Clinical trials: Respiratory Function
Sickle Cell Disease
Preventing Acute Chest Syndrome by Transfusion Feasibility Study
Acute chest syndrome (ACS) is similar to severe pneumonia and is a common cause of hospitalizations for people with sickle cell disease (SCD). Blood transfusions are one treatment option for ACS.
- Trial name
- PROACTIVE (NCT00951808)
- Testing
- Single blood transfusion, Standard care
- Where
- 24 sites in United States
- Volunteers
- 237 people
- Sponsor
- Carelon Research
Continuous Positive Airway Pressure, Noninvasive Ventilation
Effects of a Therapeutic Education Program on Treatment Adherence Among Patients Prescribed At-home CPAP or At-home NIV
The primary objective of this study is to study the effect of therapeutic education on patient adherence for at-home continuous positive airway pressure (CPAP) or at-home non-invasive ventilation.
- Trial name
- APARDetp (NCT03151317)
- Where
- France
- Volunteers
- 1,200 people
- Sponsor
- University Hospital, Montpellier
Bronchopulmonary Dysplasia
Fluid Filled Lung Oxygenation Assistance Trial
The primary study objective is to assess the safety and feasibility of perfluorooctylbromide (PFOB) partial liquid ventilation (PLV) in infants with severe Bronchopulmonary Dysplasia (BPD).
- Trial name
- FFLOAT (NCT03041740)
- Testing
- Perfluorooctyl Bromide
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Children's Hospital of Philadelphia
Hypoxemia, Ventilator Lung
Driving Pressure-guided Lung Protective Ventilation
The study, named as "The Efficacy of Driving Pressure-guided Lung Protective Ventilation in Surgical Repair of Acute Type A Aortic Dissection: an open-label, randomized control clinical trial", aims to investigate whether driving…
- Trial name
- DPV (NCT06361420)
- Testing
- Driving pressure-guided positive end expiratory pressure, Optimal oxygenation-guided positive end expiratory pressure, Ventilation strategy
- Where
- China
- Volunteers
- 43 people
- Sponsor
- Yong Lin, PhD
Acute Respiratory Distress Syndrome
PEEP Recruitment-comparison Between Ultrasonographic Assessment and LIP Assessment
The purpose of this study is to compare lung recruitment in acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) based on lower inflection point with transthoracic ultrasonographic assessment of lung recruitment.
- Trial name
- NCT01478217
- Where
- Croatia
- Volunteers
- 17 people
- Sponsor
- Sisters of Mercy University Hospital
Asthma
A Study to Compare Severe Asthma Patients Who Start Biologics and Who do Not Start (PROSPECT)
Objectives in this study is to compare the change of lung function after 24 months from baseline between the two groups; one is the patient group who decided to start biologics treatment, and another is the patient group who…
- Trial name
- NCT04808518
- Where
- 28 sites in Japan
- Volunteers
- 74 people
- Sponsor
- AstraZeneca
High Frequency Oscillation Ventilation, Extreme Prematurity
Open Lung Maneuvers During High Frequency Oscillatory Ventilation in Preterm Infants
To assess whether stepwise oxygenation-guided lung recruitment at regular intervals reduces the oxygen saturation index (OSI = Mean Airway Pressure × Fraction of inspired Oxygen × 100 / peripheral Oxygen Saturation, OSI =…
- Conditions
- High Frequency Oscillation Ventilation, Extreme Prematurity, Lung Injury, Acute
- Trial name
- OPEN4HFOV (NCT04289324)
- Testing
- regular lung recruitment
- Where
- Austria
- Volunteers
- 36 people
- Sponsor
- Medical University of Vienna
Cystic Fibrosis
A Phase 3 Study of VX-121 Combination Therapy in Participants With Cystic Fibrosis (CF) Heterozygous for F508del and a Minimal Function Mutation (F/MF)
The purpose of this study evaluates the efficacy and safety of VX-121/tezacaftor/deutivacaftor (VX-121/TEZ/D-IVA) in CF participants who were heterozygous for F508del and a minimal function mutation (F/MF participants).
- Trial name
- NCT05033080
- Testing
- VX-121/TEZ/D-IVA, ELX/TEZ/IVA, IVA
- Where
- 139 sites in United States, Australia and 10 more
- Volunteers
- 435 people
- Sponsor
- Vertex Pharmaceuticals Incorporated
Ventilator Weaning
Sedation and Weaning in Children Requiring Invasive Mechanical Ventilation
A UK multi-centre cluster randomised controlled trial to determine if a protocol-based intervention incorporating coordinated care with greater nursing involvement to managing sedation and ventilator weaning can reduce the…
- Trial name
- SANDWICH (NCT03673683)
- Testing
- SANDWICH protocol, Usual care
- Where
- 17 sites in United Kingdom
- Volunteers
- 10,498 people
- Sponsor
- Queen's University, Belfast
Test Anxiety, Diaphragmatic Breathing
Diaphragmatic Breathing Exercises on Stress and Exam Anxiety in High School Seniors: A Randomized Study
This study aims to evaluate the effect of diaphragmatic breathing exercises on stress and exam anxiety in final-year high school students during the exam period.
- Conditions
- Test Anxiety, Diaphragmatic Breathing, Stress Measurement, Psychological
- Trial name
- NCT06949202
- Testing
- breating exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Igdir University
One Lung Ventilation OLV, Esophageal Atresia
The Effect of Dexmedetomidine on Oxygen During One Lung Ventilation in Pediatric Surgery.
The children who will undergo OLV (one lung ventilation) through general anesthesia will be divided into two groups: The first will be intravenous infusion of dexmedetomidine at 0.4 mcg / kg / hour, and the second will be…
- Conditions
- One Lung Ventilation OLV, Esophageal Atresia, Hydrocystoma, Pneumonectomy
- Trial name
- RCT (NCT04932746)
- Testing
- Dexmedetomidine
- Where
- Syria
- Volunteers
- 110 people
- Sponsor
- Damascus University
Chronic Tonsillitis, Sleep Disordered Breathing
Outcomes of Post-operative Diet in Children Following Tonsillectomy and Adenoidectomy
This research is being done because it is not known which dietary recommendations are best to help patients recover after a tonsillectomy and/or adenoidectomy.
- Trial name
- NCT03437954
- Testing
- Diet modification
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- Georgetown University
Anemia, Sickle Cell
Dexamethasone to Treat Acute Chest Syndrome in People With Sickle Cell Disease
People with sickle cell disease (SCD) may develop acute chest syndrome (ACS), which is a common and serious lung condition that usually requires hospitalization.
- Trial name
- NCT00530270
- Testing
- Dexamethasone
- Where
- 6 sites in United States
- Volunteers
- 12 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Transient Tachypnea of the Newborn
Role of Salbutamol and Furosemide in TTN
to see the effects of slabutamol and IV furosemide in the treatment of transient tachypnea of newborn
- Trial name
- NCT03208894
- Testing
- Furosemide Injection
- Where
- 2 sites in Pakistan
- Volunteers
- 100 people
- Sponsor
- Armed Forces Hospital, Pakistan
Pulmonary Disease, Chronic Obstructive
Randomized Controlled Trial of Mind-Body Breathing Therapy (in Chronic Obstructive Pulmonary Disease) To Improve Palliation of Dyspnea and Health-Related Quality of Life
Dyspnea (shortness of breath) is a complex experience that includes interpretation of physical impairments and associated distress to the person.
- Trial name
- NCT00243282
- Testing
- Relaxation Response (instruction, pocket practice card prov), Mindfulness training using model developed from UMass
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- US Department of Veterans Affairs
Bacterial Infection
Bacterial Pulmonary Infection in PICU
The purpose of this study is to develop a scoring system to allow doctors to accurately identify children on a mechanical ventilator who have bacterial pneumonia.
- Trial name
- NCT00271531
- Where
- 4 sites in United States
- Volunteers
- 21 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Inhalation, Respiratory Disease
Inhalation Therapy and Therapeutic Play
The aim of this clinical research study was to determine the effect of the use of a cartoon character mask on treatment compliance and parental satisfaction and to evaluate the effectiveness of the cartoon character mask in…
- Trial name
- INHALATION (NCT06197646)
- Testing
- Cartoon characters inhaler mask
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Istinye University
Obstructive Sleep Apnea Syndrome
Cow's Milk Allergy in Infants With Obstructive Sleep Apnea (OSA)
Cow's milk allergy may be involved in the evolution of sleep apnea in infants. The study will assess the effects of specifies diet changes (i.e. non-milk based formula) on the infant.
- Trial name
- NCT00659854
- Testing
- Non milk or soy based formula, milk based formula
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Soroka University Medical Center
Lung Diseases, Sleep Apnea Syndromes
Neurobehavioral Consequences of Sleep Apnea in Children
To identify physiological and clinical measures of obstructive sleep-disordered breathing that are associated with increased morbidity in children.
- Trial name
- NCT00006323
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Posterior Spinal Fusion
Changes in Cerebral Oxygenation Based on Intraoperative Ventilation Strategy
The proposed research aims to investigate how different ventilation strategies may affect cerebral tissue oxygenation in the pediatric population.
- Trial name
- NCT02651103
- Testing
- NIRS
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Joseph D. Tobias
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.