Clinical trials: Reflex Syncope
Syncope, Vasovagal
Cardioneuroablation for Reflex Syncope
Aim. To assess the effects of cardioneuroablation (CNA) on cardiac autonomic regulation and syncope recurrences in patients with vasovagal syncope (VVS), and to compare this novel approach with standard non-pharmacological…
- Trial name
- ROMAN (NCT03903744)
- Testing
- Cardioneuroablation
- Where
- Poland
- Volunteers
- 48 people
- Sponsor
- Centre of Postgraduate Medical Education
Vasovagal Syncope, Postural Tachycardia Syndrome
Mechanisms of Vasovagal Syncope
Vasovagal Syncope (simple postural faint) is the most common cause of acute loss of consciousness. Postural tachycardia syndrome(POTS) is the most common chronic form of postural lightheadedness.
- Trial name
- NCT01791816
- Testing
- Phenylephrine, L-Ng-monomethyl Arginine (L-NMMA)
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- New York Medical College
Neurally Mediated Syncope
The Iliac Arterio-venous Fistula for Treatment of Neurally Mediated Syncope Study
The purpose of the study is to investigate the efficacy of the ROX coupler in treating patients with tilt test proven Neurally mediated syncope.
- Trial name
- SHAM-ROX NMS (NCT02388087)
- Testing
- ROX COUPLER, Right heart catheterisation and routine care
- Volunteers
- 20 people
- Sponsor
- East Sussex Healthcare NHS Trust
Chronic Fatigue Syndrome, Myalgic Encephalomyelitis
Reducing Orthostatic Intolerance With Oral Rehydration in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients
We and others have shown that many younger patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) have orthostatic intolerance (OI), i.e., they can't tolerate prolonged standing.
- Conditions
- Chronic Fatigue Syndrome, Myalgic Encephalomyelitis, Systemic Exertion Intolerance Disease (SEID), Postural Tachycardia Syndrome (POTS)
- Trial name
- NCT02854683
- Testing
- Normal Saline, Oral Rehydration Solution
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- New York Medical College
Syncope, Vasovagal
Cardioneuroablation for Reflex Syncope and Exercise Capacity
Cardioneuroablation (CNA) is a new promising method to treat reflex syncope which is due to vagally-induced functional sinus arrest or atrio-ventricular block (AVB).
- Trial name
- Roman3 (NCT06440291)
- Testing
- Cardioneuroablation
- Where
- Poland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Centre of Postgraduate Medical Education
Vasovagal Syncope, Postural Tachycardia Syndrome
Hypnosis in Autonomic Function
This study will investigate the relationship between susceptibility to hypnosis and regulation of the autonomic nervous system (nerves that control involuntary body functions, such as heart rate and sweating).
- Conditions
- Vasovagal Syncope, Postural Tachycardia Syndrome, Hypnosis
- Trial name
- NCT00061009
- Where
- United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Syncope, Vasovagal
Different Catheter Ablation Strategy in Vasovagal Syncope
This study is a prospective, single-center randomized controlled clinical trial. patients with refractory vasovagal syncope were randomly divided into two groups according to the proportion of 1:1.
- Trial name
- NCT05573178
- Testing
- cardiac ganglion plexus ablation(cardioneuroablation)
- Where
- 2 sites in China
- Volunteers
- 80 people
- Sponsor
- China National Center for Cardiovascular Diseases
Blood Pressure, Depression
Essential Hypotension and Allostasis Registry
The essential arterial hypotension and allostasis registry is a prospective, observational research that has the purpose of demonstrating that essential blood pressure (BP) disorders and the associated comorbidities are a result…
- Conditions
- Blood Pressure, Depression, Panic Attack, Fibromyalgia
- Trial name
- ESSENTIAL (NCT02018497)
- Where
- Colombia
- Volunteers
- 5,000 people
- Sponsor
- CES University
Syncope, Vasovagal
Cardioneuroablation and Ventricular Proarrhythmia
Cardioneuroablation (CNA) is a promising tool to treat patients with asystolic reflex syncope. CNA acts through complete or near complete abolition of vagal nerve chronotropic and dromotropic effects on the heart, resulting in…
- Trial name
- Roman4 (NCT06458140)
- Testing
- Cardioneuroablation
- Where
- Poland
- Volunteers
- 50 people
- Sponsor
- Centre of Postgraduate Medical Education
Syncope, Neurogenic, Syncope
Efficacy of a Right-sided Ablation of the Anterior Ganglionated Plexus for Neurally Mediated Syncope
The third study on CardNM (CardNMH3 study) is a multicenter, double-blind, randomized trial with a sham control group investigating the efficacy and safety of a computed tomography (CT)-guided, right-sided ablation of the…
- Trial name
- CardNMH3 (NCT04755101)
- Testing
- EPS, electro-anatomical mapping, ARGP ablation, and pharmacological evaluation., EPS, electro-anatomical mapping, and pharmacological evaluation.
- Where
- 3 sites in Belgium
- Volunteers
- 110 people
- Sponsor
- Imelda Hospital, Bonheiden
Dysautonomia
MRI to Assess the Effects of Dysautonomia and Chronic Nausea on Brain Transmitters
The purpose of this research study is to better understand what causes dysautonomia and how this affects blood pressure and pulse. Dysautonomia is a condition of the autonomic nervous system.
- Trial name
- NCT01692561
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Syncope
Randomized Study of Midodrine, an Alpha Adrenergic Agonist, in Patients With Neurally Mediated Syncope
OBJECTIVES: Determine the efficacy of midodrine, a selective alpha 1 adrenergic agonist, in preventing neurally mediated syncope.
- Trial name
- NCT00004479
- Testing
- midodrine
- Where
- United States
- Sponsor
- Icahn School of Medicine at Mount Sinai
Reflex Syncope
Cardioneuroablation: Comparison of Right Versus Left Atrial Approach in Patients With Reflex Syncope
Introduction. Reflex vaso-vagal syncope (VVS) is the most frequent cause of transient loss of consciousness and it's treatment remains a challenge.
- Trial name
- ROMAN2 (NCT05225532)
- Testing
- Radiofrequency ablation
- Where
- Poland
- Volunteers
- 40 people
- Sponsor
- Centre of Postgraduate Medical Education
Syncope, Vasovagal
Cardioneuroablation: Fragmented Atrial Potentials, Intracardiac Echocardiography and Computed Tomography
Cardioneuroablation (CNA) is a new method for the treatment of asystolic reflex syncope, however, optimal methods for identification of presumed sites of ganglionated plexi (GP), which are the target for CNA and are located in…
- Trial name
- Roman5 (NCT06472102)
- Testing
- Cardioneuroablation
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Centre of Postgraduate Medical Education
Blood Donors
Addressing Fear and Risk of Vasovagal Reactions Among High School Donors
In this study, high school donors will be asked about their blood donation-related fears prior to their donation. Half of the donors reporting fear will be assigned to a brief coping skills intervention.
- Trial name
- NCT03835299
- Testing
- Fear Intervention
- Where
- United States
- Volunteers
- 4,035 people
- Sponsor
- Ohio University
Syncope, Vasovagal, Neurally-Mediated
Clinical Trial for the Prevention of Vasovagal Syncope
The main question in the study is whether people taking fludrocortisone are less likely to faint than people taking an inactive pill called a placebo. Fludrocortisone is a drug that stimulates the body to retain salt and water.
- Trial name
- NCT00118482
- Testing
- fludrocortisone acetate
- Where
- 14 sites in United States, Canada
- Volunteers
- 213 people
- Sponsor
- University of Calgary