Clinical trials: Remimazolam
Adverse Respiratory Events, Hypoxemia
Comparing Esketamine and Remazolam With Propofol for Breathing Safety in Pediatric Gastroscopy
Gastroscopy is important for diagnosing and treating upper gastrointestinal diseases in children. To ensure the procedure is safe and smooth, most children require sedation.
- Conditions
- Adverse Respiratory Events, Hypoxemia, Children, Gastroscopy
- Trial name
- NCT07748884
- Testing
- Fentanyl and Propofol, Esketamine and remimazolam
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Tonsillectomy With or Without Adenoidectomy
Effects of Remimazolam and Ciprofol TIVA on PRAE in Pediatric Tonsillectomy and Adenoidectomy
To observe the effects of remimazolam versus ciprofol TIVA on PRAE in pediatric tonsillectomy and adenoidectomy.
- Trial name
- NCT07118579
- Testing
- Remimazolam, Propofol, Ciprofol
- Where
- China
- Volunteers
- 114 people
- Sponsor
- Tongji Hospital
Benzodiazepine
Effect of Remimazolam Use During Perioperative Period on Brain Waves and Postoperative Cognitive Function
Benzodiazepine sedative hypnotics are commonly used intravenous anesthetics in clinical practice. Remimazolam is a new benzodiazepine with the characteristics of rapid onset, short maintenance and recovery time, no accumulation…
- Trial name
- NCT04601350
- Testing
- remimazolam group was induced with remimazolam 0.1 mg/kg followed by a maintenance dose of 0.1 mg·kg-1·h-1 for general anesthesia, control group was induced with midazolam 0.05 mg/kg followed by normal saline maintenance of 0.1 ml·kg-1·h-1
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Yangzhou University
Anesthesia, Intravenous, Hemodynamic Stability
Hemodynamic Effects of Remimazolam vs Propofol During Robot-assisted Gynecologic Surgery
This single-center study at CHA Ilsan Medical Center compares intraoperative hemodynamics between remimazolam- and propofol-based total intravenous anesthesia (TIVA) in patients undergoing robot-assisted gynecologic surgery…
- Conditions
- Anesthesia, Intravenous, Hemodynamic Stability, Gynecologic Surgery
- Trial name
- By_HD (NCT07251101)
- Testing
- Remimazolam, Propofol
- Where
- 2 sites in South Korea
- Volunteers
- 58 people
- Sponsor
- Ilsan Cha hospital
Operative Sedation of Pediatric, Operative Sedation of Adolescent Patients
A Trial of Remimazolam for Intraoperative Sedation in Pediatric and Adolescent Patients
The study is being conducted to evaluate the efficacy and safety of Remimazolam for intraoperative sedation in pediatric and adolescent patients.
- Trial name
- NCT07036419
- Testing
- Remimazolam Tosilate for injection, Propofol Injection
- Where
- China
- Volunteers
- 249 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Fiberoptic Bronchoscopy
Dexmedetomidine Nasal Spray and Pediatric Bronchoscopy
To observe the sedative effect of using dexmedetomidine nasal spray combined with remimazolam for pediatric bronchoscopy diagnosis and treatment, provide a safer and more comfortable anesthesia plan for pediatric bronchoscopy…
- Trial name
- NCT06755996
- Testing
- Dexmedetomidine injection, Remimazolam
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Tongji Hospital
General Anesthesia and Bronchoscopy Sedation
A Non-intervention Fiberoptic Bronchoscopy Study of Remazolam Toluene Sulfonate for Injection Under General Anesthesia and Fiberoptic Bronchoscopy
This is a non-interventional study of remazolam toluenesulfonate (rebenin ®) for injection in Chinese patients. A total of 1000 patients were enrolled in this study based on the preliminary safety assessment of rebenin ®, and all…
- Trial name
- NCT05549791
- Testing
- Remimazolam Tosilate for Injection
- Where
- China
- Volunteers
- 1,285 people, healthy volunteers welcome
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Adenotonsillar Hypertrophy
Remiazolam vs Propofol Total Intravenous Anesthesia on Postoperative Neurodevelopment After General Anesthesia in Children
The goal of this clinical trial is to learn the effects of remimazolam for total intravenous anesthesia on the neurodevelopment of children aged 3-6 years who underwent tonsil/adenoid removal surgery after general anesthesia when…
- Trial name
- REMPPON (NCT07194109)
- Testing
- Remimazolam based total intravenous anesthesia, Propofol based general anesthesia
- Volunteers
- 558 people
- Sponsor
- The First Affiliated Hospital of Anhui Medical University
Gastrointestinal Diseases
Varied Remimazolam Dosages for Pediatric Endoscopy
This prospective, randomized, comparative study aims to compare the efficacy and safety of three different doses of remimazolam (0.2 mg/kg, 0.3 mg/kg, and 0.4 mg/kg) combined with sufentanil and propofol for painless gastroscopy…
- Trial name
- NCT07083440
- Testing
- Remimazolam, Propofol, Sufentanil
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Children's Hospital of Hebei Province
Pediatric, Gastroscopy
Effect of Esketamine on 95% Induction Dose of Remimazolam
As an invasive operation, gastroscopy will cause children's nervousness, anxiety and uncooperative behavior, and even lead to the risk of bleeding and perforation, which will also affect the accuracy of the examination…
- Conditions
- Pediatric, Gastroscopy, ED95, Sedation
- Trial name
- EEIDR (NCT06303037)
- Testing
- Remimazolam besylate and low-dose Esketamine, Remimazolam besylate and Medium dose Esketamine
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Anesthesia
Dose of Remi in Children
Remimazolam has demonstrated the potential as a valuable medication for procedural sedation and general anesthesia. However, the effective dosage of remimazolam in pediatric patients is still unknown.
- Trial name
- DRINK (NCT05990673)
- Testing
- Remimazolam
- Volunteers
- 25 people
- Sponsor
- Zhihong LU
Endoscopy, Gastrointestinal
Paradoxical Reactions of Remimazolam in Pediatric Painless Gastrointestinal Endoscopy
Exploring the effect of remimazolam dose on paradoxical reactions in pediatric painless gastrointestinal endoscopy.
- Trial name
- NCT06419543
- Testing
- Remimazolam
- Where
- China
- Volunteers
- 333 people
- Sponsor
- Tongji Hospital
Emergence Agitation, Remimazolam
Effect of Remimazolam vs Sevoflurane Anesthesia on Incidence of Emergence Agitation and Complications in Children Undergoing Ophthalmic Surgery
As a novel ultra-short-acting benzodiazepines drugs, Remimazolam has been accepted for induction and maintenance of clinical anesthesia.
- Conditions
- Emergence Agitation, Remimazolam, Sevoflurane, Pediatric Ophthalmic Surgery
- Trial name
- NCT05527314
- Testing
- Remimazolam, Sevoflurane, Fentanyl
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Second Affiliated Hospital of Nanchang University
Pediatric ALL
Investigation of Remimazolam in Children Undergoing Sedation for Medical Procedures
To assess the efficacy of intravenous remimazolam in inducing and maintaining suitable sedation levels for paediatric patients undergoing diagnostic and/or therapeutic procedures
- Trial name
- NCT04851717
- Testing
- Remimazolam
- Where
- 8 sites in United States, Denmark
- Volunteers
- 100 people
- Sponsor
- Acacia Pharma Ltd
Emergence Delirium
Remimazolam Reduces Emergence Delirium in Preschool Children Undergoing Laparoscopic Surgery by Sevoflurane Anesthesia
Emergence delirium (ED) is a manifestation of acute postoperative brain dysfunction that occurs with a relatively high frequency after pediatric anesthesia.
- Trial name
- NCT04621305
- Testing
- normal saline, Bolus Remimazolam, Continuous Infusion Remimazolam
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Anesthesia
Dose of Remimazolam in Children for Intubation
Remimazolam has demonstrated the potential as a valuable medication for procedural sedation and general anesthesia. However, half effective dose of remimazolam required to prevent cardiovascular response to tracheal intubation…
- Trial name
- DRIP (NCT06170918)
- Testing
- Remimazolam
- Volunteers
- 40 people
- Sponsor
- Zhihong LU
Remimazolam, Dexmedetomidine
Application of Remimazolam, Dexmedetomidine, and Esketamine in Pediatric Preoperative Sedation
By comparing the application effects of three drugs in pediatric preoperative sedation, this study explores the optimal medication regimen, aiming to provide safer, more effective, and more personalized medication options for…
- Conditions
- Remimazolam, Dexmedetomidine, Esketamine
- Trial name
- NCT07050212
- Testing
- remimazolam group, dexmedetomidine group, esketamine group
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Maternal and Child Health Hospital of Hubei Province
Respiratory Depression
Effect of Propofol Versus Remimazolam Intravenous Anesthesia on Respiratory Depression
General anesthesia is the preferred choice for pediatric patients, but the induction of volatile anesthetics via face mask may cause preoperative anxiety and postoperative delirium.
- Trial name
- NCT06816173
- Testing
- Propofol group, Remimazolam group
- Where
- China
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Sedative; Anxiety Disorder
Intranasal Remimazolam for Premedication in Pediatric Patient
Anesthetic inhalation induction could be one of the most stressful experiences for children during the perioperative period, with almost 50% of them showing anxiety.
- Trial name
- NCT04720963
- Testing
- Remimazolam, Distilled water for injection, Dexmedetomidine
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Pediatric, ED95
The ED95 of Single Intravenous Bolus Remimazolam Besylate in Pediatric Patients During General Anesthesia Induction
Due to the incomplete development of systems and low pain thresholds in the pediatric population, good general anesthesia is required during the perioperative period to ensure the smooth progress of the surgery.Propofol is often…
- Conditions
- Pediatric, ED95, Sedation, General Anesthesia
- Trial name
- NCT06061159
- Testing
- Remimazolam besylate
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University