Clinical trials: Respiratory Function
Obstructive Sleep Apnea, Positive Airway Pressure
Big Data Analysis of OSA Patients on Positive Airway Pressure (PAP) Treatment: Real-life Monitoring
The present study aims to determine to what extent remote monitoring of PAP related to patients' clinical parameters is able to provide relevant data on predictors of compliance, subgroups of patients who may benefit from this…
- Trial name
- TeleVAL (NCT05495347)
- Testing
- patients diagnosed with OSA
- Where
- Spain
- Volunteers
- 2,500 people
- Sponsor
- Instituto de Investigación Marqués de Valdecilla
Bilateral Pleural Effusion
Impact of Large-Volume Pleural Effusions on Heart Function
The physiologic basis for relief from dyspnea after therapeutic thoracentesis remains poorly understood. Improvement of the heart and lung function may contribute to the dyspnea relief.
- Trial name
- TTE (NCT02548221)
- Testing
- transthoracic echocardiogram
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Beijing Chao Yang Hospital
Infant, Premature
Automated Oxygen Control in Preterms on Non-invasive Ventilation
This randomised controlled trial aims to investigate the effectiveness of closed-loop automated oxygen control (CLAC) in preterm infants receiving non-invasive respiratory support and determine if it reduces the duration of…
- Conditions
- Infant, Premature, Airway Morbidity
- Trial name
- NCT07622563
- Testing
- Closed loop automated oxygen control
- Where
- United Kingdom
- Volunteers
- 76 people
- Sponsor
- King's College Hospital NHS Trust
Sleep Apnea
Revisiting Parental Survey for Screening for Obstructive Sleep Apnea in Patients Undergoing Polysomnography
The investigators are proposing a study where the investigators would give a survey to the parents of patients having a sleep study.
- Trial name
- NCT01914198
- Testing
- Sleep apnea symptom survey
- Where
- United States
- Volunteers
- 948 people
- Sponsor
- Vidya Raman
Critical Illness, Respiratory Failure
PRactice of VENTilation in Critically Ill PEDiatric Patients
The goal of this worldwide observational study is to investigate ventilation practice in critically ill pediatric patients. The main questions it aims to answer are: 1.
- Trial name
- PRoVent-PED (NCT06220825)
- Where
- Netherlands
- Volunteers
- 2,500 people
- Sponsor
- University Medical Center Groningen
Mechanical Ventilation, Pain
Skin Conductance in Ventilated Preterms
The goal of this observational study is to learn more about the pain and stress experienced by newborn infants receiving mechanical ventilation (breathing through a machine).
- Conditions
- Mechanical Ventilation, Pain, Skin to Skin Care, Kangaroo Mother Care
- Trial name
- SCiP (NCT07568418)
- Testing
- Skin Conductance Measurement
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Uppsala University Hospital
Hypotonia, Muscle, Obstructive Sleep Apnea
Long-term Evaluation of Nasopharyngeal Airway in Hypotonia
This research is studying the long term use of a nasal airway device (self-supporting nasopharyngeal airway; "ssNPA") in children with hypotonic upper airway obstruction to learn about its effectiveness and tolerability as a…
- Conditions
- Hypotonia, Muscle, Obstructive Sleep Apnea, Nasal Airway Obstruction
- Trial name
- NCT06614582
- Testing
- Self-Supporting Nasopharyngeal Airway (ssNPA)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Michigan
Interstitial Lung Diseases
The Effects of Whole-Body Vibration Training on Clinical and Functional Outcomes in Individuals Diagnosed With Interstitial Lung Disease
This randomized controlled trial aims to investigate the clinical and functional effects of Whole Body Vibration (WBV) training when added to a standard pulmonary rehabilitation (PR) program in patients with fibrotic interstitial…
- Trial name
- NCT07709260
- Testing
- Inspiratory Muscle Training, Peripheral Muscle Strengthening Exercises, Aerobic Exercise Training (Cycle Ergometer)
- Where
- Turkey (Türkiye)
- Volunteers
- 26 people
- Sponsor
- Istinye University
Autism Spectrum Disorder, Asthma
Folic Acid Clinical Trial: Follow up of Children (FACT 4 Child)
FACT 4 Child is a follow up study of mothers who participated in the Folic Acid Clinical Trial (NCT01355159) and their children at 4-6 years of age to determine the effect of high dose folic acid supplementation on social…
- Conditions
- Autism Spectrum Disorder, Asthma, Executive Dysfunction, Emotional Problem
- Trial name
- NCT03269110
- Testing
- SRS 2, CBCL, BRIEF-P
- Where
- 58 sites in Australia, Canada and 2 more
- Volunteers
- 664 people, healthy volunteers welcome
- Sponsor
- Ottawa Hospital Research Institute
Acute Severe Respiratory Failure, Acute Respiratory Distress Syndrome
WorldwidE AssessmeNt of Separation of pAtients From Ventilatory assistancE
WEAN SAFE (WorldwidE AssessmeNt of Separation of pAtients From ventilatory assistancE) is a multi-centre, prospective, observational, 4-week inception cohort study being carried out by the Acute Respiratory Failure section of…
- Trial name
- WEAN SAFE (NCT03255109)
- Where
- Belgium
- Volunteers
- 11,000 people
- Sponsor
- European Society of Intensive Care Medicine
Neonates
Utility of Spontaneous Breathing Trial (SBT) Using ET-CPAP, in Predicting Extubation Failure in Neonates
Intubation and ventilation are lifesaving interventions in the neonatal intensive care unit (ICU), especially among preterm, low birth weight babies. However, timely extubation is also necessary.
- Trial name
- NCT03091387
- Testing
- Spontaneous Breathing Test
- Volunteers
- 110 people
- Sponsor
- Aga Khan University
Bronchiolitis, Noninvasive Ventilation
Point-of-Care Lung Ultrasound for Prognosis in Critically Ill Infants With Acute Lower Respiratory Tract Infection
Prospective, observational multicentric study which aims at identifying lung POCUS (Point of Care UltraSound) findings associated with failure of noninvasive ICU-LRS (Intensive Care Unit Level Respiratory Support) (defined as…
- Trial name
- Bacon-Pocus (NCT06425107)
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Vittore Buzzi Children's Hospital
Down Syndrome, Obstructive Sleep Apnea
Positive Airway Pressure (PAP) for Children With Down Syndrome (DS) and Obstructive Sleep Apnea Syndrome (OSAS)
Determine the efficacy of family-informed intervention (INT) vs standard clinical care over a period of twelve months in children with obstructive sleep apnea and Down Syndrome.
- Trial name
- NCT04132999
- Testing
- Family-informed intervention, Standard Clinical Care
- Where
- 3 sites in United States
- Volunteers
- 27 people
- Sponsor
- University of Miami
Sleep-Disordered Breathing, Obstructive Sleep Apnea
Efficacy of Clinical Decision Support and Sleep Navigation (Sleep PASS)
The purpose of the study is to examine the feasibility, acceptability, and initial outcomes of clinical decision support (CDS) and a Sleep Navigation program to enhance primary to specialty care management of pediatric…
- Conditions
- Sleep-Disordered Breathing, Obstructive Sleep Apnea, Sleep
- Trial name
- NCT05353998
- Testing
- CDS with Sleep Navigation, CDS-only
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Children's Hospital of Philadelphia
Obstructive Sleep Apnea, Child, Only
Study of Postoperative Respiratory Complications in Children With Obstructive Sleep Apnea (PORC)
Adenotonsillectomy is the first line surgical treatment for children with Obstructive Sleep apnea Syndrome (OSAS). Postoperative respiratory complications (PORC) may occur and are often related to co-morbidities.
- Conditions
- Obstructive Sleep Apnea, Child, Only, Surgery
- Trial name
- PORC (NCT05308108)
- Testing
- (Adeno)tonsillectomy
- Where
- Belgium
- Volunteers
- 132 people
- Sponsor
- University Hospital, Antwerp
Acute Pain, Anxiety
MOLI Technique and Virtual Reality Versus Conventional Venipuncture for Pain and Anxiety in Children
Venipuncture is one of the most frequent and distressing invasive procedures in paediatric care. Both immersive virtual reality (VR) and structured breathing-based active distraction have been proposed as effective…
- Conditions
- Acute Pain, Anxiety, Pain, Procedural, Phlebotomy
- Trial name
- MOLIVeR (NCT07878117)
- Testing
- Conventional venipuncture technique, MOLI technique, Meta Quest 3 with Fruit Ninja VR
- Where
- Spain
- Volunteers
- 201 people
- Sponsor
- José Luis Cobo Sánchez
Hyalinosis, Hyaline Membrane Disease
Biomarker for Hyaline Fibromatosis Syndrome (BioHFS)
Development of a new MS-based biomarker for the early and sensitive diagnosis of Hyaline fibromatosis syndrome from the blood
- Conditions
- Hyalinosis, Hyaline Membrane Disease, Juvenile Hyaline Fibromatosis, Fibromatosis Hyalinica Multiplex Juvenilis
- Trial name
- BioHFS (NCT03196115)
- Where
- 3 sites in Germany, India and 1 more
- Sponsor
- CENTOGENE GmbH Rostock
Pregnancy, Smoking
Evaluating the Effects of Supplemental Vitamin C on Infant Lung Function in Pregnant Smoking Women
Women who smoke during their pregnancy place their unborn child at an increased risk of health problems, including decreased lung function and possible lung diseases later in life.
- Trial name
- NCT00632476
- Testing
- Vitamin C
- Where
- United States
- Volunteers
- 282 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Respiratory Failure, Premature Neonates
Supraglottic Airway for Resuscitation in Preemies
The goal of this single-arm intervention trial is to learn whether using a supraglottic airway (SA) as the primary interface for positive pressure ventilation (PPV) is feasible during delivery room resuscitation of premature…
- Conditions
- Respiratory Failure, Premature Neonates, Delivery Room Resuscitation, Positive Pressure Ventilation
- Trial name
- SUPREEMIE (NCT07419438)
- Testing
- Supraglottic Airway
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Pennsylvania
Asthma
Nebulized Fluticasone Propionate VS Oral Prednisone in Chinese Pediatric and Adolescent Subjects With an Acute Exacerbation of Asthma
This is a multicentre, randomized, double-blind, double-dummy, active-controlled, parallel-group study to determine the efficacy and safety of nebulized fluticasone propionate 1mg twice daily compared with oral prednisone…
- Trial name
- NCT01687296
- Testing
- fluticasone propionate inhalation solution, oral prednisone, salbutamol
- Where
- 11 sites in China
- Volunteers
- 261 people
- Sponsor
- GlaxoSmithKline
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