Clinical trials: Recurrent Depression
Major Depressive Disorder, Recurrent, Mild, Depressive Disorder, Major
Cortical Excitability and Inhibition in MDD
The purpose of this study is to learn if measures of brain activity are different in children and adolescents with depression who are in different stages of treatment.
- Trial name
- NCT01718730
- Testing
- Transcranial Magnetic Stimulation (TMS), Magnetic Resonance Spectroscopy and Imaging
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Mayo Clinic
Anxiety Disorder, Depression
Combination Chemotherapy Plus Fluoxetine in Treating Patients With Advanced or Recurrent Non-Small Cell Lung Cancer
This trial is designed to test the efficacy of fluoxetine to improve patient's quality of life during chemotherapy. An innovative application of a selective serotonin reuptake inhibitor may modulate the effects of fatigue…
- Conditions
- Anxiety Disorder, Depression, Fatigue, Lung Cancer
- Trial name
- NCT00005850
- Testing
- cisplatin, fluoxetine, gemcitabine hydrochloride
- Where
- 43 sites in United States, Puerto Rico
- Volunteers
- 21 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Acute Leukemia, Recurrent Leukemia
Bright White Light Therapy for the Improvement of Sleep, Fatigue, Distress, Depression, and Anxiety in Hospitalized Leukemia Patients
This trial investigates how well bright white light therapy works in improving sleep, fatigue, distress, depression, and anxiety, side effects that are often experienced during an intense leukemia treatment regimen, in…
- Conditions
- Acute Leukemia, Recurrent Leukemia, Refractory Leukemia
- Trial name
- NCT04597086
- Testing
- Best Practice, Bright White Light Therapy, Survey Administration
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Major Depressive Disorder, Major Depressive Disorder, Recurrent
Glutamate Probes in Adolescent Depression
The purpose of this study is to learn if measures of brain chemicals from a brain scan called Magnetic Resonance Imaging and Spectroscopy (MRI/MRS) and brain activity (known as cortical excitability and inhibition) collected by…
- Conditions
- Major Depressive Disorder, Major Depressive Disorder, Recurrent, Major Depressive Disorder, Remitted
- Trial name
- GPII (NCT02307617)
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Early Intervention, Child of Impaired Parents
VIA Family - Family Based Early Intervention Versus Treatment as Usual
This RCT aims to investigate the effect of an early family-based intervention (VIA Family) focusing on reducing risk and increasing resilience for children in families where at least one parent has a severe mental illness.The…
- Conditions
- Early Intervention, Child of Impaired Parents, Child, Adolescent
- Trial name
- NCT03497663
- Testing
- VIA Family intervention, Treatment As Usual
- Where
- Denmark
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital
Breast Cancer
Lynparza Breast Cancer Clinical Experience Investigation
To characterise the development of ADRs of bone marrow depression in patients under actual post-marketing use
- Trial name
- NCT03590938
- Where
- 31 sites in Japan
- Volunteers
- 111 people
- Sponsor
- AstraZeneca
Stroke Recurrence, Cardiovascular Events
Post-stroke Depression Treatment Effect on Stroke Recurrence
It is not clear whether depresssion can predispose, or precipitate stroke recurrence in patients with stroke. We sought the relationship of post stroke depression with stroke recurrence.
- Conditions
- Stroke Recurrence, Cardiovascular Events, Depression
- Trial name
- STROKE (NCT04776226)
- Testing
- Citalopram
- Where
- Turkey (Türkiye)
- Volunteers
- 1,230 people
- Sponsor
- Ege University
Alopecia Areata, Depressive Episode
The Epidemiology, Management, and the Associated Burden of Related Conditions in Alopecia Areata
This study series consists of four related studies and aims to explore and describe many important elements of alopecia areata over three key areas: (1) the current epidemiology of alopecia areata, (2) the prevalence and…
- Conditions
- Alopecia Areata, Depressive Episode, Recurrent Depressive Disorder, Anxiety Disorders
- Trial name
- NCT04239521
- Testing
- Exposure of interest (studies 2 & 3).
- Where
- United Kingdom
- Volunteers
- 51,955 people
- Sponsor
- Momentum Data
Depression, Depressive Disorder, Major
Decentering and Relapse/Recurrence in MBCT for Depression in Adults
Objective: "Decentering" is defined as the ability to observe one's thoughts and feelings as temporary, objective events in the mind, and is increasingly regarded as a candidate mechanism in mindfulness-based interventions.
- Conditions
- Depression, Depressive Disorder, Major, Depression in Remission
- Trial name
- NCT05111665
- Testing
- Mindfulness-based Cognitive Therapy (MBCT), Relaxation Group Therapy (RGT), Treatment as usual (TAU)
- Where
- Canada
- Volunteers
- 227 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Followin Ketamine Treatment
Ketamine Long Therm Follow Up Study
Results of the study and of 5 years follow up of depressed patients who participated in the study during 2014-2015. We will locate the participants and will interview them will use the same questionnaires to evaluate their…
- Trial name
- ket_Fol_Up (NCT04238039)
- Where
- Israel
- Volunteers
- 16 people
- Sponsor
- The Chaim Sheba Medical Center
Suicide, Attempted, Suicide and Depression
Ketamine Versus Midazolam for Recurrence of Suicidality in Adolescents
This project aims to examine the signal of efficacy of ketamine, a rapidly acting medication shown to decrease suicidality in adults in as short as hours or days, as opposed to weeks.
- Conditions
- Suicide, Attempted, Suicide and Depression, Suicide Threat
- Trial name
- TASK (NCT04592809)
- Testing
- Ketamine Hydrochloride, Midazolam Hydrochloride
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Texas Southwestern Medical Center
Major Depressive Disorder, Mood Disorders
Mechanisms of Rumination Change in Adolescent Depression
This study will evaluate whether a newer treatment, rumination-focused cognitive behavioral treatment, which includes mindfulness and can be used to reduce ruminative habits, change ways in which key brain regions interact with…
- Trial name
- RuMeChange (NCT03859297)
- Testing
- Rumination-Focused CBT, Relaxation-based Therapy
- Where
- 3 sites in United States
- Volunteers
- 183 people
- Sponsor
- Ohio State University
Depression - Major Depressive Disorder, Anxiety
Impact of Behavioral Activation on Depression and Quality of Life in Patients with Colon Cancer
The purpose of this randomized clinical trial is to study anxiety and depression symptoms at diagnosis in patients with colon cancer. Previous studies have shown that so-called.
- Conditions
- Depression - Major Depressive Disorder, Anxiety, Colon Cancer
- Trial name
- BAdepCa (NCT06745700)
- Testing
- Brief Behavioural Activation, Care as usual
- Where
- Sweden
- Volunteers
- 400 people
- Sponsor
- Region Västmanland
Anxiety Disorder, Breast Cancer
Gabapentin For the Control of Hot Flashes in Women With Breast Cancer
RATIONALE: Gabapentin may be effective for the control of hot flashes. It is not yet known if gabapentin is effective in treating hot flashes.
- Conditions
- Anxiety Disorder, Breast Cancer, Depression, Hot Flashes
- Trial name
- NCT00022074
- Testing
- gabapentin, quality-of-life assessment
- Where
- 18 sites in United States
- Sponsor
- Gary Morrow
Suicide, Attempted
Bipolarity - Depression in Children and Adolescent Suicide Attempters: Better Diagnosis to Prevent Recurrence
The purpose of the study is to describe the number of diagnosis of bipolar depression and comorbid suicidal behavior according to the diagnostic criteria of the DSM-5.
- Trial name
- NCT03116503
- Testing
- diagnosis of bipolar disorder and comorbid depression
- Where
- France
- Volunteers
- 58 people
- Sponsor
- Fondation Lenval
Depressive Disorder, Anxiety Disorders
StayFine: Personalised Relapse Prevention of Anxiety and Mood Disorders in Youths
The current study examines the effectiveness of the StayFine app for relapse prevention of anxiety or depressive disorders in youth using a randomized controlled trial.
- Trial name
- StayFine (NCT05551468)
- Testing
- StayFine guided app-based personalised intervention modules, StayFine app-based monitoring
- Where
- Netherlands
- Volunteers
- 254 people, healthy volunteers welcome
- Sponsor
- Ggz Oost Brabant
Major Depressive Episode
Retrospective Observational Study DIANA Study
This Non-Interventional Study (NIS) is intended to evaluate the duration of treatment with an initial antidepressant taken as monotherapy in patients in whom treatment was changed because of suboptimal response at physician's…
- Trial name
- DIANA (NCT01976793)
- Where
- 8 sites in Russia
- Volunteers
- 450 people
- Sponsor
- AstraZeneca
Major Depressive Disorder, Major Depressive Disorder, Recurrent
Accelerated Intermittent Theta-Burst Stimulation Ameliorate Major Depressive Disorder by Regulating CAMKII Pathway
Major depressive disorder(MDD) is a complex and heterogeneous mental disorder. Repeated transcranial magnetic stimulation (rTMS), as a non-invasive neuroregulatory technique, has shown a promising function in the treatment of…
- Trial name
- NCT05913960
- Testing
- accelerated intermittent theta burst stimulation, high frequency stimulation
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Zhejiang University
Inflammatory Bowel Diseases, Depressive Episode
Risk of Mental Health Conditions in Children and Young Adults With Inflammatory Bowel Disease and Influence on Health
This study is a large population-based analysis in the United Kingdom (UK) using routine primary care data to investigate the impacts on quality-of-life outcomes and use of healthcare services in people aged 5 - 25 years…
- Conditions
- Inflammatory Bowel Diseases, Depressive Episode, Recurrent Depressive Disorder, Anxiety Disorder
- Trial name
- NCT05206734
- Testing
- No specific intervention
- Where
- United Kingdom
- Volunteers
- 19,469 people, healthy volunteers welcome
- Sponsor
- Momentum Data