Clinical trials: Refractory Depression
Bipolar Disorder
Clinical Trial of Felbamate for Treatment-Resistant Bipolar Depression
The purpose of this study is to evaluate the safety and effectiveness of the drug felbamate for treating depression in patients with bipolar disorder that has not responded to standard treatments.
- Trial name
- NCT00034229
- Testing
- Felbamate
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- National Institute of Mental Health (NIMH)
Depressive Disorder
An Investigation of the Antidepressant Efficacy of the 5-HT2A Antagonist, M100907, in Combination With Citalopram in Treatment Resistant Depression
This study will examine whether a highly specific and powerful 5-hydroxytryptamine 2A (5-HT2A) antagonist, M100907, combined with escitalopram, is responsible for an antidepressant effect.
- Trial name
- NCT00070694
- Testing
- MDL100.907
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- National Institute of Mental Health (NIMH)
Treatment Resistant Depression, Transcranial Magnetic Stimulation
rTMS Intervention on Motivational Anhedonia of Treatment Resistant Depression and Brian Network Mechanism
Study of individualized accurate targeting rTMS intervention on motivational anhedonia of treatment resistant depression and brain network mechanism
- Conditions
- Treatment Resistant Depression, Transcranial Magnetic Stimulation, Functional Magnetic Resonance Imaging, Event-Related Potentials
- Trial name
- rTMS (NCT03991572)
- Testing
- repeated transcranial magnetic stimulation with real coil
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Anhui Medical University
Treatment Resistant Depression
Linear Asymmetric rTMS in Adolescent Treatment-Resistant Depression: Tolerability of Treatment Durations Ranging From Ten Days to One Day
This is a pilot interventional study to investigate the acceptability, tolerability, and side effect profile for varying numbers of treatment sessions/day of a new rTMS treatment in adolescents with treatment-resistant depression…
- Trial name
- NCT03986658
- Testing
- Linear Asymmetric rTMS System
- Where
- Canada
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- NeuroQore Inc.
Depression
iTBS in Refractory Pediatric Depression
This work will mark the first step in understanding the neural targets for rTMS in youth with difficult to treat depressive symptoms, creating benchmarks for optimizing the safety and efficacy of rTMS for pediatric populations…
- Trial name
- NCT03845504
- Testing
- Intermittent Theta Burst Stimulation
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Stanford University
Treatment Resistant Depression (TRD)
Risk-Targeted Behavioural Activation for the Management of Treatment-Resistant Depression.
Depression is the leading cause of disability worldwide. Major Depressive Disorder (MDD) is the most common diagnosis made for individuals seeking treatment for depression.
- Trial name
- NCT06729580
- Testing
- Behavioural Activation
- Where
- Canada
- Volunteers
- 118 people
- Sponsor
- McGill University
Treatment-Resistant Depression, Major Depressive Disorder
Observation of Safety and Tolerability Within 1 Year of the Use of R-ketamine / Placebo in Drug-resistant Depression
An observational-comparative study, without interfering with the treatment, based on an operationalized interview.
- Trial name
- NCT06232291
- Where
- Poland
- Volunteers
- 3 people
- Sponsor
- Medical University of Gdansk
Acute Leukemia, Recurrent Leukemia
Bright White Light Therapy for the Improvement of Sleep, Fatigue, Distress, Depression, and Anxiety in Hospitalized Leukemia Patients
This trial investigates how well bright white light therapy works in improving sleep, fatigue, distress, depression, and anxiety, side effects that are often experienced during an intense leukemia treatment regimen, in…
- Conditions
- Acute Leukemia, Recurrent Leukemia, Refractory Leukemia
- Trial name
- NCT04597086
- Testing
- Best Practice, Bright White Light Therapy, Survey Administration
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Depression, Electroencephalography
Intermittent Theta Burst Stimulation on Anhedonia in Depression
Study comparing the efficacy of two TMS patterns (intermittent theta-burst stimulation, iTBS, and repetitive transcranial magnetic stimulation, rTMS) in treating anhedonia and their associated brain network mechanisms.
- Conditions
- Depression, Electroencephalography, Transcranial Magnetic Stimulation
- Trial name
- NCT06552026
- Testing
- repeated transcranial magnetic stimulation
- Where
- China
- Volunteers
- 33 people
- Sponsor
- Anhui Medical University
Treatment-resistant Depression, Major Depressive Disorder
Low-dose Ketamine Infusion Among Adolescents With Treatment-resistant Depression
In the past decades, the prevalence of adolescent depression and suicide increased significantly in Taiwan and worldwide. To date, the suicide mortality is the second mortality cause in the adolescent and young adult population…
- Trial name
- NCT05045378
- Testing
- Ketamine
- Where
- Taiwan
- Volunteers
- 12 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Bipolar II Disorder, Most Recent Episode Major Depressive
Lamotrigine Alone Compared to Lamotrigine Plus Antidepressant for the Treatment of Bipolar II Depression
Depression is a medical condition characterized by feeling sad even when good things happen, having low energy and motivation, and sometimes even experiencing suicidal thoughts.
- Trial name
- NCT00475137
- Testing
- Lamotrigine
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- University of British Columbia
Major Depressive Disorder (MDD), Depression - Major Depressive Disorder
Efficacy and Safety of a Theta Burst Stimulation Protocol of Repetitive Transcranial Magnetic Stimulation in Treatment-Resistant Depression
This study will evaluate the efficacy and safety of a theta burst stimulation (TBS) protocol of repetitive transcranial magnetic stimulation (rTMS) in adults with treatment-resistant depression.
- Trial name
- NCT07529574
- Testing
- antidepressant therapy, Active rTMS Theta Burst Stimulation
- Where
- South Korea
- Volunteers
- 120 people
- Sponsor
- Jung-Sun Lee
Bipolar Disorder
The Treatment of Children and Adolescents With Treatment-Resistant Depression
This study seeks to learn about brain function in adolescents with depression and to determine whether adding lithium carbonate to antidepressant medication can reduce depression in children and adolescents.
- Trial name
- NCT00029640
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- National Institute of Mental Health (NIMH)
Major Depression
Effects of ECT on Monoamine Oxidase A in Depression Investigated With PET
This study aims at evaluating the effect of electroconvulsive therapy in treatment-resistant depressed patients on the major serotonin degrading enzyme in the human brain using neuroimaging methods, the monoamine oxidase A.
- Trial name
- NCT02379767
- Testing
- Electroconvulsive therapy, Positron emission tomography of the brain using [11C]harmine, Structural magnetic resonance imaging
- Where
- Austria
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Depression, Depressive Disorder, Major
Comparing the Efficacy of Accelerated vs. Standard fMRI-guided iTBS in Treating Adolescents Depression
Repetitive transcranial magnetic stimulation (rTMS) is a Health Canada approved treatment for major depression. Theta burst stimulation (TBS), a type of rTMS, is a very promising new treatment for major depression in adults and…
- Trial name
- NCT06528938
- Testing
- Theta Burst Stimulation
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- The Royal Ottawa Mental Health Centre
Treatment Resistant Depression
Repetitive Transcranial Magnetic Stimulation for Adolescent Depression: Efficacy, Predictive Biomarkers, and Mechanisms
This study will be an open-label 6-week (30 session) trial of active repetitive transcranial magnetic stimulation (rTMS) using a fixed frequency (10 Hz) but varying stimulation intensities using a 3+3 study design for safety and…
- Trial name
- NCT02611206
- Testing
- Active Repetitive Transcranial Magnetic Stimulation (rTMS): intensity 80% MT, Device: Active Repetitive Transcranial Magnetic Stimulation (rTMS); Stimulation intesity: 100% of MT, Device: Active Repetitive Transcranial Magnetic Stimulation (rTMS); Stimulation intesity: 120% of MT
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Minnesota
Depression, Unipolar, Treatment Resistant Depression
PF-04995274 and Emotional Processing in Treatment Resistant Depression
This study will test whether seven days adjunctive administration of a serotonin receptor subtype 4 (5HT4) agonist called PF-04995274 has positive effects on emotional processing and non-emotional cognition in medicated…
- Trial name
- RESTART (NCT03515733)
- Testing
- PF-04995274
- Where
- United Kingdom
- Volunteers
- 54 people
- Sponsor
- University of Oxford
Autism Spectrum Disorder, Major Depressive Disorder
Transcranial Magnetic Stimulation for Depression in Autism Spectrum Conditions
In this research study the investigators aim to learn more about the therapeutic effects of a newer form of non-invasive transcranial magnetic stimulation (TMS), called theta burst simulation (TBS), on refractory depression in…
- Trial name
- RESTORE (NCT05271357)
- Testing
- Bilateral TMS, Unilateral TMS
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Psychiatric Disorder, Major Depressive Disorder
Exploring Blood Plasma Metabolomics: Unraveling the Metabolic Landscape in Treatment-Resistant Adolescent Depression
This study contributes new evidence for the identification of adolescent TRD and sheds light on differing pathophysiologies by delineating distinct plasma metabolic profiles between adolescent TRD and FEDN-MDD.
- Conditions
- Psychiatric Disorder, Major Depressive Disorder, Metabolic Disorder
- Trial name
- NCT06331572
- Testing
- 17-HAMD
- Where
- China
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Chongqing Medical University
Adolescent Depression
Lamotrigine in Treatment Resistant Depression in Adolescents
The primary hypothesis of this study is that in fluoxetine (Prozac)-resistant adolescents with Major Depressive Disorder (MDD), Lamotrigine plus fluoxetine will be safe and as effective as sertraline (Zoloft).
- Trial name
- NCT00284791
- Testing
- Lamotrigine (drug), Fluoxetine (drug), sertraline (drug)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- MaineHealth