Clinical trials: Randomized-controlled Trial
Angle Class II
Maxillary Molar Distalization Supported by Mini-implants With the Advanced Molar Distalization Appliance (Amda®)
The aim of this randomized controlled clinical trial is to evaluate the dentoalveolar and skeletal treatment effects of the AMDA when used for distalization of the maxillary first molars in patients with Class II malocclusion in…
- Trial name
- NCT06011382
- Testing
- Advanced Molar Distalization Appliance (amda®), Buccal mini-implants
- Where
- Romania
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Grigore T. Popa University of Medicine and Pharmacy
Atopic Dermatitis
Twice Daily Versus Twice Weekly Soak-and-Seal Baths in Pediatric Atopic Dermatitis
There are few studies evaluating best bathing practices in the management of pediatric atopic dermatitis (AD). Trans-epidermal water loss plays a key role in the pathophysiology of AD.
- Trial name
- NCT03397979
- Testing
- Infrequent versus Frequent Soaking Baths
- Where
- United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- MaineHealth
Weight Gain
Growth and Safety Clinical Trial on a New Infant Formula
The aim of this study is to assess age-appropriate growth of healthy infants fed a new infant formula. In this randomized, controlled trial, healthy, term, formula-fed infants will be randomized to one of two infant formulas: a…
- Trial name
- NCT05508750
- Testing
- New Infant Formula, Commercial Infant Formula
- Where
- United States
- Volunteers
- 420 people, healthy volunteers welcome
- Sponsor
- Jovie USA, LLC
Hyponatremia
0.9% NaCl/Dextrose 5% vs 0.45% NaCl/Dextrose 5% as Maintenance Intravenous Fluids in Critically Ill Children
The primary objective of this study is to compare the mean serum sodium after 48 hours of therapy with either 0.45% NaCl/dextrose 5% or 0.9% NaCl/dextrose 5%, in critically ill children requiring IV maintenance fluid…
- Trial name
- NaCrICh (NCT01301274)
- Testing
- hypotonic, isotonic
- Where
- Argentina
- Volunteers
- 66 people
- Sponsor
- Hospital General de Niños Pedro de Elizalde
Metastatic Breast Cancer
Capecitabine in Combination With Aromatase Inhibitor Versus Aromatase Inhibitors, in Hormonal Receptor Positive Recurrent or Metastatic Breast Cancer Patients, Randomized Controlled Study
Women with recurrent or metastatic breast cancer who are hormone receptor positive are candidates for first line hormonal therapy including aromatase inhibitors.
- Trial name
- CONCEPT (NCT04012918)
- Testing
- Capecitabine plus aromatase inhibitor, A.I.
- Where
- Egypt
- Volunteers
- 124 people
- Sponsor
- Ain Shams University
Childhood Apraxia of Speech
Motor-based Intervention for Childhood Apraxia of Speech: DTTC-Connect
Childhood apraxia of speech (CAS) is a complex motor speech disorder that significantly limits a child's ability to communicate in daily activities, with difficulties often persisting into adolescence and adulthood.
- Trial name
- NCT07526246
- Testing
- Dynamic Temporal and Tactile Cueing - Connect (DTTC-Connect)
- Where
- 2 sites in United States
- Volunteers
- 68 people
- Sponsor
- New York University
Diastasis Recti Abdominis (DRA), Diastasis Recti Abdominis
Manual Therapy for Diastasis Recti Abdominis
This randomized, single-blind trial compared the effects of a standardized manual therapy closure protocol, delivered alone or combined with therapeutic exercise, with therapeutic exercise alone on inter-rectus distance (IRD) in…
- Trial name
- MTDRA-RCT (NCT07861646)
- Testing
- Standardized Manual Therapy Closure Protocol, Therapeutic Exercise for Deep Abdominal Activation
- Where
- Bosnia and Herzegovina
- Volunteers
- 64 people
- Sponsor
- Studio Vita
Orthodontic Appliance Complication
Evaluation of the Use of Photobiomodulation After the Installation of Elastometric Separators
The greatest dropout rate of orthodontic treatments is pain, from the installation of the elastomeric separators, to the exchange of wires and accessories.
- Trial name
- NCT03939988
- Testing
- Photobiomodulation
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Nove de Julho
Perinatal Depression
Clinical and Cost-effectiveness of an Online Self-help Intervention and a Face-to-face Intervention Versus Usual Care in Mothers at Moderate Risk for Perinatal Depression
The perinatal period (pregnancy and the first postnatal year) (O'Hara \& Wisner, 2014) involves important changes and considerable challenges for parents (Milgrom \& Gemmill, 2015).
- Trial name
- MaMHI (NCT07027761)
- Testing
- Online self-help, Maternal Mental Health Intervention (MaMHI), Usual Care
- Where
- Belgium
- Volunteers
- 210 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Pain Assessment
Effect of Starpen CCLAD in Injection and Extraction
The present study aims to evaluate the effect of computer-controlled Starpen automatic injection device versus the traditional syringe on pain perception during Injection of nerve block anesthesia and extraction of mandibular…
- Trial name
- Starpen CCLAD (NCT06827223)
- Testing
- computer-controlled Starpen Automatic Injection Device, Traditional Syringe
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Cairo University
Pediatric Regional Anesthesia, Retrolaminar Block
Retrolaminar Plane Block Versus Anterior Quadratus Lumborum Block in Pediatric Urogenital Surgery
Effective control of postoperative pain following pediatric lower urogenital surgery is important for enhancing recovery and reducing opioid requirements.
- Conditions
- Pediatric Regional Anesthesia, Retrolaminar Block, Pediatric Postoperative Pain
- Trial name
- NCT07711496
- Testing
- Anterior Quadratus Lumborum Block, Retrolaminar Block
- Where
- Turkey (Türkiye)
- Volunteers
- 76 people
- Sponsor
- Istanbul University - Cerrahpasa
Mediolateral Episiotomy After Delivery
Comparison of Adhesive Glue With Skin Suture for Repair of Episiotomy
Surgical repair of perineal lesions after delivery is frequently associated with pain and discomfort interfering with the normal activities of the puerperium.
- Trial name
- NCT00840788
- Testing
- octyl-2-cyanoacrylate adhesive glue, Subcuticular suture of perineal skin
- Where
- Portugal
- Volunteers
- 100 people
- Sponsor
- Hospital Sao Joao
ASD
Evaluate the Efficacy and Safety of DHA in the Adjuvant Treatment of Children With ASD.
In the etiopathogenesis of autistic spectrum disorder (ASD) several hypotheses have been described that include inflammation, metabolic alterations, activation of oxidative stress, changes in the intestinal microbiota and in the…
- Trial name
- NCT03620097
- Testing
- EuPoly-3 DHA Infant
- Volunteers
- 60 people
- Sponsor
- Maimónides Biomedical Research Institute of Córdoba
Screen Time Exposure
Reactions to Social Media Warning Labels Among Teens and Young Adults
The primary objective of this study is to evaluate whether social media warnings are perceived as more effective than control labels among teens and young adults, and to identify the most promising topics for social media…
- Trial name
- NCT07199660
- Testing
- Human-developed negative body image warning, Voluntary warning, Human-developed depression and anxiety warning
- Where
- United States
- Volunteers
- 1,012 people, healthy volunteers welcome
- Sponsor
- Stanford University
Mothers of Newborn Infants
A Randomized Controlled Trial About Teaching Parents How to Manage Childhood Immunization Pain
There is no effect of a parent-directed fact sheet about pain management during childhood immunization and pre-test on parent learning about evidence-based pain relieving methods.
- Trial name
- NCT01637779
- Testing
- Fact sheet
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- University of Toronto
Concussion
Vitamin Therapy in Concussion Management: A Randomized Control Trial
The purpose of this study is to assess the efficacy of vitamin therapy in concussion when compared to placebo with respect to multiple endpoints including symptom severity, cognitive performance on computer based…
- Trial name
- NCT02382679
- Testing
- Experimental: Vitamin Mixture
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Neuromuscular Diseases in Children, Cerebral Palsy, Spastic
Muscle Spasticity Reduction in Children With Cerebral Palsy by Means of Hippotherapy
The aim of this study is to evaluate if a intervention with hippotherapy will improve spasticity for children ages 3-14 who have cerebral palsy.
- Conditions
- Neuromuscular Diseases in Children, Cerebral Palsy, Spastic, Spasticity, Muscle
- Trial name
- NCT03212846
- Testing
- Hippotherapy
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- University of Cadiz
Music Therapy, Anxiety
Receptive Music Interventions During Intradermal Testing in Children
The study summary and design were to assess procedural anxiety and stress in parents and pain perception in children during intradermal testing.
- Conditions
- Music Therapy, Anxiety, Pain Management, Skin Tests
- Trial name
- NCT07013669
- Testing
- Receptive Music Therapy - Solfeggio Frequencies, Receptive Music Therapy - Traditional Turkish Music
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Hilal Gungor
Pain, Fear
Effects of Active and Passive Distraction Methods on Children's Pain, Fear and Anxiety
Background: It is important that reduce children's pain, fear, and anxiety during the invasive procedures for building effective communication with children and their parents.
- Conditions
- Pain, Fear, Anxiety
- Trial name
- RCT (NCT06826352)
- Testing
- Active Distraction, Passive Distraction
- Where
- Turkey (Türkiye)
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Developmental Disability, Food Assistance
Integrating WIC With Early Childhood Systems of Developmental Care
This study's goals are to improve connections between Oregon Women, Infants, \& Children (WIC) clinics, primary care providers, and Early Intervention/Early Childhood Special Education programs (EI/ECSE), in order to help…
- Conditions
- Developmental Disability, Food Assistance, Health Care Disparity
- Trial name
- CDC-WIC (NCT04159038)
- Testing
- Intervention Group, Control group
- Where
- 4 sites in United States
- Volunteers
- 46 people
- Sponsor
- Oregon Health and Science University
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