Clinical trials: Respiratory Illness
RESPIRATORY SYNCYTIAL VIRUS (RSV)
A Study to Learn About the Safety and Immune Activity of RSVpreF in Children 2 to <18 Years of Age
The purpose of this study is to learn about the safety and immune activity of the vaccine (called RSVpreF) in children 2 to <18 years of age.
- Trial name
- PICASSO (NCT05900154)
- Testing
- RSVpreF 120 µg, RSVpreF 60 µg
- Where
- 17 sites in United States
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Pfizer
Respiratory Infection
Unclogging the Pediatric Emergency Room: Impact of Rapid Viral Diagnostics
Acute respiratory tract infections are among the most common problems of childhood, particularly among infants and children younger than 3 years, and account for most antibiotic prescriptions to children.
- Trial name
- NCT00278759
- Testing
- Nasopharyngeal washing for viral antigen detection by immunofluorescence initiated early in ED visit.
- Where
- Canada
- Volunteers
- 275 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Tobacco Smoke Pollution
PRIDE: Preventing Respiratory Illnesses During Childhood Study
Environmental tobacco smoke (ETS0, also known as secondhand smoke, is the combination of smoke given off by the burning end of a tobacco product and the smoke exhaled by the smoker.
- Trial name
- PRIDE (NCT00927264)
- Testing
- Motivational Interviewing Intervention for ETS Reduction, Educational Program for ETS Reduction
- Where
- United States
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Cardiovascular Diseases, Respiratory Diseases
Study on Intervention Effect of Heat-related Health Risk Early Warning Digital Technology for School-age Children
This cluster randomized trial is conducted in Beijing primary schools to evaluate the efficacy of a WeChat mini-program-based high-temperature early warning intervention on the physical and cognitive health of school-age…
- Conditions
- Cardiovascular Diseases, Respiratory Diseases, Mental Health Disorders, Heat Illness
- Trial name
- NCT07643571
- Testing
- WeChat Mini-program Based Heat Health Risk Early Warning Intervention
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention, China
Influenza -Like Illness, Influenza (Healthy Volunteers)
Mucosal and Systemic Immunity Correlates of Protection Against Influenza in Young Children, Aged 2-5 Years (MUSIC-Flu)
Title: Mucosal and systemic immunity correlates of protection against influenza in young children (MUSIC-Flu). The goal of this observational study is to better understand how immune responses in the blood and mucosa are linked…
- Trial name
- MUSIC-Flu (NCT07861854)
- Where
- South Africa
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- National Institute for Communicable Diseases, South Africa
High Altitude Pulmonary Hypertension, Sleep Apnea
Sleep Related Breathing Disturbances and High Altitude Pulmonary Hypertension in Kyrgyz Highlanders
High altitude pulmonary hypertension, a form of altitude illness that occurs in long-term residents at altitudes >2500 m, is characterized by dyspnea, hypoxemia, impaired exercise performance and hypertension in the pulmonary…
- Trial name
- NCT01621061
- Where
- Kyrgyzstan
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Influenza-like Illness, Influenza
REDucing Influenza Among University Students, University of California at Berkeley
We will be testing the hypothesis whether online education for UC Berkeley students on respiratory hygiene, cough etiquette, hand hygiene/awareness, as well as face mask use (while ill) will reduce the acquisition and…
- Trial name
- REDI-US (NCT00448773)
- Testing
- Online education
- Where
- United States
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
Critical Congenital Heart Disease, High Altitude
Oxygen Saturation and Perfusion Index ın Neonates at High Altitude
Congenital heart diseases are among the most common congenital anomalies and occur with an incidence of approximately 8ınd12 / 1,000 live births worldwide.
- Trial name
- NCT04290481
- Testing
- oxygen saturation and perfusion index screening
- Where
- Turkey (Türkiye)
- Volunteers
- 501 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Healthy Volunteers
Effects of Bifidobacterium Longum BB536 on Incidence of Acute Diarrhea and/or Respiratory- Related Illnesses in Children
This project aims to study the benefits of probiotics namely Bifidobacterium longum BB536 in prevention of acute diarrhea and/or respiratory-related illnesses, which are found common among children in Malaysia aged from 2 to 6…
- Trial name
- NCT02434042
- Testing
- BB536
- Where
- Malaysia
- Volunteers
- 520 people, healthy volunteers welcome
- Sponsor
- Universiti Sains Malaysia
Type 1 Diabetes, Asthma
EmoTIChealth: Promoting Adolescent Health Through a Serious Game.
The intervention program targets adolescents between 12 and 16 years of age. The intervention program is designed for adolescents during a critical developmental stage marked by significant life transitions, where building strong…
- Conditions
- Type 1 Diabetes, Asthma, Allergic Rhinitis, Food Allergy
- Trial name
- NCT07212530
- Testing
- EmoTIChealth
- Where
- Spain
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of Valencia
Other Acute Illnesses Presenting to the Hospital, Heart Failure
Evaluation of Implementation of a National Point-of-Care Ultrasound Training Program
This VA QUERI Partnered Evaluation Initiative will evaluate the impact of an immersive Point-of-care Ultrasound (POCUS) Training Course on provider skill acquisition and retention; the frequency of POCUS use by trained providers…
- Conditions
- Other Acute Illnesses Presenting to the Hospital, Heart Failure, Pneumonia, Deep Venous Thrombosis
- Trial name
- NCT03296280
- Where
- United States
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
COVID-19, SARS-CoV-2
COVID-19 Pandemic Response Network
Coronavirus Disease 19 (COVID-19) represents an unprecedented challenge to the operations and population health management efforts of health care systems around the world.
- Conditions
- COVID-19, SARS-CoV-2, Coronavirus, Influenza -Like Illness
- Trial name
- NCT04320862
- Where
- United States
- Volunteers
- 9,207 people, healthy volunteers welcome
- Sponsor
- Duke University
Child, Only, Infant, Newborn, Diseases
Capnography Monitoring in Ventilated Children
End-tidal CO2 measurements in children will be assessed for their accuracy with arterial CO2 measurements.
- Conditions
- Child, Only, Infant, Newborn, Diseases, Critical Illness, ARDS, Human
- Trial name
- NCT04354220
- Testing
- capnography monitoring, arterial blood gas
- Where
- Switzerland
- Volunteers
- 178 people, healthy volunteers welcome
- Sponsor
- Vincenzo Cannizzaro
Respiration Disorders, Respiratory Disease
The Gut-Lung Axis and Respiratory Illness in Children
The goal of this single-centre observational study conducted at the Royal Hospital for Children in Glasgow, Scotland, is to employ a multi-omics approach to investigate the "gut-lung axis" in health and disease.
- Conditions
- Respiration Disorders, Respiratory Disease, Asthma in Children, Wheezing
- Trial name
- NCT06271213
- Testing
- observational only - no interventions as part of study
- Where
- United Kingdom
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- NHS Greater Glasgow and Clyde
Asthma, Wheezing
Oral Bacterial Extract for the Prevention of Wheezing Lower Respiratory Tract Illness
The primary objective of this study is to evaluate if Broncho-Vaxom® given to high risk infants for 10 days, monthly, for two consecutive years can increase time to occurrence of the first episode of wheezing lower respiratory…
- Trial name
- ORBEX (NCT02148796)
- Testing
- Broncho-Vaxom (BV)
- Where
- 11 sites in United States
- Volunteers
- 822 people, healthy volunteers welcome
- Sponsor
- University of Arizona
High Altitude Pulmonary Hypertension, Sleep Apnea
Time Course and Prognostic Significance of Pulmonary Artery Pressure in Highlanders.
The purpose of the current study is to evaluate the clinical and physiologic course of Kyrgyz highlanders with high altitude pulmonary hypertension (HAPH) by performing a longitudinal cohort study.
- Trial name
- NCT03165019
- Where
- Kyrgyzstan
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Neonatal Congenital Heart Disease
Optimization of Two-Indicator Screening Protocol for Neonatal Congenital Heart Disease at High Altitude
This is a prospective observational screening study. First, researchers will optimize a two-indicator screening protocol for neonatal congenital heart disease (NCHD) adapted to high-altitude regions and evaluate its screening…
- Trial name
- NCT07901998
- Volunteers
- 6,300 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Fudan University
Central Fatigue, Altitude Training
Effect of Hot Spring Therapy on Central Fatigue Elimination During Altitude Training
This randomized controlled trial investigates the effects of hot spring balneotherapy on central fatigue elimination in adolescent rowers undergoing altitude training at approximately 1600 meters (Tengchong, Yunnan).
- Conditions
- Central Fatigue, Altitude Training, Cognitive Impairment, Hydrotherapy
- Trial name
- HSCF-AHT (NCT07615478)
- Testing
- Natural recovery, Hot water immersion, Hot spring balneotherapy
- Where
- China
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Macao Polytechnic University
Acute Lower Respiratory Illness
Cookstove Replacement for Prevention of ALRI and Low Birthweight in Nepal
At our field site in southern Nepal, acute respiratory illness (ARI) has been a leading cause of mortality among young children.
- Trial name
- NCT00786877
- Testing
- Improved biomass cookstove with exterior ventilation, Phase 2 intervention arm (LPG stove)
- Where
- Nepal
- Volunteers
- 4,678 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Virus, Asthma
Microbes and Respiratory Illnesses
This study is called the Microbes and Respiratory Illnesses (MARI) Study. Children growing up on farms are exposed to many types of microbes that could be beneficial.
- Trial name
- MARI (NCT06059027)
- Where
- United States
- Volunteers
- 290 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison