Clinical trials: Respiratory Disease
Chronic Graft-versus-host-disease
A Study of Axatilimab at 3 Different Doses in Participants With Chronic Graft Versus Host Disease (cGVHD)
This is a Phase 2 study to evaluate the efficacy, safety, and tolerability of axatilimab at 3 different dose levels in participants with recurrent or refractory active chronic graft versus host disease (cGVHD) who have received…
- Trial name
- AGAVE-201 (NCT04710576)
- Testing
- Axatilimab
- Where
- 121 sites in United States, Australia and 14 more
- Volunteers
- 296 people
- Sponsor
- Syndax Pharmaceuticals
Balanced; Rearrangement, Respiratory Function Test
The Effect of Lycra Garment on Spastic Diplegic Cerebral Palsy Individuals With Scoliosis
The primary aim of this study was to investigate the effects of lycra clothing on balance and respiratory functions in individuals with cerebral palsy with scoliosis, and the secondary aim was to investigate the effects of lycra…
- Trial name
- NCT06295991
- Testing
- Lycra garment
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people
- Sponsor
- Hacettepe University
Asthma
Family-Focused, Stress-Reduction Program to Improve the Health Care of Urban Children With Asthma
Stress and anxiety can negatively affect children with asthma. Reducing the stress of asthmatic children and their families may lead to improved asthma care and fewer asthma symptoms in the children.
- Trial name
- ASPIRE (NCT00384813)
- Testing
- Project ASPIRE Home-Based Family Intervention, Project ASPIRE Enhanced Treatment As Usual
- Where
- 2 sites in United States
- Volunteers
- 43 people
- Sponsor
- Emory University
Asthma, Hypersensitivity
Effect of Heredity and Environment on Asthma Development and Severity in Puerto Rican Children
Asthma is a major public health problem among Puerto Ricans. Little is known, however, about the effect of heredity and environment on the development and severity of asthma in this population.
- Trial name
- NCT00461227
- Where
- Puerto Rico
- Volunteers
- 1,127 people
- Sponsor
- University of Pittsburgh
Bronchopulmonary Dysplasia
Mesenchymal Stem Cell Therapy for Bronchopulmonary Dysplasia in Preterm Babies
Bronchopulmonary Dysplasia (BPD) is the most frequent disease related to a premature birth, 15-50% of very low birth newborns (<1500 gr.) will develop BPD.
- Trial name
- NCT02443961
- Testing
- Mesenchymal Stem Cell (MSC) therapy
- Where
- 4 sites in Spain
- Volunteers
- 10 people
- Sponsor
- Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal
COVID-19
Epidemiological Study on Asymptomatic Infections and Mild Illness With Covid-19 in Shanghai
this study is to clarify the epidemiological characteristics of Omicron variant infected persons in Shanghai, such as distribution characteristics, host and clinical characteristics, disease outcome and risk factors.
- Trial name
- NCT05375786
- Testing
- Vaccination completion status
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Ruijin Hospital
Pneumonia, Bloodstream Infection
Clinical Outcomes in Patients With Infection by Resistant Microorganism
The goal of this individual patient data meta-analysis is to estimate the attributed and the associated health burden related to bloodstream infections, pneumonia, skin and soft tissue infections, surgical site infections and…
- Conditions
- Pneumonia, Bloodstream Infection, Urinary Tract Infections, Skin Infection
- Trial name
- NCT05880069
- Testing
- Pathogen resistant phenotype
- Where
- Spain
- Volunteers
- 5,000 people
- Sponsor
- Hospital Universitario Virgen Macarena
Asthma
Can Education for South Asians With Asthma and Their Clinicians Reduce Unscheduled Care? A Randomised Trial
People from ethnic minority groups suffer worse ill-health from asthma than those from majority groups. No studies have reduced emergency care for people from minority groups.
- Trial name
- OEDIPUS (NCT00214669)
- Testing
- PACE (Professional Asthma Care Education), Lay Led Expert Patient Programme, Asthma self management education by a specialist nurse
- Where
- United Kingdom
- Volunteers
- 375 people
- Sponsor
- Barts & The London NHS Trust
Upper Respiratory Tract Infection
Homeopathic Cold Medicine for Children
The purpose of this study is to determine if a commercially available homeopathic cold remedy for children is effective in providing relief from cold symptoms in children 2-5 years old.
- Trial name
- NCT00858494
- Testing
- Hyland's Cold 'n Cough 4 Kids
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Washington
Asthma, Allergy
Preventing Childhood Asthma Using Prophylactic House Dust Mite Allergen Immunotherapy
To establish efficacy and safety of HDM sublingual Immunotherapy (HDM-SLIT) by comparing Odactra and placebo, when given sublingually for 3 years to high risk infants aged between 6 to 12 months at enrollment in preventing the…
- Trial name
- PAPA (NCT05113394)
- Testing
- HDM sublingual Immunotherapy
- Volunteers
- healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Serious Game, Asthma in Children
Serious gaMes as Emerging E-health Interventions for Young People With neurologicaL or rEspiratory disoRders
The main purpose of 'Serious Games' (SG) is to provide opportunities for constructive learning and training. They are well-accepted instruments in therapeutic interventions and have been found to be efficient to improve cognitive…
- Conditions
- Serious Game, Asthma in Children, Children, Only
- Trial name
- SMILER (NCT05974917)
- Testing
- Serious Game (SG)
- Volunteers
- 30 people
- Sponsor
- Istituto di Farmacologia Traslazionale - sede di Palermo, Consiglio Nazionale delle Ricerche (CNR)
Tonsillitis
Children Recovering From Tonsil Surgery
Children recovering from tonsil surgery following day surgery Tonsil surgery - self-care and treatment - the TONIST-study The main objective of this study is to evaluate the effect and experience of acupuncture, acupressure…
- Trial name
- TONIST (NCT03292068)
- Testing
- Acupuncture, acupressure, Timbal diet, Extended telephone counseling
- Where
- Sweden
- Volunteers
- 576 people, healthy volunteers welcome
- Sponsor
- Lund University
COVID-19
Communities Fighting COVID Return to School
San Diego State University (SDSU), a designated Hispanic-serving institution, is partnering with Sweetwater Union High School District, an independent public school district serving 90% ethnic minority and a high proportion of…
- Trial name
- NCT05150860
- Testing
- At-home COVID-19 testing, Onsite COVID-19 testing
- Where
- United States
- Volunteers
- 852 people, healthy volunteers welcome
- Sponsor
- San Diego State University
Covid19, Pregnancy Related
Safety, Testing/Transmission, and Outcomes in Pregnancies With COVID-19
Pregnant women are a vulnerable and high-risk population, as COVID-19 is associated with an increased risk preterm birth, cesarean section, and maternal critical care.
- Conditions
- Covid19, Pregnancy Related, Maternal Complication of Pregnancy, Coronavirus
- Trial name
- STOPCOVID19 (NCT04718220)
- Testing
- Antibody testing for SARS-CoV-2 IgG, Testing for SARS-CoV-2 RNA, Testing for SARS-CoV-2 IgM/IgG
- Where
- United States
- Volunteers
- 448 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Acute Respiratory Distress Syndrome, Conventional Mechanical Ventilation
Invasive Ventilation for Neonates With Acute Respiratory Distress Syndrome(ARDS)
Acute respiratory distress syndrome (ARDS) in neonates has been defined in 2017.The death rate is over 50%. HFOV and CMV are two main invasive ventilation strategies. However, which one is better needing to be further elucidated.
- Conditions
- Acute Respiratory Distress Syndrome, Conventional Mechanical Ventilation, High Frequency Oscillation Ventilation
- Trial name
- NCT03591796
- Testing
- HFOV, CMV
- Where
- China
- Volunteers
- 386 people
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Asthma
FASENRA SCEI for Long-term Use
The purpose of the investigation is to confirm the safety and efficacy under the post-marketing actual long-term use of FASENRA Subcutaneous Injection 30 mg Syringe.
- Trial name
- NCT03588546
- Where
- 29 sites in Japan
- Volunteers
- 653 people
- Sponsor
- AstraZeneca
SARS CoV 2 Infection, Alveolar; Injury
The Potential Role of sRAGE, KL-6, and SP-D as Prognostic Factors in Children With COVID-19
COVID-19 causes a wide spectrum of clinical illness, from upper respiratory symptoms to severe respiratory failure and death. Several plasma biomarkers -such as IL-6, C-reactive protein (CRP), D-dimer, the…
- Conditions
- SARS CoV 2 Infection, Alveolar; Injury, Children, Pneumonia, Viral
- Trial name
- NCT05619640
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Haseki Training and Research Hospital
Shortness of Breath, Chest Pain
Checklists Resuscitation Emergency Department
The study will systematically evaluate how an emergency manual-a collection of checklists and fact sheets-affects the performance of resuscitation teams during the management of priority one patients in an emergency department.
- Conditions
- Shortness of Breath, Chest Pain, Abdominal Pain, Altered Mental Status
- Trial name
- NCT05649891
- Testing
- Emergency Manual
- Volunteers
- 2,000 people
- Sponsor
- Region Skane
Asthma
A Randomized Study To Evaluate The Efficacy And Safety Of An Investigational Drug In Adolescent And Adult Subjects With Asthma Uncontrolled on Non-steroidal Therapy.
This study is designed to determine if the investigational drug is effective and safe in individuals with asthma.
- Trial name
- NCT00603382
- Testing
- GW685698X
- Where
- 149 sites in United States, Bulgaria and 12 more
- Volunteers
- 599 people
- Sponsor
- GlaxoSmithKline
SMARD1, CMT2S
Gene Therapy for IGHMBP2-Related Diseases
Open-label, single intrathecal injection study of a AAV9 vector carrying the IGHMBP2 gene for IGHMBP2-related diseases.
- Trial name
- NCT05152823
- Testing
- Gene Therapy
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Megan Waldrop
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