Clinical trials: Root Canal
Root Canal Infection
Clinical and Radiographic Evaluation of the Synergistic Effect of Nano Silver Particles and Calcium Hydroxide Versus Triple Antibiotic Paste as Antibacterial Agents for Lesion Sterilization and Tissue Repair (LSTR) in Necrotic Primary Molars
Could the clinical and radiographic success of Nano Silver Particles and Calcium Hydroxide be comparable to that of Triple Antibiotic Paste as antibacterial agents for Lesion Sterilization and Tissue Repair (LSTR) in necrotic…
- Trial name
- NCT05681221
- Testing
- Nano silver particles and calcium hydroxide, TAP
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Cairo University
Antimicrobial Photodynamic Therapy
The Effect of Antimicrobial Photodynamic Therapy on the Success of Root Canal Treatment
The decontamination of the root canal system from pathological microflora is essential for the success of endodontic treatment. Mechanical instrumentation and irrigation solutions, known as the chemomechanical process, are…
- Trial name
- NCT06634745
- Testing
- Standard Needle Irrigation (SNI), Passive Ultrasonic Irrigation (PUI, EndoActivator (EA)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Root Canal Therapy
Novel Collagen Scaffold vs Conventional Scaffold in Regeneration of Human Dental Pulp Tissue
The purpose of this investigation is to assess the use of a novel scaffold (an FDA-approved collagen-hydroxyapatite material called Syn-Oss) for regeneration of pulp tissues versus the use of a traditional scaffold (blood clot).
- Trial name
- NCT03613090
- Testing
- Collagen-hydroxyapatite scaffold (Syn-Oss), Collagen Scaffold (Colla-Plug)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Apical Periodontitis
Accuracy of ERCLMDs in Teeth With Apical Periodontitis
The aim of this in vivo study is to evaluate the influence of apical periodontitis (AP) on the accuracy of Dentaport ZX, Raypex 5, and i-Root electronic root canal length measurement devices.
- Trial name
- ERCLMDs (NCT01904552)
- Testing
- Electronic Root Canal Length Measurement Device
- Where
- Iran
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Isfahan University of Medical Sciences
Pulpitis - Irreversible
Full Pulpotomy Versus Root Canal Treatment for Teeth With Symptomatic Irreversible Pulpitis
Background The European Society of Endodontology (ESE) and the American Association of Endodontists (AAE) position statements on the management of deep caries and exposed pulp recommended adoption and promotion of strategies…
- Trial name
- NCT06002698
- Testing
- Root canal treatment (Control), Full pulpotomy (Experimental)
- Where
- Malaysia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Malaya
Otomycosis
Efficacy and Safety Study of Miconazole Oil Versus Vehicle on Fungal Infection of the Ear Canal (Otomycosis)
This study involves two portions, a randomized, double-blind portion and an open-label portion, to evaluate the efficacy and safety of Miconazole oil 2% versus its Vehicle in the treatment of fungal infection of the outer ear…
- Trial name
- NCT04432376
- Testing
- miconazole 2% oil, vehicle oil
- Where
- 12 sites in United States
- Volunteers
- 382 people, healthy volunteers welcome
- Sponsor
- Hill Dermaceuticals, Inc.
Necrotic Pulp, Primary Teeth
Clinical and Radiographic Evaluation of Zinc Oxide Modified 3Mixtatin Versus Zical in Root Canal Treatment of Necrotic Primary Molars.
Primary molars with necrotic pulp or abscess are common unfortunate event faced in pediatric dentistry .The traditional treatment is either pulpectomy or extraction.
- Trial name
- NCT06752889
- Testing
- Group( 1): Control Group (pulpectomy using zic oxide eugenol based sealer Zical):, Group ( 2) Experimental group modified 3-MIX-TATIN):
- Where
- Egypt
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Postoperative Pain
Can the Different Instruments Used ın Root Canal Treatment Have an Effect on Postoperative Pain?
Root canal treatment is a treatment method in which the pulp is irreversibly infected due to caries or trauma or when the pulp loses its vitality.
- Trial name
- NCT05927025
- Testing
- Hand K-files
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Necmettin Erbakan University
Birth Injuries
The Effect of Primary Delivery of the Anterior Compared With the Posterior Shoulder on Perineal Trauma: a Randomized Controlled Trial
It is unknown if primary delivery of the anterior or the posterior shoulder causes less perineal tear. The objective of this trial is to evaluate the incidence and degree of perineal trauma after primary delivery of the anterior…
- Trial name
- NCT01937546
- Testing
- Primary delivery of anterior shoulder, Primary delivery posterior shoulder
- Where
- Denmark
- Volunteers
- 650 people, healthy volunteers welcome
- Sponsor
- Holbaek Sygehus
Pulpitis
Vital Pulp Therapy to Treat Irreversible Pulpitis
The purpose of this study is to demonstrate non-inferiority of pulpotomy treatment (with new endodontic bio-materials) as a new treatment with one-visit root canal therapy as reference treatment in pain relief and clinical and…
- Trial name
- VPT (NCT00748280)
- Testing
- One-visit root canal therapy, pulpotomy
- Where
- Iran
- Volunteers
- 615 people, healthy volunteers welcome
- Sponsor
- Shahid Beheshti University of Medical Sciences
Acute Irreversible Pulpitis With Apical Periodontitis
Ketorolac Irrigant on Post Operative Pain
Endodontic post-treatment pain management is one of the most challenging problems in the clinical practice of endodontics. Although this pain is decreased after root canal treatment, there may be residual symptoms due to…
- Trial name
- NCT04319549
- Testing
- Ketorolac Tromethamine irrigant, sodium hypochlorite irrigant
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Cairo University
Apical Periodontitis, Periapical Radiolucency
Comparative Evaluation of Clinical and Radiographic Treatment Outcomes of Garlic Gel and Calcium Hydroxide as an Intracanal Medicament in Nonsurgical Root Canal Treatment of Permanent Teeth.
Researchers want to check how well garlic works inside permanent teeth as a medicament during root canal treatments. Garlic has shown to possess many helpful properties, like reducing inflammation, helping wounds heal, and…
- Trial name
- NCT07289971
- Testing
- Allium Sativum as an intracanal medicament
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- University of Health Sciences Lahore
Peripheral Nerve Injuries
Prospective Comparison of Adductor Canal Block Performed With a Multiport Versus Single Bevel Needle
Early ambulation after knee replacement surgery is made possible in large part by providing safe and effective pain control. Peripheral nerve blocks are increasingly used for postoperative analgesia since they can provide…
- Trial name
- NCT02786888
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Utah
Root Canal Infection, Pain, Postoperative
Effect of Cryotherapy and LLLT on Postoperative Pain After Root Canal Treatment
The aim of this study is to evaluate the effect of low-level laser therapy (LLLT) and intracanal cryotherapy applications on postoperative pain in endodontic interventions of primary molar teeth with apical periodontitis.
- Conditions
- Root Canal Infection, Pain, Postoperative, Cryotherapy Effect, Laser
- Trial name
- NCT05476445
- Testing
- Control, Laser, Cryotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Root Canal
AI-Based Root Canal Length, Curvature, and Morphology Assessment Using CBCT
The primary aim of this study is to develop, evaluate, and validate a deep learning-based software system capable of generating automated, comprehensive clinical reports that detect, segment, and quantify root canal curvature…
- Trial name
- NCT07843992
- Testing
- AI-Based Deep Learning System for Root Canal Assessment
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- Cairo University
Chronic Apical Periodontitis, Pulp Necrosis
Clinical and Inflammatory Outcomes of Regenerative Endodontic Treatment Using Injectable Platelet-Rich Fibrin in Mature Necrotic Teeth With Chronic Apical Periodontitis.
This randomized clinical trial aims to compare regenerative endodontic treatment using injectable platelet-rich fibrin (i-PRF) with conventional root canal treatment in mature necrotic anterior teeth with chronic apical…
- Trial name
- REGEN-iPRF (NCT07913399)
- Testing
- Conventional Root Canal Treatment, Regenerative Endodontic Treatment with i-PRF, Injectable Platelet-Rich Fibrin (i-PRF)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Medipol University
Irreversible Pulpitis, Apical Periodontitis
Evaluation of iRoot SP as Root Canal Sealer: A Clinical Study
The purpose of this study was to evaluate the clinical and radiological outcomes of iRoot SP as a root canal sealer in comparison with AH Plus sealer within 1-year follow up.Patients needing root canal treatment were enrolled and…
- Trial name
- NCT02981693
- Testing
- Root canal sealer
- Volunteers
- 283 people, healthy volunteers welcome
- Sponsor
- Hui Chen
Root Canal Obturation, Root Canal Filling
Outcome of SBO With Calcium Silicate Sealer vs WVC With Resin Based Sealer
A single blinded randomized controlled trial. 212 subjects (teeth), 106 in each of the 2 groups will be recruited from the patients referred to Kuwait Board of Endodontics for primary root canal treatment.
- Conditions
- Root Canal Obturation, Root Canal Filling, Sealer-based Obturation, Randomized Clinical Trial
- Trial name
- NCT04753138
- Testing
- TotalFill Bioceramic Sealer, AH+ Sealer
- Where
- Kuwait
- Volunteers
- 212 people, healthy volunteers welcome
- Sponsor
- Kuwait Institute for Medical Specialization
Drug Effect
Evaluation of Antibacterial Effect of Allium Sativum, Calcium Hydroxide and Their Combination in Infected Mature Teeth
This study was to evaluate and compare garlic extract antibacterial effect when used as an intra-canal medicament in infected mature anterior teeth with calcium hydroxide and a mixture of calcium hydroxide and garlic, using real…
- Trial name
- Garlic (NCT05050071)
- Testing
- Allium Sativum, Polymerase chain reaction
- Where
- Egypt
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Suez Canal University
Root Canal Infection
Evaluation of Post Operative Pain in Retreatment of Molars Using Different Irrigant
This study evaluates the efficacy of dexamethasone as a intracanal irrigant along with sodium hypochlorite 1% and 5.25% concentrations in post treatment pain for molar root canal retreatment.
- Trial name
- NCT04250519
- Testing
- Sodium Hypochlorite
- Where
- India
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Tamil Nadu Dr.M.G.R.Medical University