Clinical trials: Refractive Disorders
Myopia
Comparing Silicone Hydrogel Contact Lens Wearers to Hydrogel Contact Lens Wearers and Non-lens Wearers
This study was a multi-site, prospective, randomized, non-masked, unilateral, non-dispensing study.
- Trial name
- NCT04886479
- Testing
- Control, Test Lens
- Where
- 2 sites in Canada, United Kingdom
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- CooperVision, Inc.
Myopia, Myopia, Progressive
Can Distance Center and Near Center Multifocal Contact Lenses Control Myopia Progression in Children?
Myopia has been increasing in prevalence and severity throughout the world over the last 30 years. Increasing levels of myopia are associated with increased frequency and severity of various ocular pathologies.
- Trial name
- ADPADP (NCT03519490)
- Testing
- Hybrid Contact Lens
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Thomas A. Aller, OD
Obesity, Myopia
Beijing (Peking)---Myopia and Obesity Comorbidity Intervention (BMOCI)
Based on the RE-AIM framework, this project intends to integrate the prevention and control measures of myopia and obesity, and establish a set of key suitable technical packages and guarantee systems for the…
- Trial name
- NCT05275959
- Testing
- A cluster randomized trial of a comprehensive intervention nesting family and clinic into school centered implementation to reduce myopia and obesity among children and adolescents in Beijing, China
- Where
- 3 sites in China
- Volunteers
- 3,963 people, healthy volunteers welcome
- Sponsor
- Peking University
Keratoconus, Corneal Ectasia
Safety & Efficacy of Corneal Collagen Cross-Linking in Eyes With Keratoconus or Corneal Ectasia After Refractive Surgery
The objectives of this study are to evaluate and compare the safety and efficacy of three treatment regimens for corneal collagen cross-linking performed with VibeX (riboflavin ophthalmic solution) and the KXL System in impeding…
- Trial name
- NCT01459679
- Testing
- KXL System (15 mW/cm2), KXL System (30 mW/cm2), KXL System (45 mW/cm2)
- Where
- 83 sites in United States, Puerto Rico
- Volunteers
- 1,721 people
- Sponsor
- American-European Congress of Ophthalmic Surgery
Myopia, Progressive
Adverse Events Related to Low Dose Atropine
Progressive myopia can lead to severe vision loss and is associated with retinal detachment, glaucoma, and other comorbidities. Several studies have shown that off-label, low-dose atropine eye drops slow the progression of…
- Trial name
- AELDA (NCT05683535)
- Testing
- Atropine Sulfate
- Where
- United States
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Scripps Health
Myopia
Binocular Peripheral Myopic Defocus Using a Clinical Prototype Device
Kubota Vision Inc. has developed a spectacle-like prototype device which is designed to be used as a light-based therapy to reduce myopia progression.
- Trial name
- NCT05425108
- Testing
- Binocular CP1
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Kubota Vision Inc.
Dry Eye Disease
Assess the Effects of Spectacles or Orthokeratology on Dry Eye Parameters in Children and Adolescents.
Orthokeratology(OK) is currently one of the effective methods for treating myopia, reshaping the corneal epithelium to change refractive power.
- Trial name
- NCT06023108
- Testing
- Orthokeratology, Spectacles
- Where
- China
- Volunteers
- 300 people
- Sponsor
- He Eye Hospital
Myopia, Astigmatism
Safety and Efficacy Evaluation of a New Contact Lens Disinfecting Solution in Gas Permeable Contact Lens Wearers
The purpose of this study is demonstrate substantial equivalence of an investigational contact lens disinfecting solution to a commercially available contact lens solution in gas permeable lens wearers.
- Conditions
- Myopia, Astigmatism, Hyperopia, Refractive Error
- Trial name
- NCT01912781
- Testing
- FID 120947A contact lens disinfecting solution, Boston Simplus multi-action solution, Gas permeable contact lenses
- Volunteers
- 112 people
- Sponsor
- Alcon Research
Astigmatism
Incisional Correction of Corneal Astigmatism During Phacoemulsification
Today, cataract surgery is regarded as refractive surgery, mainly aiming emmetropia, and this makes eliminating corneal astigmatism is critical.
- Trial name
- NCT04418986
- Testing
- opposite clear corneal incisions (OCCI)
- Where
- Iraq
- Volunteers
- 40 people
- Sponsor
- Al-Rasheed University College
Cataract, Refractive Errors
Comparison of Intraocular Lens Power Calculation Methods After Corneal Laser Refractive Surgery in Axial and Refractive Ammertropia
The study aims at determining the best biometry calculation formula to be used in IOL calculation of cataract patients how previously underwent laser refractive correction surgery
- Trial name
- NCT01979172
- Where
- Egypt
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- The National Eye Hospital, Cairo, Egypt
Astigmatism
Clinical Comparison of Two Silicone Hydrogel Toric Lenses in the US
The purpose of this trial is to compare the performance of two different contact lenses for contact lens wearers with astigmatism.
- Trial name
- NCT01007812
- Testing
- Lotrafilcon B contact lens, Comfilcon A contact lens
- Volunteers
- 50 people
- Sponsor
- CIBA VISION
Myopia
Microdosed Atropine 0.1% and 0.01% Ophthalmic Solutions for Reduction of Pediatric Myopia Progression
This study evaluates the progression of myopia in participants using microdosed atropine 0.01%, atropine 0.1%, or placebo ophthalmic solution. Eligible subjects will administer study medication daily in each eye for 48 months.
- Trial name
- NCT03942419
- Testing
- Atropine 0.1% Ophthalmic Solution, Atropine 0.01% Ophthalmic Solution
- Where
- 18 sites in United States
- Volunteers
- 438 people
- Sponsor
- Eyenovia Inc.
Myopia
Exploratory Study on the Effect of SAT-001 on Choroidal Thickness in Pediatric Myopia Patients
This clinical trial aims to exploratively compare and evaluate the structural changes in the eye (specifically changes in choroidal thickness) pre- and post-treatment of the investigational medical devices ('SAT-001' and…
- Trial name
- NCT06729723
- Testing
- SAT-001, modified SAT-001
- Where
- 2 sites in South Korea
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- S-Alpha Therapeutics, Inc.
Myopia Progressing, Childhood
Topical 0.01% Atropine for the Control of Fast Progressing Myopia
Myopia prevalence has dramatically increased worldwide in recent years in the general population and among children. Progressive myopia increases gradually with growth until the age of 20-25 years.
- Trial name
- Myopie-STOP (NCT04173780)
- Testing
- Atropine 0.01%
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Strasbourg, France
Hyperopia, Amblyopia
Effect of Peripheral Defocus on Axial Growth in Hyperopes
Hyperopia, also known as farsightedness, is a common type of refractive error where distant objects may be seen more clearly than objects that are near.
- Conditions
- Hyperopia, Amblyopia, Anisohyperopia
- Trial name
- NCT02686879
- Testing
- Multifocal contact lenses, Single vision contact lenses
- Where
- 2 sites in United Kingdom
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Aston University
Pathological Myopia
Genomewide Screening of Pathological Myopia
The purpose of this study is to evaluate the possible candidate gene of pathological myopia
- Trial name
- NCT00155753
- Where
- Taiwan
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Myopia
Daily Low-level Red Light and 0.01% Low-dose Atropine for Myopia Prevention
To compare the preventive effects of daily low-level red-light and 0.01% low-dose atropine eye drops on myopia.
- Trial name
- NCT06727019
- Testing
- low-level red-light, Atropine (0.01%)
- Where
- China
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Beijing Tongren Hospital
Myopia Progression, Myopia
Inhibition of Myopia Progression With Optical Devices
This observational study aims to determine whether optical devices designed to slow myopia progression and/or environmental factors can prevent myopia progression in the pediatric and adolescent myopic population.
- Conditions
- Myopia Progression, Myopia, Myopia, Child Myopia Progression
- Trial name
- NCT07698977
- Testing
- Wearing myopia-control D.I.M.S. glasses while awake, DIMS (Defocus Incorporated Multiple Segments) lenses
- Where
- Hungary
- Volunteers
- 50 people
- Sponsor
- Semmelweis University
Amblyopia, Strabismus
Vision In Preschoolers Study (VIP Study)
To identify vision-screening tests that can accurately predict those three- and four-year old preschoolers who would benefit from a comprehensive vision examination because of signs of amblyopia, strabismus, and/or significant…
- Conditions
- Amblyopia, Strabismus, Refractive Error
- Trial name
- NCT00038753
- Testing
- Vision Screening
- Where
- 5 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Eye Institute (NEI)
Myopia
To Evaluate The Performance Of Two Monthly Replacement Silicone Hydrogel Contact Lenses After 1-month Of Wear
To evaluate the performance of two monthly replacement silicone hydrogel contact lenses in habitual FRP CL wearers when worn for 1-month.
- Trial name
- NCT05333965
- Testing
- Lens A (lehfilcon A lens), Lens B (comfilcon A lens)
- Where
- Canada
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- CooperVision, Inc.