Clinical trials: Replacement
Psychological Stress, Cardiopulmonary Bypass Surgery
CARINAE for Stress Relief in Perioperative Care
Preventing pre-surgical stress can help patients achieve positive outcomes on health and well-being. However, very few patients receive adequate stress relief support prior to a surgical procedure.
- Conditions
- Psychological Stress, Cardiopulmonary Bypass Surgery, Coronary Artery Bypass Surgery, Cardiac Valve Replacement
- Trial name
- CARINAE (NCT05184725)
- Testing
- SaMD CARINAE
- Where
- 5 sites in Italy, Netherlands and 1 more
- Volunteers
- 50 people
- Sponsor
- Adhera Health, Inc.
Total Hip Replacement
Effectiveness of Patient-Controlled Intravenous Analgesia (PCIA) With Fentanyl
To enhance post-operative pain management, patient-controlled intravenous analgesia (PCIA) has been employed. The fentanyl background PCIA therapy was created to solve the limitations of IV-based PCIA, such as programming errors…
- Trial name
- NCT05429567
- Testing
- Fentanyl
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Egymedicalpedia
Arthroplasty, Replacement, Knee
The Association of Gait Kinematics, Instability and Patient Reported Outcomes in Patients With Total Knee Replacement
It is unclear why 20% of patients with total knee replacements (TKR) are dissatisfied. Few studies have specifically assessed the way people walk ('gait') with an 'unhappy' or unstable knee or following re-do ('revision') TKR…
- Trial name
- NCT03896191
- Testing
- Revision TKR surgery, No intervention.
- Where
- United Kingdom
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Bath
Mitral Valve or Aortic Valve Replacement
Clinical Study to Evaluate the Performance of Perimount Heart Valve in Chinese Patients
To recruit patients who implanted with Perimount Heart Valve (Type Number: 6900PTFX or 2800TFX) from three hospitals in China. To track the patients'situations during one year after surgery and to collect the relevant clinical…
- Trial name
- NCT02400489
- Where
- 3 sites in China
- Volunteers
- 265 people
- Sponsor
- Edwards Lifesciences
Arthroplasty, Replacement
The Impact of Medicare Bundled Payments
Bundled payments (BP) are a key part of Medicare's shift away from the traditional fee-for-service (FFS) payment model. The investigators propose to study a nationwide randomized-controlled trial (RCT) of bundled payments for…
- Trial name
- NCT03407885
- Testing
- Bundled payments for knee and hip replacement
- Volunteers
- 196 people
- Sponsor
- Amy Finkelstein
Arthroplasty, Replacement, Hip
Cementless New Alumina-zirconia Ceramic Bearing Total Hip Arthroplasty (THA) in Asian Patients
This study will evaluate a midterm clinical and radiologic outcome patients who undergo new alumina-zirconia composite ceramic bearing THA.
- Trial name
- NCT00935519
- Testing
- 4th generation ceramic bearing composite ceramic bearing
- Where
- South Korea
- Volunteers
- 310 people
- Sponsor
- Seoul National University Bundang Hospital
Menopause, Opinions
Opinion of Brazilian Gynecologists on Hormone Therapy for Menopause and Prescriptive Habits
To evaluate Brazilian gynecologists, through structured online questionnaires, with questions directed to their opinions and prescriptive habits about menopause hormone therapy.
- Conditions
- Menopause, Opinions, Hormone Replacement Therapy
- Trial name
- NCT05072756
- Testing
- Applying a questionnaire
- Where
- Brazil
- Volunteers
- 1,339 people, healthy volunteers welcome
- Sponsor
- Faculdade de Medicina do ABC
Arthroplasty, Replacement, Knee
Men and Women With Different Designs and Semi-individual Total Knee Replacement
This study aims to evaluate the effectiveness of femoral condyle prosthesis, tibial tray prosthesis and meniscus prosthesis of semi-individualized total knee replacement prostheses designed with gender differences; and compare…
- Trial name
- NCT04976400
- Testing
- semi-individualized total knee replacement treatment with a gender-specific design, Zimmer total knee replacement prostheses (Zimmer, Warsaw, IN, USA)
- Volunteers
- 1,600 people
- Sponsor
- Peking University Third Hospital
Cardiac Double Valve Replacement
Patient Outcome After Cardiac Double Valve Replacement at University Hospital Basel/ Switzerland
To compare patient outcome data after cardiac double valve replacement (aortic and mitral valve) with patient outcome data after aortic valve replacement and mitral valve reconstruction
- Trial name
- NCT03667274
- Testing
- cardiac valve surgery
- Where
- Switzerland
- Volunteers
- 106 people
- Sponsor
- University Hospital, Basel, Switzerland
Aortic Valve Stenosis, Limited Access Aortic Valve Replacement
Patient Reported Health-Related Quality of Life After Limited Access and Conventional Aortic Valve Replacement
The LIAR-Trial is a single-center, single blind randomized controlled clinical trial comparing patients undergoing isolated AVR via J-shaped upper hemi-sternotomy (UHS) and conventional AVR through a full median sternotomy (FMS).
- Conditions
- Aortic Valve Stenosis, Limited Access Aortic Valve Replacement, Quality of Life
- Trial name
- LIAR (NCT04012060)
- Testing
- Limited access aortic valve replacement., Conventional aortic valve replacement
- Where
- Netherlands
- Volunteers
- 161 people
- Sponsor
- St. Antonius Hospital
Menopause, Atherosclerosis
Discontinuation of Postmenopausal Hormone Therapy: Impact on the Cardiovascular System and Quality of Life
Although the impact of postmenopausal hormone therapy (HT) on cardiovascular disease risk has been studied in several large randomized trials, little is known about the acute cardiovascular consequences of HT discontinuation.
- Conditions
- Menopause, Atherosclerosis, Cardiovascular Diseases, Estrogen Replacement Therapy
- Trial name
- NCT04050592
- Testing
- Estradiol
- Where
- Finland
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Hanna Savolainen-Peltonen
Arthroplasty, Replacement, Knee, Pain, Postoperative
Central Sensitization and Alteration of Circulating Neurosteroid
For patients who underwent two-stage replacement of both knee joints (one knee surgery - one week term- the other knee surgery), postoperative pain and analgesic usage with patient-controlled analgesia (PCA) increased at the…
- Trial name
- NCT03298711
- Where
- South Korea
- Volunteers
- 69 people
- Sponsor
- Seoul National University Bundang Hospital
Arthroplasty, Replacement, Knee, Nerve Block
Epidural Catheter With or Without Adductor Canal Nerve Block for Postoperative Analgesia Following Total Knee Arthroplasty
The purpose of this study is to further investigate the efficacy of adductor canal nerve blocks for pain management after total knee replacement.
- Trial name
- NCT02121392
- Testing
- Adductor Canal Nerve Block Catheter, Bupivacaine
- Where
- United States
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Pediatric Continuous Renal Replacement Therapy, Dialysis
Safety and TDM of Continuous Infusion Vancomycin Through Continuous Renal Replacement Therapy Solution
The purpose of this investigation is to evaluate the safety of delivering continuous infusion (CI) vancomycin in pediatric CRRT by utilizing CI via by mixing the vancomycin into the CRRT solution(s).
- Conditions
- Pediatric Continuous Renal Replacement Therapy, Dialysis, Renal Failure
- Trial name
- NCT02663596
- Testing
- Vancomycin
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Drexel University
Renal Replacement Therapy, Pharmacokinetics
Safety and Therapeutic Drug Monitoring of Cefazolin in Continuous Renal Replacement Therapy
This investigation is intended to collect safety information for the technique of mixing cefazolin in the CRRT solution on the CRRT circuit, the patient, in addition to collecting information regarding the ability to obtain…
- Trial name
- NCT03672149
- Testing
- Cefazolin
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Drexel University
Joint Replacement
MCJR Joint Replacement Clinical Outcomes Database
The purpose of this research study is to develop a database of information regarding the diagnosis, treatment, and outcome of participants who have had a joint replacement.
- Trial name
- NCT03328611
- Testing
- Hip and Knee Joint Replacement
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- Midwest Center for Joint Replacement
Arthroplasty, Replacement, Knee
Knee Connect: Measuring Range of Motion and Gait Metrics After Total Knee Arthroplasty
The main goals of total knee replacement (TKR) surgery are to relieve pain and to allow patients to remain active. Sunnybrook is working with Kineris Inc.to advance a wearable device, the Knee Connect, aimed at tracking the…
- Trial name
- NCT03651739
- Testing
- Knee Connect
- Where
- Canada
- Volunteers
- 51 people
- Sponsor
- Sunnybrook Health Sciences Centre
Osteo Arthritis, Osteoporosis
Determining the Feasibility of Implementing a Combined Cognitive and Exercise Training Program for Older Adults in a Community Setting.
The overarching aim of this project is to implement and evaluate a proven cognitive training regimen in combination with a community exercise program among older adults who attend wellness exercise programs at the YMCA.
- Conditions
- Osteo Arthritis, Osteoporosis, Joint Replacement, Fibromyalgia
- Trial name
- NCT04515758
- Testing
- Exercise and Cognitive Training, Exercise Training Only
- Where
- Canada
- Volunteers
- 43 people
- Sponsor
- University of Waterloo
Transcatheter Aortic Valve Replacement, Mechanical Circulatory Support
Application of Emergent Peripheral Mechanical Circulatory Support in Transcatheter Aortic Valve Replacement for 6 Patients
Objective: To explore the experience of transcranial aortic valve replacement (TAVR) under emergency mechanical assisted circulation (MCS).Methods: A total of 6 patients who completed TAVR with the assistance of emergency MCS in…
- Trial name
- NCT04464356
- Testing
- mechanical circulatory support
- Where
- China
- Volunteers
- 6 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Spinal Fusion, Total Hip Replacement
Examining Effects of Spinal Fusion on Outcomes Following Total Hip Replacement
The purpose of the study is to explore the long term functional status of people who have had both a spinal fusion procedure and a total hip replacement.
- Trial name
- NCT03240484
- Testing
- X-Ray Imaging, Gait Analysis
- Where
- Canada
- Volunteers
- 160 people
- Sponsor
- Ottawa Hospital Research Institute