Clinical trials: Rupture
Anterior Cruciate Ligament Tear
IL-1RA Treatment in Patients With Acute ACL Tear and Painful Effusions
Injury to the knee during sports participation often involves partial or full detachment of the anterior cruciate ligament (abbreviated as ACL). ACL tears cause pain, swelling and inflammation.
- Trial name
- EASI ACL (NCT02930122)
- Testing
- anakinra (150mg), Saline intraarticularly
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Cale Jacobs, PhD
ACL, ACL Injury
Acupuncture ACL (Anterior Cruciate Ligament)
Acupuncture research in regards to PONV has been fairly well established, however, studies about perioperative pain control and acupuncture are a little more murky.
- Conditions
- ACL, ACL Injury, Anterior Cruciate Ligament Injury, Anterior Cruciate Ligament Rupture
- Trial name
- NCT03711734
- Testing
- Acupuncture + Standard of Care
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hospital for Special Surgery, New York
Anterior Cruciate Ligament (ACL) Tear, Physical Therapy
The Effect of Various Strength Training Protocols in ACL Reconstructed Participants
The purpose of the study is to determine how two different blood flow restriction training programs used in conjunction with standard rehabilitation affect leg strength.
- Trial name
- NCT03364647
- Testing
- Arm A - blood flow restriction training, Arm B - standard of care
- Where
- 2 sites in United States
- Volunteers
- 55 people
- Sponsor
- Brian W. Noehren
Anterior Cruciate Ligament Rupture, Deficiency of Anterior Cruciate Ligament
Comparison of Three Methods for Anterior Cruciate Ligament Reconstruction
The purpose of this randomized clinical trial is to determine the difference in quality of life outcome at two years, in patients undergoing an Anterior Cruciate Ligament (ACL) reconstruction procedure with either a patellar…
- Conditions
- Anterior Cruciate Ligament Rupture, Deficiency of Anterior Cruciate Ligament, Chronic Instability of Knee, Anterior Cruciate Ligament Injury
- Trial name
- NCT00529958
- Testing
- Patellar Tendon, Hamstring Tendon, Double-Bundle
- Where
- Canada
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Rupture of Anterior Cruciate Ligament, Tear of Anterior Cruciate Ligament
Trial Evaluating Postop Pain and Muscle Strength Among Regional Anesthesia Techniques for Ambulatory ACL Reconstruction
Despite the apparent multifaceted benefit in differentiating blockade sites and duration of nerve blockade, the efficacy of continuous adductor canal blockade utilized specifically in ACL reconstruction has not been extensively…
- Trial name
- NCT02584452
- Testing
- Mepivacaine, adductor canal continuous nerve catheter, Normal Saline as bolus followed by bupivacaine
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- Vanderbilt University Medical Center
Pregnancy, Premature Rupture of Membranes
Cervical Ripening in Premature Rupture of Membranes
Premature rupture of membranes (PROM) is diagnosed by demonstrating amniotic fluid in the vaginal canal before the onset of labor.
- Conditions
- Pregnancy, Premature Rupture of Membranes, Preterm Premature Rupture of Membranes, Unfavorable Cervix
- Trial name
- NCT02314728
- Testing
- Misoprostol, Oxytocin
- Where
- United States
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Premature Rupture of Membranes
FOLCROM Trial: Foley Catheter in Rupture of Membranes
Multicenter randomized clinical trial comparing oxytocin versus oxytocin and foley catheter for induction in women who present with premature rupture of membranes who are not in labor.
- Trial name
- FOLCROM (NCT01973036)
- Testing
- Foley Catheter, Oxytocin
- Where
- 5 sites in United States
- Volunteers
- 201 people, healthy volunteers welcome
- Sponsor
- Geisinger Clinic
Intrauterine Devices
Study on Medical Records of Women Using an Intrauterine Device (IUD) to Analyze the Risks That the IUD Will be Expelled or Perforates the Womb in Relation to Breastfeeding, the Point in Time When the IUD Was Inserted After Childbirth and in Relation to Different Types of IUDs
Study to analyze electronic medical records of women using an intrauterine device (IUD). The study was required by the FDA for the marketed IUD Mirena (US Post-marketing requirement; short name of study: APEX IUD).
- Trial name
- APEX IUD (NCT03754556)
- Testing
- Intrauterine device
- Where
- 4 sites in United States
- Volunteers
- 326,658 people, healthy volunteers welcome
- Sponsor
- Bayer
White Blood Cells
Study of the Cell Response in the Tear Film After Overnight Contact Lens Wear
The purpose of this study was to count and analyze the white blood cells in tear samples collected from study participants following sleep.
- Trial name
- CORNWALL (NCT01379768)
- Testing
- Lotrafilcon A contact lens, Lotrafilcon B contact lens, Clear Care Cleaning and Disinfection Solution
- Where
- Canada
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- CIBA VISION
Blood Flow Restriction, ACL Tear
Blood Flow Restriction Training (BFR) in an Adolescent Population
While there are a number studies that have reported on the use of BFR in the adult population, there is limited information about the use of BFR in the adolescent population.
- Conditions
- Blood Flow Restriction, ACL Tear, ACL Injury
- Trial name
- NCT04285879
- Testing
- Blood Flow Restriction using Delfi Personalized Tourniquet System
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- Connecticut Children's Medical Center
Femoro Acetabular Impingement, Pain, Postoperative
Outcomes of CPM Usage Following Arthroscopic Acetabular Labral Repair
The purpose of this study is to measure whether CPM (continuous passive motion) usage improves outcomes following arthroscopic hip surgery that includes labral repair.
- Conditions
- Femoro Acetabular Impingement, Pain, Postoperative, Hip Labral Tear
- Trial name
- NCT03407612
- Testing
- Continuous Passive Motion
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Ohio State University
Anterior Cruciate Ligament (ACL) Tears
Early Treatment for Acute ACL Tear
This research study is the first of its kind and will allow health care professionals and researchers to answer many questions about the reasons why anterior cruciate ligament (ACL) injury leads to knee pain and disability and…
- Trial name
- AAA (NCT01692756)
- Testing
- Kenalog
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Cale Jacobs
Anterior Cruciate Ligament Tear, Anterior Cruciate Ligament Rupture
Effects of Platelet Rich Plasma Injections on Biomarkers After Anterior Cruciate Ligament Tears
A potential long-term consequence of anterior cruciate ligament injuries is the development of post-traumatic osteoarthritis in the years following injury.
- Trial name
- NCT04088227
- Testing
- Experimental Group, Control Group
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Andrews Research & Education Foundation
Meibomian Gland Dysfunction
Meibography and Tear Scan Using the Oculus Keratograph 4
The purpose of this study is to look at both the meibomian glands and the tear film using a new clinical instrument marketed in Canada which was recently acquired by the Centre for Contact Lens Research.
- Trial name
- KITCHENER (NCT01382108)
- Where
- Canada
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Waterloo
Osteoarthritis, Rotator Cuff Tear Arthropathy
Prediction of Development of Scapular Notching Following Reverse Total Shoulder Arthroplasty
The hypothesis is that computer simulated bony impingement of the bone surrounding the spherical glenoid implant (the glenosphere) along the scapular neck on three-dimensional (3-D) computed tomography (CT) imaging analysis is…
- Conditions
- Osteoarthritis, Rotator Cuff Tear Arthropathy, Reverse Total Shoulder Arthroplasty, Scapular Notching
- Trial name
- NCT02052466
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Eric Ricchetti
Anterior Cruciate Ligament Rupture
Initial Graft Tension and ACL Surgery
The anterior cruciate ligament (ACL) is one of four strong ligaments connecting the bones of the knee joint. If overstretched, the ACL can tear. Reconstruction of a torn ACL is now a common surgical procedure.
- Trial name
- NCT00434837
- Testing
- Initial graft tension during ACL reconstruction surgery
- Where
- 2 sites in United States
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- Rhode Island Hospital
Anterior Cruciate Ligament Tear
IPACK Versus Popliteal Sciatic Nerve Block in ACL Reconstruction
This is a prospective study comparing femoral nerve block plus sciatic nerve block to femoral nerve block plus infiltration of the posterior knee capsule (IPACK) in patients undergoing arthroscopic anterior cruciate ligament…
- Trial name
- NCT03983941
- Testing
- Ropivacaine injection
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Sujana Dontukurthy
Anterior Cruciate Ligament Rupture
Are Opioids Needed After ACL Reconstruction
As the public health sector continues to confront the opioid epidemic, orthopaedic surgeons must revisit pain management protocols to reduce unnecessary opioid prescriptions.
- Trial name
- NCT04285853
- Testing
- Oxycodone
- Where
- 3 sites in United States
- Volunteers
- 98 people
- Sponsor
- Emory University
Pregnancy Complications
Progesterone for the Management of Preterm, Premature Rupture of the Membranes: A Randomized Controlled Trial.
Preterm birth is the leading cause of neonatal death and a significant cause of life long disability and health problems. It has been shown that the drug 17-hydroxyprogesterone caproate can help reduce the risk of preterm…
- Trial name
- NCT01050647
- Testing
- 17-Hydroxyprogesterone Caproate, Caster Oil injections
- Where
- 2 sites in United States
- Volunteers
- 21 people
- Sponsor
- Stanford University
Anterior Cruciate Ligament Rupture
Blood Flow Restriction Following ACL Reconstruction
The main objective is to determine the impact of Blood Flow Restriction (BFR) therapy, in comparison to a standard rehabilitation protocol, on preventing atrophy, improving quadriceps strength and improving functional outcomes of…
- Trial name
- BFR (NCT03758755)
- Testing
- Blood Flow Restriction Therapy, ACL Reconstruction rehabilitation
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Inova Health Care Services