Clinical trials: Rectal Cancer Surgery
Extranodal Extension
Tumor Deposits in Colorectal Cancers
Tumor deposits (TDs) are emerging as an adverse prognostic factor in colorectal cancers (CRCs), but they are quite ignored in the current staging system.
- Trial name
- TD (NCT05923450)
- Testing
- Colorectal Resection
- Volunteers
- 243 people
- Sponsor
- University of Campania Luigi Vanvitelli
Colorectal Cancer, Bowel Ileus
Efficacy of Mosapride on Recovery of Intestinal Motility After Elective Colorectal Cancer Surgery
Postoperative ileus (POI) is one of the most common causes of prolonged hospital stays after abdominal surgery. The pathophysiology of POI is multifactorial and complex.It is known to be associated with sympathetic neural…
- Trial name
- NCT04905147
- Testing
- Mosapride
- Where
- Thailand
- Volunteers
- 44 people
- Sponsor
- Mahidol University
Rectal Cancer, Colo-rectal Cancer
Pre-therapeutic MRI Assessment of Early-Stage Rectal Cancer and Significant Rectal Polyps to Avoid Major Resectional Surgery
When a patient is diagnosed with a rectal (bowel) polyp or cancer, radiology doctors read MRI scans to describe how deeply the cancer invades into the bowel wall (this is the 'stage' of the cancer).
- Trial name
- PRESERVE (NCT04103372)
- Testing
- MRI scan, Radiologist training
- Where
- 23 sites in United Kingdom
- Volunteers
- 200 people
- Sponsor
- Imperial College London
Colorectal Cancer, Surgery
Incremental Cost-Utility Study on Prehabilitation Among Older Patients With Colorectal Cancer Undergoing Surgery
A prospective multicenter observational cost-utility study following older or high-risk patients with colorectal cancer with and without prehabilitation before surgery.
- Trial name
- PreColo CU (NCT04097795)
- Testing
- Prehabilitation
- Where
- 5 sites in Netherlands
- Volunteers
- 72 people
- Sponsor
- Radboud University Medical Center
Colorectal Cancer
Indicators of Anastomotic Leak After Colorectal Surgery
We reviewed the patient underwent colorectal surgery with anastomosis and identified patients with anastomotic leak. Then we started to figure out what blood investigation could be related to anastomotic leak.
- Trial name
- NCT06156358
- Testing
- No intervention
- Volunteers
- 441 people
- Sponsor
- King Abdulaziz University
Colorectal Cancer, Surgical Procedure, Unspecified
Perioperative Management of Colorectal Cancer Patients Infected With COVID-19: a Multicenter Prospective Cohort Study.
This trial is a multicenter prospective cohort study to explore timing of colorectal cancer surgery after COVID-19 infection so that can assist clinicians and patients.
- Trial name
- NCT05682898
- Testing
- Timing of colorectal cancer surgery
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Prostate Cancer
Intra-operative Trans-rectal Ultrasound Guidance for Robot-assisted Radical Prostatectomy
Radical prostatectomy, or the surgical extirpation of the prostate, is a standard treatment for prostate cancer. The state of the art radical prostatectomy involves a robotic laparoscopic surgery system (the da Vinci) which…
- Trial name
- TRUS-RP (NCT02001597)
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of British Columbia
Colorectal Neoplasms, Surgical Wound Infection
Reduction of Surgical Site Infections in Elective Colorectal Surgery After the Implementation of a Bundle of Care.
Background. The Nosocomial Infection Surveillance Program in Catalonia (VINCat) monitors SSI in elective colorectal surgery since 2007 in 56 hospitals (7.5 million population).
- Trial name
- NCT04129177
- Testing
- Implementation of a bundle of surgical infection preventive measures
- Where
- Spain
- Volunteers
- 12,000 people
- Sponsor
- Hospital de Granollers
Colo-rectal Cancer, Anastomosis, Leaking
The Factors Influencing the Success of Redo Surgery and Anal Function for Anastomosis Failure or Local Tumor Recurrence
To analyze the influencing factors of the success of redo surgery due to anastomotic fistula or anastomotic recurrence after rectal cancer surgery and to evaluate the anal function of patients
- Trial name
- NCT07440888
- Testing
- redo surgery
- Volunteers
- 143 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Rectal Cancer
ArtiSential® for Rectal Cancer Surgery
This study aimed to assess efficacy of ArtiSential® in reducing laparoscopic rectal cancer surgery duration. We retrospectively reviewed the data of patients who underwent laparoscopic low or ultralow anterior resection for…
- Trial name
- NCT06236282
- Testing
- ArtiSential®
- Where
- South Korea
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Colorectal Tumors
Effect of Peritoneal Lavage With Clindamycin-Gentamicin Solution & Oncologic Outcome
Antibiotic lavage reduces bacterial contamination and decreases SSI infection rate. SSI leads to an immunocompromised situation, leaving unattended the neoplasm.
- Trial name
- NCT02399059
- Testing
- Antibiotic lavage, Normal saline lavage
- Volunteers
- 106 people
- Sponsor
- Hospital General Universitario Elche
Rectal Cancer
Quality of Life After Abdominoperineal Resection for Rectal Cancer, Comparing Two Surgical Techniques
The purpose of the study is to compare self-reported health related quality of life after two different operating techniques for low rectal cancer operated by rectal amputation, using a specific and detailed questionnaire.
- Trial name
- APR (NCT01323166)
- Testing
- Excision of the levator muscle
- Where
- Sweden
- Volunteers
- 75 people
- Sponsor
- Sahlgrenska University Hospital
Rectal Cancer
Quality Initiative in Rectal Cancer (QIRC) Trial
The Quality initiative in rectal cancer (QIRC) trial will test if a strategy designed to positively influence surgeon practice can decrease hospital rates of permanent colostomy and local tumour recurrence for surgically treated…
- Trial name
- NCT00182130
- Testing
- Quality Initiative in Rectal Cancer (QIRC) strategy
- Volunteers
- 691 people
- Sponsor
- Hamilton Health Sciences Corporation
Rectal Cancer, Pelvic Cancer
Advanced Pelvic Surgical Oncology Database - Prospective Observational Study
Retrospective and prospective observational study of patients undergoing advanced pelvic oncological resection for maligancy including multi visceral resection, beyond TME resection and sacrectomy/flap reconstruction/urinary…
- Conditions
- Rectal Cancer, Pelvic Cancer, Gynecologic Cancer, Colon Cancer
- Trial name
- NCT05696002
- Where
- United Kingdom
- Volunteers
- 300 people
- Sponsor
- Glasgow Royal Infirmary
Colonic Neoplasms, Colorectal Neoplasms
Study of an Individualized Vaccine Targeting Neoantigens in Combination With Immune Checkpoint Blockade for Patients With Colon Cancer
The primary objective is to assess and characterize the antitumor activity and safety and tolerability of adjuvant treatment with an individualized neoantigen vaccine called GRT-C901/GRT-R902 (chimpanzee adenovirus [ChAd] and…
- Trial name
- NCT05456165
- Testing
- GRT-C901, GRT-R902, Atezolizumab
- Where
- 3 sites in United States
- Sponsor
- Gritstone bio, Inc.
Rectal Cancer, Organ Preservation
Treatment Strategy for Rectal Cancer Patients With Complete Clinical Response
This was a propensity-score matched observational analysis, comparing the oncological outcome of surgical resection vs watch and wait apporach for rectal cancer patients with a cCR.
- Trial name
- NCT03846726
- Testing
- standard TME surgery
- Where
- China
- Volunteers
- 513 people
- Sponsor
- Yuan-hong Gao
Adenocarcinoma of the Rectum
Can we Save the Rectum by Watchful Waiting or TransAnal Surgery Following (Chemo)Radiotherapy Versus Total Mesorectal Excision for Early REctal Cancer?
Bowel cancer is the second most common tumour with 41 000 new cases diagnosed annually in the UK, 447 000 across Europe and 1.36 million worldwide; of which one third are located in the rectum.
- Trial name
- STAR-TREC (NCT02945566)
- Testing
- Standard TME surgery, Long course concurrent chemoradiation with capecitabine and radiotherapy, Short course radiotherapy
- Where
- 5 sites in Belgium, Denmark and 3 more
- Volunteers
- 380 people
- Sponsor
- University of Birmingham
Rectal Cancer
Magnetic Resonance Tumour Regression Grade (mrTRG) as a Novel Biomarker - Phase III Non CTIMP Trial
Open to patients undergoing any pre-operative treatment for locally advanced rectal cancer, TRIGGER is the only phase III clinical trial in the UK offering watch and wait.
- Trial name
- TRIGGER (NCT02704520)
- Testing
- High resolution MRI scan, mrTRG assessment
- Where
- 10 sites in United Kingdom
- Volunteers
- 441 people
- Sponsor
- Imperial College London
Colorectal Neoplasms
Using Multimodal Prehabilitation to Improve Outcomes for Frail Patients Undergoing Resection of Colorectal Cancer
The purpose of this study is to determine if a program of physical activity, nutritional supplements and relaxation techniques is effective at decreasing post operative complications in frail colorectal cancer patients undergoing…
- Trial name
- NCT02502760
- Testing
- Physical Exercise Program, Whey Protein Isolate Powder, Relaxation Techniques
- Where
- 2 sites in Canada
- Volunteers
- 120 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Colorectal Neoplasm
A LAparoscopic and TransAnal Total Mesorectal Excision (TME) for Rectal Cancer Trial
All patients planned for an anterior resection due to rectal cancer with a total mesorectal excision are included. This is a feasibility study, thus no randomization will be performed.
- Trial name
- LATA (NCT02324556)
- Where
- 2 sites in Sweden
- Volunteers
- 6 people
- Sponsor
- Sahlgrenska University Hospital