Clinical trials: Renal Function Disorder
Malaria
Paracetamol Effect on Oxidative Stress and Renal Function in Severe Malaria
Blackwater fever, characterized by intravascular haemolysis and hemoglobinuria, is an important cause of renal impairment and mortality in severe malaria caused by Plasmodium falciparum.
- Trial name
- NCT01641289
- Testing
- Paracetamol, No Paracetamol
- Where
- 2 sites in Bangladesh
- Volunteers
- 62 people
- Sponsor
- University of Oxford
Bladder Function
Unilateral Cutaneous Ureterostomy - Long Term Follow up
This observational study is aimed at exploring bladder function following temporary unilateral low loop cutaneous ureterostomy carried out in newborns suffering from severe congenital hydro-ureteronephrosis
- Trial name
- ureterostomy (NCT00546208)
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Sheba Medical Center
Premature Infants, Patent Ductus Arteriosus
Ibuprofen and Renal Function in Premature Infants
Purpose of the study: 1. To evaluate renal function maturation within the first month of life in very premature infants. 2. To determine whether a treatment with Ibuprofen for patent ductus arteriosus would alter renal function…
- Trial name
- NCT00217191
- Testing
- Ibuprofen
- Where
- 3 sites in France
- Volunteers
- 120 people
- Sponsor
- Maternite Regionale Universitaire
Chronic Renal Failure
Evluation of Thyroid Functions in Hemodialysis Childern in Sohag University Hospital
Thyroid gland and its hormones play an important role in organ development and the homeostatic control of many physiological mechanisms such as body growth and energy expenditure.
- Trial name
- NCT05451472
- Testing
- thyroid function tests, complete blood count, serum creatinine
- Volunteers
- 39 people
- Sponsor
- Sohag University
Premature Infant
Urine Biomarkers for Renal Function Monitoring in Preterm Infants
The true renal function of preterm infants is difficult to evaluate. Serum creatinine (Cr) levels in infants are unreliable as a detector of renal function in the first few days of life because they may continue to reflect…
- Trial name
- NCT02813109
- Where
- 2 sites in South Korea
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Inha University Hospital
Diabetes Mellitus, Kidney, CPB
Kidney Function in Diabetics During CPB (Cardio Pulmonary Bypass)
Filtration of urine in the kidney requires sufficient oxygen supply. The filtration of urine is greater in patents with diabetes.
- Trial name
- DM-ECC (NCT03405532)
- Testing
- DM-ECC
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Sahlgrenska University Hospital
Fabry Disease
Registry of Fabry Disease - A Multicenter Observational Study
The purpose of this study is to compile a registry of patients with Fabry disease, an inherited metabolic disorder. In this disease, an enzyme called a-galactosidase A, which normally breaks down a lipid (fatty substance) called…
- Trial name
- NCT00055016
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
End Stage Kidney Disease, Delayed Graft Function
Better Evidence for Selecting Transplant Fluids
End-stage kidney disease (ESKD) is a significant, expensive health problem. Kidney transplantation improves survival, quality of life, and is much cheaper than dialysis treatment for ESKD.
- Conditions
- End Stage Kidney Disease, Delayed Graft Function, Kidney Transplant; Complications
- Trial name
- BEST-Fluids (NCT03829488)
- Testing
- Plasma-Lyte 148 (approx. pH 7.4) IV Infusion, 0.9% SODIUM CHLORIDE 9g/L injection BP
- Where
- 18 sites in Australia, New Zealand
- Volunteers
- 808 people
- Sponsor
- The University of Queensland
Acute Coronary Syndrome
Protective Effect of Early High Dose stATins On Cardiovascular and Renal Events in Acute Coronary Syndrome
Registration of all ACS patients (STEMI and NSTEMI) admitted to the cardiology ward and scheduled for early invasive strategy. The aim is to evaluate the protective effects of early (on admission) high-dose high-potency statin…
- Trial name
- PRATO-ACS (NCT04087200)
- Where
- Italy
- Volunteers
- 2,500 people
- Sponsor
- Centro Cardiopatici Toscani
End Stage Renal Disease, Hemolysis
Ventilatory Functions and Physical Intolerance in ESRD Adolescents: Response to Program of Walking With Dogs
adolescents with chronic renal failure going on hemodialysis usually complain many problems including compromised ventilation, early fatigue, early physical intolerance, and bad life quality.
- Trial name
- NCT06861816
- Testing
- incentive spirometer and walking with dog, training by incentive spirometer only
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Primary Immunoglobulin A Nephropathy (IgAN)
Study to Assess the Efficacy, Pharmacokinetics, Safety and Tolerability of Iptacopan in Pediatric Patients With Primary IgAN
The study is an open-label, single arm, multicenter, Phase III study to determine proteinuria reduction, pharmacokinetics (PK), safety and tolerability (including CV surveillance) of iptacopan in primary immunoglobulin A…
- Trial name
- NCT06994845
- Testing
- iptacopan
- Where
- 20 sites in United States, Argentina and 6 more
- Volunteers
- 31 people
- Sponsor
- Novartis Pharmaceuticals
Renal Transplantation, Chronic Kidney Insufficiency
Urinary Biomarkers in Paediatric Kidney Transplantation (pKTx)
This study aims to test and validate the panel of study urinary biomarker to assess whether (1) reference values differ between paediatric renal transplant patients, patients with chronic kidney disease stage IV and V (CKD IV-V)…
- Conditions
- Renal Transplantation, Chronic Kidney Insufficiency, Healthy Controls
- Trial name
- NCT05208788
- Testing
- Biomarker test
- Where
- Germany
- Volunteers
- 186 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Diabetes
Effect of Magnesium Supplementation on Patients With Diabetic Nephropathy
This is a double-blind randomized clinical trial which will start at June 2014 and end on June 2015 in Isfahan city. Serum creatinine level is considered as a key variable and the sample size calculated 80 persons (40 persons for…
- Trial name
- NCT02220036
- Testing
- Magnesium Oxide
- Where
- Iran
- Volunteers
- 80 people
- Sponsor
- Isfahan University of Medical Sciences
Type 1 Diabetes, Diabetic Kidney Disease
MANATEE-T1D: Metformin ANd AutomaTEd Insulin Delivery System Effects on Renal Vascular Resistance, Insulin Sensitivity, and Cardiometabolic Function in Youth With Type 1 Diabetes
Diabetic kidney disease and cardiovascular disease remain the leading causes of morbidity and mortality in people with type 1 diabetes and are exacerbated with longer duration of diabetes and time outside goal glycemic range.
- Conditions
- Type 1 Diabetes, Diabetic Kidney Disease, Cardiovascular Diseases, Endothelial Dysfunction
- Trial name
- MANATEE-T1D (NCT05065372)
- Testing
- Metformin Hcl 1000Mg Tab, Aminohippurate Sodium 20 % Injection, Iohexol 300 Mg/mL Injectable Solution
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Kalie Tommerdahl
Disorder Related to Renal Transplantation, Renal Transplant Rejection
Testing Immunosuppression Threshold in Renal Allografts To Extend eGFR
This study evaluates the addition of "Kidney Solid Organ Rejection Test" (kSORT), in the clinical follow-up of renal transplant recipients, compared to clinical standard surveillance in the first two years after kidney…
- Conditions
- Disorder Related to Renal Transplantation, Renal Transplant Rejection, Acute Graft Rejection
- Trial name
- TITRATE (NCT02581436)
- Testing
- kSORT assay based follow-up, Standard follow-up
- Where
- Mexico
- Volunteers
- 70 people
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Chronic Renal Failure
Relations Between Residual Renal Function and Oxidative and Carbonyl Stress in Peritoneal Dialysis Patients
Residual renal function is reported to contribute to the survival and cardiovascular disease of peritoneal dialysis patients. Oxidative and carbonyl stress are increased in peritoneal dialysis patients and are associated with…
- Trial name
- NCT00692068
- Where
- Japan
- Sponsor
- Iwata City Hospital
Diabetes, Type I
Diabetes Type 1, Treatment Study Atacand/Placebo After Kidney Biopsy
The type 1 diabetes patients who were still normoalbuminuric and normotensive, after 17 years duration and a second research kidney biopsy, could enter the double blind treatment study of Atacand or Placebo.
- Trial name
- NCT00328302
- Testing
- Candesartan
- Where
- Sweden
- Volunteers
- 13 people
- Sponsor
- Karolinska University Hospital
Chronic Kidney Disease, Heart Rate Variability
Heart Rate Variability in Chronic Kidney Disease Patients
Use 24hr Holter ECG, ultrasound and cardiac fibrosis markers in the chronic kidney disease patients
- Trial name
- NCT00824577
- Where
- Taiwan
- Volunteers
- 300 people
- Sponsor
- National Taiwan University Hospital
Myelofibrosis
To Evaluate the Pharmacokinetics and Safety of TQ05105 Tablet in Renal Impairment Subjects
This is an open, open-label, parallel, single-dose, phase I clinical study designed to evaluate the pharmacokinetic (PK) profile of TQ05105 tablet in patients with renal impairment after a single dose, and to evaluate the urinary…
- Trial name
- NCT06598956
- Testing
- TQ05105
- Where
- China
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
Diabetes Mellitus, Lactic Acidosis
Safety of Continuing Metformin in Diabetic Patients With Normal Kidney Function Receiving Contrast Media
The purpose of this study is to determine whether metformin causes lactic acidosis in diabetic patients with preserved kidney function, undergoing coronary angiography or angioplasty with new contrast media.
- Trial name
- NCT01873859
- Testing
- Metformin
- Where
- Iran
- Volunteers
- 166 people
- Sponsor
- Shahid Beheshti University of Medical Sciences