Clinical trials: Randomized-controlled Trial
Chronic Pain
Study to Evaluate the Efficacy of Dronabinol (Marinol) as Add-On Therapy for Patients on Opioids for Chronic Pain
The purpose of this research study is to determine if Marinol alleviates pain in patients with chronic pain who are currently taking opioids.
- Trial name
- NCT00153192
- Testing
- Marinol (dronabinol)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Brigham and Women's Hospital
Arthroplasty, Replacement, Knee, Nerve Block
Epidural Catheter With or Without Adductor Canal Nerve Block for Postoperative Analgesia Following Total Knee Arthroplasty
The purpose of this study is to further investigate the efficacy of adductor canal nerve blocks for pain management after total knee replacement.
- Trial name
- NCT02121392
- Testing
- Adductor Canal Nerve Block Catheter, Bupivacaine
- Where
- United States
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Amblyopia
Evaluation of AmblyoFix for the Treatment of Unilateral Amblyopia
This is a prospective, randomized, parallel-group, assessor-masked, non-inferiority clinical trial designed to compare the efficacy, safety, and adherence of AmblyoFix binocular digital therapy with standard occlusion (patching)…
- Trial name
- NCT07240311
- Testing
- AmblyoFix binocular digital therapy, Occlusion therapy (Patching)
- Where
- Iran
- Volunteers
- 40 people
- Sponsor
- Eyesight Electronics
Dental Caries in Children
Water From Bottles to Establish Strong Teeth
The waterBEST study is a proof-of-concept, randomized, double-masked, placebo controlled, parallel group study evaluating dental caries-preventive effects of fluoridated bottled water compared to non-fluoridated bottled water in…
- Trial name
- waterBEST (NCT04893681)
- Testing
- Fluoridated bottled drinking water, Non-fluoridated drinking water
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Methylene Blue, Recurrent Laryngeal Nerve Injuries
Methylene Blue Spray for Identification of Recurrent Laryngeal Nerve and Parathyroid Gland
Thyroidectomy is the procedure by which surgeons treat various thyroid diseases and is considered the commonest endocrinal surgery. Yet, it carries a risk for intraoperative complications.
- Conditions
- Methylene Blue, Recurrent Laryngeal Nerve Injuries, Parathyroid Gland
- Trial name
- NCT05113628
- Testing
- methylene blue identification
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Zagazig University
Discoid Meniscus of Knee
Application of Smart Wearable Device-Based Remote Rehabilitation in Postoperative Recovery After Arthroscopic Surgery for Discoid Meniscus
This study is designed as a single-center, prospective, randomized controlled trial. The aim of this clinical trial is to evaluate the effectiveness, safety, and feasibility of a wearable device-based telerehabilitation approach…
- Trial name
- NCT07549867
- Testing
- Telerehabilitation intervention based on wearable devices, Clinic rehabilitation
- Volunteers
- 60 people
- Sponsor
- West China Hospital
Unintended Pregnancy, Adolescent Problem Behavior
Multi-site Evaluation of an Evidence-based Positive Youth Development Program
Investigators are carrying out a study to assess the immediate and long-term effects of a positive youth development program (the Teen Outreach Program) on high school youth in Florida.
- Trial name
- NCT02519530
- Testing
- Teen Outreach Program
- Volunteers
- 8,161 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Urinary Tract Infections
Oral vs Initial Intravenous Antibiotic Treatment of Urinary Tract Infections in Children: a RCT
The main objectives of the study are 1. to compare the efficacy of oral vs initial iv antibiotic treatment in children with a first episode of UTI 2.
- Trial name
- NCT00161330
- Testing
- oral amoxicilline/clavulanic acid, iv ceftriaxone
- Volunteers
- 440 people
- Sponsor
- University of Padova
Dental Anxiety in Children, Pain
Virtual Reality for Pain and Anxiety in Pediatric Dental Treatment
The goal of this clinical trial is to learn whether immersive virtual reality (VR) reduces pain and anxiety in children aged 6-12 years during routine dental procedures.
- Trial name
- NCT07636330
- Testing
- Immersive Virtual Reality Headset, Standard Behaviour Guidance
- Where
- Canada
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Alzheimer's Disease, Agitation
Citalopram for Agitation in Alzheimer's Disease
The purpose of this study is to evaluate the safety and efficacy of citalopram for agitation in Alzheimer's dementia.
- Trial name
- CitAD (NCT00898807)
- Testing
- citalopram
- Where
- 8 sites in United States, Canada
- Volunteers
- 186 people
- Sponsor
- JHSPH Center for Clinical Trials
Post-operative Pain, Opioid Use
QL vs LAI for Palatoplasty
This study will consist of patients ages 6-18 who are undergoing a surgery on the hard or soft palate of the mouth (palatoplasty), with removal of bone from the front of the hip (anterior iliac bone graft harvesting).
- Conditions
- Post-operative Pain, Opioid Use, Cleft Palate
- Trial name
- NCT06420336
- Testing
- Quadratus lumborum block, Local anesthetic infiltration
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Medical University of South Carolina
Spinal Muscular Atrophy
A Trial of Hydroxyurea in Spinal Muscular Atrophy
Spinal muscular atrophy (SMA) is an autosomal recessive disorder in humans which results in the loss of motor neurons. It is caused by reduced levels of the survival motor neuron (SMN) protein as a result of loss or mutation of…
- Trial name
- NCT00485511
- Testing
- Hydroxyurea
- Where
- Taiwan
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Hand, Foot and Mouth Disease
Safety and Immunogenicity of Concomitant Administration of EV71 Vaccine With EPI Vaccines
The purpose of this study is to evaluate the safety and immunogenicity of concomitant administration of EV71 vaccine with recombinant hepatitis B vaccine/Group A meningococcal polysaccharide vaccine.
- Trial name
- NCT03274102
- Testing
- Concomitant administration of EV71 vaccine with EPI vaccines, Single injection of EPI vaccine, EV71 Vaccine only
- Where
- China
- Volunteers
- 780 people, healthy volunteers welcome
- Sponsor
- Sinovac Biotech Co., Ltd
Dengue Fever
Zanamivir Treatment of Vascular Permeability in Dengue (ZAP-DENGUE)
ZAP-DENGUE is a pilot randomized, double-blind, placebo-controlled evaluation of the safety and efficacy of five days of intravenous zanamivir treatment to treat vascular permeability syndrome which is the main cause of death in…
- Trial name
- ZAP-DENGUE (NCT04597437)
- Testing
- Zanamivir
- Where
- 2 sites in Colombia
- Volunteers
- 74 people
- Sponsor
- George Washington University
Intubation
The Effects of Jaw Thrust on the Time to Successful Fiberoptic Pediatric Orotracheal Intubation During Residents Training Program
In this study, the authors aim to investigate the effect of adding jaw thrust maneuver on time to successful orotracheal fiberoptic intubation of pediatrics during resident training program.
- Trial name
- NCT06300437
- Testing
- jaw thrust, control (sub laxed jaw)
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Kasr El Aini Hospital
Ankle Injury, Foot Injury
Dance Mental Health App
This project aims to enhance self-compassion in adolescent dancers recovering from a foot and ankle injury by incorporating the use of a mental health intervention app using gamified design during their recovery.
- Conditions
- Ankle Injury, Foot Injury, Lower Extremity Injury
- Trial name
- NCT07219095
- Testing
- Mental Health App
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of California, San Diego
Dental Caries, Child Behavior
Efficacy of Moderate Sedation for Dental Treatment of Young Children
There is lack of clinical trials on pediatric dental sedation. The purpose of this study is to test (using a randomized controlled trial design) the hypothesis that young children behavior during dental treatment improves with…
- Conditions
- Dental Caries, Child Behavior, Conscious Sedation Failure During Procedure
- Trial name
- NCT00902395
- Testing
- Midazolam, Protective stabilization, Midazolam, ketamine
- Where
- Brazil
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Goias
Pancreatic Neoplasm
Tight Glycemic Control by Artificial Pancreas
This study evaluated a closed-loop system providing continuous monitoring and strict control of perioperative blood glucose following pancreatic resection.
- Trial name
- NCT00657995
- Testing
- Artificial Pancreas (STG-22)
- Where
- Japan
- Volunteers
- 32 people
- Sponsor
- Kochi University
Inattentive, Hyperactivity
Assessment of Probiotics Lactobacillus in the Management of Attention Deficit Hyperactive Disorder
ADHD is a neurodevelopmental disorder characterized by persistent symptoms of inattention and/or hyperactivity and impulsivity that are present before age 18.
- Conditions
- Inattentive, Hyperactivity, Impulsivity
- Trial name
- ADHD (NCT04167995)
- Testing
- Probiotic Formula lacteal forte
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Respiratory Distress Syndrome
Comparing Weaning of Nasal Continuous Positive Airway Pressure (CPAP) From Preterm Infants
To compare the 2 methods of weaning of nasal continuous positive airway pressure (CPAP) in premature babies born between 26 and 32 weeks
- Trial name
- NCT02126501
- Testing
- Gradual pressure wean
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Maimonides Medical Center
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