Clinical trials: Root Canal Infection
Otomycosis
Comparative Efficacy of Topical Clotrimazole Versus 2% Salicylic Acid in Otomycosis
Otomycosis is a fungal infection of the outer ear canal that commonly causes itching, discomfort, discharge, and a feeling of blockage in the ear.
- Trial name
- NCT07535424
- Testing
- clotrimazole, 2% Salicylic Acid
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Mayo Hospital Lahore
Root Canal Infection
Radicular Dentin Remaining, Risk of Perforation and Canal Transportation in Manual Versus Rotary Instrumentation in Primary Molars
Background: Root canal preparation techniques using manual instruments have found to be time-consuming and may lead to iatrogenic errors such as ledging, zipping, canal transportation, and apical blockage.
- Trial name
- NCT04793308
- Testing
- Endodontic files
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cairo University
Root Canal Infection, Pain, Postoperative
Effect of Cryotherapy and LLLT on Postoperative Pain After Root Canal Treatment
The aim of this study is to evaluate the effect of low-level laser therapy (LLLT) and intracanal cryotherapy applications on postoperative pain in endodontic interventions of primary molar teeth with apical periodontitis.
- Conditions
- Root Canal Infection, Pain, Postoperative, Cryotherapy Effect, Laser
- Trial name
- NCT05476445
- Testing
- Control, Laser, Cryotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Irreversible Pulpitis
Effect of Temperature Elevation on the Antimicrobial Efficacy of Two Root Canal Irrigants in Primary Root Canal Infections: A Randomized Controlled Clinical Trial
evaluate the antimicrobial efficacy of preheated sodium hypochlorite and dexamethasone sodium phosphate and at room temperature in patients with primary root canal infection.
- Trial name
- NCT07906925
- Testing
- Dexamethasone Sodium Phosphate 10 MG/ML, Sodium Hypochlorite 2,5%
- Volunteers
- 40 people
- Sponsor
- Tanta University
Pulp Disease, Dental, Obturation
Clinical & Radiographic Evaluation of Zinc Oxide-Ozonated Oil as a New Primary Root Canal Filling
Preserving primary teeth is essential for many aspects such as the child's growth and development, esthetic, functional, psychological, and dental arch integrity aspects.
- Conditions
- Pulp Disease, Dental, Obturation, Root Canal Infection
- Trial name
- NCT05633537
- Testing
- pulpectomy procedure and the clinical evaluation, radiographic evaluation
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Tanta University
Otomycosis
Efficacy and Safety Study of Miconazole Oil Versus Vehicle on Fungal Infection of the Ear Canal (Otomycosis)
This study involves two portions, a randomized, double-blind portion and an open-label portion, to evaluate the efficacy and safety of Miconazole oil 2% versus its Vehicle in the treatment of fungal infection of the outer ear…
- Trial name
- NCT04432376
- Testing
- miconazole 2% oil, vehicle oil
- Where
- 12 sites in United States
- Volunteers
- 382 people, healthy volunteers welcome
- Sponsor
- Hill Dermaceuticals, Inc.
Root Canal Infection, Periapical; Infection
Bacteria Elimination in Retreatment Cases Using Different Disinfection Techniques
Nonsurgical root canal retreatment may become essential when the initial endodontic treatment fails because of the persistent intracanal or extracanal infections.It has been stated that the one of the main cause of posttreatment…
- Trial name
- NCT03750162
- Testing
- VDW Ultra, AMD picasso, ProtaperNext X3 gutta-percha
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Bulent Ecevit University
Apical Periodontitis, Root Canal Infection
Clinical Investigation of Chemomechanical Parameters for an Efficient Disinfection of the Root Canal
The aim of the study is first, to evaluate the clinical antibacterial efficacy of two different NaOCl concentrations (2,5% and 5%) under a predefined irrigant flow rate in teeth with pulp necrosis and apical periodontitis by…
- Trial name
- ENDOA (NCT06949176)
- Testing
- Root canal tratment using mecchanical and chemical preparation., Sodium Hypochlorite., Hydrogen peroxide.
- Where
- Greece
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- National and Kapodistrian University of Athens
Dental Caries, Pulp Necrosis
Moringa Oleifera vs Sodium Hypochlorite for Root Canal Irrigation in Nonvital Primary Molars
This randomized clinical trial aims to evaluate and compare the antimicrobial efficacy of Moringa Oleifera leaf extract versus sodium hypochlorite as root canal irrigants in pulpectomy of nonvital primary molars in pediatric…
- Conditions
- Dental Caries, Pulp Necrosis, Primary Tooth Pulpectomy, Pediatric Dentistry
- Trial name
- MORvNAOCL (NCT06971055)
- Testing
- Sodium hypochlorite, Moringa Oleifera Leaf Extract
- Where
- Egypt
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Cairo University
Periapical Periodontitis, Periapical Abscess
A Retrospective Cohort Study on the Non-Surgical Treatment of Periapical Inflammatory Lesions With Vitapex Paste
Background: Periapical inflammation is a common clinical condition, classified into periapical periodontitis, periapical granuloma, and periapical cyst.
- Conditions
- Periapical Periodontitis, Periapical Abscess, Periapical Radiolucency
- Trial name
- NCT07907367
- Testing
- Vitapex Paste
- Where
- China
- Volunteers
- 80 people
- Sponsor
- The Affiliated Hospital of Jinggangshan University
Endodontic Disease, Root Canal Infection
Comparison of Antibacterial Efficacy of Three Final Irrigants
This study was conducted to determine the antibacterial affect of three different solutions used as final irrigant during endodontic therapy.
- Trial name
- NCT03853200
- Testing
- QMix Root Canal Irrigant, 17%EDTA+2%Chlorhexidine, EDTA
- Where
- Pakistan
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Dow University of Health Sciences
Pulpitis - Irreversible, Pulp Necroses
Lesion Sterilization Tissue Repair and Conventional Pulpectomy in Primary Molars
The aim of this study was to compare the clinical and radiographic success of conventional root canal treatment and lesion sterilisation tissue repair methods in deciduous molars with necrotic or irreversible pulpitis.
- Conditions
- Pulpitis - Irreversible, Pulp Necroses, Root Canal Infection
- Trial name
- NCT06811636
- Testing
- Lesion sterilization and tissue repair, Conventional pulpectomy
- Where
- Turkey (Türkiye)
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Çanakkale Onsekiz Mart University
Root Canal Infection
Evaluation of Post Operative Pain in Retreatment of Molars Using Different Irrigant
This study evaluates the efficacy of dexamethasone as a intracanal irrigant along with sodium hypochlorite 1% and 5.25% concentrations in post treatment pain for molar root canal retreatment.
- Trial name
- NCT04250519
- Testing
- Sodium Hypochlorite
- Where
- India
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Tamil Nadu Dr.M.G.R.Medical University
Root Canal Infection, Periapical Abscess
Comparing Different Single and Combination Chelating Agents on Sealer Penetration and Dentin Erosion.
The basic aim of root canal treatment is to reduce the microbial content and prevent further recontamination in the canal. Every tooth has a variable, complex canal anatomy consisting of ramifications, accessory and lateral…
- Conditions
- Root Canal Infection, Periapical Abscess, Irreversible Pulpitis, Apical Periodontitis
- Trial name
- NCT05778227
- Testing
- Ethylene Diamine Tetra Acetic acid, smearOFF, Etidronic acid /sodium hypochlorite
- Where
- Pakistan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Dow University of Health Sciences
Dental Caries, Infection, Bacterial
Evaluation of Gel and Solution of Chlorhexidine in Disinfection Root Canals of Primary Anterior Teeth.
The process of removing bacteria and their products from the root canals is an essential step that is achieved through the combination of mechanical preparation and irrigation with chemicals.
- Conditions
- Dental Caries, Infection, Bacterial, Tooth, Deciduous
- Trial name
- NCT05361278
- Testing
- Chlorhexidine solution, Activated chlorhexidine solution, Chlorhexidine gel
- Where
- Syria
- Volunteers
- 15 people
- Sponsor
- Damascus University
Root Canal Infection
Clinical and Radiographic Evaluation of the Synergistic Effect of Nano Silver Particles and Calcium Hydroxide Versus Triple Antibiotic Paste as Antibacterial Agents for Lesion Sterilization and Tissue Repair (LSTR) in Necrotic Primary Molars
Could the clinical and radiographic success of Nano Silver Particles and Calcium Hydroxide be comparable to that of Triple Antibiotic Paste as antibacterial agents for Lesion Sterilization and Tissue Repair (LSTR) in necrotic…
- Trial name
- NCT05681221
- Testing
- Nano silver particles and calcium hydroxide, TAP
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Cairo University
Root Canal Infection
Evaluation of Post Operative Pain Following Reciprocating and Rotary Heat-treated NiTi Instrumentation of Root Canals: a Randomized Controlled Clinical Trial
The present clinical evaluation was planned for comparing the post-operative pain incidence in maxillary premolar teeth with acute irreversible pulpitis treated by recently introduced heat treated TruNatomy TM and other widely…
- Trial name
- NCT04655105
- Testing
- root canal rotary files
- Where
- India
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Tamil Nadu Dr.M.G.R.Medical University
Dentoalveolar Abscess
C-reactive Protein Levels in Acute Apical Abscess Due to Root Canal Infection
C-reactive protein levels of patients with acute apical abscess are evaluated before and after root canal treatment
- Trial name
- NCT04684407
- Testing
- ROOT CANAL TREATMENT
- Where
- India
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- CSI College of Dental Sciences and Research, Madurai
Periapical Diseases, Root Canal Infection
Comparing Efficacy of a Stainless-steel Rotary File with Two Nickel-titanium Systems on Periapical Lesion Healing
Background: This study used cone-beam computed tomography (CBCT) to compare a stainless-steel Tornado file system with OneShape and WaveOne rotary systems for biomechanical canal preparation as indicated by the healing of…
- Trial name
- NCT06752837
- Testing
- Tornado rotary system, WaveOne rotary system, OneShape rotary system
- Where
- 2 sites in Lebanon
- Volunteers
- 60 people
- Sponsor
- Beirut Arab University
Endodontic Disease, Periapical Diseases
Comparison of Clinical Outcomes Between GentleWave® and Biolase®
Introduction: In the US, 15 million root canal treatments (RCTs) are carried out annually. Success rates decrease with conventional chemo-mechanical root canal preparation techniques used on teeth with periapical radiolucencies…
- Conditions
- Endodontic Disease, Periapical Diseases, Periapical Periodontitis, Root Canal Infection
- Trial name
- NCT05555043
- Testing
- Irrisafe ip, GentleWave System, Waterlase iPlus
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill