Clinical trials: Replacement
Total Elbow Replacement
Prognostic Factors Associated With Failure of Total Elbow Replacement
This observational study aims to evaluate potential prognostic factors for TER failure . The National Joint Registry (NJR) currently contains the largest elbow registry dataset in the world, which has been shown to have high…
- Trial name
- NCT06760585
- Where
- United Kingdom
- Volunteers
- 4,073 people
- Sponsor
- University of Manchester
Primary Ovarian Insufficiency, Hypogonadotropic Hypogonadism
Assessment of Endometrial Thickness Among Adolescent and Young Adult Patients on Estrogen Replacement Therapy Using Daily Oral Micronized Progesterone Versus the Etonogestrel Implant.
The goal of this observational study is to compare endometrial stripe thickness in adolescent and young adult (AYA) patients with a uterus on estrogen replacement therapy using oral progesterone versus the etonogstrel implant for…
- Conditions
- Primary Ovarian Insufficiency, Hypogonadotropic Hypogonadism, Hormone Replacement Therapy
- Trial name
- NCT06357442
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- University of Colorado, Denver
Semilunar Heart Valve Replacement
Partial Heart Transplantation for Severe Pediatric Semilunar Valve Dysfunction
The long-term goal of this research initiative is to develop a new valve replacement option for neonates, infants and young children.
- Trial name
- NCT05372757
- Testing
- Partial Heart Transplantation
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Medical University of South Carolina
Arthroplasty, Replacement
Knee Connect: Physiotherapy Exercise Performance With Visual Feedback After Total Knee Arthroplasty
The main objective of this pilot study is to determine if using a portable, accelerometer based, visual feedback system improves exercise quality.
- Conditions
- Arthroplasty, Replacement, Knee
- Trial name
- NCT03738384
- Testing
- Knee Connect + Visual Feedback System
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Sunnybrook Health Sciences Centre
Total Knee Arthroplasty, Total Knee Replacement
ALknee Follow-up Study of the Cementless ATTUNE Rotating Platform and the Cementless LCS Rotating Platform Knee System
The cementless ATTUNETM Rotating Platform Knee system was compared in a single-blind, randomized RSA trial to its predecessor, the LCS rotating platform Knee System.
- Conditions
- Total Knee Arthroplasty, Total Knee Replacement, Knee Osteoarthritis
- Trial name
- NCT05623215
- Testing
- Radiographs of the knee for radiostereometric analysis (RSA)
- Where
- Netherlands
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Spaarne Gasthuis
Arthroplasties, Hip Replacement
REDAPT Retrospective-Prospective Modular Stem Study
A Retrospective-Prospective Study of REDAPT Revision Femoral System Modular Stem is a post-market, retrospective-prospective, multi-center, single arm, consecutive series study design to provide data on the post market…
- Trial name
- NCT02661620
- Testing
- REDAPT Revision Femoral System modular stem
- Where
- 5 sites in United States, Belgium and 1 more
- Volunteers
- 140 people
- Sponsor
- Smith & Nephew, Inc.
Arthroplasty, Replacement, Knee
Stryker NTX Registry Scorpio NRG (Re-"Energize"), Triathlon Total Knee, Triathlon Partial Knee Resurfacing (PKR) With X3 Polyethylene Insert
Provide outcomes information with regard to surgical and implant performance and patient clinical outcomes of the patients who are eligible for either a Total Knee Arthroplasty (TKA) replacement surgery or Partial Knee…
- Trial name
- NTX (NCT02525562)
- Testing
- Triathlon Total Knee System with X3 insert, Scorpio NRG Total Knee System with X3 insert, Triathlon PKR System with X3 insert
- Where
- 3 sites in Germany, Luxembourg and 1 more
- Volunteers
- 237 people
- Sponsor
- Stryker Orthopaedics
Hip Replacement
A Novel Study Evaluating Patients Awaiting Total Hip Arthroplasty (PRIORITEES)
Hip replacements are one of the NHS's highest volume procedures, with ~14,000 operations per month before the onset of the COVID-19 pandemic.
- Trial name
- PRIORITEES (NCT06178185)
- Where
- United Kingdom
- Volunteers
- 240 people
- Sponsor
- Robert Jones and Agnes Hunt Orthopaedic and District NHS Trust
Arthroplasty; Replacement; Knee, Radiotherapy; Image-Guided
Surgical Outcomes of the Accelerometer-based Navigation System for Total Knee Arthroplasty
Osteoarthritis (OA) is a very common condition in the elderly population. Treatment for end-stage OA is total knee Replacement (TKR)
- Trial name
- NCT04037228
- Testing
- KneeAlign 2 system (OrthAlign Inc, Aliso Viejo, California)
- Where
- Hong Kong
- Volunteers
- 40 people
- Sponsor
- Chinese University of Hong Kong
Aortic Valve Stenosis, Transcatheter Aortic Valve Replacement
The JUMPSTART Program: Encouraging Early Mobilization and Optimizing Recovery of TAVR Patients' Post-hospital Discharge
A virtual, self-directed, and tailored early mobilization program called JUMPSTART, that aims to bridge cardiac rehabilitation intake for post-TAVR patients has been developed at the Hamilton General Hospital.
- Trial name
- NCT06040398
- Testing
- JUMPSTART exercise program
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- Hamilton Health Sciences Corporation
Cardiac Surgery, Coronary Artery Bypass Graft CABG
Effects of a Hybrid Model of Cardiac Rehabilitation on Patient Outcomes
Determine if the standard of care at a cardiac rehabilitation center using what the investigators term to be "hybrid model" on the exercise component of cardiac rehabilitation is associated with improved adherence and outcomes.
- Conditions
- Cardiac Surgery, Coronary Artery Bypass Graft CABG, Stent, Valve Replacement
- Trial name
- NCT06030115
- Testing
- Exercise Component Of Cardiac Rehabilitation (Hybrid Model) Intensity Recovery Progression Protocol (IRPP)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Good Shepherd Integrated Healthcare Systems
Lower Thighbone and Knee Joint Replacement
Evaluation of the Compress Distal Femoral Replacement System
Patients in this study require a replacement of a lower thighbone and knee joint. A new device, called the ComPreSs, will be used in this study to replace the lower thighbone.
- Trial name
- NCT00591812
- Testing
- ComPreSs Distal Femoral Replacement System.
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Transcatheter Aortic Valve Replacement
Post-TAVI Coronary Access Study
Coronary access after trans-catheter aortic valve implantation (TAVI) remains a major challenge. With the evolution of TAVI procedure and the inclusion of lower-risk patients with aortic stenosis, future coronary access is an…
- Trial name
- PTCA (NCT04649190)
- Testing
- TAVI
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Sheba Medical Center
Heart Valve Replacement
The German Plug - Registry
In approximately 10-15% of all patients after surgical or interventional heart valve replacement, flapping defects appear as complications in the long-term course, so-called paravalvular / paraprothetic leaks (PVL).
- Trial name
- PLUG (NCT03179969)
- Testing
- paravalvular leak
- Where
- Germany
- Volunteers
- 49 people
- Sponsor
- Stiftung Institut fuer Herzinfarktforschung
Arthroplasty, Hip, Replacement
Study to Evaluate the Performance and Safety of ATF Implants and Lapé Médical Devices Implanted During Hip Arthroplasty
Observational and prospective multicenter study to evaluate the long-term (10 years) performance and safety (10 years) of ATF Implants and Lapé Médical devices implanted during total hip arthroplasty or hemiarthroplasty.
- Trial name
- NCT05044767
- Testing
- total hip arthroplasty
- Where
- 13 sites in France
- Volunteers
- 4,500 people
- Sponsor
- ATF Implants
Follow up of Moderate Aortic Regurge After Rheumatic Mitral Valve Replacement
Follow up of Moderate Aortic Regurge After Mitral Valve Replacement
Aim of the study is to follow of of moderate aortic regurge after mitral valve replacement to figure out if the aortic regurge has been improved or it is getting worse
- Trial name
- NCT05680610
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University
Transcatheter Aortic Valve Replacement
Prognostic Factors in NOP-LBBB After TAVI
The goal of this observational study is to find prognostic factors in patients with a new-onset persistent left bundle branch block (NOP-LBBB) after transcatheter aortic valve implantation (TAVI).
- Trial name
- ProgNOP-LBBB (NCT05654792)
- Testing
- Transcatheter aortic valve implantation
- Volunteers
- 230 people
- Sponsor
- Central Hospital, Nancy, France
Total Knee Replacement
Qualitative Interviews With Healthcare Professionals
PLANNING PHASE- Qualitative interviews with Healthcare Professionals to assist in the development of a new Patient Reported Outcome Measure (PROM) to assess patient's emotional wellbeing, and perceptions of Total Knee Replacement…
- Trial name
- NCT05597046
- Testing
- Interview
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Invibio Ltd
Primary Osteoarthritis, Secondary Osteoarthritis
Anthology Hip Replacement System - Orthopaedic Data Evolution Panel (ODEP) Surveillance Study
This clinical study will verify the clinical and radiographic performance of the prosthesis when used in human subjects over a period of 10 years. All complications will be documented.
- Conditions
- Primary Osteoarthritis, Secondary Osteoarthritis, Avascular Necrosis, Primary Total Hip Replacement (THR)
- Trial name
- NCT04425603
- Testing
- Anthology Hip Replacement System
- Where
- 4 sites in United Kingdom
- Volunteers
- 270 people
- Sponsor
- Smith & Nephew Orthopaedics AG
Severe Tricuspid Regurgitation Medically Treated and Not Operated (Without Valve Replacement or Repair)
Evaluation of the Impact of Tricuspid Regurgitation on Patients Lives. Exploration of Experience and Impact on a Daily Basis.
The purpose of this study is to objectively assess the impact of the pathology on the patient's life so as to best inform the choices of evaluators "the French National Authority for Health" (HAS) and decision makers "the…
- Trial name
- EVOQUE (NCT05532956)
- Volunteers
- 24 people
- Sponsor
- Gérond'if