Clinical trials: Respiratory Exacerbation
Asthma
Mold Sensitization Associated Severe Asthma Exacerbation
Mold sensitization is associated with severe asthma exacerbation.
- Trial name
- NCT03690349
- Testing
- Skin test
- Volunteers
- 102 people
- Sponsor
- Mahidol University
Duchenne Muscular Dystrophy, Amyotrophic Lateral Sclerosis
Evaluation of a Mechanical Device During Acute Respiratory Failure in Patients With Neuromuscular Disorders
The hypothesis is that a mechanical insufflation-exsufflation (MI-E) is associated with a decrease in the number of intubations and more rapid clinical improvement in children and adults with neuromuscular disease who are…
- Conditions
- Duchenne Muscular Dystrophy, Amyotrophic Lateral Sclerosis, Neuromuscular Diseases
- Trial name
- Nemucough (NCT00839033)
- Testing
- mechanical insufflation - exsufflation, Standard respiratory physiotherapy
- Where
- France
- Volunteers
- 14 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cystic Fibrosis, Cystic Fibrosis in Children
Program Of Exercises During The Hospitalization Of Children And Adolescents With Cystic Fibrosis
The objective of this study was to evaluate the effect of a physical exercise program on the functional capacity of children and adolescents with cystic fibrosis hospitalized at the Hospital de Clínicas of Porto Alegre (HCPA)…
- Conditions
- Cystic Fibrosis, Cystic Fibrosis in Children, Cystic Fibrosis Pulmonary Exacerbation, Cystic Fibrosis With Exacerbation
- Trial name
- NCT03273959
- Testing
- Exercise protocol
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Asthma, Vitamin D Deficiency
Rapid vs Maintenance Vitamin D Supplementation in Deficient Children With Asthma to Prevent Exacerbations.
The role of vitamin D in respiratory health remains uncertain. Whether vitamin D reduces clinically important exacerbations of childhood asthma remains uncertain.
- Trial name
- NCT01395589
- Testing
- Vitamin D
- Where
- Qatar
- Volunteers
- 597 people, healthy volunteers welcome
- Sponsor
- Hamad Medical Corporation
Asthma
Digital Action Plan for Asthma Attacks
It is recommended that patients with asthma owned a written action plan which must include the names, doses and dosing of the treatment they should take when acute respiratory symptoms occur.
- Trial name
- PANAME (NCT02869958)
- Testing
- Digital action plan for asthma exacerbations + Written action plan, Written action plan
- Where
- 2 sites in France
- Volunteers
- 280 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
COPD
Exacerbation and Training in Patients With Chronic Obstructive Pulmonary Disease
When patients with chronic obstructive lung disease (COPD) are admitted to the hospital with a severe exacerbation they lose muscle strength. This muscle weakness predisposes these patients to further hospital admissions.
- Trial name
- EXTRA (NCT00877084)
- Testing
- Resistance training, Usual care
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- KU Leuven
Asthma
Peak Expiratory Flow Rate for Emergency Department Management of Acute Asthma Exacerbation
Patients presenting to the emergency department with acute asthma exacerbation will be assigned to peak-expiratory flow rate (PEFR) guided management and non-PEFR guided management.
- Trial name
- NCT03420651
- Testing
- Peak Expiratory Flow Rate (PEFR), Standard Clinical Judgement
- Where
- United States
- Volunteers
- 188 people
- Sponsor
- Hennepin Healthcare Research Institute
Asthma
Initiation of Chronic Asthma Care Regimens in the Pediatric Emergency Department
Hypothesis: Initiating chronic management treatment plans in conjunction with an asthma educational intervention in the pediatric Emergency Department (ED) with anti-inflammatory medication will result in an improvement of ED…
- Trial name
- IRUSBUPR0045 (NCT00388739)
- Testing
- Intervention: Budesonide, Usual care: albuterol + systemic steroids
- Where
- United States
- Sponsor
- Baylor College of Medicine
Cystic Fibrosis
Cystic Fibrosis Foundation (CFF) Biomarkers of Exacerbation
Clinical and translational research in cystic fibrosis (CF) is hampered by a lack of biomarkers that can be used to identify promising new therapies.
- Trial name
- NCT00788359
- Where
- 5 sites in United States
- Volunteers
- 123 people
- Sponsor
- University of Colorado, Denver
Severe Respiratory Exacerbation
Respiratory Exacerbations in Children With Bronchopulmonary Dysplasia (BPD): A Case-Control Study
This is an ambispective observational case-control study evaluating respiratory exacerbations in pediatric patients affected by bronchopulmonary dysplasia (BPD) compared with children without BPD.
- Trial name
- BPD-CC25 (NCT07666438)
- Where
- Italy
- Volunteers
- 800 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Asthma
Azithromycin for Children Hospitalized With Asthma
Asthma is a chronic lung condition in children, and often requires hospitalization for acute exacerbations. Azithromycin has been used successfully in other chronic lung diseases, including cystic fibrosis.
- Trial name
- NCT02003911
- Testing
- Azithromycin
- Where
- United States
- Volunteers
- 159 people
- Sponsor
- Montefiore Medical Center
Chronic Obstructive Pulmonary Disease
The Impact of Early Pulmonary Rehabilitation on Multidimensional Aspect of Dyspnea in COPD Patients After Exacerbation
Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are associated with severe dyspnea and exercise intolerance.
- Trial name
- NCT03611127
- Testing
- pulmonary rehabilitation
- Volunteers
- 80 people
- Sponsor
- Ain Shams University
Asthma
Trial of One Versus Two Doses of Dexamethasone for Pediatric Asthma Exacerbation
Comparing one versus two doses of oral dexamethasone for the treatment of asthma in the pediatric emergency department.
- Trial name
- R2D2 (NCT02725008)
- Testing
- Dexamethasone
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- Geoffrey W Jara-Almonte
Asthma
Use of Dexamethasone in Pediatric Asthma Exacerbations
The purpose of this study is to compare the efficacy of a single dose of dexamethasone vs. two doses of dexamethasone in mild and moderate asthma exacerbations pediatric patients.
- Trial name
- NCT02192827
- Testing
- Dexamethasone Sodium Phosphate Injection
- Where
- United States
- Volunteers
- 318 people
- Sponsor
- University at Buffalo
Cystic Fibrosis
Continuous Infusion Piperacillin-tazobactam for the Treatment of Cystic Fibrosis
Cystic fibrosis is an inherited disorder leading to chronic pulmonary inflammation and infection. A majority of people with cystic fibrosis have large quantities of bacteria residing in their lungs.
- Trial name
- PIPE-CF (NCT01694069)
- Testing
- Piperacillin-tazobactam combination product
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- West Virginia University
Cystic Fibrosis, Impaired Glucose Tolerance
Cystic Fibrosis (CF) Exacerbation and Insulin Treatment
The purpose of the study is to evaluate whether insulin treatment during pulmonary exacerbation (PE) in patients with Cystic Fibrosis (CF)and normoglycemia improves their short term outcome by normalizing the glycemic profile and…
- Conditions
- Cystic Fibrosis, Impaired Glucose Tolerance, Pulmonary Exacerbation
- Trial name
- NCT01149005
- Testing
- novorapid / humalog short acting insulin, Novo Rapid Insulin (Novonordisk)
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Hadassah Medical Organization
Asthma
Identification of Plasma miRNAs as Potential Biomarkers in Asthma Exacerbation
We hypothesize that there is a statistically significant difference in miRNA profiling and expression of subjects with asthma upon its exacerbation compared to patient's baseline level or following effective treatment of an…
- Trial name
- NCT01631760
- Testing
- no intervention
- Where
- 2 sites in United States
- Sponsor
- University of South Florida
Asthma
A Trial of Mepolizumab Adjunctive Therapy for the Prevention of Asthma Exacerbations in Urban Children
The purpose of this study is to see if treatment with a medication called Nucala® (mepolizumab), given along with standard asthma care, makes children less likely to have asthma attacks.
- Trial name
- MUPPITS-2 (NCT03292588)
- Testing
- Mepolizumab
- Where
- 9 sites in United States
- Volunteers
- 335 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Asthma
Adequacy of Management of Patients With Asthma Exacerbation in Martinique
Asthma is a chronic respiratory disease whose goal of therapeutic, educational and preventive care is to prevent the onset of acute crisis, the most serious of which are life threatening.
- Trial name
- APEXA (NCT05253391)
- Testing
- Routine care
- Where
- 7 sites in Martinique
- Volunteers
- 339 people
- Sponsor
- University Hospital Center of Martinique
Primary Ciliary Dyskinesia
Utilizing Hyperpolarized 129Xe Magnetic Resonance Imaging in Children With Primary Ciliary Dyskinesia
This study investigates the use of hyperpolarized 129Xe magnetic resonance imaging (MRI) in children with primary ciliary dyskinesia (PCD) in detecting ventilation defects.
- Trial name
- PCD MRI (NCT04858191)
- Where
- Canada
- Volunteers
- 16 people
- Sponsor
- The Hospital for Sick Children