Clinical trials: Regenerative Endodontics
Pulp Necrosis
Photo-Activated Disinfection Versus Triple-Antibiotic Paste for Management of Necrotic Young Permanent Anterior Teeth
This study aims to compare regenerative endodontics for necrotic young permanent anterior teeth using oral photo-activated disinfection versus triple antibiotic paste in terms of: 1.
- Trial name
- NCT03763110
- Testing
- Photo Activated Disinfection, antibiotic paste
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cairo University
Tooth Injuries, Endodontically Treated Teeth
Regenerative Endodontic Treatment of Traumatised Teeth
Aim: The aim of this prospective study was to evaluate the treatment outcomes of regenerative endodontic technique (RET) for the management of traumatised non-vital immature teeth in children.
- Trial name
- NCT03045185
- Testing
- RET using Ciprofloxacin 100mg, and Metronidazole 100mg.
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Leeds
Chronic Apical Periodontitis, Pulp Necrosis
Clinical and Inflammatory Outcomes of Regenerative Endodontic Treatment Using Injectable Platelet-Rich Fibrin in Mature Necrotic Teeth With Chronic Apical Periodontitis.
This randomized clinical trial aims to compare regenerative endodontic treatment using injectable platelet-rich fibrin (i-PRF) with conventional root canal treatment in mature necrotic anterior teeth with chronic apical…
- Trial name
- REGEN-iPRF (NCT07913399)
- Testing
- Conventional Root Canal Treatment, Regenerative Endodontic Treatment with i-PRF, Injectable Platelet-Rich Fibrin (i-PRF)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Medipol University
Endodontic Disease, Regenerative Endodontics
Evaluation of Different Scaffolds in Regenerative Endodontic Treatment
The aim of this study is to evaluate and compare the regenerative potentials of Injectable Platelet-Rich Fibrin (I-PRF), Platelet-Rich Fibrin (PRF), and Blood Clot (BC) as different scaffolds regarding: Radiographic outcomes…
- Trial name
- NCT06945965
- Testing
- Injectable platelet-rich fibrin (i-PRF) scaffold, platelet-rich fibrin (PRF)scaffold, blood clot (BC) scaffold
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- British University In Egypt
Regenerative Endodontics
Clinical and Radiographic Outcomes of PRF, Chitosan, and Blood Clot in Regenerative Endodontics of Molars
This clinical trial aimed to evaluate the long-term effects of using chitosan, blood clots, and platelet-rich fibrin as scaffolds in regenerative endodontics on tooth development.
- Trial name
- NCT07119619
- Testing
- Regenerative Endodontic Treatment Using a Blood Clot as a Scaffold, Regenerative Endodontic Treatment Using a Chitosan as a Scaffold, Regenerative Endodontic Treatment Using a Platelet Rich Fibrin as a Scaffold
- Where
- Turkey (Türkiye)
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Inonu University
Apical Periodontitis
Lesion Healing After Regenerative Endodontic Treatment
Endodontics involves various therapeutic interventions for diagnosing, preventing, and managing pulpal and periradicular pathologies.
- Trial name
- NCT06843850
- Testing
- regenerative endodontics
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Regenerative Endodontic, Apexification
Comparison of Apexification and Regenerative Endodontic Therapy: a Retrospective Study
In this study, the effects of mineral trioxide aggregation (MTA) apexification and regenerative endodontic treatment (RET) methods on periapical healing was compared with fractal analysis (FD) and periapical index (PAI).
- Conditions
- Regenerative Endodontic, Apexification, Fractals
- Trial name
- NCT05213026
- Testing
- Regenerative endodontics
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Dental Pulp Necroses
Efficacy of Regenerative Endodontic Treatment With PRF as a Secondary Treatment of Mature Necrotic Incisors in Adolescents
Evalaution of clinical success of secondary treatment for total 40 permanent incisors with failed root canal treatment with apical radiolucency.
- Trial name
- PRF (NCT05517187)
- Testing
- no intervention, Platelet rich fibrin
- Where
- 2 sites in Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Nahda University
Pulp and Periapical Tissue Disease
Regenerative Endodontics for Non-vital Primary Molars
Non-vital primary molars will be treated with regenerative endodontic idea using different capping materials aiming to replace the necrotic pulp tissue with biological one and to provide perfect seal over the scaffold
- Trial name
- NCT05098483
- Testing
- Regeneration in primary molars by using MTA, Regeneration in primary molars by using biodentine, Conventional Root canal treatment in primary molars
- Where
- Egypt
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Regenerative Endodontics
Regenerative Endodontics Using Different Intracanal Medicaments on Radiographic Outcomes and Periapical MMP-8 Levels
Two-session regenerative endodontic treatment was applied to 20 immature mandibular first molars with symptomatic irreversible pulpitis and symptomatic apical periodontitis.
- Trial name
- NCT05581706
- Testing
- Place the freshly prepared calcium hydroxide in to the root canals, Place the freshly prepared double antibiotic paste in to the root canals, Taking standart periapical radiography with film holder
- Where
- Turkey (Türkiye)
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Ege University
Necrosis, Pulp
Antimicrobial Effect of Modified Antibiotic Nanofibers for Regenerative Endodontics Procedures
The treatment for immature teeth with pulp necrosis can be carried out through apexification or regenerative endodontics procedures including platelet rich plasma (PRP), platelet rich fibrin (PRF) and injectable PRF, these…
- Trial name
- NCT03690960
- Testing
- electrospun TAP nanofibers, modified TAP paste
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Incomplete Root Formation of Anterior Teeth
Efficacy of Combined Scaffolds and Sodium Hypochlorite in Regenerative Endodontics of Immature Teeth
The aim of the study is to evaluate the efficacy of combinations of different scaffolds (blood clot, platelet rich fibrin, collagen) and sodium hypochlorite concentrations (0.5%- 2.5%) in regenerative endodontics of immature…
- Trial name
- NCT05803525
- Testing
- Intra-canal medication protocol
- Where
- Egypt
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Tanta University
Randomized Clinical Trial
Clinical and Radiographic Outcome of Regeneration in Immature Permanent Human Teeth Using a New Scaffold
This study aimed to evaluate clinical and radiographic outcome of regeneration in immature permanent human teeth using two different types of scaffolds: 1. Collagen-hydroxyapatite scaffold (Osteon III collagen) after blood clot.
- Trial name
- NCT06812351
- Testing
- Osteon III collagen, Blood clot
- Where
- Egypt
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Pulpal Necrosis
Evaluation of Regenerative Endodontic Treatment for Immature Teeth
The goal of this clinical trial is to evaluate if regenerative endodontic treatment using two different forms of demineralized dentin matrix (DDM) can effectively treat immature permanent single-rooted teeth compared to treatment…
- Trial name
- NCT07210359
- Testing
- human treated dentin matrix hydrogel, Theracal LC - Demineralized dentin matrix combination, Retro Mta
- Where
- Egypt
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Kafrelsheikh University
Immature Permanent Teeth With Open Apex, Pulp Necrosis
Regenerative Root Canal Treatment of Immature Teeth Using Omega-3 Fatty Acids
This clinical study will be conducted to evaluate the effect of using intracanal Omega-3 Fatty acids during revascularization of necrotic immature teeth compared to the traditional induced bleeding technique.
- Trial name
- Regeneration (NCT07371416)
- Testing
- Omega -3 fatty acids, Calcium Hydroxide (Ca(OH)2)
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Apical Periodontitis, Endodontic Disease
Postoperative Pain After OCT or EDTA Irrigation in Regenerative Endodontic Treatment
This randomized clinical trial evaluated the effect of two different irrigation solutions on postoperative pain following regenerative endodontic treatment of necrotic immature permanent teeth with apical periodontitis.
- Trial name
- NCT07722416
- Testing
- Regenerative Endodontic Treatment Using Different Irrigation Solutions
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Dental Pulp Regeneration, Dental Pulp Diseases
Development of a Model to Evaluate Regenerative Endodontic Techniques Using Extract Human Teeth
Millions of teeth are saved each year by root canal therapy. Although current treatment modalities offer high levels of success for many conditions, an ideal form of therapy might consist of regenerative approaches in which…
- Trial name
- NCT00595595
- Where
- United States
- Volunteers
- 1,080 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Infected Immature Permanent Teeth
Regenerative Endodontic Therapy (RET) for the Management of Immature Non-vital Permanent Teeth in Children
This study evaluates the efficacy of Antibiotic pastes or Calcium hydroxide disinfection on healing of periapical pathology and continued root development of infected non-vital immature permanent teeth in children.
- Trial name
- NCT03327844
- Testing
- RET using antibiotics (Ciprofloxacin and Metronidazole), RET using non-setting Calcium Hydroxide
- Where
- 2 sites in Singapore
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National University Health System, Singapore
Regenerative Endodontics
Regenerative Endodontics in Mature Permanent Teeth
this study was designed to compare the clinical and radiographic success of REPs after using blood clot scaffold in non-vital mature permanent teeth with or without photobiomodultion therapy
- Trial name
- NCT05892536
- Testing
- dental regenerative endodontics
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Salma fathy
Dental Pulp Regeneration
Comparison of Tissue in Regenerative Endodontic Procedures and Apexification
The purpose of our study is to characterize the composition of the hard and soft tissues present after regenerative endodontic procedures in root canals of teeth previously diagnosed with the need for extraction for orthodontic…
- Trial name
- NCT01805388
- Testing
- Experimental: Regeneration Treatment Group, Control Non-Study Drug Group
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Kenneth Hargreaves