Clinical trials: Randomized-controlled Trial
Prescribing, Off-Label
CMO Letter to Reduce Inappropriate Antibiotic Prescribing Winter 2019/2020
This trial aims to reduce inappropriate prescription of antibiotics and broad spectrum antibiotics by general practitioners (GPs) in England.
- Trial name
- NCT04051281
- Testing
- Letter
- Where
- United Kingdom
- Volunteers
- 2,963 people
- Sponsor
- Public Health England
Hemorrhage
Trial Comparing Tisseel as an Adjunct to Traditional Hemostasis After Redo Cardiac Surgery
Bleeding after redo cardiac surgery is a common, unresolved and consequences-heavy event as per present day. Tisseel (Baxter inc) sprayed on the already hemostased mediastinum jut before closing seems a promising technique to…
- Trial name
- RETICO (NCT02360800)
- Testing
- Spray Fibrin Sealant, Traditional Hemostasis and chest Closure Routine
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- Cardiochirurgia E.H.
Urinary Catheterization, Device
Positioning Device for Female Urinary Catheterization
In female patients, the dorsal recumbent position is required to visualize the urethral meatus. In female patients, direct visualization of the urethral meatus after providing a suitable position is very important for successful…
- Conditions
- Urinary Catheterization, Device, Nursing, Positioning (Prone, Right Lateral and Semi-Elevated Supine Position)
- Trial name
- NCT07327671
- Testing
- dorsal recumbent positioning device
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi Gulhane Tip Fakultesi
Pain
Efficacy of Topical Lidocaine to Decrease Discomfort With Intranasal Midazolam Administration
The purpose of this study was to establish whether premedication with topical lidocaine would reduce the pain associated with IN midazolam administration in children.
- Trial name
- NCT02396537
- Testing
- Lidocaine, Midazolam, 0.9% Saline
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Malaria
Chloroquine for Malaria in Pregnancy
The purpose of this study is to test prevention strategies for pregnancy-related malaria. Researchers will compare different malaria treatments and treatment schedules which include chloroquine therapy (weekly doses versus being…
- Trial name
- NCT01443130
- Testing
- Chloroquine, Sulfadoxine-pyrimethamine
- Where
- Malawi
- Volunteers
- 900 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Acute Medical Patients Hospitalized in Internal Medicine
Decrease the Frequency of Inappropriate Intravenous Lines in Internal Medicine
Aim: to determine whether a nationwide teaching program delivered to medical doctors can decrease the use of inappropriate intravenous lines in internal medicine
- Trial name
- PERMI (NCT01633307)
- Testing
- Education
- Volunteers
- 59 people
- Sponsor
- Hopital Lariboisière
Prematurity, Immune Defect
Different Doses of Vitamin D and T Regulatory Cells in Preterm Infants
This study evaluate the effect of two different doses of vitamin D on T-regulatory cells in preterm infants. Half of the subjects receives 400 IU vitamin D and the other half receives 800 IU vitamin D.
- Trial name
- NCT03793309
- Testing
- Vitamin D
- Volunteers
- 40 people
- Sponsor
- Cairo University
Anti-anxiety Agents, Moderate Sedation
Sublingual Versus Intranasal Administration of Dexmedetomidine for Sedation of Children Undergoing Dental Treatment
The aim of this study is to assess the efficacy of Dexmedetomidine drug either used sublingually or intranasally in managing healthy children during dental treatment
- Trial name
- NCT04237532
- Testing
- Intranasal Dexmedetomidine, Sublingual Dexmedetomidine
- Where
- Egypt
- Volunteers
- 42 people
- Sponsor
- Nourhan M.Aly
Health Knowledge, Attitudes, Practice
Effect of a Nutritional Education Intervention in Female Athletes
This cluster randomized controlled trial aimed to evaluate the effect of a nutritional education intervention on sports nutrition knowledge, dietary intake, and body composition in adolescent female handball players.
- Trial name
- ATHENEA (NCT07460102)
- Testing
- Nutritional education program
- Where
- Spain
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Andreu Farran-Codina
Recurrent Congenital Talipes Equinovarus
SPLATT to Peroneus Brevis vs TATT to Lateral Cuneiform
Congenital talipes equinovarus, is a common congenital foot deformity involving hindfoot equinus and varus, along with mid-/forefoot adduction and cavus.
- Trial name
- Recurrent CTEV (NCT06300645)
- Testing
- SPLATT
- Where
- Egypt
- Volunteers
- 25 people
- Sponsor
- Assiut University
Candidiasis, Sepsis
Fluconazole Versus Micafungin for Candida Bloodstream Infection in Non-Neutropenic Patients
The purpose of this study is to verify the equivalence in clinical efficacy of fluconazole and micafungin for the treatment of Candida bloodstream infection in non-neutropenic patients.
- Trial name
- NCT00304772
- Testing
- Fluconazole, Micafungin
- Where
- Japan
- Sponsor
- Kyoto University
Dental Caries
Effectiveness of Fissure Sealant and Topical Fluoride Application in Preventing Dental Caries
Nearly half of the 12-year-old children in China have dental caries (tooth decay) and most of the lesions are in the fissures of the first permanent molars.
- Trial name
- NCT01446107
- Testing
- placement of fissure sealant, fluoride varnish, silver fluoride
- Where
- China
- Volunteers
- 502 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Pain During and After Endovenous Laser Obliteration of Large Saphenous Vein Based on Lidocaine Tumescent Concentration
Efficacy of Variable Lidocaine Concentrations in Tumescent Anesthesia for Pain Control During and After Endovenous Laser Procedure; Non-inferiority Trial
Endovenous laser treatment is a minimally invasive procedure that has been shown to be a safe and effective treatment for varicose veins.
- Trial name
- NCT02192411
- Testing
- Lidocaine
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Midwest Vein Center
Motor Development, Physical Activity
Evaluation of the Move 2 Learn (M2L) Program for Young Children
Move 2 Learn (M2L) is a 10-week movement and pre-literacy program for preschool aged children and their parents designed to improve both movement and reading skills as well as support their overall cognitive, physical, and…
- Trial name
- NCT03999619
- Testing
- Move 2 Learn
- Where
- Canada
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Toronto
This Study Will Evaluate Whether TXA Reduces Pain
Effect of Tranexamic Acid (TXA) Administered Prior to Shoulder Arthroscopy on Postoperative Pain Medication Usage: A Randomized Controlled Trial
To our knowledge, no studies examining the use of TXA after shoulder arthroscopy in an outpatient setting have been published. This study will evaluate whether TXA reduces pain as measured by opioid consumption and a visual…
- Trial name
- NCT06920264
- Testing
- Tranexamic acid
- Where
- United States
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- St. Louis Joint Replacement Institute
Influenza
A Study of Oseltamivir (Tamiflu) for the Seasonal Prophylaxis of Influenza in Immunocompromised Participants
This 2 arm study will evaluate the efficacy and safety of oseltamivir in the seasonal prophylaxis of influenza in immunocompromised participants (as represented by transplant recipients).
- Trial name
- NCT00412737
- Testing
- Oseltamivir
- Where
- 78 sites in United States, Belgium and 12 more
- Volunteers
- 477 people
- Sponsor
- Hoffmann-La Roche
Internet Gaming Disorder
Collective Motivational Interviewing (CMI) for Adolescents With Internet Gaming Disorder
The present study examines the efficacy of CMI in reducing adolescent IGD symptoms and enhancing social support given by CSOs among adolescents with high risk of IGD (probable IGD cases screened positive by validated tools).
- Trial name
- NCT05917977
- Testing
- Collective Motivational Interviewing plus Education Materials, Control group (Education Materials)
- Where
- Hong Kong
- Volunteers
- 172 people
- Sponsor
- Hong Kong College of Technology
Sickle Cell Disease, Cognitive Impairment
Cognitive Remediation Intervention to Prepare for Transition of Care
Randomized Controlled Trial (RTC) testing the efficacy of a telehealth adaptation of the Cognitive-Remediation of Executive and Adaptive Deficits in Youth (C-READY) intervention to prepare adolescents with sickle cell disease for…
- Conditions
- Sickle Cell Disease, Cognitive Impairment, Adolescent Behavior, Self Efficacy
- Trial name
- NCT05336201
- Testing
- CREADY (Cognitive-Remediation of Executive and Adaptive Deficits in Youth)
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Alabama at Birmingham
Atopic Dermatitis (AD)
A Phase 3 Trial of OPA-15406 Foam in Children and Infants With Atopic Dermatitis
To investigate the superiority of 0.3% OPA-15406 foam to the vehicle in children with atopic dermatitis (AD)
- Trial name
- NCT07184645
- Testing
- OPA-15406, Vehicle
- Where
- Japan
- Volunteers
- 198 people
- Sponsor
- Otsuka Pharmaceutical Co., Ltd.
Learning Problems
Educational Support Interventions for Children in Care
A Randomized controlled study of two different educational support interventions developed for children in foster care (age 6-13).
- Trial name
- NCT02217072
- Testing
- School intervention, Parents as Tutors
- Where
- Denmark
- Volunteers
- 190 people
- Sponsor
- VIVE - The Danish Center for Social Science Research
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