Clinical trials: Reperfusion
Myocardial Infarction, Reperfusion Injury
Role of Adiponectin and Endothelial Progenitor Cells in Reperfusion Injury in Patients With Acute Myocardial Infarction
There is experimental evidence that low levels of adiponectin are associated with more reperfusion injury. In addition experimental studies have demonstrated that endothelial progenitor cells may have a favorable effect on…
- Trial name
- R²ACE (NCT01414452)
- Where
- Belgium
- Volunteers
- 250 people
- Sponsor
- Universiteit Antwerpen
Cardiotoxicity
Remote Ischaemic Preconditioning in Childhood Cancer
Survival rates of children with cancers have improved significantly in the recent few decades. Nonetheless, the side effect of this class of drugs on heart function remains to be an issue of concern.
- Trial name
- NCT03166813
- Testing
- Remote Ischaemic Preconditioning, Control
- Where
- Hong Kong
- Volunteers
- 68 people
- Sponsor
- The University of Hong Kong
Kidney Disease, Liver Disease
Remote Ischemic Preconditioning In Abdominal Organ Transplantation
Does remote ischemic preconditioning (RIPC) induced by a brief period of occlusion of blood flow to the lower extremity prior to organ recovery in deceased donors, improve short and long term outcomes after transplantation of…
- Conditions
- Kidney Disease, Liver Disease, Pancreas Disease
- Trial name
- RIPCOT (NCT00975702)
- Testing
- RIPC by Inflation of Pneumatic Tourniquet
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- University of Medicine and Dentistry of New Jersey
Congenital Heart Disease
Inhaled NO as an Anti-inflammatory and Anti-reperfusion Agent in Infants and Children Undergoing Cardiopulmonary Bypass
Each year, there are over 400,000 cardiac surgical operations performed in the United States; of which 10,000 are performed on children.
- Trial name
- NCT00585013
- Testing
- Nitric Oxide
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Washington University School of Medicine
Infarction
Myocardial Infarction Safe Emergency Medicine Accompanying Study: Providing Reperfusion Therapy Within the Recommended Time Limits
The project is a prospective observational study with the aim of system improvement. It represents accompanying research in connection with the implementation of Safe Emergency Medicine , - an initiative under the auspices of the…
- Trial name
- NCT07092904
- Where
- Norway
- Volunteers
- 200 people
- Sponsor
- University Hospital of North Norway
Placenta Accreta
The Role of Transdermal CO2 in MDA Level in Patient Underwent Abdominal Aortic Temporary Cross Clamp
The Role of Transdermal Carbon Dioxide in Malondialdehyde Level as Predictor of Ischemia Reperfusion Injury in Patients Underwent Abdominal Aortic Temporary Cross Clamp
- Trial name
- NCT05205304
- Testing
- D'Oxyva
- Where
- Indonesia
- Volunteers
- 30 people
- Sponsor
- Universitas Airlangga
Ischemic Reperfusion Injury
Single-cycle Remote Ischemic Preconditioning and Postconditioning for Prevention of Contrast-Induced Nephropathy
This trial is a 2 x 2 factorial design, double-blinded, randomized controlled trial to evaluate efficacy and safety of remote ischemic preconditioning and postconditioning for prevention of contrast-induced acute kidney injury in…
- Trial name
- NCT02729155
- Testing
- RIPre, RIPost
- Where
- Thailand
- Volunteers
- 596 people
- Sponsor
- Phramongkutklao College of Medicine and Hospital
Myocardial Injury, Cardiac Surgery
Effect of Cyclosporine and Remote Ischemic Preconditioning in Reperfusion Ischemia Injury on Tetralogy Fallot Patients With Correction Surgery
The study aimed to evaluate the combined effects of cyclosporine and remote ischemic preconditioning on MDA, calcium cytosol concentration, and mitochondrial edema in tetralogy Fallot patients undergoing corrective surgery.
- Trial name
- NCT05691764
- Testing
- Cyclosporin, remote ischemic preconditioning
- Where
- Indonesia
- Volunteers
- 40 people
- Sponsor
- Universitas Indonesia
Lung Transplantation, Primary Graft Dysfunction
The Use of Surfactant in Lung Transplantation: A Randomized Control Pilot Study
1. Working Hypothesis: The purpose of the trial is to study the effect of exogenous calf surfactant (calfactant) on the prevention of primary graft failure due to ischemic-reperfusion lung injury in lung transplant patients. 2.
- Trial name
- NCT00506532
- Testing
- Surfactant (calfactant)
- Where
- Israel
- Volunteers
- 42 people
- Sponsor
- Rabin Medical Center
Hepatic Ischemic and Reperfusion Injury
Liver Protection of RIPC in Pediatric Living Donor Liver Transplantation
Remote ischemic preconditioning(RIPC) is emerging as an promising therapeutic paradigm to combat the detrimental impact of ischemic and reperfusion injury.
- Trial name
- RIPC-PLDT (NCT02830841)
- Testing
- remote ischemic preconditioning(RIPC)
- Where
- China
- Volunteers
- 208 people
- Sponsor
- RenJi Hospital
Reperfusion Injury, Post Cardiac Arrest Brain Injury
Light Utilization COX-Inhibitory Device Therapy for Infant Cardiac Arrest (LUTICA Study). The LUCID Device is Used in the Treatment of Ischemic Brain Reperfusion Injury Caused by Cardiac Arrest in Pediatric Patients.
Approximately 15,200 children receive cardiopulmonary resuscitation (CPR) for in-hospital cardiac arrest (IHCA) each year in the United States. Of these, about 60% are less than one year of age.
- Trial name
- LUTICA (NCT07556939)
- Testing
- LUTICIA - Light Utilization COX-Inhibitory Device)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Mitovation, Inc
ST Elevation Myocardial Infarction
Supplemental Oxygen in Catheterized Coronary Emergency Reperfusion
The aim of SOCCER is to evaluate the effects of treatment with supplemental O2 before and during acute balloon angioplasty (PCI) for patients with ST-elevation myocardial infarction (STEMI).
- Trial name
- SOCCER (NCT01423929)
- Testing
- Oxygen, Room air
- Where
- 3 sites in Sweden
- Volunteers
- 100 people
- Sponsor
- Region Skane
Acute Myocardial Infarction
Timely Reperfusion in Acute ST-segment Myocardial Infarction
The aim of the study is to monitor outcomes, especially time to reperfusion, in ST-elevation acute myocardial infarction patients.
- Trial name
- NCT04614805
- Testing
- Mobilizing clinical leaders
- Where
- Norway
- Volunteers
- 146 people
- Sponsor
- University Hospital of North Norway
Myocardial Infarction, Reperfusion Injury
Pilot Study of Edaravone to Treat Acute Myocardial Infarction
Early reperfusion therapy has improved the clinical outcomes of patients with acute myocardial infarction (AMI), but these benefits are limited in some patients by reperfusion injuries.
- Trial name
- NCT00265239
- Testing
- edaravone
- Where
- Japan
- Volunteers
- 104 people
- Sponsor
- Kumamoto University
Ventricular Septal Defect, Pulmonary Hypertension
The Effect of Remote Ischemic Preconditioning on the Ischemic Reperfusion Injury in Infants With Ventricular Septal Defect and Pulmonary Hypertension
Intraoperative myocardial and pulmonary protection is important for better outcome after cardiac surgery. Ischemic preconditioning is one of organ protective strategies against ischemia-reperfusion injury by applying brief…
- Trial name
- NCT01313832
- Testing
- remote ischemic preconditioning (RIPC)
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Seoul National University Hospital
Priapism, Reperfusion Injury
Investigation of the Protective Effect of Alpha Lipoic Acid on Ischemic Reperfusion Damage in Ischemic Priapism in Rats
The condition known in medical terminology as 'Priapism' refers to the state of erection in the male sexual organ persisting partially or completely for more than 4 hours without sexual stimulation or orgasm.
- Trial name
- NCT07391709
- Testing
- Ischemic priapism + reperfusion, Ischemic priapism + reperfusion + ALA
- Where
- Turkey (Türkiye)
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Trabzon Kanuni Education and Research Hospital
Anemia of Prematurity, Necrotizing Enterocolitis
Transfusion-related Inflammatory Cytokine and Neutrophil Extracellular Trap Quantification in Neonates
Despite many advances in neonatal care, necrotizing enterocolitis (NEC) remains a leading cause of morbidity and mortality among premature infants.
- Trial name
- NCT01735552
- Where
- 3 sites in United States
- Volunteers
- 12 people
- Sponsor
- University of Utah
Lung Transplant Recipients
The Effect of Cold Storage Solutions on Ischemic Injury in Lung Transplantation
The purpose of this study is to compare 2 different cold storage solutions, used to preserve donor lungs for lung transplantation, and their effect on cytokine activation related to ischemic reperfusion injury.
- Trial name
- NCT00284726
- Testing
- Celsior Cold Storage Solution
- Sponsor
- Johns Hopkins University
Acute Myocardial Infarction
Mortality Analysis of ST Elevation Myocardial Infarction (STEMI) Patients in Belgium
The purpose of this observational study is to assess predictors of in-hospital mortality in patients with acute myocardial infarction admitted to Belgian hospitals.
- Trial name
- NCT00727623
- Where
- Belgium
- Volunteers
- 20,000 people
- Sponsor
- Universiteit Antwerpen
Congenital Heart Disease, Ischemia-reperfusion Injury
Pediatric Remote Ischemic Pre-conditioning Prior to Complex Cardiac Surgery
In 2012, infants having surgery for congenital heart disease have a high survival. The investigators are now focused on improving how sick these infants become after surgery (short term outcomes) and their later neurodevelopment…
- Trial name
- PREP (NCT01739088)
- Testing
- Remote ischemic pre-conditioning stimulus.
- Where
- Canada
- Volunteers
- 53 people
- Sponsor
- University of Alberta