Clinical trials: Randomized-controlled Trial
Acute Hypoxemic Respiratory Failure
Lucinactant for Treatment of Acute Hypoxemic Respiratory Failure in Children up to Two Years Old
Treatment with lucinactant, a peptide-containing synthetic lung surfactant, will be evaluated in young children with acute respiratory failure who require mechanical ventilation (life support), to determine if it is safe and if…
- Trial name
- KL4-AHRF-01 (NCT00578734)
- Testing
- Lucinactant
- Where
- 3 sites in United States, Chile
- Volunteers
- 165 people
- Sponsor
- Windtree Therapeutics
Atrial Septal Defect, Ventricular Septal Defect
Intravenous L-Citrulline to Treat Children Undergoing Heart Bypass Surgery : Revised Protocol
This clinical trial will determine the safety and effectiveness of intravenous L-citrulline in children undergoing cardiopulmonary bypass during heart surgery.
- Conditions
- Atrial Septal Defect, Ventricular Septal Defect, Atrioventricular Septal Defect
- Trial name
- NCT01120964
- Testing
- Intravenous L-Citrulline
- Where
- 2 sites in United States
- Volunteers
- 22 people
- Sponsor
- Asklepion Pharmaceuticals, LLC
Dysautonomia of Adolescence
Effect of Ivabradine on Adolescent Dysautonomia
Dysautonomia of Adolescence (dysautonomia) is an umbrella term used to describe symptoms experienced by adolescents and young adults related to dysfunction of the autonomic nervous system.
- Trial name
- ADAPT (NCT07881302)
- Testing
- Ivabradine
- Where
- Canada
- Volunteers
- 5 people
- Sponsor
- Kathryn Armstrong
Traumatic Brain Injury
MLC901 for Moderate to Severe Traumatic Brain Injury (Specified Drug Code)
Patients with a diagnosis of moderate to severe traumatic brain injury (TBI) will be enrolled. Subjects will be randomly assigned to receive either MLC901 (Specified Drug Code) or placebo capsules three times per day over 6…
- Trial name
- MLC901 (NCT04487275)
- Where
- Iran
- Volunteers
- 80 people
- Sponsor
- Ali Amini Harandi
Caries
Effectiveness of an ICCMS™ Caries Management Program.
The aim of this study is to compare in schoolchildren the effectiveness of an updated caries management program based on the current caries paradigm with the ICCMS™ system (International Caries Classification and Management…
- Trial name
- NCT04676230
- Testing
- Experimental group, Control group
- Where
- Colombia
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Universidad El Bosque, Bogotá
Breast Cancer, Hot Flashes
Acupuncture in Treating Hot Flashes in Women With Breast Cancer
RATIONALE: Acupuncture may help relieve hot flashes in women with breast cancer. It is not yet known whether acupuncture is more effective than a placebo in treating hot flashes in women with breast cancer PURPOSE: This…
- Trial name
- NCT00081965
- Testing
- acupuncture therapy, hot flashes attenuation, management of therapy complications
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Infants Admitted to Neonatal Units, NICU
Effects of Early Physiotherapy Program on the Infants in NICU
High-risk of Infants are defined as one with a history of negative environmental and biological factors that could lead to neuromotor developmental problems.
- Conditions
- Infants Admitted to Neonatal Units, NICU, NICU Infants, Family Centered Care
- Trial name
- NCT07201792
- Testing
- Early Physiotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Kahramanmaras Sutcu Imam University
Cerebral Palsy, Spastic, Diplegic
Potential Benefits of Home Based Exercise Programs in the Management of Spastic Cerebral Palsy
The study will be conducted to see the potential benefits of home based exercise program comprising routine physical therapy and traditional massage in the management of spastic cerebral palsy (CP).
- Trial name
- HEP&CP (NCT05111236)
- Testing
- Routine physical therapy, Traditional massage
- Where
- Pakistan
- Volunteers
- 86 people
- Sponsor
- National Institute of Rehabilitation Medicine, Islamabad, Pakistan
Neovascular, Glaucoma
Intravitreal Bevacizumab for Neovascular Glaucoma
Several studies have confirmed high levels of vascular endothelial growth factor (VEGF) in eyes with neovascular glaucoma (NVG).
- Trial name
- IVB NVG (NCT00384631)
- Testing
- subconjunctival normal saline, Avastin
- Where
- Iran
- Volunteers
- 26 people
- Sponsor
- Shahid Beheshti University of Medical Sciences
Tuberculosis, Tubercular Meningitis
Cyclophosphamide in the Treatment of Refractory Proliferative Arachnoiditis in CNS Tuberculosis
Tubercular meningitis occurs in around 10% of those with extrapulmonary tuberculosis and is a major cause of mortality and morbidity.
- Conditions
- Tuberculosis, Tubercular Meningitis, Arachnoiditis; Tuberculous (Etiology)
- Trial name
- NCT04620772
- Testing
- Cyclophosphamide injection
- Volunteers
- 40 people
- Sponsor
- All India Institute of Medical Sciences
Class II Malocclusion
Evaluation of the Levels of Pain, Discomfort, and Functional Impairment With Two Techniques of Retraction
Thirty-eight patients requiring extraction of maxillary first premolars will participate in the study. They will be divided randomly into two groups: an en-masse retraction group and a two-step group.
- Trial name
- NCT05652244
- Testing
- Mini-implants, Transpalatal arche (TPA)
- Where
- Syria
- Volunteers
- 38 people
- Sponsor
- Damascus University
Gastroenteritis, Vomiting
Symptomatic Treatment of Acute Gastroenteritis
Vomiting in children with acute gastroenteritis is a major factor of failure of oral rehydration therapy. Effective symptomatic treatment of vomiting would lead to an important reduction in the use of Intravenous Fluid Therapy.
- Conditions
- Gastroenteritis, Vomiting, Acute Gastroenteritis
- Trial name
- NCT01257672
- Testing
- Ondansetron, Domperidone
- Where
- 15 sites in Italy
- Volunteers
- 356 people
- Sponsor
- IRCCS Burlo Garofolo
Leishmaniasis, Cutaneous, Helminthiasis
Antihelminthic Therapy Combined With Antimony in the Treatment of Cutaneous Leishmaniasis
The purpose of this project is to investigate the efficacy of early, empiric anti-helminthic therapy combined with standard pentavalent antimony in the treatment of subjects co-infected with helminths and cutaneous leishmaniasis…
- Trial name
- NCT00469495
- Testing
- Anti-helminthic, meglumine antimony
- Where
- Brazil
- Volunteers
- 90 people
- Sponsor
- Hospital Universitário Professor Edgard Santos
Irritability Associated With Autism Spectrum Disorder (ASD)
Brexpiprazole in Treatment of Children and Adolescents With Irritability Associated With Autism Spectrum Disorder
The purpose of this study is to find out about the potential benefits and safety of brexpiprazole in children and adolescent participants, aged 5 to 17, with irritability associated with autism spectrum disorder.
- Trial name
- NCT04174365
- Testing
- Brexpiprazole
- Where
- United States
- Volunteers
- 119 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Pain, Postoperative, Phimosis
An Evaluation of Pain Outcomes of Ketorolac Administration in Children Undergoing Circumcision
Circumcision is the most common surgical procedure performed by Pediatric Urologists. Ketorolac has been shown to have an efficacy similar to morphine in multi-modal analgesic regimens without the commonly associated adverse…
- Conditions
- Pain, Postoperative, Phimosis, Paraphimosis, Balanitis
- Trial name
- NCT04646967
- Testing
- Bupivacain, Sevoflurane, Acetaminophen
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Alberta Children's Hospital
Influenza
A Phase III Clinical Trial of An Inactivated Quadrivalent Influenza Vaccine in Healthy Subjects Aged 3 Years and Older
Influenza is an acute respiratory disease caused by influenza viruses. There are three types of the virus including A, B and C. Both type A and type B viruses can cause acute febrile respiratory tract infection, characterized by…
- Trial name
- NCT02710409
- Testing
- Quadrivalent influenza vaccine, Trivalent influenza vaccine A, Trivalent influenza vaccine B
- Where
- China
- Volunteers
- 3,664 people, healthy volunteers welcome
- Sponsor
- Jiangsu Province Centers for Disease Control and Prevention
Systemic Sclerosis
Effect of Rosuvastatin on Systemic Sclerosis-related Pulmonary Hypertension
Although the aetiology of SSc-PAH remains elusive, vascular dysfunction seems to be the initial event and statins through their vasculoprotective effect might be of value in the treatment armamentarium of PAH related to SSc.
- Trial name
- NCT00984932
- Testing
- Rosuvastatin
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Alexandria
Cancer
Teens Taking Charge: Managing Cancer Online
Cancer is the most common potentially fatal disease of adolescence and the Internet represents an ideal means to deliver education, self-monitoring capabilities, and social support to enhance disease self-management by…
- Trial name
- NCT02299219
- Testing
- Taking Charge: Managing Cancer Online, Standard Medical Care and Cancer Resource Center
- Where
- 3 sites in Canada
- Volunteers
- 73 people
- Sponsor
- The Hospital for Sick Children
Infantile Colic, Reflexology
The Effect of Foot Reflexology on Infantile Colic Symptoms
Aim: To compare the effect of foot reflexology and placebo foot reflexology on colic symptoms such as pain, ineffective sleep, and colicky crying periods in infants with colic.
- Trial name
- NCT03939611
- Testing
- Foot Reflexology
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Acute on Chronic Liver Failure, Hepatitis B
Randomized Controlled Trial of Tenofovir in Patients of Reactivation of Hepatitis B Presenting as Acute on Chronic Liver Failure
Background: Reactivation of hepatitis B is a well-characterized syndrome marked by the abrupt reappearance or rise of hepatitis B virus (HBV) DNA in the serum of a patient with previously inactive or resolved HBV infection.
- Trial name
- ACLF (NCT01074645)
- Testing
- Tenofovir disoproxil fumarate (TDF)
- Where
- India
- Volunteers
- 27 people
- Sponsor
- Govind Ballabh Pant Hospital
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