Clinical trials: Randomized Controlled Trial (RCT)
Sedentary Behavior, Physical Activity
Teen Mom Study: A Confirmatory Pragmatic Cluster RCT
The goal of this clinical trial is to test the effectiveness of #BabyLetsMove - a 24-week mobile Health and peer health coaching intervention paired with the Special Supplemental Nutrition Program for Women, Infants, and Children…
- Conditions
- Sedentary Behavior, Physical Activity, Gestational Weight Gain, Arterial Pressure
- Trial name
- NCT06216925
- Testing
- #BabyLetsMove, WIC Antenatal Care
- Volunteers
- 144 people
- Sponsor
- University of Mississippi Medical Center
Community Acquired Pneumonia, Childhood Pneumonia
3 vs. 5 Days of Amoxicillin for Childhood Pneumonia: An RCT
Pneumonia is the most common infection in children and leading to most common cause of mortality and morbidity in in children globally. Bacterial cause is mostly streptococcus pneumonia in children of 3 months to 5 years of age.
- Trial name
- Pnemonia (NCT07647835)
- Testing
- Amoxicillin
- Where
- Pakistan
- Volunteers
- 250 people
- Sponsor
- Khyber Teaching Hospital
B ALL, Allogenetic Hematopoietic Stem Cell Transplantation
CD19 CAR-T vs DLI for Post-HSCT MRD in Ph- ALL: A RCT
This prospective, open-label randomized controlled trial compares CD19 CAR-T therapy with chemotherapy plus donor lymphocyte infusion (DLI) in 70 patients with Ph-negative B-cell acute lymphoblastic leukemia (B-ALL) who exhibited…
- Conditions
- B ALL, Allogenetic Hematopoietic Stem Cell Transplantation, MRD-positive
- Trial name
- NCT07441291
- Testing
- CAR-T, DLI
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Peking University People's Hospital
To Compare Efficacy Intrauterine vs Sublingual MISOPROSTOL in Addition to Oxytocin in Reducing Blood Loss of Post-cesarean Section in High Risk Women
Sublingual vs Intrauterine MISOPROSTOL Plus Oxytocin Infusion for Prevention of Post-cesarean Hemorrhage in High Risk Pregnant Women: A Double-blind Placebo RCT
Research Objective: Primary outcome -To compare efficacy Intrauterine vs Sublingual MISOPROSTOL in addition to Oxytocin in reducing blood loss of post-cesarean section in high risk women Secondary outcome -To study…
- Trial name
- NCT04560218
- Testing
- sublingual Misoprostol, Intrauterine Misoprostol
- Where
- Thailand
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Department of Medical Services Ministry of Public Health of Thailand
Malocclusion, Angle Class II
Treatment of Class II Malocclusion Combined With Low-level Laser
This experimental study will evaluate the effect of combined treatment with low-level laser and functional appliances (twin-block) on the correction of Class II malocclusion, compared with the control group treated with…
- Trial name
- NCT03239912
- Testing
- Twin-block appliance, Low level laser
- Where
- Syria
- Volunteers
- 40 people
- Sponsor
- Damascus University
Monkeypox
Smallpox Vaccine for Mpox Post-Exposure Prophylaxis: A Cluster RCT
A cluster randomized controlled trial to determine if smallpox vaccine reduces secondary cases and symptom severity in persons exposed to mpox.
- Trial name
- SMART (NCT05745987)
- Testing
- Bavarian Nordic smallpox vaccine, Typhoid VI Polysaccharide Vaccine Injectable Solution
- Where
- 10 sites in Democratic Republic of the Congo, Nigeria and 1 more
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- McMaster University
Infertility
Evaluation of a Mobile Preconception Lifestyle Programme in Couples Undergoing In Vitro Fertilisation
The aim of the PreLiFe RCT is to assess the effects of a new mobile preconception lifestyle programme (PreLiFE-programme) for couples undergoing IVF.
- Trial name
- PreLiFe-RCT (NCT03790449)
- Testing
- PreLiFe-programme, Attention Control Programme
- Where
- 5 sites in Belgium
- Volunteers
- 211 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Safety Issues, Infant Nutrition Disorders
Clinical Evaluation of a Low Protein Content Formula in the First Months of Life: a RCT
This study aimed to evaluate the tolerance and safety of a low-protein formula in healthy full-term infants by investigating effects on growth and gastrointestinal tolerance and by identifying any adverse effects.
- Trial name
- NCT03035721
- Testing
- Low protein formula, Standard protein formula
- Where
- Italy
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Hepatocellular Carcinoma
Randomized Control Trial (RCT) of Transarterial Chemoembolization (TACE) Versus TACE and Oral Drug Therapy in the Treatment of Unresectable Hepatocellular Carcinoma
Background Hepatocellular carcinoma, a malignant tumor of liver is one of the most common cancers worldwide. All India Institute Of Medical Sciences (AIIMS) being a tertiary care hospital receives about two to three cases of…
- Trial name
- NCT00522405
- Testing
- TACE
- Where
- India
- Sponsor
- All India Institute of Medical Sciences
Addiction
Evaluating Improvement Strategies in Addiction Treatment
Addiction treatment is often characterized by long delays between first contact and treatment as well as high no-show and drop out rates leading to unused capacity in apparently full agencies.
- Trial name
- NIATx 200 (NCT00934141)
- Testing
- Learning Session, Interest Circle Calls, Coaching
- Where
- United States
- Volunteers
- 201 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Clinical Competence, Self-Confidence
Neurocritical Care Video Training in Palestine: RCT on Nursing Students' EVD Knowledge, Attitude, Skills, Confidence
This randomized controlled trial aims to evaluate the effect of a video-based educational program on nursing students' knowledge, attitude, self-reported practice, and confidence related to external ventricular drainage (EVD)…
- Conditions
- Clinical Competence, Self-Confidence, Knowledge Level
- Trial name
- NCT07284537
- Testing
- video based education, Flashcard
- Where
- Palestinian Territories
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Modern University College
E-cigarette Use
Middle School Cluster Randomized Controlled Trial (RCT) to Evaluate E-Cigarette Prevention Program: CATCH My Breath
This is a two-arm, cluster randomized trial designed to to evaluate the effectiveness of an e-cigarette curriculum [called the CATCH My Breath (CMB) program] in delaying the onset of e-cigarette use in middle schoolers.
- Trial name
- NCT04843501
- Testing
- CATCH My Breath (CMB) program for E-cigarette prevention among adolescents, Texas Education Agency (TEA) required tobacco prevention program
- Where
- United States
- Volunteers
- 2,059 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Distal Radius Fracture
Distal Radius Buckle Fracture RCT
This study evaluates the influence of cost information on decision-making for immobilization for treatment of distal radial buckle fractures.
- Trial name
- NCT04032873
- Testing
- Monetary Cost of Immobilization Treatments, Physician, Study Team
- Where
- United States
- Volunteers
- 129 people
- Sponsor
- Children's Hospital of Philadelphia
Cannabis Use Disorder
Rewards for Cannabis Abstinence-study
The goal of this clinical trial is to investigate the (cost-)effectiveness of contingency management (CM) compared with Cognitive Behavioural Therapy (CBT) for the treatment of cannabis use disorder (CUD) in youth (16-22 years).
- Trial name
- RECAB (NCT05836207)
- Testing
- Abstinence-focused Contingency Management (CM) - stand alone, Standard Outpatient Cognitive Behavioural Therapy (CBT)
- Where
- 5 sites in Netherlands
- Volunteers
- 154 people
- Sponsor
- Parnassia Addiction Research Centre
Postpartum Complication
Healing, Equity, Advocacy and Respect for Mamas
The goal of the proposed research is to test the comparative effectiveness of AIM safety bundles for post-partum women delivered in-person vs.
- Trial name
- HEAR4Mamas (NCT06273436)
- Testing
- H.E.A.R. for Mamas
- Where
- United States
- Volunteers
- 2,894 people
- Sponsor
- Medical University of South Carolina
Anxiety Disorder of Adolescence
RCT of CBT Based C.A.T Project for Pakistani Adolescents With Anxiety Disorders.
Anxiety Disorders are the most prevalent mental health conditions among adolescents. The current randomized control trial aims to assess the efficacy of the C.A.T Project protocol among adolescents aged 14 to 17 years diagnosed…
- Trial name
- NCT07202715
- Testing
- CBT Based C.A.T Project- Intervention for Anxious Adolescents.
- Where
- 3 sites in Pakistan
- Volunteers
- 50 people
- Sponsor
- National University of Science and Technology
Severe Pneumonia
Randomized Controlled Trial (RCT) in Children With Severe Pneumonia
Pneumonia is the leading cause of childhood morbidity and death in many developing countries including Bangladesh, causing about 2 million deaths worldwide each year.
- Trial name
- NCT00455468
- Testing
- Day-care treatment vs. hospital care
- Where
- Bangladesh
- Volunteers
- 368 people
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Intervention, Waitlist Control
Coach-Led Body Image Intervention for Girls in Sport - RCT
According to the World Health Organization, only 15% of 11-17-year-old girls meet the recommended daily physical movement guidelines (e.g., 60 minutes per day).
- Trial name
- NCT05594524
- Testing
- Body Confident Athletes
- Where
- United Kingdom
- Volunteers
- 568 people, healthy volunteers welcome
- Sponsor
- University of the West of England
Complex Congenital Heart Disease
Multicenter Randomized Controlled Trial (RCT) and Efficacy Evaluation System Study on Surgical Innovation Strategies for Neonatal Complex Congenital Heart Disease
There remains controversy regarding the optimal timing of surgical treatment for neonatal CCHD (Complex Congenital Heart Disease).
- Trial name
- NCT07363538
- Testing
- Surgical operation is performed on neonates aged >7 days (postnatal age), Surgical operation is performed on neonates aged < 7 days (postnatal age).
- Where
- 12 sites in China
- Volunteers
- 738 people
- Sponsor
- Central China Fuwai Hospital of Zhengzhou University
Peer Group, Parents
Cluster-RCT Collective Nasopharyngeal COVID-19 Testing Amongst Pupils
Does the presence of fellow pupils and parents improves a pupil's resistance to undergo a nasopharyngeaal swab test?
- Trial name
- NCT04993547
- Testing
- Parent and peer presence
- Where
- Belgium
- Volunteers
- 952 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent