Clinical trials: Redness
Anemia, Aplastic, Red-Cell Aplasia, Pure
Rituximab to Treat Moderate Aplastic Anemia, Pure Red Cell Aplasia, or Diamond Blackfan Anemia
This study will test whether the immune-suppressing drug rituximab can increase blood counts and reduce the need for transfusions in patients with moderate aplastic anemia, pure red cell aplasia, or Diamond Blackfan anemia.
- Conditions
- Anemia, Aplastic, Red-Cell Aplasia, Pure, Anemia, Diamond-Blackfan
- Trial name
- NCT00229619
- Testing
- Rituximab
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Sepsis, Shock, Septic
Early Identification of Sepsis in Children
This observational nation-wide study is focused on evaluation of the new possible biomarkers for pediatric sepsis and their specificity/sensitivity in combination with usual diagnostic markers for sepsis in the terms of early…
- Conditions
- Sepsis, Shock, Septic, Sepsis, Severe, SIRS
- Trial name
- NCT03884595
- Testing
- IG, IPF, NRBC, CRP, PCT, presepsin
- Where
- Czechia
- Volunteers
- 100 people
- Sponsor
- Brno University Hospital
Fibrosis, Scarring
High Fluence Light Emitting Diode-Red Light (LED-RL) in Human Skin
The goal of this study is to establish the safety of high fluence LED-RL from 160 J/cm2 up to 640 J/cm2 in healthy subjects. The hypothesis is that high fluence LED-RL phototherapy is safe in human skin.
- Conditions
- Fibrosis, Scarring, Scar, Wounds
- Trial name
- NCT02630303
- Testing
- LED-RL Phototherapy, Mock Therapy
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Jared Jagdeo, MD, MS
Primary Immunodeficiency (PID), Congenital Bone Marrow Failure Syndromes
Reduced Intensity Conditioning for Non-Malignant Disorders Undergoing UCBT, BMT or PBSCT
The objective of this study is to evaluate the efficacy of using a reduced-intensity condition (RIC) regimen with umbilical cord blood transplant (UCBT), double cord UCBT, matched unrelated donor (MUD) bone marrow transplant…
- Conditions
- Primary Immunodeficiency (PID), Congenital Bone Marrow Failure Syndromes, Inherited Metabolic Disorders (IMD), Hereditary Anemias
- Trial name
- HSCT+RIC (NCT01962415)
- Testing
- Hydroxyurea, Alemtuzumab, Fludarabine
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Paul Szabolcs
Attention Deficit Disorder With Hyperactivity, Attention Deficit Disorder
Near Infrared Spectroscopy in Children With Autism and ADHD
Background: Near-infrared spectroscopy (NIRS) is a functional imaging technique that can be uses light to study brain function while allowing for movement.
- Conditions
- Attention Deficit Disorder With Hyperactivity, Attention Deficit Disorder, Attention Deficit Hyperactivity Disorder, Autism
- Trial name
- NCT01730079
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Myopia
A Real-world Study of 650nm Low-intensity Single-wavelength Red Light for Children and Adolescents
To evaluate the efficacy and safety of 650nm low-level red-light irradiation for myopia control and prevention in children under less restrictive conditions than randomized controlled trials.
- Trial name
- NCT05832723
- Testing
- 650 nm low-level red-light
- Where
- China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Beijing Tongren Hospital
Myopia, Repeated Low-level Red Light
Real-world Registry Study of Red Light Treatment on Myopia Control: a Focus on Non-responders to Conventional Treatments
This real-world observational registry study aims to assess the effectiveness of Repeated Low-Level Red Light (RLRL) therapy in controlling myopia progression among children aged 8 to 16 who have not responded to conventional…
- Trial name
- NCT06569810
- Testing
- Repeated Low-Level Red Light (RLRL) therapy
- Volunteers
- 2,500 people
- Sponsor
- The Hong Kong Polytechnic University
Acute Leukemia, Severe Aplastic Anemia
AlloSCT for Malignant and Non-malignant Hematologic Diseases Utilizing Alpha/Beta T Cell and CD19+ B Cell Depletion
Children, adolescents, and young adults with malignant and non-malignant conditionsundergoing an allogeneic stem cell transplantation (AlloSCT) will have the stem cells selected utilizing α/β CD3+/CD19+ cell depletion.
- Conditions
- Acute Leukemia, Severe Aplastic Anemia, Non-hodgkin Lymphoma, Hodgkin Lymphoma
- Trial name
- NCT04099966
- Testing
- alpha beta depletion
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Mitchell Cairo
Epilepsy, Neuropathy
HLA Screening in Reducing the Risk of Antiepileptic Drug-induced Cutaneous Adverse Reactions
Cutaneous adverse drug reactions (cADRs) include mild maculopapular exanthema (MPE) and severe cutaneous reactions such as hypersensitivity syndrome, Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN).
- Conditions
- Epilepsy, Neuropathy, Psychiatric Illness, Blepharospasm
- Trial name
- NCT03184597
- Testing
- HLA screening before commencing aromatic AEDs
- Where
- China
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Guangzhou Medical University
Necrotizing Enterocolitis of Newborn, Feeding Intolerance
Impact of Enteral Feeding on Splanchnic Oxygenation During Packed Red Blood Cell Transfusion in Preterm Infants
This clinical trial aims to learn if enteral feeding influences cerebral and splanchnic oxygenation during red blood cell infusion in very low birth-weight preterm infants.
- Conditions
- Necrotizing Enterocolitis of Newborn, Feeding Intolerance, PreTerm Neonate, Transfusion Related Complications
- Trial name
- TANEC (NCT06632314)
- Testing
- Enteral feeding
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Akdeniz University
Ankle Dorsiflexion
Red Light Therapy: a Potential Strategy to Reduce Sports Injury Risk?
This study investigates whether near-infrared light therapy can acutely improve ankle dorsiflexion mobility and hamstring flexibility, two factors associated with sports injury risk.
- Trial name
- DIAERESIS (NCT07477678)
- Testing
- Near-infrared photobiomodulation, Cycling Warm-up
- Where
- Portugal
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cláudio da Silva Ferreira
Pure Red-cell Aplasia
A Study of Risk Factors for Anti-erythropoietin Antibody Positive Pure Red Cell Aplasia Among Patients With Chronic Kidney Disease Receiving Epoetin Alfa
The purpose of this study is to collect historical occurrences of risk factors that are potentially associated with the development of anti-erythropoietin (EPO) antibody positive pure red cell aplasia (PRCA) in participants with…
- Trial name
- NCT00211068
- Testing
- No intervention
- Where
- 22 sites in Brazil, France and 5 more
- Volunteers
- 124 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Breast Cancer
Combined Optical and Infrared Imaging for Early Prediction of Erythema During Breast and Chestwall Radiotherapy
The aim of this study is to develop a computer model, based on photographs and heat images of patients' skin, to provide early prediction of painful reddening of the skin during radiotherapy treatment.
- Trial name
- NCT04363892
- Testing
- Optical and infrared imaging
- Where
- Canada
- Volunteers
- 7 people
- Sponsor
- Nova Scotia Health Authority
Myopia, Amblyopia
Real Word Study on Myopia Control With Repeated Red Light Therapy for Ages of 3~6 Years Old
Repeated Red Light Therapy had been used as an amblyopia therapy for children as well as the myopia control in primary schools. However, ultra low lever of red light therapy with irradiance of 0.37mW and 0.60mW effectiveness and…
- Trial name
- RMC (NCT05811598)
- Testing
- repeated ultra low lever red light
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Beijing Airdoc Technology Co., Ltd.
Lyme Disease
ImmuneSense Lyme Study
ImmuneSense Lyme is a study, which is designed to better understand the immune response to Lyme disease. This is critically important because the immune system may be able to tell us important information about how our own bodies…
- Trial name
- NCT04422314
- Testing
- T-Detect Lyme
- Where
- 34 sites in United States
- Volunteers
- 893 people
- Sponsor
- Adaptive Biotechnologies
Aplastic Anemia, Pure Red Cell Aplasia
A Study to Determine Whether Therapy With Daclizumab Will Benefit Patients With Bone Marrow Failure
Participants in this study are suffering from rare and serious blood disorders. In aplastic anemia, the bone marrow stops producing red blood cells, platelets, and white blood cells.
- Conditions
- Aplastic Anemia, Pure Red Cell Aplasia, Diamond Blackfan Anemia
- Trial name
- NCT00001962
- Testing
- Daclizumab
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Toxic Epidermal Necrolysis
Topical Clobetasol for the Treatment of Toxic Epidermal Necrolysis
The primary objectives of this study are to investigate the efficacy and safety of topical steroid ointment (clobetasol 0.05%) for the treatment of the cutaneous manifestations of toxic epidermal necrolysis (TEN).
- Trial name
- TEN (NCT02319616)
- Testing
- Clobetasol 0.05% ointment
- Where
- United States
- Sponsor
- University of California, Davis
Erythema Chronicum Migrans
Duration of Antibiotic Treatment of Erythema Migrans
The purpose of this study is to compare the efficacy of 15-day versus 10-day doxycycline treatment in patients with erythema migrans.
- Trial name
- NCT00910715
- Testing
- doxycycline
- Where
- Slovenia
- Volunteers
- 306 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Ljubljana
Alpha-Gal Syndrome, Allergy
Beginning to Assess an Appropriate CONtrol for Oral Food Challenges in Alpha-Gal Syndrome (CoFAR-13) - BeACON4AG
This is a multisite, randomized, double-blind, controlled cross-over trial with detailed characterization of participants with varying clinical sub-phenotypes of Alpha-gal Syndrome (AGS) who are then evaluated by oral food…
- Trial name
- BeACON4AG (NCT07611435)
- Testing
- DBFC with 150g of Alpha-gal Knock Out (KO) pork, DBFC with 150g of Wild Type (WT) pork
- Where
- 4 sites in United States
- Volunteers
- 160 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Sickle Cell Disease
A New Reagent Assay Examining Natural Parvovirus B19 Infection in Sickle Cell Disease
Parvovirus B19 is a small virus that is the cause of "fifth" disease, a common infection in childhood. In people with sickle cell disease (SCD), parvovirus B19 infection causes the bone marrow to stop producing red blood cells…
- Trial name
- NCT02261480
- Testing
- Blood draw, Nasopharyngeal wash
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- St. Jude Children's Research Hospital