Clinical trials: Refractive Disorders
Myopia, Randomized Controlled Trials
Effect of a Myopia Prediction System on Myopia Prevention and Control
The global rise in myopia, particularly among children and adolescents in China, underscores the inadequacy of current prevention strategies, indicating that conventional screening and education alone are insufficient to curb the…
- Conditions
- Myopia, Randomized Controlled Trials, Artificial Intelligence (AI)
- Trial name
- NCT06633393
- Testing
- Feedback on Predicted High Myopia Risk at Age 18 Using the Myopia Prediction System, Feedback on Ophthalmic Examinations
- Where
- China
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Astigmatism
Comparison of Clinical Outcomes of Toric Intraocular Lens
This study is to compare the clinical outcome of Precizon toric intraocular lens(IOL) to that of Tecnis toric IOL.
- Trial name
- NCT03085901
- Testing
- Precizon toric intraocular lens, Tecnis toric intraocular lens
- Volunteers
- 40 people
- Sponsor
- Samsung Medical Center
Myopia
Evolution of Ocular Growth in Myopic Children: A Prospective Cohort Study
Myopia and high myopia are the leading causes of visual impairment and blindness worldwide. The total number of myopic people globally was estimated to be 2.6 billion in 2020, and it could reach 4.8 billion by 2050 unless…
- Trial name
- PREMYOM1000 (NCT06895044)
- Testing
- ophtalmologic follow-up, ophtalmological follow-up
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Myopia, Progressive
Novel Lenses for Myopia Progression Trial
This is a multi-center , prospective, randomised, longitudinal study to evaluate rate of myopia progression with novel lenses compared to Single-Vision spectacles.
- Trial name
- NCT06563700
- Testing
- spectacle lens, single vision lens
- Where
- China
- Volunteers
- 342 people
- Sponsor
- Shanghai Eye Disease Prevention and Treatment Center
Myopia
The Model Building and Empirical Research of Eye Health Interventions for Children
The purpose of this study is to determine whether Eye Health Intervention can obviously reduce and delay myopia onset and development and improved the awareness rate of knowledge apparently .
- Trial name
- NCT02903628
- Testing
- eye health education
- Volunteers
- 1,517 people, healthy volunteers welcome
- Sponsor
- Wenzhou Medical University
Myopia, Hyperopia
Corneal Asphericity Adjustment (Q Adjustment) in Myopic and Hyperopic Patients Undergoing Refractive Correction With Excimer Laser
To study the postoperative results in myopic and hyperopic eyes treated with two different laser ablation algorithms (STD and F-CAT), both FDA approved.
- Trial name
- NCT01296867
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Democritus University of Thrace
Myopia
Pilot Study on the Adaptation and Tolerance of Essilor® Myopia-control Spectacle Lenses
This observational pilot study aims to evaluate the adaptation and tolerance of Essilor® Stellest® myopia-control spectacle lenses in children with progressive myopia.
- Trial name
- STELLAR (NCT07340931)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Nantes University Hospital
Myopia
Comparative Clinical Evaluation of Daily Disposable Lenses in Symptomatic Lens Wearers
The purpose of this trial is to evaluate the extent to which symptoms improve in symptomatic contact lens wearers when fit with one of 5 different daily disposable contact lenses.
- Trial name
- NCT00953407
- Testing
- Nelfilcon A contact lens, Narafilcon A contact lens, Etafilcon A contact lens
- Volunteers
- 128 people
- Sponsor
- CIBA VISION
Keratitis, Myopia
Safety of Overnight Corneal Reshaping Lenses
This retrospective chart review study compares the incidence of corneal inflammation due to infection in children vs. adult patients wearing overnight corneal reshaping lenses.
- Trial name
- NCT01272271
- Volunteers
- 1,317 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Myopia
Atropine (0.02%, 0.04%) Combined With Defocus DIMS for Moderate and High Myopia Control
To evaluate the effectiveness and safety of DIMS, low concentration atropine eye drops,and atropine combined with DIMS in controlling axial length and refraction in children with moderate to high myopia.
- Trial name
- atropine (NCT06523504)
- Testing
- DIMS, The 0.02% ATP Group, The 0.04% ATP Group
- Where
- China
- Volunteers
- 410 people
- Sponsor
- Ruihua Wei
Astigmatism
Comparison of Comfilcon A Toric Contact Lenses and Samfilcon A Toric Contact Lenses
The objective of this study is to evaluate the subjective acceptance of comfilcon A toric contact lens, compared to samfilcon A toric lens.
- Trial name
- NCT03519932
- Testing
- comfilcon A toric lens, samfilcon A toric lens
- Where
- Canada
- Volunteers
- 49 people
- Sponsor
- CooperVision, Inc.
Myopia
Choroidal Response to the Modified Defocus Incorporated Multiple Segments Spectacle Lenses
The goal of this study is to investigate the short-term changes in choroidal thickness and efficacy of the study spectacle lenses in children.
- Trial name
- NCT07547072
- Testing
- Modified Defocus Incorporated Multiple Segments lens (D1), Modified Defocus Incorporated Multiple Segments lens (D2)
- Where
- Hong Kong
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Myopia, Progressive
Myopia Prevention Through Monitoring and Motivating Outdoor Activities With Smartwatches
The goal of this multi-center, randomized, parallel-controlled clinical trial is to evaluate the effectiveness of outdoor activities monitoring and motivating by smartwatches to prevent myopia progression in children.
- Trial name
- NCT05760911
- Testing
- Outdoor activities motivation with smartwatches
- Volunteers
- 1,200 people
- Sponsor
- Shanghai Eye Disease Prevention and Treatment Center
Myopia
Efficacy of Multi-Type Photolithography Flat Microstructure Lenses for Childhood Myopia Control
The goal of this clinical trial is to learn if photolithographic flat microstructure lenses work to prevent myopia in children. It will also learn about the safety of different designs of photolithographic flat microstructure…
- Trial name
- NCT07535658
- Testing
- wearing photolithography plano microstructure lenses with multi-point defocus design, non-fading optical property, wearing Plano microstructure lenses featuring multi-point defocus design with aspherical lenslets (Essilor Stellest), wearing Photolithography Plano Microstructure Lenses incorporates a multi-point defocus optical architecture , featuring photochromic properties with a light transmittance of 55% post-activation
- Where
- China
- Volunteers
- 255 people
- Sponsor
- Shanghai Eye Disease Prevention and Treatment Center
Myopia, Progressive
Impact of Digital Screen Time in Progression of Myopia in Children
Research suggests that prolonged digital screen time is a significant contributing factor to the progression of myopia in children.
- Trial name
- NCT07055815
- Testing
- Progression of Myopia
- Where
- Pakistan
- Volunteers
- 79 people
- Sponsor
- Superior University
Myopia
Effectiveness of DIMS Spectacle as a Function of the Age
Purpose: To evaluate the effectiveness of Defocus Incorporated Multiple Segments (DIMS) in slowing myopia progression as a function of age in pediatric patients.
- Trial name
- NCT06556849
- Testing
- Defocus Incorporated Multiple Segments (DIMS)
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Luca Buzzonetti
Myopia
A Phase III Clinical Study of the Efficacy and Safety of Two Low-concentration Atropine Sulfate Eye Drops
This study was a randomized, double-blind, placebo-controlled, multicenter, superiority design, phase III clinical trial to compare the efficacy and safety of two low-concentration atropine sulfate eye drops versus placebo in…
- Trial name
- Mini-CHAMP (NCT06209281)
- Testing
- Lower dose atropine sulfate eye drops, Low dose atropine sulfate eye drops
- Where
- China
- Volunteers
- 526 people
- Sponsor
- Zhaoke (Guangzhou) Ophthalmology Pharmaceutical Ltd.
Myopia
Dual Focus Soft Contact Lens Wear Cessation Study
The purpose of this study is to investigate the effect of ceasing treatment with dual focus soft contact lenses.
- Trial name
- NCT05779072
- Testing
- Single Vision Soft Contact Lens
- Where
- 4 sites in Canada, Portugal and 2 more
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- CooperVision, Inc.
Refractive and Accommodative Disorders
Capsulotomy YAG Laser
Study of refractive changes after capsulotomy with YAG laser in facectomized patients.
- Trial name
- RCYAG (NCT02993081)
- Volunteers
- 67 people
- Sponsor
- Instituto de Olhos de Goiania
Myopia
Myopia Control With a Innovative Spectacle Lens
The purpose of this study is to demonstrate that the test spectacle lens is safe and effective in slowing myopia progression in children.
- Trial name
- NCT05174780
- Testing
- innovative myopia control spectacle lens, Single vision spectacle lens
- Where
- 9 sites in United States
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- Essilor International