Clinical trials: Randomized Controlled Trials
Full Spectrum
A Self-controlled Study of the Effect of Partial Spectral Absence of Visible Light on the Pupil
Previous studies have shown that the spectrum of light influences myopia. LED lights with a partially absent light spectrum increase the risk of myopia progression compared to LEDs with a full spectrum, potentially mediated by…
- Trial name
- NCT06501131
- Testing
- full-spectrum light exposure, specific spectrum absence light exposure
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Appendicitis
Practical Advantages of Single-port Over Three-port Laparoscopic Appendectomy in Children
Despite growing popularity, practical advantages of single-port laparoscopic appendectomy (SLA) over conventional three-port laparoscopic appendectomy (CLA) have yet to be established well in pediatric population.
- Trial name
- PASTA (NCT03106467)
- Testing
- Single-port laparoscopic appendectomy, Three-port laparoscopic appendectomy
- Where
- South Korea
- Volunteers
- 400 people
- Sponsor
- Hallym University Medical Center
Hepatocellular Carcinoma, Laser Ablation
Laser Ablation for Intermediate and Advanced Hepatocellular Carcinoma With Portal Vein Tumor Thrombus
Hepatocellular carcinoma (HCC) is the fifth most-common cancer worldwide and the second most-common cause of cancer mortality. Liver resection is the first-line curative treatment for huge HCC.
- Conditions
- Hepatocellular Carcinoma, Laser Ablation, Portal Vein Tumor Thrombus
- Trial name
- NCT02724475
- Testing
- LA, 3D-CRT
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Eastern Hepatobiliary Surgery Hospital
Dental Caries, Child Behavior
Efficacy of Moderate Sedation for Dental Treatment of Young Children
There is lack of clinical trials on pediatric dental sedation. The purpose of this study is to test (using a randomized controlled trial design) the hypothesis that young children behavior during dental treatment improves with…
- Conditions
- Dental Caries, Child Behavior, Conscious Sedation Failure During Procedure
- Trial name
- NCT00902395
- Testing
- Midazolam, Protective stabilization, Midazolam, ketamine
- Where
- Brazil
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Goias
Human Immunodeficiency Virus, Sexually Transmitted Diseases
A Non-inferiority Randomized Controlled Trial to Evaluate Promoting Condom Use Among MSM and Transgender Individuals in China
This is a pragmatic, non-inferiority, randomized controlled trial comparing the effectiveness of two methods (crowdsourcing versus social marketing) for creating one-minute videos promoting condom use among MSM and TG in China.
- Trial name
- NCT02516930
- Testing
- crowdsourced video, social marketing video
- Where
- China
- Volunteers
- 1,173 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Pulp Exposure, Dental
Biodentine Vital Pulpotomy in Immature Molars
This study aimed to evaluate the clinical and radiographic success of pulpotomy in cariously exposed vital immature first permanent molars using calcium hydroxide and calcium silicate-based material (Biodentine ™).
- Trial name
- NCT04989036
- Testing
- pulpotomy
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Cairo University
Food Allergy, Egg Allergy
Efficacy and Safety of Egg Ladders in Children With IgE-Mediated Hen's Egg Protein Allergy
Hen's Egg Allergy is one of the most common food allergies in early childhood. The first-line treatment is the elimination of hen's egg proteins from the child's or maternal diet.
- Conditions
- Food Allergy, Egg Allergy, Hen Egg Allergy
- Trial name
- NCT07040111
- Testing
- oral food challenge (OFC)
- Where
- 2 sites in Poland
- Volunteers
- 94 people
- Sponsor
- Medical University of Warsaw
CPTSD, Compelx Post-traumatic Stress Disorder
The Effectiveness of Guided Written Exposure Therapy for Complex PTSD in Adolescents
This study aims to examine the effectiveness of group Guided Written Exposure Therapy for Complex Post-Traumatic Stress Disorder (GWE-C) among Chinese adolescents through a randomized controlled trial.
- Trial name
- NCT07325734
- Testing
- Group Guided Written Exposure Therapy for CPTSD (GWE-C), Supportive Group
- Where
- 4 sites in China
- Volunteers
- 130 people
- Sponsor
- Peking University
Ear Deformity External
Adaptation of Conventional Versus Virtually Fabricated Ear Prosthesis in Patients With Auricular Defects
: patients were recruited for auricular prosthetic reconstruction. Preoperative data was collected including personal and medical history, plain photographs and CT scans.
- Trial name
- NCT05708339
- Testing
- virtually fabricated ear prosthesis, conventionally fabricated ear prosthesis
- Where
- Egypt
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Fatima Elmougi
Landing Biomechanics, Jumping Performance
Effectiveness of Core Training on the Biomechanics of Jump Landing in Amateur Female Basketball Players
The goal of this clinical trial is to evaluate the effectiveness of a core training intervention on jump-landing biomechanics in female amateur basketball players.
- Conditions
- Landing Biomechanics, Jumping Performance, Trunk Stability
- Trial name
- NCT06633237
- Testing
- Core training program in female amateur basketball players
- Where
- Spain
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Universitat Internacional de Catalunya
Health Knowledge, Attitudes, Practice
Promoting Child Development Practices in the First Year of Life Through a Video Administered at Two Different Times
There is an increasing need for parenting programs aimed at promoting parent-child interaction. A variety of interventions have been proposed.
- Trial name
- NCT02120430
- Testing
- Video
- Where
- Italy
- Volunteers
- 105 people
- Sponsor
- IRCCS Burlo Garofolo
Colonic Adenomatous Polyps
Effectiveness and Safety of the Endoscopic Removal of Large and Flat Colonic Polyps With LumenR RetractorTM
Colorectal cancer accounted for 142,570 new cancer cases and 51,370 cancer deaths in USA in 2010 and worldwide has become the third most common cancer and second leading cause of cancer related deaths.
- Trial name
- NCT02051465
- Testing
- LumenR Retractor, Removal without overtube
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Mercy Medical Center
Posterior Fossa Tumor
Dexmedetomidine Use for Greater Occipital Nerve Block in Pediatric Posterior Fossa Tumor Surgery.
The goal of this clinical trial is to evaluate the effects of ultrasound-guided versus blind greater occipital nerve block (GONB), with or without Dexmedetomidine as an adjuvant, in pediatric patients undergoing posterior fossa…
- Trial name
- NCT07878156
- Testing
- Bupivacaine 0.25%, Dexmedetomidine 1mcg/kg, Blind greater occipital nerve block
- Where
- Egypt
- Volunteers
- 260 people
- Sponsor
- Children's Cancer Hospital Egypt 57357
Stroke
Power-Assisted Therapeutic Electrical Stimulation to Upper Extremities
Power-assisted therapeutic electrical stimulation (TES) or conventional TES to upper extremities in acute stroke patients were performed in a randomized controlled trial. The changes in finger and hand function will be evaluated.
- Trial name
- TES (NCT00823537)
- Testing
- therapeutic electrical stimulation
- Sponsor
- Fujita Health University
Suicidal Ideation, Suicide, Attempted
Reducing Suicide Ideation Among Young People
It is Cluster Randomized Control Trial research to examine feasibility and relevance of the modified tool Nae Disha for Life, which will incorporate suicide prevention and resilience to reduce suicide ideation among young people…
- Trial name
- NCT06474312
- Testing
- Nae Disha
- Where
- India
- Volunteers
- 363 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Healthy Infants
Efficacy of Two HMOs in Chinese Infants
This is a randomized, controlled, double-blind, intervention trial of healthy male and female term infants to evaluate the efficacy of the 2 HMOs on beneficially modulating the gut microbiota, gut maturation, gut barrier…
- Trial name
- NCT06361719
- Testing
- Experimental Group (EG), Control Group (CG)
- Where
- China
- Volunteers
- 262 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Compare Operational Performance of Three Technology in Lung Models
The Assessment of the Feasibility and Operational Performance of Automated System Bronchoscopy in a Simulated Environment
Recruit 30 trainee physicians from 6 centers and compare their performance in operating lung models using automatic bronchoscopy, robotic bronchoscopy, and electromagnetic navigation bronchoscopy.
- Trial name
- NCT06741267
- Testing
- RBS, AB, ENB
- Where
- Chad
- Volunteers
- 30 people
- Sponsor
- Guangzhou Medical University
Behavior, Health, Behavior, Smoking
Evaluation of The Stanford Tobacco Prevention Toolkit
The Stanford Tobacco Prevention Toolkit is a free online curriculum developed for use by educators and health professionals in providing tobacco-specific prevention education to middle and high school students.
- Trial name
- NCT04467034
- Testing
- Stanford Tobacco Prevention Toolkit curriculum
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Stanford University
Infant/ Neonate Lumbar Puncture
Bedside Ultrasound Assisted Pediatric Lumbar Puncture
This is a prospective, randomized study evaluating the efficacy of bedside ultrasound assisted lumbar puncture in pediatric patients
- Trial name
- NCT02193763
- Testing
- Ultrasound assisted lumbar puncture
- Where
- United States
- Sponsor
- Wake Forest University Health Sciences
Dental Caries
A Study to Evaluate the Cariostatic Efficacy of Nano Silver Fluoride (NSF) vs. Silver Diamine Fluoride (SDF) in Children
This study, titled "A Randomized Controlled Trial to Evaluate the Cariostatic Efficacy of Nano Silver Fluoride (NSF) vs. Silver Diamine Fluoride (SDF) in Children" (Study Number: ATSU-YI-NSF 2025), is sponsored by Young…
- Trial name
- NCT07861321
- Testing
- Nano Silver Fluoride / NSF
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- A.T. Still University of Health Sciences