Clinical trials: Rhinosinusitis Chronic
Chronic Rhinosinusitis (Diagnosis), Cohort Study
A Prospective Single-center Cohort Study of Surgical Treatment of Chronic Rhinosinusitis
Chronic Rhinosinusitis (CRS) is a common and frequent disease in otorhinolaryngology. The main symptoms of patients include nasal congestion, runny nose, swelling pain of the frontal area and decreased sense of smell.
- Conditions
- Chronic Rhinosinusitis (Diagnosis), Cohort Study, Evidence-based Medicine
- Trial name
- NCT06010316
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Beijing Tongren Hospital
Chronic Sinusitis
Study of ONO-1078 in Patients With Chronic Sinusitis
To determine the efficacy and safety of ONO-1078 in patients with chronic sinusitis in a double-blind, randomized, placebo-controlled, parallel group, multi-center study
- Trial name
- NCT00410735
- Testing
- Pranlukast hydrate
- Where
- 6 sites in Japan
- Volunteers
- 495 people
- Sponsor
- Ono Pharmaceutical Co., Ltd.
Voice Disorders in Children
Effect of Chronic Rhinosinusitis on Voice of Children
Evaluation of the effect of chronic rhinosinusitis on the laryngeal mucosa and voice quality in children. This is important to know factors affecting voice disorders
- Trial name
- NCT03696693
- Testing
- acoustic vocal analysis
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assiut University
Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)
China CRSwNP Registry Study
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a long-lasting inflammatory disease of the nose and sinuses that can cause nasal blockage, loss of smell, nasal discharge, facial discomfort, sleep problems, and reduced…
- Trial name
- POLARIS (NCT07795658)
- Testing
- Routine Clinical Care for CRSwNP
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Beijing Tongren Hospital
Cystic Fibrosis, Rhinosinusitis
Sino-nasal Inhalation of Sodium Chloride 6,0% in Patients With Cystic Fibrosis and Chronic Rhinosinusitis
Rhinosinusitis disorders are almost regularly associated to Cystic Fibrosis (CF). The basic defect in CF is a dysfunction of chloride channels in exocrine glands which equally concerns upper airway mucosa.
- Trial name
- NCT01086839
- Testing
- sodium chloride 6%, sodium chloride 0,9%
- Where
- 11 sites in Germany
- Volunteers
- 69 people
- Sponsor
- University of Jena
Sinusitis
Comparing the Use of Saline or Saline Plus Gentamycin in Nasal Irrigation to Treat Chronic Sinusitis in Children
Healthy children may develop symptoms of chronic sinusitis such as chronic cough, chronic runny nose, nasal congestion, even headaches.
- Trial name
- NCT00465530
- Testing
- Saline, Gentamycin
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Julie Wei, MD
Rhinosinusitis
The Efficacy and Complication of Gentamicin Nasal Irrigation in Chronic Rhinosinusitis and Recurrent Sinusitis
Topical antibiotic therapy in patients with refractory sinusitis has been shown to improve symptoms, quality of life, and mucosal aspect.
- Trial name
- NCT02582099
- Testing
- Gentamicin nasal irrigation, Normal saline nasal irrigation
- Where
- Thailand
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Sinusitis, Cystic Fibrosis
Pulmozyme in Cystic Fibrosis With Sinusitis
The hypothesis is that the intranasal use of Pulmozyme will decrease the severity of sinusitis in Cystic Fibrosis and lead to an improved quality of life.
- Trial name
- NCT01155752
- Testing
- Pulmozyme single use ampule
- Where
- United States
- Sponsor
- Milton S. Hershey Medical Center
Chronic Sinusitis, Adenoid Disease - Chronic
Management of Pediatric Chronic Rhinosinusitis in Asthmatic Children
The objectives of this study would be to determine the most effective management for pediatric patients with chronic rhinosinusitis and asthma who fail medical management.
- Trial name
- NCT03336671
- Testing
- Endoscopic Sinus surgery, Adenoidectomy
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- State University of New York - Upstate Medical University
Chronic Rhinosinusitis With Nasal Polyps
A Study to Investigate the Clinical Outcome and Quality of Life in Chinese Post-operative CRSwNP Patients
This is a prospective, multicenter real-world observational study designed to describe post-operative outcomes, quality of life, disease control, recurrence-related characteristics, economic burden and post-operative treatment…
- Trial name
- PREDICT (NCT07446738)
- Testing
- Other: Routine Clinical Care for CRSwNP
- Where
- 21 sites in China
- Volunteers
- 146 people
- Sponsor
- AstraZeneca
Chronic Sinusitis
Vitamin D Supplementation in Chronic Rhinosinusitis With Nasal Polyps
The purpose of this study is to determine if Vitamin D supplementation improves clinical and immunologic parameters in chronic rhinosinusitis with nasal polyps.
- Trial name
- VDinCRS (NCT01185808)
- Testing
- Vitamin D
- Where
- United States
- Sponsor
- Medical University of South Carolina
Chronic Sinusitis
Clinical Study to Improve Diagnosis and Treatment of Sinusitis
Chronic rhinosinusitis (CRS) is the most common chronic medical condition that affects Americans between 18-44 years of age. While significant advances have been made in the understanding of the molecular pathogenesis underlying…
- Trial name
- NCT00962689
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Ohio State University
Chronic Sinusitis
Results of Endoscopic Sinus Surgery in Management of Ophthalmological Complications of Chronic Rhino Sinusitis
Investigate the clinical features of orbital complications of sinusitis in the Egyptian population, and observed that certain ophthalmological manifestations and outcomes were significantly associated with disease stage
- Trial name
- NCT04617223
- Testing
- Endoscopic sinus evacuation
- Where
- Egypt
- Volunteers
- 64 people
- Sponsor
- Tanta University
Chronic Sinusitis, Radiology
Research on Identifying and Treatment Prognosis of Chronic Rhinosinusitis Based on Image and Sequencing Data
This project focuses on researching chronic rhinosinusitis in patients, employing image processing techniques and molecular biology methods to jointly determine the research objectives: 1. Investigating heterogeneity. 2.
- Conditions
- Chronic Sinusitis, Radiology, Pathology, Surgery
- Trial name
- NCT05983003
- Testing
- endoscopic sinus surgery
- Where
- China
- Volunteers
- 3,500 people
- Sponsor
- Zheng Liu
Conscripts, Military Induction Board
Prevalence of ENT Diseseas
The aim of the present study will be to evaluate in conscripts at the military induction board the prevalence of rhinosinusitis, the prevalence of HPV vaccinations, the prevalence of hearing impairments and the prevalence of…
- Conditions
- Conscripts, Military Induction Board, ENT Disease, Rhinosinusitis Chronic
- Trial name
- PrENT (NCT06105346)
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Epistaxis, Nasal Obstruction
The Effect of Packing in Post Operative Management of FESS
Chronic sinusitis is a very common problem. The functional endoscopic sinus surgery is a prevalent option to treat this disease.During usage of different techniques of surgery, the need for packing after surgery is debatable…
- Conditions
- Epistaxis, Nasal Obstruction, Pain
- Trial name
- NCT00793117
- Testing
- packing
- Where
- Iran
- Volunteers
- 66 people
- Sponsor
- Tehran University of Medical Sciences
Pediatric Cancer, Chronic Sinusitis
Post-radiotherapy Rhinosinusitis in Children
Chronic rhinosinusitis (CRS) is a frequent complication of facial cancer treatment, mainly related to radiotherapy. However, while radiological involvement is frequent, clinical expression seems less important.
- Trial name
- PRRSC (NCT05454163)
- Testing
- SNOT 22 questionnaire
- Sponsor
- University Hospital, Lille
Chronic Rhinosinustis With Polyps
Ciclesonide vs Fluticasone Nasal Sprays in Nasal Poplyposis
This study is designed to compare ciclesonide nasal spray once daily with fluticasone propionate aquas nasal spray BD, which is commonly prescribed in patients with nasal polyposis, in order to relieve symptoms of these patients.
- Trial name
- NCT02665806
- Testing
- Ciclesonide, Fluticasone
- Volunteers
- 32 people
- Sponsor
- Tehran University of Medical Sciences
Postoperative Agitation: Impaired Awareness, Abnormal Cognitive Function, Confusion, and Verbal and Physical Agitation During Recovery From General Anesthesia, Deviated Nasal Septum
Anterior Ethmoidal Nerve Block in Prevention of Postoperative Agitation
Postoperative agitation is an important complication of general anesthesia, moreover, it has been found with high incidence in ear, nose, throat (ENT) surgeries.
- Conditions
- Postoperative Agitation: Impaired Awareness, Abnormal Cognitive Function, Confusion, and Verbal and Physical Agitation During Recovery From General Anesthesia, Deviated Nasal Septum, Chronic Rhinosinusitis (Diagnosis), Nasal Polyps
- Trial name
- NCT03427502
- Testing
- Bupivacaine-epinephrine, normal saline
- Where
- Nepal
- Volunteers
- 100 people
- Sponsor
- Lumbini Medical College
Chronic Rhinosinusitis
The Sinonasal Outcome Test - 22, Validated for Danish Patients
Introduction: Chronic rhinosinusitis (CRS) is a significant health problem increasing in both incidence and prevalence. It calls into attention consensus about diagnosing, assessing symptoms and treatment of patients with CRS.
- Trial name
- NCT01254916
- Where
- Denmark
- Volunteers
- 44 people
- Sponsor
- Odense University Hospital