Clinical trials: Replacement, Total Knee
Arthroplasty, Overweight and Obesity
Healthy Living After Knee Replacement
The purpose of this study is to examine if a weight loss program designed for adults after knee replacement improves weight loss, physical activity, pain, and function, as well as if the program is cost effective, as compared to…
- Trial name
- NCT05190666
- Testing
- PACE Weight Loss program, Chronic Disease Self-Management
- Where
- United States
- Volunteers
- 182 people, healthy volunteers welcome
- Sponsor
- University of South Carolina
Osteoarthritis, Traumatic Arthritis
Prospective Multicenter Post Approval Study of the LPS-Flex Mobile Bearing Knee
The purpose of the study is to assess the long-term performance of the NexGen LPS-Flex Mobile Bearing Knee in the treatment of patients with severe knee pain or degenerative knee disease.
- Conditions
- Osteoarthritis, Traumatic Arthritis, Avascular Necrosis of the Femoral Condyle, Moderate Varus
- Trial name
- NCT00854295
- Testing
- NexGen LPS-Flex Mobile Bearing Knee
- Where
- 3 sites in United States
- Volunteers
- 266 people, healthy volunteers welcome
- Sponsor
- Zimmer Biomet
Knee Replacement, Knee Replacement Revision
Prevalence and Incidence of Multiple Revisions Following Knee Arthroplasty in Denmark 1998-2021: A Nationwide Population-based Study
The purpose of this study is to investigate the incidence and prevalence rates of multiply revised knee arthroplasty patients in Denmark from 1998-2021.
- Trial name
- EMKAR ONE (NCT06064318)
- Testing
- Revision
- Where
- Denmark
- Volunteers
- 161,384 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Stress
Effect of Audio Book applıcatıon on patıents Blood Pressure, Pulse Rate and anxıety Levels Before Total Knee Replacement Surgery
Before the TDP surgery, the anxiety levels of the patients in the experimental group will be measured by listening to an audio book.
- Trial name
- NCT06905899
- Testing
- audiobook app
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Beyza Yilmaz
Total Knee Replacement
Prediction of Leg Length Discrepancy After Unilateral Total Knee Replacement in Varus Deformity
To What degree total knee replacement (TKA) affects leg length discrepancy in patients with varus deformity? Varus deformity, the most commonly encountered deformity in patients undergoing TKA is associated with limb alignment…
- Trial name
- NCT03502382
- Testing
- x-ray
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Assiut University
Registries, Quality Improvement
Improving Quality Based on the Joint Registry
Test whether an intervention, consisting of frequently feedback of performance outcomes and education will improve patient care, expressed in better functional outcomes, fewer complications and more quality improving…
- Conditions
- Registries, Quality Improvement, Hip Arthropathy, Knee Arthropathy
- Trial name
- IQ Joint (NCT04055103)
- Testing
- Monthly feedback, education and linking hospitals
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Knee Osteoarthritis, Knee Arthritis
Effectiveness of Reduced Frequency Physical Therapy in Total Knee Arthroplasty
Rehabilitation after Total Knee Arthroplasty surgery involves physical therapy services to address limitations in range of motion, strength, and participation in normal daily activities.
- Conditions
- Knee Osteoarthritis, Knee Arthritis, Knee Arthropathy
- Trial name
- NCT03302832
- Testing
- Physical Therapy, In-home Exercise Equipment
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Campbell University, Incorporated
Total Knee Replacement
Long Term Foundation Knee Study
The purpose of this study is to obtain long-term (10+ yrs) clinical and patient outcomes data on patients who received the cruciate-retaining Foundation Knee system during or prior to the year 2000.
- Trial name
- NCT01274546
- Testing
- cruciate-retaining Foundation Knee system
- Where
- 2 sites in United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Encore Medical, L.P.
Knee Osteoarthritis, Hip Osteoarthritis
Comparison of Knotless Barbed Suture and Standard Suture in Knee Replacement Patients
Barbed suture use has been gaining increased acceptance and has been reported to offer potential advantages in wound closure of hip and knee replacement surgeries.
- Trial name
- NCT03031314
- Testing
- barbed suture, standard suture
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Washington Hospital Healthcare System
Periprosthetic Knee Infection
Outcome After Revisions of Infected Knee Arthroplasties
A prospective multicenter cohort study on all types of revision knee arthroplasty procedures performed due to infection.
- Trial name
- RIKA (NCT04427943)
- Testing
- revision surgery
- Where
- 8 sites in Denmark
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Knee Pain Treated With Knee Arthroplasty
Changes of Plantar Pressure After Knee Reconstructive Surgery
Knee reconstructive surgery (knee prosthesis, osteotomies) often results in changes of alignment of the lower limb axis. This affects also biomechanics of the hindfoot.
- Trial name
- PEDKnee (NCT02906735)
- Testing
- Surgery
- Where
- Germany
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Total Knee Arthroplasty, Total Knee Arthroplasty Recovery
Effects of Stress Ball Use and Breathing Exercises on Pain and Vital Signs During Drain Removal After Total Knee Arthroplasty
This randomized controlled trial aims to evaluate the effects of stress ball use and breathing exercises on procedural pain and vital signs during drain removal in patients undergoing total knee arthroplasty.
- Conditions
- Total Knee Arthroplasty, Total Knee Arthroplasty Recovery, Pain After Knee Arthroscop
- Trial name
- TDP (NCT07586436)
- Testing
- 3. Control Group Description, 1. Stress Ball Intervention Description, 2. Breathing Exercise Intervention Description
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Arthroplasty, Replacement, Knee
Fitbit and Social Support in Knee Replacement Patients & Buddies
Patients undergoing knee replacement typically report improved health-related quality of life, increased physical function, and reduced pain.
- Trial name
- NCT03037619
- Testing
- Fitbit, Fitbit+Support
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of South Carolina
Postoperative Pain, Analgesia
Evaluation of Dexketoprofen in Total Knee Arthroplasty
Pain is a global public health issue and represents the most common reason for both physician consultation and hospital admissions. Dexketoprofen is a new NSAID treating acute postoperative pain.
- Trial name
- NCT04161690
- Testing
- Dexketoprofen Trometamol, Ropivacaine Hydrochloride 7.5 MG/ML
- Where
- Greece
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- KAT General Hospital
Primary Osteoarthritis of Knee Nos
Rate of Infection After Using Antibiotic Loaded Cement and Regular Cement in Total Knee Arthroplasty
Our study will be a prospective study To compare between the rate of infection after using antibiotic loaded cement and regular cement after total knee arthroplasty in primary knee osteoarthritis.this will be at assiut university…
- Trial name
- NCT06117839
- Testing
- using antibiotic loaded cement and regular cement after total knee arthroplasty in primary knee osteoarthritis.
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Assiut University
Radiofrequency, Arthroplasty
Phenol Neurolysis and Radiofrequency Thermocoagulation in Knee Arthroplasty Surgery
Patients who presented to the Department of Neurology, Algology, and underwent knee arthroplasty surgery for chronic knee osteoarthritis between 2025 and 2026 and underwent radiofrequency or chemical neurolysis of the geniculate…
- Conditions
- Radiofrequency, Arthroplasty, Knee Osteoarthritis
- Trial name
- NCT07381335
- Testing
- genicular nerve radiofrequency thermocoagulation and fenole neurolysis
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Osteoarthritis
Comparing Fixed-bearing Versus Mobile-bearing Prosthesis in Total Knee Arthroplasty: A Prospective Randomized Trial
The purpose of this study is to determine which prosthesis is better in total knee arthroplasty
- Trial name
- NCT01312532
- Testing
- fixed-bearing (P.F.C.® Sigma), mobile-bearing (P.F.C.® Sigma)
- Where
- Iran
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Isfahan University of Medical Sciences
Osteoarthritis Knee
Comparison of an Old Versus a New Total Knee Replacement
A randomized controlled clinical and RSA study, comparing 2 knee implants: 1. NexGen CR cemented total knee arthroplasty 2. Persona CR cemented total knee arthroplasty 3 hospitals will participate in the study: Helse Bergen HF…
- Trial name
- NCT03548792
- Testing
- RSA radiostereometric analysis, Clinical comparison
- Where
- Norway
- Volunteers
- 185 people, healthy volunteers welcome
- Sponsor
- Helse-Bergen HF
Osteoarthritis
The Role of Intra-Operative Intracapsular Blocks in Post-Operative Pain Management Following Total Knee Arthroplasty
The purpose of this study is to use a new combination of anesthesia techniques in an attempt to minimize early pain after surgery and improve the patient's ability to participate more fully with physical therapy.
- Trial name
- NCT00620828
- Testing
- Ropivicaine 0.5%
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Duke University
Postoperative Pain
Arthroplasty Inflammation Prophylaxis With Celecoxib
This double blinded, placebo controlled, study seeks to determine the efficacy of preoperative anti-inflammatory therapy on the reduction of postoperative pain in knee arthroplasty surgery.
- Trial name
- NCT00533247
- Testing
- Celecoxib
- Where
- Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Zanbilowicz, Adam, DPM MS