Clinical trials: SARS-CoV-2 Infections
HIV, Organ Transplantation
Bringing Optimised COVID-19 Vaccine Schedules To ImmunoCompromised Populations (BOOST-IC): an Adaptive Randomised Controlled Clinical Trial
Despite the greater risk of adverse COVID-19 outcomes, antibody and cell-mediated immune responses to COVID-19 vaccines vary amongst immunocompromised (IC) people and are poorly defined.
- Conditions
- HIV, Organ Transplantation, Lymphoma, Non-Hodgkin, Chronic Lymphocytic Leukemia
- Trial name
- BOOST-IC (NCT05556720)
- Testing
- Pfizer Bivalent COVID-19 Vaccine, Moderna Bivalent mRNA vaccine
- Where
- 13 sites in Australia
- Volunteers
- 960 people
- Sponsor
- Monash University
COVID 19
Surgical Management During the Era of COVID-19
In Lower middle-income countries (LMICs) like Pakistan with limited health care facilities the gravity of COVID 19 is severe. Effective management and implementation of processes and planning is imperative.
- Trial name
- NCT04911868
- Where
- Pakistan
- Volunteers
- 6,846 people
- Sponsor
- Aga Khan University
Myocarditis, Pediatric Inflammatory Multisystem Syndrome
Multiparametric Echocardiography and Cardiac Biomarkers in Pediatric Inflammatory Heart Diseases
Acquired inflammatory or infectious cardiac diseases, in pediatrics, include Kawasaki disease, myocarditis, and Covid-19-related Pediatric Multisystemic Inflammatory Syndrome (PIMS).
- Conditions
- Myocarditis, Pediatric Inflammatory Multisystem Syndrome, Kawasaki Disease
- Trial name
- NCT05911386
- Testing
- study of biological samples and echocardiographic data and link with need of hemodynamic support
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Central Hospital, Nancy, France
COVID-19 Pandemic
Research on Community Based ATK Test Study to Control Spread of COVID-19 in Migrant Community
Thousands of migrants from Myanmar have arrived in Thailand for their safety, better living standards and employment opportunities. They are often in Thailand illegally and have poor access to the Thai health care system.
- Trial name
- CATK (NCT05557513)
- Testing
- STANDARD Q COVID-19 Ag Test
- Where
- Thailand
- Volunteers
- 1,310 people, healthy volunteers welcome
- Sponsor
- University of Oxford
COVID-19
Colchicine Plus Phenolic Monoterpenes to Treat COVID-19
In this randomized controlled clinical trial, defined cases of COVID-19 with mild, moderate, or severe pneumonia (according to the NIH guideline) were treated with conventional treatment regimens (controls) as well as in…
- Trial name
- NCT04392141
- Testing
- Standard Treatment, Oral administration of Colchicine plus Herbal Phenolic Monoterpene Fractions
- Where
- Iran
- Volunteers
- 120 people
- Sponsor
- Kermanshah University of Medical Sciences
Mother-Child Interaction
Effects of Contact Restrictions During the COVID-19 Pandemic on Newborns and Their Parents
In the study, the researchers aim to investigate the impact of contact restrictions during the pandemic of coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on newborns…
- Trial name
- NCT04732702
- Testing
- no intervention
- Where
- Germany
- Volunteers
- 32 people
- Sponsor
- University of Cologne
Covid19
Transmission Dynamics of COVID-19 in a Rural Setting of the Democratic Republic of the Congo
A fixed cohort of adults in rural Kimpese will be followed up every two months since they are assumed to be at above average risk of contracting COVID-19.
- Trial name
- DynaCovid (NCT04701996)
- Testing
- serological surveillance
- Where
- Democratic Republic of the Congo
- Volunteers
- 1,709 people, healthy volunteers welcome
- Sponsor
- Institute of Tropical Medicine, Belgium
Newborn, Infant, Disease, Neurodevelopmental Disorders
Perinatal Covid-19 Infection, NO Pathway, and Minipuberty
Some evidence exists that SARS-COV-2 may infect pituitary axis, and therefore may alter hypothalamic function. Whether perinatal COVID-19 is associated with alterations in the maturation of the Hypothalamic-Pituitary-Gonadal…
- Trial name
- miniNO-COVID (NCT04952870)
- Testing
- Inhaled NO, routine care
- Where
- 2 sites in France, Greece
- Volunteers
- 180 people
- Sponsor
- University Hospital, Lille
Myocarditis, Myocarditis Acute
MYocarditis and/or Pericarditis Following mRNA COVID-19 VACCination National Surveillance Study
Myocarditis is inflammation of the heart muscle. Pericarditis is inflammation of the lining surrounding the heart muscle. Symptoms of these conditions can include pain in the chest and rapid or irregular heartbeat.
- Conditions
- Myocarditis, Myocarditis Acute, Pericarditis, Pericarditis Acute
- Trial name
- MYCOVACC (NCT06103123)
- Testing
- Stand of care ECG, Holter, MRI, ECHO, Quality of life questionnaire, Baseline Quality of Life questionnaire
- Where
- Canada
- Volunteers
- 500 people
- Sponsor
- Cardiology Research UBC
Covid-19, Cancer
Screening of Cancer Patients to Assess Impact of COVID-19
The purpose of this study is to investigate the impact of COVID -19 in the cancer patient population. This will be done by looking at the rate of asymptomatic COVID-19 infection in cancer patients receiving cancer therapy, as…
- Trial name
- NCT04373005
- Testing
- Nasopharyngeal (NP) swab
- Where
- Canada
- Volunteers
- 83 people
- Sponsor
- University Health Network, Toronto
COVID-19
Clinical Characteristics and Outcomes of 187 Critically Ill Patients With Coronavirus Disease 2019 (COVID-19)
This case series describes the clinical characteristics, treatment and outcomes of patients with laboratory confirmed COVID-19 admitted to a 35 beds intensive care unit of a tertiary hospital in Northeast Brazil.
- Trial name
- NCT04454372
- Testing
- demographic and clinical data obtained from hospital's electronic medical record.
- Where
- Brazil
- Volunteers
- 187 people
- Sponsor
- Hospital Sao Domingos
COVID-19
Drug Use Investigation of COMIRNATY Intramuscular Injection
Post-marketing study, Chotor study of COMIRNATY vaccenees followed for 11months. Serious adverse events and COVID-19 observed during the follow-up period will be collected, and the long-term safety of this product will be…
- Trial name
- NCT04815031
- Testing
- BNT162b2
- Where
- Japan
- Volunteers
- 14,570 people, healthy volunteers welcome
- Sponsor
- Pfizer
Coronavirus, Machine Learning
Clinical and Radiomic Model of COVID-19
To develop and validate a machine-learning model based on clinical, laboratory, and radiological characteristics alone or combination of COVID-19 patients to facilitate risk Assessment before and after symptoms and triage (home…
- Trial name
- NCT04337502
- Testing
- Machine learning model
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Maastricht University
Number of Patients During the Studying Period, Reason for Consultation
Conséquences of the COVID-19 Lockdown Measures on the CHRU Nancy Pediatric Emergency Services
The first period of COVID 19 Lockdown Measures (From 18 March to 11 may 2020) change the French people way of life and their medicine knowledges.
- Trial name
- NCT04668937
- Where
- France
- Volunteers
- 11,000 people
- Sponsor
- Central Hospital, Nancy, France
Speech Perception, Communication Barriers
The Effects of Operating Room COVID-19 Personal Protective Equipment on Speech Perception and Listening Effort
BACKGROUND: The aim of this study is to evaluate the effects of the combination surgical mask+N95 mask+face shield in operating room on speech perception and listening effort during the COVID-19 process.
- Conditions
- Speech Perception, Communication Barriers, Operating Rooms, Protective Devices
- Trial name
- NCT07505953
- Where
- Turkey (Türkiye)
- Volunteers
- 219 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
COVID-19, SARS-CoV-2 Infection
PERC Health Canada COVID-19
Although there are several licensed vaccines for SAR-CoV-2 (COVID-19) in Canada, none of them are approved for use in children under the age of 12, leaving five million children under 12 years unvaccinated.
- Trial name
- NCT05040763
- Testing
- Buccal Swabc- Copan flocked swab, Standard of Care COVID-19 swab
- Where
- 13 sites in Canada
- Volunteers
- 7,263 people
- Sponsor
- University of Calgary
Respiratory Tract Infections (RTI), Influenza -Like Illness
Virological Surveillance of Acute Respiratory Infection in Primary Health Care in Metropolitan France
Every year in the fall and winter, numerous respiratory viruses (such as influenza viruses, SARS-CoV-2 (COVID-19), RSV, rhinovirus, and metapneumovirus) circulate in mainland France, causing acute respiratory infections (ARIs).
- Conditions
- Respiratory Tract Infections (RTI), Influenza -Like Illness, Influenza, COVID - 19
- Trial name
- RS-viro IRA (NCT07599449)
- Testing
- saliva sampling, Nasopharyngeal swab
- Where
- France
- Volunteers
- 25,000 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Acute Respiratory Distress Syndrome, COVID-19 Pneumonia
Recruitment Assessment in Patients With Acute Respiratory Distress Syndrome and Covid-19
Respiratory failure associated with Covid-19 can be expressed as acute respiratory distress syndrome (ARDS), which is an acute inflammatory lung injury,which generally requires the use of invasive mechanical ventilation (MV).
- Conditions
- Acute Respiratory Distress Syndrome, COVID-19 Pneumonia, Recruitment
- Trial name
- NCT05248243
- Testing
- Recruitment assessment
- Where
- Argentina
- Volunteers
- 41 people
- Sponsor
- Ramos Mejía Hospital
ME/CFS, CFS/ME
Multi-Center Registry for ME/CFS
The ME/CFS study (MECFS-R) aims to create a large-scale registry that provides data on epidemiology, phenotypes, and disease trajectories of and health care for ME/CFS at any age in Germany, which can be used for future clinical…
- Conditions
- ME/CFS, CFS/ME, ME/CFS Following EBV-associated Infectious Mononucleosis, ME/CFS Following COVID-19
- Trial name
- MECFS-R (NCT05778006)
- Where
- Germany
- Volunteers
- 650 people
- Sponsor
- Technical University of Munich
Bacteremia, Catheter-Related Infections
Evaluation of Bacteremia Epidemiology During the COVID Period in One French University Hospital
The main objective of this retrospective cohort is to evaluate the impact of the first epidemic wave during lockdown on bacteremia epidemiology in one French University Hospital.
- Trial name
- NCT05640349
- Testing
- Positive blood culture
- Where
- France
- Volunteers
- 4,200 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
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