Clinical trials: Renal Failure, open to volunteers
Endothelial Dysfunction, End-Stage Renal Disease
Ramipril vs. Amlodipine in Pediatric Hemodialysis Patients
The goal of this clinical trial is to learn if Ramipril works better than Amlodipine to reduce endothelial dysfunction in pediatric patients (aged 5-18 years) with end-stage kidney disease undergoing maintenance hemodialysis and…
- Conditions
- Endothelial Dysfunction, End-Stage Renal Disease, Pediatric Kidney Disease
- Trial name
- ADMA /PedsQL (NCT07879560)
- Testing
- Ramipril tablet, Amlodipine tablet
- Volunteers
- 50 people
- Sponsor
- Ain Shams University
Chronic Kidney Failure in Children and Young Adults
Phase 3 Clinical Trial With Dapagliflozin in Chronic Kidney Disease in Adolescents and Young Adult Patients
Recent trials have demonstrated positive renal outcomes of sodium-glucose co-transporter-2 inhibitors (SGLT2i) additive to angiotensin-converting-enzyme inhibitors (ACEis) in adult patients with diabetic and non-diabetic chronic…
- Trial name
- DOUBLE_PROTECT (NCT05944016)
- Testing
- Dapagliflozin
- Where
- 16 sites in Germany
- Volunteers
- 102 people
- Sponsor
- University Hospital Goettingen
Chronic Kidney Diseases, Bladder Dysfunction
Concomitant Renal and Urinary Bladder Allograft Transplantation
The purpose of this study is to establish if concomitant renal and vascularized urinary bladder allograft transplantation is feasible.
- Conditions
- Chronic Kidney Diseases, Bladder Dysfunction, Bladder Absence, Posterior Urethral Valve
- Trial name
- NCT04626167
- Testing
- Concomitant Renal and Urinary Bladder Allograft Transplantation
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Mayo Clinic
Renal Failure, CVVHD
Analysis of Paediatric Treatments With multiFiltratePRO
This clinical study evaluates the performance of the MultifiltratePro in pediatric mode for Continuous Venovenous Hemodiafiltration (CVVHD) in children.
- Trial name
- ECHOped (NCT06603324)
- Testing
- CVVHD treatment in paediatric mode with multiFiltratePRO
- Where
- 2 sites in Czechia, Germany
- Volunteers
- 43 people
- Sponsor
- Fresenius Medical Care Deutschland GmbH
Acute Kidney Injury, Renal Failure
Analysis of Continuous Kidney Replacement Therapy (CKRT) Treatments With multiFlux Hemofilters Using Regional Citrate Anticoagulation (RCA) or Systemic Heparin Anticoagulation
The goal of this observational study is to assess the performance of the multiFlux hemofilterwith regional or systemic anticoagulation during CKRT treatments.
- Trial name
- RCA-Flux (NCT07679568)
- Testing
- multiFlux 160 hemofilter with regional heparin anticoagulation, multiFlux 160 hemofilter with RCA with regional citrate anticoagulation, multiFlux 130 hemofilter with regional heparin anticoagulation
- Where
- Germany
- Volunteers
- 62 people
- Sponsor
- Fresenius Medical Care Deutschland GmbH
Kidney Transplantation in Highly Sensitized Patients
Imlifidase Prior to Kidney Transplant in Highly Sensitised Children
The goal of this clinical trial is to learn about the efficacy and safety of imlifidase in highly sensitized paediatric patients, 1-17 years old, with end stage renal disease (ESRD).
- Trial name
- DINKY (NCT05753930)
- Testing
- Imlifidase
- Where
- 6 sites in Finland, France and 3 more
- Volunteers
- 10 people
- Sponsor
- Hansa Biopharma AB
Cardiac Diseases, Sickle Cell Disease
Domestication and Implementation of the PEN-Plus Clinical Model in the Zambian Health System
Cognizant of the prevalence of complicated non communicable diseases (NCD) and the attendant capacity problems faced by the health workers in primary care settings, we propose to adapt and pilot the Package of Essential…
- Conditions
- Cardiac Diseases, Sickle Cell Disease, Hypertension, Diabetes Mellitus
- Trial name
- PEN Plus (NCT07753681)
- Testing
- Supportive treatment
- Where
- Zambia
- Volunteers
- 2,084 people
- Sponsor
- Centre for Infectious Disease Research in Zambia
Quality of Life, Posterior Urethral Valve
Study of the Quality of Life in School Aged-children With Posterior Urethral Valves
Posterior urethral valves (PUV) are the most common congenital obstructive lesion of the urethra, affecting from 1 per 3000 to 1 per 8000 live births.
- Conditions
- Quality of Life, Posterior Urethral Valve, Renal Insufficiency, Chronic Renal Disease
- Trial name
- QUALIVUP (NCT06439862)
- Testing
- Children with PUV
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Hospices Civils de Lyon
Anemia
Efficacy and Safety of Spironolactone in Pediatric Hemodialysis Patients With Anemia.
The goal of this clinical trial is to learn if Spironolactone drug works to treat anemia in hemodialysis pediatric patients. It will also learn about the safety of Spironolactone drug.
- Trial name
- NCT07715318
- Testing
- Spironolactone (drug), Iron Supplement, Erythropoietin stimulating agent
- Volunteers
- 40 people
- Sponsor
- Ain Shams University
BK Viremia, Kidney Transplant Infection
A Trial to Treat Polyomavirus Infections (BKPyV) in Kidney and Simultaneous Kidney Pancreas Transplant Recipients
BEAT-BK will see the effect of immunosuppression reduction/modification with and without IVIG on BKPyV infection, allograft function, allograft loss, acute transplant rejection, immunosuppression load and death in kidney and…
- Conditions
- BK Viremia, Kidney Transplant Infection, Kidney Transplant Failure and Rejection
- Trial name
- BEAT-BK (NCT05325008)
- Testing
- Immunosuppression reduction/modification + intravenous immunoglobulin, Immunosuppression reduction/modification
- Where
- 13 sites in Australia
- Volunteers
- 280 people
- Sponsor
- The University of Queensland
Renal Injury, Acute
Acute Kidney Injury : Long-term Renal and Cardiovascular Prognosis and Biomarker-based Risk Assessment
Patients who develop severe acute kidney injury (AKI) in intensive care remain at increased long-term risk of mortality, major cardiovascular events, and chronic renal complications, including prolonged dependence on renal…
- Trial name
- AKIRA (NCT07596407)
- Where
- France
- Volunteers
- 412 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Postprandial Hypoglycemia, End-stage Renal Disease (ESRD)
Anakinra for the Treatment of Postprandial Hypoglycemia in a Patient With Total Gastrectomy and End-Stage Renal Disease
Post-meal low blood sugar (postprandial hypoglycemia) is a common problem after certain stomach surgeries like gastric bypass or stomach removal.
- Conditions
- Postprandial Hypoglycemia, End-stage Renal Disease (ESRD), Gastrectomy, Glucose Metabolism Disorders
- Trial name
- AnPHy-ReD (NCT07580079)
- Testing
- Anakinra (interleukin-1 receptor antagonist)
- Where
- Switzerland
- Volunteers
- 1 people
- Sponsor
- Marc Donath
Kidney Failure, Chronic, Peritoneal Dialysis Complication
International (Pediatric) Peritoneal Biobank
Within few years the peritoneal membrane of adult peritoneal dialysis (PD) patients undergoes substantial morphological transformation, including progressive fibrosis, vasculopathy and neoangiogenesis.
- Conditions
- Kidney Failure, Chronic, Peritoneal Dialysis Complication, Transplantation, Healthy
- Trial name
- NCT01893710
- Testing
- biopsy sampling
- Where
- 26 sites in United States, Austria and 13 more
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Heidelberg University
End Stage Chronic Renal Failure
Impact of SGLT2 Inhibitors on Chronic Peritoneal Dialysis Patients.
This project aims to examine the effects of six-month treatment with selective SGLT2 inhibitor dapagliflozin in patients with end-stage kidney disease on chronic peritoneal dialysis.
- Trial name
- NCT07491042
- Testing
- Dapagliflozin
- Where
- Oman
- Volunteers
- 38 people
- Sponsor
- Oman Ministry of Health
Acute Renal Failure (ARF), Acute Tubular Necrosis
Use of QRX3 for Acute Tubular Necrosis Type of Renal Failure in Hospitalized Patients ( QRX-3 in ARF)
Use of QRX-3 in hospitalized patients with pediatric and adult patients with acute tubular necrosis renal failure
- Trial name
- QRX3 in ARF (NCT07161843)
- Testing
- QRX-3
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Ebima Clifford Okundaye
Diabetes Mellitus, Type 2, End Stage Renal Disease
Drug Interaction Potential of Pro-Inflammatory Conditions
Pro-inflammatory cytokines, which are elevated in pro-inflammatory disease states (e.g., type II diabetes mellitus [T2DM], irritable bowel diseases [IBD], and end stage renal disease [ESRD]) have been shown to inhibit hepatic…
- Conditions
- Diabetes Mellitus, Type 2, End Stage Renal Disease, Irritable Bowel Syndrome
- Trial name
- DIPPIC (NCT07360938)
- Testing
- None (Observational)
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Indiana University
Kidney Failure, Kidney Transplant
Worldwide Assessment of Deceased Donor Kidney Utilization
The persistent imbalance between kidney transplant demand and organ availability remains a major global challenge. Optimizing the utilization of kidneys from deceased donors is a critical strategy to expand the donor pool and…
- Conditions
- Kidney Failure, Kidney Transplant, Deceased Donor Kidney Transplant
- Trial name
- NCT07341516
- Where
- 2 sites in United States, France
- Volunteers
- 300,000 people
- Sponsor
- Paris Translational Research Center for Organ Transplantation
End Stage Renal Disease, Cardio-Renal Syndrome
Cardio-Renal Registry
Cardiovascular disease is the leading cause of morbidity and mortality among patients with chronic kidney disease (CKD). Even after adjustment for known cardiovascular risk factors, including diabetes and hypertension, mortality…
- Conditions
- End Stage Renal Disease, Cardio-Renal Syndrome, Myocardial Infarction, Cerebrovascular Accident
- Trial name
- BHCRR (NCT06521801)
- Testing
- Observation
- Where
- United Kingdom
- Volunteers
- 60,000 people
- Sponsor
- Queen Mary University of London
Primary Hyperoxaluria Type 1, End Stage Renal Disease
Safety & Efficacy of DCR-PHXC in Patients With PH1 and ESRD
The aim of this study is to evaluate DCR-PHXC in participants with PH1 and severe renal impairment, with or without dialysis.
- Trial name
- PHYOX7 (NCT04580420)
- Testing
- DCR-PHXC
- Where
- 18 sites in United States, France and 8 more
- Volunteers
- 28 people
- Sponsor
- Dicerna Pharmaceuticals, Inc., a Novo Nordisk company
Renal Failure Congenital, Congenital Renal Anomaly Nos
Serial Amnioinfusions as Regenerative Therapy for Pulmonary Hypoplasia
Congenital lower urinary tract obstruction (LUTO) is a heterogeneous group of congenital anomalies that lead bladder outlet obstruction.
- Conditions
- Renal Failure Congenital, Congenital Renal Anomaly Nos, Renal Agenesis and Dysgenesis, Lower Urinary Tract Obstructive Syndrome
- Trial name
- NCT03723564
- Testing
- Lactated Ringers Solution for Injection
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Mayo Clinic