Clinical trials: Retinoschisis
Retinoschisis
Clinical and Genetic Studies of X-Linked Juvenile Retinoschisis
This study will explore the causes and eye problems of X-linked juvenile retinoschisis (XLRS), an inherited disease that causes vision loss primarily in young males.
- Trial name
- NCT00055029
- Where
- 2 sites in United States
- Volunteers
- 351 people
- Sponsor
- National Eye Institute (NEI)
X-linked Retinoschisis
Safety and Efficacy Study of LX103 Treatment of X-Linked Retinoschisis (XLRS)
The goal of this study is to evaluate the safety and efficacy of LX103 treatment of X-linked retinoschisis. This study will enroll subjects aged ≥ 6 years old to receive a single unilateral intravitreal (IVT) injection of LX103…
- Trial name
- NCT05814952
- Testing
- LX103 Injection
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
X-linked Retinoschisis
ATSN-201 Gene Therapy in RS1-Associated X-linked Retinoschisis
This study will evaluate the safety and efficacy of ATSN-201 in subjects ≥ 5 years of age with RS1-associated X-linked retinoschisis (XLRS).
- Trial name
- LIGHTHOUSE (NCT05878860)
- Testing
- ATSN-201
- Where
- 21 sites in United States, Canada and 1 more
- Volunteers
- 97 people
- Sponsor
- Atsena Therapeutics Inc.
Retinoschisis, Retinal Disease
Safety and Efficacy Study of IVB102 Injection in Subjects With X-linked Retinoschisis
The goal of this clinical trial is to evaluate the safety and efficacy of IVB102 injection in subjects with XLRS.
- Conditions
- Retinoschisis, Retinal Disease, Retinal Degeneration, Eye Diseases
- Trial name
- NCT06289452
- Testing
- IVB102 Injection
- Where
- China
- Volunteers
- 18 people
- Sponsor
- InnoVec Biotherapeutics Inc.
X-linked Retinoschisis
Safety and Efficacy of rAAV-hRS1 in Patients With X-linked Retinoschisis (XLRS)
This study will evaluate the safety and efficacy of a recombinant adeno-associated virus vector expressing retinoschisin (rAAV2tYF-CB-hRS1) in patients with X-linked retinoschisis.
- Trial name
- NCT02416622
- Testing
- rAAV2tYF-CB-hRS1
- Where
- 9 sites in United States
- Volunteers
- 27 people
- Sponsor
- Beacon Therapeutics
Macular Detachment, Macular Retinoschisis
Macular Detachment Associated With Intrachoroidal Cavitation
Evaluation of clinical characteristics and surgical outcome for macular detachment associated with peripapillary intrachoroidal cavitation with or without pathologic myopia.
- Conditions
- Macular Detachment, Macular Retinoschisis, Intrachoroidal Cavitation
- Trial name
- NCT01959724
- Testing
- Vitrectomy
- Where
- Japan
- Volunteers
- 69 people
- Sponsor
- Kyorin University
X Linked Retinoschisis
Safety and Efficacy of a Single Subretinal Injection of JWK002 Gene Therapy in Subjects With X-linked Retinoschisis(XLRS)
This trial is to evaluate the safety and efficacy of JWK002 treatment of X-linked retinoschisis(XLRS). This study will enroll subjects aged 5-18 years old to receive a sub-retinal injection of JWK002.
- Trial name
- NCT06345898
- Testing
- JWK002
- Where
- China
- Volunteers
- 12 people
- Sponsor
- West China Hospital
X-linked Retinoschisis
Safety and Efficacy Study of Novel Gene Therapy ZM-01 for X-linked Retinoschisis Patients
This trial is meant to evaluate the safety and efficacy of ZM-01 of X-linked retinoschisis. Unilateral intravitreal injections (IVT) will be given into the subject's Study Eye.
- Trial name
- NCT06066008
- Testing
- ZM-01-L, ZM-01-H
- Where
- China
- Volunteers
- 2 people
- Sponsor
- Zhongmou Therapeutics
Retinoschisis
The AXIS Study: the Efficacy of Acetazolamide for the Treatment of Cystoid Fluid Collections in Retinoschisis
X-linked retinoschisis (XLRS) is a rare hereditary eye disease that causes irreversible vision loss in boys and young men. This disease occurs in 1 in 10,000-30,000.
- Trial name
- AXIS (NCT06114537)
- Testing
- Acetazolamide
- Where
- Netherlands
- Volunteers
- 19 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Optic Disc Pit Maculopathy
Vitrectomy for Optic Disc Pit Maculopathy
The purpose of this study is to evaluate the efficacy of vitrectomy, without gas tamponade or laser photocoagulation to the margin of the optic nerve, for the treatment of macular detachment associated with optic disc pits and to…
- Trial name
- NCT01340703
- Testing
- vitrectomy without laser or gas tamponade
- Where
- Japan
- Volunteers
- 8 people
- Sponsor
- Kyorin University
Retinal Disease, Macular Retinoschisis
Pars Plana Vitrectomy Alone in the Treatment of Macular Schisis in High Myopic Eyes
High myopic schisis (HMF) has the clinical feature of separation between retinal layers. It is sometimes accompanied with foveal retinal detachment, macular lamellar hole, epiretinal membrane and vitreous retraction.
- Trial name
- NCT03586193
- Testing
- Pars plana vitrectomy
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Aier School of Ophthalmology, Central South University
Eye Diseases Hereditary, Retinal Disease
Inherited Retinal Degenerative Disease Registry
The My Retina Tracker® Registry is sponsored by the Foundation Fighting Blindness and is for people affected by one of the rare inherited retinal degenerative diseases studied by the Foundation.
- Conditions
- Eye Diseases Hereditary, Retinal Disease, Achromatopsia, Bardet-Biedl Syndrome
- Trial name
- MRTR (NCT02435940)
- Where
- United States
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Foundation Fighting Blindness
Macular Retinoschisis, Macular Detachment
Macular Retinoschisis and Detachment Associated With Glaucomatous Optic Neuropathy
Clinical features, optical coherence tomography findings and surgical outcome in eyes with macular retinoschisis and detachment with normal tension glaucoma but without optic disc pit or high myopia were evaluated.
- Conditions
- Macular Retinoschisis, Macular Detachment, Normal Tension Glaucoma
- Trial name
- NCT01862627
- Testing
- Optical coherence tomography
- Where
- Japan
- Volunteers
- 11 people
- Sponsor
- Kyorin University
X-linked Retinoschisis, XLRS
Clinical Evaluation of Patients With X-linked Retinoschisis
The purpose of this study is to evaluate subjects with X-linked retinoschisis in a clinical setting to collect data on disease progression.
- Trial name
- NCT02331173
- Testing
- Dorzolamide 2% TID or brinzolamide 1% TID
- Where
- 3 sites in United States
- Volunteers
- 66 people
- Sponsor
- Beacon Therapeutics