Clinical trials: Respiratory Function
Airway Morbidity, Airway Disease
Video Laryngoscopy in Pre-hospital Critical Care
Difficult conditions and critically ill and injured patients may complicate endotracheal intubation in the pre-hospital setting.
- Conditions
- Airway Morbidity, Airway Disease, Respiratory Insufficiency, Respiratory Failure
- Trial name
- NCT02035449
- Testing
- McGrath MAC
- Where
- Denmark
- Volunteers
- 150 people
- Sponsor
- University of Aarhus
Sleep Disorders
Validation of Home Sleep Testing (WP) Compared to an Overnight Sleep Testing in the Sleep Laboratory
Obstructive sleep apnea syndrome (OSAS) is considered to be a major public health problem. The prevalence of OSAS is estimated at 2% and 4% for adult women and men respectively, most of whom are undiagnosed and untreated.
- Trial name
- NCT01570738
- Where
- Israel
- Volunteers
- 274 people, healthy volunteers welcome
- Sponsor
- Itamar-Medical, Israel
Critically Ill, H1N1/Influenza Infection
Collaborative H1N1 Adjuvant Treatment Pilot Trial
Study Design: A, multinational, double blind, placebo-controlled pilot RCT involving 80 patients in the general ICUs of 30 centres.
- Trial name
- CHAT (NCT01033955)
- Testing
- Rosuvastatin
- Where
- 9 sites in Canada
- Volunteers
- 8 people
- Sponsor
- Canadian Critical Care Trials Group
Apnea, Obstructive
Validation of the French Version of the OSA-18 Questionnaire
Obstructive sleep apnea (OSA) is characterized by repetitive partial and/or total closure of the upper airway during sleep, inducing oxygen desaturation and sleep disturbance. Its prevalence in the pediatric population is 1-5%.
- Trial name
- French OSA18 (NCT07136909)
- Testing
- Completion of the OSA-18 questionnaire by parents, during hospitalization planned as part of routine care.
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Hospices Civils de Lyon
Respiratory Disease
Clinical Performance Evaluation of the NeuMoDx™ FluA/FluB/RSV/Severe Acute Respiratory Syndrome-CoV-2 Assay
To demonstrate the clinical performance of the NeuMoDx™ FluA/FluB/RSV/SARS-CoV-2 Assay on the NeuMoDx Systems by determining clinical sensitivity and specificity of the Assay.
- Trial name
- NCT05162547
- Testing
- NeuMoDx™ FluA/FluB/RSV/SARS-CoV-2 Assay
- Where
- United Kingdom
- Volunteers
- 2,383 people
- Sponsor
- QIAGEN Gaithersburg, Inc
Monitoring of Regional Distribution of Ventilation, Monitoring of Lung Volume
Prospective, Open, Non-interventional Study to Assess the Ability of an Electrical Impedance Tomograph (PlumoVista 500)
This observational PMCF study will be conducted to generate and gather clinical data from the intended target population of pediatric patients.
- Trial name
- PV500ped (NCT04873999)
- Where
- Germany
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Drägerwerk AG & Co. KGaA
Apnea
Different Flow Rates on Gas Exchange in Children During Apnea
Background: Children desaturate rapidly during apnea following anesthetic induction. The optimal apneic oxygenation flow rate and its effect on CO2 accumulation remain unclear.
- Trial name
- NCT06659887
- Testing
- nasal cannula
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Yasser S Mostafa, MD
Acute Respiratory Distress Syndrome
The Effect of High Frequency Oscillation on Biological Markers of Lung Injury
Mechanical ventilation, although life-saving, damages the lungs through what is known as ventilator-induced lung injury. High frequency oscillation ventilation has been proposed as a ventilation method that may be less injurious…
- Trial name
- NCT01581255
- Where
- 2 sites in Canada
- Volunteers
- 2 people
- Sponsor
- Canadian Critical Care Trials Group
Lateral Sinus Thrombosis, Mastoiditis
Otogenic CSVT Retrospective Case Series and Associated Thrombophilia
The aim of this study is to report the clinical presentation, Microbiological, laboratory and imaging evaluation, prothrombotic factors analysis, medical and surgical management and outcomes in children with Otogenic Cerebral…
- Conditions
- Lateral Sinus Thrombosis, Mastoiditis, Otitis Media
- Trial name
- CSVT PCR (NCT03864055)
- Where
- Israel
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- HaEmek Medical Center, Israel
Narcolepsy, Sleep Apnea, Obstructive
PROVIGIL® (Modafinil) Treatment in Children and Adolescents With Excessive Sleepiness Associated With Narcolepsy or Obstructive Sleep Apnea/Hypopnea Syndrome
The primary objective of the study is to evaluate the safety and tolerability of treatment with PROVIGIL in children and adolescents with excessive sleepiness (ES) associated with narcolepsy or OSAHS (obstructive sleep…
- Trial name
- NCT00107848
- Testing
- Modafinil
- Where
- 61 sites in United States, Canada
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Cephalon
Pediatric Respiratory Diseases, Bronchiolitis
Assessment of NeuroBOX and NeuroPAP in Infants.
Non-invasive ventilation (NIV, delivered via a mask or cannulas) permits to reduce the need for tracheal intubation in infants who needs a ventilatory support.
- Conditions
- Pediatric Respiratory Diseases, Bronchiolitis, Infant Respiratory Distress Syndrome
- Trial name
- NeuroPap2 (NCT03650478)
- Testing
- NeuroPAP ventilation (2h) and NeuroBox monitoring (23h), NeuroPAP ventilation (4h) and NeuroBox monitoring (25h)
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- St. Justine's Hospital
Respiratory Disease
Procedural Skills Transfer in Bronchoscopy
Brief summary The goal of this Feasibility study is to capture bronchoscopy data from patients (Group1) and bronchoscopists (Group 2) over a period of three years.
- Trial name
- NCT07168408
- Where
- United Kingdom
- Volunteers
- 320 people
- Sponsor
- University of Edinburgh
Cystic Fibrosis
Use of Formula Fortified With DHA in Infants With Cystic Fibrosis
The hypothesis of this study is that feeding infants diagnosed with CF via newborn screening a formula enhanced with a specific fish-oil fatty acid known as DHA will improve growth and decrease pancreatic dysfunction (as measured…
- Trial name
- DHA (NCT00530244)
- Testing
- Docosahexaenoic acid (DHA), Standard formula (Enfamil)
- Where
- 24 sites in United States
- Volunteers
- 76 people
- Sponsor
- University of Massachusetts, Worcester
Atelectasis
VCV vs PRVC in Pediatric Anesthesia; an EIT- and LS-based Study
The primary objective of this study is to evaluate and compare the incidence and severity of intraoperative pulmonary atelectasis, measured by Lung Ultrasound Score (LUS) and EIT (Electrical Impedance Tomography), between two…
- Trial name
- VentiEIT_ped (NCT07182539)
- Testing
- PRVC ventilation, VCV ventilation
- Where
- Italy
- Volunteers
- 88 people
- Sponsor
- Vittore Buzzi Children's Hospital
Lung Diseases
Investigating Novel Strategies in Pediatric Immune Responses and Microbiome Environment: Comprehensive Lung Disease Investigation in Children.
The INSPIRE CHILD-study is a clinical research project focused on understanding lung diseases in children. The study aims to explore how the presence of certain bacteria, immune responses, and inflammatory markers in the lungs…
- Trial name
- INSPIRE CHILD (NCT06746077)
- Testing
- No intervention
- Where
- Denmark
- Volunteers
- 200 people
- Sponsor
- Aarhus University Hospital
Sleep-Disordered Breathing, Sleep Apnea Syndromes in Children
Lateral Pharyngoplasty Outcomes in Children Undergoing Tonsillectomy
The goal of this treatment study is to determine if doing lateral pharyngoplasty with tonsillectomy is better for children than doing tonsillectomy alone.
- Conditions
- Sleep-Disordered Breathing, Sleep Apnea Syndromes in Children, Sleep Apnea, Obstructive, Tonsillitis
- Trial name
- NCT05575401
- Testing
- Lateral pharyngoplasty, Tonsillectomy
- Where
- 4 sites in United States
- Volunteers
- 160 people
- Sponsor
- Loma Linda University
Pain, Postoperative, Tonsillar Hypertrophy
Optimization of Pediatric Tonsillectomy to IMprove AnaLgesia
The purpose of this study is to compare the use of short acting opioids (fentanyl/hydromorphone) with long acting opioids (methadone) for pain control following tonsillectomy surgery in children and adolescents.
- Conditions
- Pain, Postoperative, Tonsillar Hypertrophy, Tonsillitis, Pediatric Sleep Apnea
- Trial name
- OPTIMAL (NCT06576830)
- Testing
- Methadone, Fentanyl/Hydromorphone
- Where
- United States
- Volunteers
- 440 people, healthy volunteers welcome
- Sponsor
- Duke University
Sleep Disordered Breathing, Drug Induced Sleep Disorder
DISE in Pediatric Sleep Disordered Breathing
Adenotonsillar hypertrophy is the most common reason for children to have sleep disordered breathing (SDB). Even though adenotonsillectomy improves sleep apnea in children, 20-40% of children will still have persistent SDB.
- Trial name
- NCT06756971
- Testing
- Propofol, Dexmedetomidine
- Sponsor
- University of Iowa
Bronchopulmonary Dysplasia
Inhaled Nitric Oxide (INO) for the Prevention of Bronchopulmonary Dysplasia (BPD) in Preterm Infants
This phase 3, multi-center, double blind, placebo-controlled, randomized clinical trial will attempt to demonstrate if preterm infants who require mechanical ventilation and/or positive pressure support at any point during days 5…
- Trial name
- NCT00931632
- Testing
- Inhaled Nitric Oxide
- Where
- 33 sites in United States, Canada
- Volunteers
- 451 people
- Sponsor
- Mallinckrodt
Prematurity, Respiratory Distress Syndrome
Curosurf and Survanta Treatment(CAST)of RDS in Very Premature Infants
Approval of surfactant by the FDA in 1989 for the treatment of Respiratory Distress Syndrome (RDS) in premature infants greatly improved survival rates.
- Conditions
- Prematurity, Respiratory Distress Syndrome, Patent Ductus Arteriosus
- Trial name
- CAST (NCT00767039)
- Testing
- Survanta (beractant), Curosurf (poractant)
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Alan Fujii
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