DLI) in 70 patients with Ph-negative B-cell acute lymphoblastic leukemia (B-ALL) who exhibited…
- Conditions
- B ALL, Allogenetic Hematopoietic Stem Cell Transplantation, MRD-positive
- Trial name
- NCT07441291
- Testing
- CAR-T, DLI
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Peking University People's Hospital
Anxiety, Stress
Breathing for Adolescent Stress Reduction Feasibility RCT
The purpose of this study was to test a simple slow breathing curriculum for reducing stress among high school students. The curriculum was developed by the Health and Human Performance Foundation and implemented for this study…
- Trial name
- NCT05266833
- Testing
- Slow diaphragmatic breathing
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Health and Human Performance Foundation
Breastfeeding, Exclusive
PUMP (Providing the Underprivileged With Manual Pumps): An RCT
The primary objective of this study is to pilot an intervention of providing manual breast pumps at hospital discharge to low-income, first-time mothers and to generate initial estimates of the effect of this intervention on…
- Trial name
- PUMP (NCT03192241)
- Testing
- Pump, Book
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of California, Davis
Physical Activity, Sedentary Lifestyle
The PACO RCT Study
The aim of this school-based cycling intervention called "Cycling and Walk to School" (PACO, for its Spanish acronym) will be to examine their effects on adolescent's cycling to and from school and physical activity (PA).
- Conditions
- Physical Activity, Sedentary Lifestyle, Behavior
- Trial name
- PACO (NCT03937336)
- Testing
- Bike Intervention Group
- Where
- Spain
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Universidad de Granada
Food Allergy in Children
Sustained Unresponsiveness (SU) to Cashew Nut Protein Following Oral Allergen-Specific Immunotherapy
This study is a long-term follow-up of participants from the randomized controlled trial (RCT) "Efficacy of Cashew Nut Protein Immunotherapy: A Protocol of a Single-Center Randomized Controlled Trial in the Pediatric Population"…
- Trial name
- NCT07158619
- Testing
- OIT with cashew nut protein
- Where
- Poland
- Volunteers
- 39 people
- Sponsor
- Medical University of Warsaw
Complex Congenital Heart Disease
Multicenter Randomized Controlled Trial (RCT) and Efficacy Evaluation System Study on Surgical Innovation Strategies for Neonatal Complex Congenital Heart Disease
There remains controversy regarding the optimal timing of surgical treatment for neonatal CCHD (Complex Congenital Heart Disease).
- Trial name
- NCT07363538
- Testing
- Surgical operation is performed on neonates aged >7 days (postnatal age), Surgical operation is performed on neonates aged < 7 days (postnatal age).
- Where
- 12 sites in China
- Volunteers
- 738 people
- Sponsor
- Central China Fuwai Hospital of Zhengzhou University
HIV
Spurring Innovation to Promote HIV Testing: An RCT Evaluating Crowdsourcing
Crowdsourcing may be a powerful tool to spur the development of innovative videos to promote HIV testing among key populations such as men who have sex with men (MSM) and transgender (TG) individuals.
- Trial name
- NCT02248558
- Testing
- Conventional Video, Crowdsourced Video
- Where
- China
- Volunteers
- 721 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
X-linked Hypophosphatemia (XLH)
Prevention of Spontaneous Dental Abscesses in Children With X-linked Hypophosphatemia : a RCT
This study is a prospective, randomized, single-blind, split-mouth, national multicenter trial, comparing the efficacy of a self-etch adhesive system combined (SAM) with a flowable composite to that of a fluoride varnish for the…
- Trial name
- PRADEX (NCT04872907)
- Testing
- adhesive system, fluoride varnish, flowable composite
- Volunteers
- 60 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Birth Related Brachial Plexus Injury, Obstetrical Brachial Plexus Palsy
Sup-ER Protocol RCT
This study evaluates the ability of a supination and external rotation protocol to improve the arm function and anatomy of children with birth related brachial plexus injuries.
- Trial name
- NCT01933438
- Testing
- Sup-ER Protocol, Control
- Where
- Canada
- Volunteers
- 2 people
- Sponsor
- University of British Columbia
Substance Use
A Family-Centered Ojibwe Substance Abuse Prevention
This study will complete a multisite randomized controlled trial (RCT) of a family-centered alcohol and drug prevention program for Anishinabe (Ojibwe) pre-adolescents in 3rd or 4th grade (Fall 2017) or who are age 8-10 years on…
- Trial name
- BZDDD (NCT02700035)
- Testing
- Bii-Zin-Da-De-Dah (Listening to One Another)
- Volunteers
- 705 people, healthy volunteers welcome
- Sponsor
- University of Nebraska Lincoln
Distal Forearm Fractures
Long Arm Vs Short Arm Fiberglass Cast for Treatment of Displaced Distal Radius Fractures
The aim of the study is to determine by multicenter randomized controlled trial whether short arm fiberglass casts are as effective as long arm casts for immobilizing displaced pediatric distal third forearm fractures that have…
- Trial name
- NCT03835065
- Testing
- Closed Reduction, Long Arm Fiberglass Cast, Short Arm Fiberglass Cast
- Where
- United States
- Sponsor
- Hospital for Special Surgery, New York