Clinical trials: Resource-Limited Setting
Cesarean Section Complications, Anesthesia Complication
Prophylactic Phenylephrine Co-administration During Caesarean Section
This single centre prospective alternating intervention study will aim to compare prophylactic phenylephrine given in the first litre of Ringers lactate as co-load in healthy patients having an elective caesarean section under…
- Trial name
- NCT04005664
- Testing
- Phenylephrine
- Where
- South Africa
- Volunteers
- 300 people
- Sponsor
- University of KwaZulu
Jaundice, Serum Bilirubin
A Study to Evaluate a New Jaundice Stick Test
This is an observational prospective study. The main purpose is to evaluate the stability of the Bilistick system in a humid and hot climate compared to the quantitative test for serum bilirubin (SBR) measurement currently used…
- Trial name
- Bilistick (NCT02926131)
- Testing
- Blood sampling
- Where
- Thailand
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Neonatal Resuscitation
Outcomes of Neonatal Resuscitation
The primary objective of this study is to describe mortality of newborns who received basic, advanced or no neonatal resuscitation immediately after birth at Shoklo Malaria Research Unit.
- Trial name
- NCT02840682
- Where
- Thailand
- Volunteers
- 15,073 people, healthy volunteers welcome
- Sponsor
- University of Oxford
HIV/AIDS
"Switch Either Near Suppression Or THOusand"
This trial addresses the question of the viral load (VL) threshold for switching from first-line to second-line antiretroviral therapy (ART). The WHO currently sets the threshold at 1000 copies/mL.
- Trial name
- SESOTHO (NCT03088241)
- Testing
- switch
- Where
- 8 sites in Lesotho
- Volunteers
- 80 people
- Sponsor
- Niklaus Labhardt
Maternal Death, Maternal Morbidity
BetterBirth: A Trial of the WHO Safe Childbirth Checklist Program
The purpose of this study is to measure the impact of a checklist-based childbirth safety program (the WHO Safe Childbirth Checklist Program) on reduction of severe maternal, fetal, and newborn harm in institutional deliveries in…
- Conditions
- Maternal Death, Maternal Morbidity, Stillbirth, Neonatal Death
- Trial name
- BetterBirth (NCT02148952)
- Testing
- WHO Safe Childbirth Checklist Program
- Where
- India
- Volunteers
- 157,689 people, healthy volunteers welcome
- Sponsor
- Harvard School of Public Health (HSPH)
Malnutrition, Pneumonia
Childhood Acute Illness and Nutrition Network
The CHAIN Network aims to identify modifiable biomedical and social factors driving the greatly increased risk of mortality among young undernourished children admitted to hospital with acute illness, as inpatients and after…
- Conditions
- Malnutrition, Pneumonia, Diarrhea, Sepsis
- Trial name
- CHAIN (NCT03208725)
- Where
- 8 sites in Bangladesh, Kenya and 3 more
- Volunteers
- 4,335 people
- Sponsor
- University of Oxford
Sickle Cell Disease
Sub-dissociative Intranasal Ketamine for Pediatric Sickle Cell Pain Crises
The purpose of this study is to determine if the use of ketamine, sniffed in the nose, is a safe and effective way to help reduce pain in pediatric sickle cell patients with pain crises in resource-limited settings.
- Trial name
- NCT02573714
- Testing
- Ketamine, Normal Saline, Standard Pain Therapy
- Where
- 2 sites in Cameroon, Tanzania
- Volunteers
- 160 people
- Sponsor
- Cameroon Baptist Convention Health
HIV
Pediatric HIV Disclosure Benefits Study (PhD-BS) - Sankofa 2
The purpose of this study is to conduct a pragmatic, stepped wedge cluster randomized trial in 12 HIV pediatric clinics in Ghana to determine effectiveness, health benefits, cost and implementation to inform scale-up and…
- Trial name
- NCT04791865
- Testing
- Disclosure intervention, Usual Care
- Where
- Ghana
- Volunteers
- 748 people
- Sponsor
- Boston University
Maternal Death
Critically-Ill Women Admitted to an Obstetric High Dependency Unit in a Resource-Limited Setting
Sierra Leone faces the highest maternal mortality ratio in the world. Despite this extreme burden, the potential roles of obstetric critical care and high dependency units (HDUs) in this and other resource-limited settings remain…
- Trial name
- NCT04121234
- Testing
- Exposure: " being admitted to HDU with a red code to OEWS"
- Where
- Sierra Leone
- Volunteers
- 523 people
- Sponsor
- Doctors with Africa - CUAMM
Type 1 Diabetes
Comparative Efficacy of a Two Daily Mixed Insulin Injection Versus a Basal-bolus Scheme With Human Insulin
The goal of this clinical trial is to compare glycemic control and variability between children and adolescents with type 1 diabetes treated by a two daily injection of premixed human insulin (Humulin 30/70) and those who have a…
- Trial name
- NCT05768191
- Testing
- premix insulin human isophane suspension and insulin human, Humulin N plus Humulin R
- Where
- 3 sites in Burkina Faso
- Volunteers
- 22 people
- Sponsor
- Université NAZI BONI
Family Involvement/Empowerment, Family-centered Care
Effectiveness of Family-Integrated Newborn Care to Improve Outcomes for Preterm and Low-birth-weight Neonates
The goal of this quasi-experimental study is to learn if integrating family in newborn care units as a key partner can improve the outcomes of preterm and low-birth-weight neonates.
- Conditions
- Family Involvement/Empowerment, Family-centered Care, Intensive Care Units, Neonatal, Family Integrated Newborn Care
- Trial name
- FINC (NCT07364903)
- Testing
- Family Integrated Newborn Care, an intervention to integrate family in the care targeted their preterm and Low-birth weight neonates, Standard medical treatment
- Where
- 2 sites in Ethiopia
- Volunteers
- 1,020 people
- Sponsor
- Laerdal Foundation
Pain Management, Acute Injuries
Ultrasound Guided Regional Anesthesia for Acute Injury in Low Resource Settings
The purpose of this study is to determine feasibility, perceived utility and sustainability of training local providers in ultrasound guided regional anesthesia for acute pain management in a limited-resource conflict setting.
- Trial name
- NCT02084225
- Testing
- ultrasound guided regional nerve block
- Where
- 3 sites in Ethiopia, Republic of the Congo
- Volunteers
- 60 people
- Sponsor
- Salmon, Margaret, M.D.
HIV Infections
A Study of Zidovudine/Lamivudine and Either Nevirapine or Nelfinavir for Reduction of Mother-to-child HIV Transmission During Breastfeeding
The purpose of the study is to demonstrate that a regimen using highly active antiretroviral therapy (HAART) to maximally suppress maternal viral load in the late antenatal period and during the first six months of lactation is…
- Trial name
- KiBS (NCT00146380)
- Testing
- Zidovudine/Lamivudine and either Nevirapine or Nelfinavir, Breastfeeding for 6 months postpartum
- Where
- Kenya
- Volunteers
- 520 people
- Sponsor
- Centers for Disease Control and Prevention
Circumcision, Adolescents
Safety and Efficacy Study of Non-Surgical MC Device for Adolescent Male Population Including Contraindicated Subjects
A new Male Circumcision (MC) device, PrePex, has shown great promise as a way to radically shift the MC landscape. PrePex is an innovative circumcision device requiring no injected anesthesia, sutures, or sterile settings.
- Trial name
- NCT02581722
- Testing
- PrePex Device
- Where
- Rwanda
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Ministry of Health, Rwanda
Pediatric Status Epilepticus
Childhood Convulsive Status Epilepticus Management In A Resource Limited Setting
Convulsive status epilepticus (CSE) is a potentially devastating condition which can result in significant morbidity and mortality.
- Trial name
- NCT03650270
- Testing
- Phenobarbital
- Where
- South Africa
- Volunteers
- 198 people
- Sponsor
- University of Cape Town
Vomiting in Infants and/or Children, Acute Gastroenteritis
Ondansetron Versus Domperidone for Treating Vomiting in Acute Gastroenteritis in Children
Most of the trials conducted comparing ondansetron and domperidone have been conducted among children aged below 5 or 6 years of age while no study from Pakistan has compared efficacy of these antiemetic agents among children up…
- Trial name
- NCT05076461
- Testing
- Ondansetron
- Where
- Pakistan
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Tehsil Headquarter Hospital
HIV
SANKOFA Pediatric HIV Disclosure Intervention
A culturally-relevant, theoretically and empirically sound, patient-centered, standardized disclosure intervention that can be integrated into routine clinical pediatric HIV care has potential to prevent transmission and improve…
- Trial name
- NCT01701635
- Testing
- Disclosure intervention, usual care
- Where
- 2 sites in Ghana
- Volunteers
- 446 people
- Sponsor
- Yale University