Clinical trials: Refractive Disorders
Myopia, Myopia, Progressive
Can Distance Center and Near Center Multifocal Contact Lenses Control Myopia Progression in Children?
Myopia has been increasing in prevalence and severity throughout the world over the last 30 years. Increasing levels of myopia are associated with increased frequency and severity of various ocular pathologies.
- Trial name
- ADPADP (NCT03519490)
- Testing
- Hybrid Contact Lens
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Thomas A. Aller, OD
Myopia
Essilor® Stellest® Lenses Multicentre European Study (SLOMES)
The goal of this post-market clinical follow up Study is to demonstrate the efficacy, safety, acceptability, and quality of life implications of Essilor® Stellest® spectacle lenses in slowing myopia progression in European…
- Trial name
- SLOMES (NCT06263946)
- Testing
- Essilor® Stellest® spectacle lenses
- Where
- 3 sites in France, Ireland and 1 more
- Volunteers
- 150 people
- Sponsor
- Essilor International
Myopia
Atropine Eyedrops for Myopia Progression in Children and Adolescents (MODERATO STUDY)
Myopia, or shortsightedness, is a multifactorial disorder, governed by environmental and genetic factors. Myopia is the most common ocular disorder worldwide with an increasing prevalence over the past few decades and affecting…
- Trial name
- MODERATO (NCT07028827)
- Testing
- 0.05% atropine eye drops, 0.025% atropine eye drops
- Where
- 11 sites in Albania, Italy and 3 more
- Volunteers
- 234 people
- Sponsor
- Ocus Innovation Ireland Limited
Myopia, Refractive Errors
Community Intervention and Demonstration Area Construction
The objective of this intervention study was to understand the visual health status of nearly one million children and adolescents in ten provinces in China, and then to conduct intervention and evaluate the effect of…
- Trial name
- NCT05715424
- Testing
- Six interventions for children and adolescents
- Where
- China
- Volunteers
- 1,000,000 people, healthy volunteers welcome
- Sponsor
- Anhui Medical University
Myopia
Exploratory Study on the Effect of SAT-001 on Choroidal Thickness in Pediatric Myopia Patients
This clinical trial aims to exploratively compare and evaluate the structural changes in the eye (specifically changes in choroidal thickness) pre- and post-treatment of the investigational medical devices ('SAT-001' and…
- Trial name
- NCT06729723
- Testing
- SAT-001, modified SAT-001
- Where
- 2 sites in South Korea
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- S-Alpha Therapeutics, Inc.
Myopia
Peripheral Optics in Myopia and Orthokeratology
The primary objective of the current study is to investigate changes in peripheral refraction and aberration in children wearing orthokeratology lenses and single-vision spectacles.
- Trial name
- NCT00978679
- Testing
- Orthokeratology lenses, Spectacles
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Astigmatism, Presbyopia
North American Comfilcon A Clinical Study
The main objective of this study is to demonstrate acceptable safety and effectiveness (performance) of comfilcon A Sphere, Toric, Multifocal, Toric Multifocal and Energys lenses, when used in the general population.
- Conditions
- Astigmatism, Presbyopia, Ametropia
- Trial name
- NCT06902584
- Testing
- comfilcon A Sphere lens, comfilcon A Toric lens, comfilcon A Multifocal lens
- Where
- 4 sites in United States
- Volunteers
- 102 people
- Sponsor
- CooperVision International Limited (CVIL)
Myopia, Physical Fitness
Influence of Strength Training on Myopia Care in Kindergarten Children
With the advancement of technology and changes in lifestyle, the physical activity levels of modern children have gradually decreased.
- Conditions
- Myopia, Physical Fitness, Muscle Strength
- Trial name
- NCT07121049
- Testing
- Strength training
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Hungkuang University
Refractive Errors, Amblyopia
Performance of 2WIN Photoscreener With Corneal Reflex Compared to School Bus Retinoscopy by AAPOS Guidelines
Pediatric eye patients receive infrared photoscreener screening and skiascopy as a part of routine examination to compare ability to detect amblyopia risk factors.
- Conditions
- Refractive Errors, Amblyopia, Strabismus, Development Delay
- Trial name
- 2WINbus (NCT03668067)
- Testing
- 2WIN photoscreener
- Where
- United States
- Volunteers
- 471 people
- Sponsor
- Alaska Blind Child Discovery
Eye--Refractive Errors
Effect of Using Myopia Prediction Algorithm
In this study, the investigators aim to perform a prospective, randomized controlled study to compare the myopia development between children using myopia prediction algorithm and children without using myopia prediction…
- Trial name
- NCT04005014
- Testing
- Myopia prediction algorithm
- Volunteers
- 1,680 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Retinopathy of Prematurity
Long Term Outcome of Intravitreal Ranibizumab for ROP
premature infants who had a history of intravitreal injection of (Ranibizumab) not less than one year were examined for refractive state and biometry
- Trial name
- NCT04537065
- Testing
- cycloplegic refraction
- Where
- Egypt
- Volunteers
- 140 people
- Sponsor
- Ameera Gamal Abdelhameed
Myopia, Myopia Progression
Evaluation of Performance of MiYOSMART Photochromic and Clear Spectacle Lenses in Myopic Children
This clinical study aims to evaluate the non-inferiority of the photochromic DIMS spectacles lenses performance (PDIMS) compared to clear DIMS spectacles lenses (DIMS) in myopia management.
- Trial name
- PDIMS (NCT06717035)
- Testing
- EYE001
- Where
- Singapore
- Volunteers
- 202 people
- Sponsor
- Singapore National Eye Centre
Myopia
Trial of Myopia Prevention Using +3D Lenses
The purpose of this study is to assess whether a short-term imposed myopic defocus is effective in preventing the development and progression of juvenile-onset myopia in Chinese children.
- Trial name
- PLS (NCT00627874)
- Testing
- +3D Lenses
- Volunteers
- 1,200 people
- Sponsor
- Sun Yat-sen University
Myopia
Myopia Control Using Novel Soft Contact Lenses
The goal of this study is to investigate the myopic control efficacy of two study soft contact lenses in children. Participants will be prescribed Lens A, Lens B or single vision contact lenses for the first year.
- Trial name
- NCT07547085
- Testing
- Lens A, Lens B
- Where
- Hong Kong
- Volunteers
- 126 people
- Sponsor
- The Hong Kong Polytechnic University
Myopia
The Effect of +3.00ADD on Myopia Progression in Chinese Children
The purpose of this study is to evaluate the effect of +3.00ADD vs single vision spectacle on the progression of myopia in children.
- Trial name
- NCT03242226
- Testing
- two spectacles, single vision spectacles
- Where
- China
- Volunteers
- 440 people
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Juvenile Myopia, Myopia
CYPRESS Efficacy and Safety Study Extension
This is an open-label, controlled, multisite, two-arm parallel group clinical trial of 36-month duration to evaluate the continued safety and efficacy of SightGlass Vision Diffusion Optics Technology (DOT) Spectacles in reducing…
- Trial name
- CYPRESS (NCT04947735)
- Testing
- Novel spectacle lens design, Spectacle lenses
- Where
- 12 sites in United States, Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- SightGlass Vision, Inc.
Refractive Error, Myopia
Clinical Performance of a New Daily Disposable Contact Lens Worn in an Established Contact Lens Wearing Population
This study seeks to evaluate the clinical and subjective performance of a new daily disposable soft contact lens.
- Trial name
- NCT00708643
- Testing
- Habitual Silicone Hydrogel Contact Lens, narafilcon A
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Johnson & Johnson Vision Care, Inc.
Myopia, Progressive
Low Concentration Atropine in the Prevention of Myopia in Children.
This double-blind, randomized controlled clinical study is to evaluate the effectiveness and safety of low concentration atropine in preventing myopia in pre-myopia children, and to explore whether there is a dose effect…
- Trial name
- NCT05939882
- Testing
- low concentration atropine (0.01%), low concentration atropine (0.02%), low concentration atropine (0.04%)
- Where
- China
- Volunteers
- 428 people
- Sponsor
- Shanghai Eye Disease Prevention and Treatment Center
Myopia, Progressive, Refractive Errors
Repeated Low-Level Red-Light Therapy and Orthokeratology in Fast-progressing Myopia Control
The purpose of this multicenter randomized clinical trial is to evaluate the adjunctive effect of repeated low-level red-light therapy (RLRL) and orthokeratology (ortho-k) on myopia control in ortho-k non-responders who have…
- Conditions
- Myopia, Progressive, Refractive Errors, Eye Diseases
- Trial name
- NCT04722874
- Testing
- Ortho-k lenses, RLRL
- Where
- 3 sites in China
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Myopia
Association of Genetic Variants With Myopia
This study aims to identify genetic factors linked to myopia, including those that influence a person's risk of developing it and how quickly it progresses (like changes in eye length).
- Trial name
- NCT07030153
- Testing
- Oral swab DNA analyzed for myopia-related gene variants
- Where
- 2 sites in China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Beijing Visionly Plus Eye Hospital