Clinical trials: Randomized Controlled Trial (RCT)
Posttraumatic Stress Disorder
Group Based Exposure Therapy for Combat-Related PTSD
The purpose of this randomized controlled trial is to determine if Group Based Exposure Therapy (GBET) is more effective than treatment as usual in reducing the symptoms of war-related Posttraumatic Stress Disorder (PTSD).
- Trial name
- NCT00535223
- Testing
- Group Based Exposure Therapy, Present Centered Group Therapy
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- US Department of Veterans Affairs
Mother-child Relationship Disturbances
Mother-Infant Psychoanalysis Project of Stockholm (MIPPS)- Follow-up at 4½ Years
An RCT comparing mother-infant psychoanalytic treatment (MIP) with Child Health Centre care in cases of mother-infant relationship disturbances was performed on 80 cases in Stockholm 2005-2008.
- Trial name
- MIPPS-02 (NCT01087112)
- Testing
- Mother-Infant Psychoanalytic tmt, Child Health Centre care
- Where
- Sweden
- Volunteers
- 71 people
- Sponsor
- Karolinska Institutet
Juvenile Delinquency
Feasibility Trial of a Correctional Management for Juvenile Offenders
The goal of this clinical trial is to learn if a structured Correctional Management intervention can be feasibly implemented with incarcerated juveniles in a correctional institution.
- Trial name
- NCT07516080
- Testing
- A Correctional Management for Juvenile Offenders
- Where
- Pakistan
- Volunteers
- 56 people
- Sponsor
- University of the Punjab
Mental Health Wellness 1, Positive and Negative Affect
Effects of a Relaxation and Guided Imagery Intervention in School Context
Specific aims - To test the effects of a relaxation and guided imagery intervention with socioemotional learning content on a range of socioemotional, physiological, cognitive and academic outcomes of school-aged children…
- Conditions
- Mental Health Wellness 1, Positive and Negative Affect, Social Skills, Happiness
- Trial name
- MR (NCT06101225)
- Testing
- MindRegulation Intervention, Relaxation, Waiting List Control Group
- Where
- Portugal
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Universidade Autónoma de Lisboa
Autism Spectrum Disorder, Attention Deficit Hyper Activity
Digital-based Psychosocial Intervention for Parents of Children With Neurodevelopmental Disorders
The goal of this clinical trial is to implement a structured psychosocial intervention program with digital support (randomized and with a control group) that will be conducted virtually and synchronously to families of children…
- Trial name
- INPSYD (NCT06303791)
- Testing
- Digital Psychosocial intervention
- Where
- Spain
- Volunteers
- 90 people
- Sponsor
- University of Valencia
Gonorrhea Male, Chlamydia;M
Pay-it-forward RCT for Gonorrhea and Chlamydia Testing
This is a randomized controlled trial which will evaluate dual gonorrhea/chlamydia test uptake and other outcomes in men who have sex with men (MSM) in three trial arms - 1) a pay-it-forward testing arm, 2) a pay-what-you-want…
- Trial name
- NCT03741725
- Testing
- Pay-it-forward, Pay-what-you-want
- Where
- 3 sites in China
- Volunteers
- 301 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Malocclusion, Angle Class III
Treatment of Class III Malocclusion Using Modified Fixed Mandibular Retractor Appliance
This experimental study aims to evaluate the efficiency of the Modified Fixed Mandibular Retractor Appliance in the treatment of skeletal class III malocclusion.
- Trial name
- NCT03354442
- Testing
- Modified Fixed Mandibular Retractor Appliance
- Where
- Syria
- Volunteers
- 44 people
- Sponsor
- Damascus University
Impacted Mandibular Third Molar Extraction, Post Operative Complications
A Comparison of Recovery After Impacted Wisdom Tooth Removal
Justification of the Study There is a high prevalence of impacted third molars, often accompanied by a range of postoperative complications.
- Trial name
- CESE-3M (NCT07304882)
- Testing
- serratiopeptidase, Escin, Conventional drugs
- Where
- Yemen
- Volunteers
- 24 people
- Sponsor
- University of Science and Technology, Yemen
Postoperative Pain, Pediatric Surgery
Caudal Epidural Vs. TAP Block for Postoperative Analgesia in Pediatric Infraumbilical Surgery: a RCT
This randomized controlled trial investigates the postoperative analgesic efficacy of caudal epidural block versus ultrasound-guided transversus abdominis plane (TAP) block in pediatric patients undergoing infraumbilical surgery.
- Conditions
- Postoperative Pain, Pediatric Surgery, Anesthesia, Local, Regional Anesthesia
- Trial name
- NCT06895382
- Testing
- Caudal Epidural Block, Transversus Abdominis Plane (TAP) Block, Bupivacaine 0.25%
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Namik Kemal University
Child Development, Executive Functions (EF)
Sharing Tales That Teach: Shared Picturebook Reading for Early Childhood Emotional and Cognitive Development
Sharing Tales That Teach is a randomised study of a shared picturebook reading programme for 4- to 5-year-old children and their primary caregivers.
- Conditions
- Child Development, Executive Functions (EF), Emotion Regulation
- Trial name
- STTT (NCT07666802)
- Testing
- Emotion-Focused Shared Picturebook Reading, Standard Dialogic Picturebook Reading
- Where
- United Kingdom
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Greenwich
Microtia, Outcome Assessment
Safety and Efficacy of Connecting the Residual Ear to the Cartilage Scaffold in First- vs. Second-Stage Surgery
Eligible patients will be admitted from the outpatient clinic to complete the relevant examinations after admission（Preoperative routine examination and chest CT）.
- Conditions
- Microtia, Outcome Assessment, RCT, Surgery Related Complications Rate
- Trial name
- NCT06763991
- Testing
- Two-stage connection, One-stage connection
- Where
- China
- Volunteers
- 78 people
- Sponsor
- Sichuan Provincial People's Hospital
Orbital Cellulitis
Dexamethasone vs. Placebo in Children and Youth Hospitalized for Orbital Cellulitis
The goal of this pilot randomized controlled trial is to understand whether we can successfully conduct a larger definitive clinical trial in the future.
- Trial name
- VISION (NCT07345819)
- Testing
- Dexamethasone 0.3mg/kg
- Where
- 2 sites in Canada
- Volunteers
- 30 people
- Sponsor
- The Hospital for Sick Children
Suicide Attempt, Suicide Ideation
Electronic, Self-Guided Safety Plan in Adolescents: Project SAFER
Suicide is a leading cause of death for youth 10-24, and nearly ¼ of adolescents report nonfatal suicidal thoughts and behaviors (STB).
- Trial name
- Project SAFER (NCT06868407)
- Testing
- Psychoeducation about Suicide Crisis Resources (Control Intervention), Experimental: Self-Guided Electronic Safety Plan Intervention
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of Denver
Literacy, Child Development
Rx for Success: RCT of an App for Dialogic Reading Training
The purpose of this randomized controlled trial is to explore the efficacy of amplifying dialogic reading training provided to families of infants and toddlers in the ROR program using a novel, smartphone-based application (Rx…
- Conditions
- Literacy, Child Development, Parenting
- Trial name
- NCT03828721
- Testing
- Rx for Success Smartphone Application, Control - screen time reduction
- Where
- United States
- Volunteers
- 252 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Anxiety
Youth Mayo Clinic Anxiety Coach Randomized Controlled Trial
This research study aims to test the feasibility and effectiveness of using the Mayo Clinic Anxiety Coach smartphone app as an addition to traditional therapy for the treatment of anxiety disorders in youth, particularly those…
- Trial name
- NCT02205203
- Testing
- Mayo Clinic Anxiety Coach, Treatment as Usual
- Where
- United States
- Volunteers
- 145 people
- Sponsor
- Stephen Whiteside
Stress
Early Interventions for Primary Care Patients With Stress-related Ill-health: a Non-inferiority RCT
Stress-related ill-health is rated one of the largest health challenges in the western world. The most empirically supported treatment for stress-related disorders is cognitive behaviour therapy (CBT), but accessibility is low…
- Trial name
- NCT04820283
- Testing
- Care manager intervention (nurse), CBT
- Where
- Sweden
- Volunteers
- 172 people
- Sponsor
- Karolinska Institutet
Physical Activity, Academic Achievement
The Effect of Increased Physical Activity on Adolescents' Health and Academic Performance: The School in Motion Study
This study evaluates the effect of 120 minutes extra of physical education (PE) or physical activity (PA) on adolescents' physical health, mental health, academic performance and learning environment.
- Conditions
- Physical Activity, Academic Achievement, Mental Health
- Trial name
- ScIM (NCT03817047)
- Testing
- Physical education, Physical active learning, Physical activity
- Where
- Norway
- Volunteers
- 2,045 people, healthy volunteers welcome
- Sponsor
- Norwegian School of Sport Sciences
Orthopedic Disorder, Anterior Cruciate Ligament Injuries
Quadriceps Tendon Versus Bone Patellar Tendon Bone Autograft ACL Reconstruction RCT
The choice of autograft for ACL reconstruction continues to be debated. To date, there has only be one completed randomized controlled trial with quad tendon to BTB and the tendon included a bone plug.
- Trial name
- NCT05461326
- Testing
- Quad tendon, BTB
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Alabama at Birmingham
IBS - Irritable Bowel Syndrome
RCT of VR Therapy for IBS
Through a pilot randomized controlled trial (RCT), the aim is to test the clinical impact and feasibility of a virtual reality (VR) cognitive behavioral therapy (CBT) program versus sham VR among patients with irritable bowel…
- Trial name
- NCT06687616
- Testing
- SynerGI
- Where
- 2 sites in United States
- Volunteers
- 73 people
- Sponsor
- Christopher Almario
Dientamoebiasis
Treatment Study of Metronidazole to Treat Dientamoebiasis in Children
Introduction: Dientamoeba fragilis (DF) is a commonly occurring intestinal protozoan that is considered a possible cause of infectious gastrointestinal disease in adults and children.
- Trial name
- DFPT (NCT01314976)
- Testing
- Metronidazole
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Statens Serum Institut