Clinical trials: SCS
Spina Bifida, Myelomeningocele
tSCS in Children With Spina Bifida
A single-center, open-label, investigational pilot trial to explore potential effects of transcutaneous spinal cord stimulation on leg muscle strength and walking in children with myelomeningocele.
- Trial name
- NCT07615686
- Testing
- Transcutaneous stimulator
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Bailey Petersen
Craniosynostosis
Osteogenic Profiling of Tissue From Children With Craniosynostosis
The primary objectives of this study are to procure human temporalis muscle, subcutaneous adipose (fat), and bone tissue samples from children with craniosynostosis, to grow cells from these tissues in vitro, to evaluate the…
- Trial name
- NCT00773643
- Testing
- biopsy
- Where
- 2 sites in United States
- Volunteers
- 29 people
- Sponsor
- University of Pittsburgh
Neurogenic Bowel, Spinal Cord Injuries (SCI)
Transcutaneous Spinal Cord Stimulation for Bowel Management in Individuals with Motor Complete Spinal Cord Injury
The primary goals of this pilot trial are to understand the feasibility and safety of thoracolumbar transcutaneous spinal cord stimulation for neurogenic bowel management in individuals with new onset, traumatic, cervicothoracic…
- Trial name
- NCT06801431
- Testing
- Transcutaneous spinal cord stimulation
- Volunteers
- 5 people
- Sponsor
- Nova Scotia Health Authority
Craniosynostosis
Child and Infant Learning Project
To learn more about the cognitive and motor development of infants and young children born with a craniofacial defect called craniosynostosis.
- Trial name
- CILP (NCT00077831)
- Testing
- neurobehavioral development
- Where
- 4 sites in United States
- Volunteers
- 535 people
- Sponsor
- Seattle Children's Hospital
Craniosynostoses
Neurodevelopmental Outcomes in Craniosynostosis Repair
Context: Craniosynostosis is a common craniofacial abnormality which can be associated with various clinical syndromes. Though it has been established that children with craniosynostosis score lower on certain developmental…
- Trial name
- NCT04072783
- Testing
- MRI,DTI, functional MRI
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Cerebral Palsy, Spasticity
Spinal Cord Stimulation for Children With Cerebral Palsy
The goal of this clinical trial is to help understand spinal cord excitability in children with cerebral palsy compared to neurologically typical children.
- Trial name
- NCT07516067
- Testing
- Transcutaneous Spinal Cord Stimulation (tSCS)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Martin Piazza
Craniosynostosis, Anesthesia
Influence of General Anesthesia on the Dynamic Changes in Brain Damage Markers During and After Craniosynostosis Operations in Infancy
The issue of anesthetics neurotoxicity is one of the most discussed topics in pediatric anesthesiology, thus it opens the question of the safety of commonly used anesthetics in the pediatric patient.
- Trial name
- TAnBrainDam (NCT05911139)
- Where
- Slovakia
- Volunteers
- 45 people
- Sponsor
- Comenius University
Neuromuscular Blocking Agents, Residual Neuromuscular Block
Measuring of the Duration of Action of Different Doses of Rocuronium-induced Neuromuscular Block in Infants During Surgical Treatment of Craniosynostosis
The use of intravenous muscle relaxants during anaesthesia can significantly facilitate endotracheal intubation and reduce the chance of possible airway complications during intubation.
- Conditions
- Neuromuscular Blocking Agents, Residual Neuromuscular Block, Neuromuscular Blockade Monitoring
- Trial name
- NCT07080528
- Testing
- Sevofluorane, Propofol
- Where
- Hungary
- Volunteers
- 20 people
- Sponsor
- Tamas Vegh, MD
Churg-Strauss Syndrome
CHUSPAN SCS BP Treatment of Churg-Strauss Syndrome Without Poor-Prognosis Factors
To assess the efficacy of systemic corticosteroids alone as first-line treatment of Churg-Strauss syndrome without poor-prognosis factors as defined by the five-factor score (FFS=0), and to compare the efficacy and safety of…
- Trial name
- NCT00399399
- Testing
- azathioprine, cyclophosphamide
- Where
- Switzerland
- Volunteers
- 72 people
- Sponsor
- Hospices Civils de Lyon
Craniosynostoses
Investigation of Anthropometric Properties of Babies With Craniosynostosis
Craniosynostosis is a malformation affecting the head and face, in which one or more sutures in the skull are fused prematurely.
- Trial name
- NCT04827524
- Testing
- Anthropometric measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Yuksek Ihtisas University
Craniosynostoses, Crouzon Syndrome
ASO Treatment for Syndromic Craniosynostoses
Syndromic craniosynostoses (SCS) are rare genetic disorders defined by premature cranial suture fusion, resulting in abnormal craniofacial development and constrained brain growth.
- Conditions
- Craniosynostoses, Crouzon Syndrome, Saethre Chotzen Syndrome, Muenke Syndrome
- Trial name
- NAUTILUS (NCT07535372)
- Testing
- Design of patient specific ASO
- Where
- Italy
- Volunteers
- 12 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Craniosynostosis, Muenke Syndrome
Clinical Study of Muenke Syndrome (FGFR3-Related Craniosynostosis)
This study will explore the range and type of medical and developmental problems in patients with Muenke syndrome, a condition that results when one or more of the suture between the bones of the skull close before birth.
- Trial name
- NCT00106977
- Where
- 2 sites in United States
- Volunteers
- 137 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
Chronic Pain Syndromes, CRPS
Neuro-Pain Provides a Dynamic and Interactive Register for the Invasvive Neuromodulatory Therapies for Different Chronic Pain Syndromes. Patients Living in Belgium and Suffering From Persistent Spinal Pain Syndromes Type 2 as Well as Suffering From Complex Regional Pain Syndromes Are Included.
Patients suffereing from chronic pain due to persistent spinal pain syndromes or complex regional pain syndromes and living in Belgium will be included in this register once they are being considered for a treatment with invasive…
- Trial name
- NCT06835868
- Testing
- Spinal cord stimulation
- Where
- Belgium
- Volunteers
- 7,000 people
- Sponsor
- University Hospital, Antwerp
Chronic Pain
Long-term Effectiveness, Safety, and Performance of the Evoke Closed-Loop SCS System to Treat Patients With Chronic Pain of the Trunk and/or Limbs
The objective of this multicountry, multicentre, prospective study is to evaluate the long-term clinical effectiveness, safety, and performance of the Evoke System in the treatment of chronic pain of the trunk and/or limbs in a…
- Trial name
- Domburg (NCT04627974)
- Testing
- Evoke Spinal Cord Stimulation (SCS) System
- Where
- 8 sites in Belgium, Germany and 2 more
- Volunteers
- 70 people
- Sponsor
- Saluda Medical Pty Ltd
Post Herpetic Neuralgia
Predictive Models for the Treatment of Recurrent Herpes Zoster Neuralgia Following Spinal Cord Electrical Stimulation.
Shingles is a neuropathic disease caused by varicella-herpes virus(VZV) invading nerves and accompanying pain.Currently, the treatment of postherpetic neuralgia (PHN) includes medication and minimally invasive interventional…
- Trial name
- NCT06410222
- Testing
- Recurrence after undergo spinal cord stimulation
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Feng Gao
Spinal Cord Injuries (SCI), Spinal Cord Injury
Clinical Testing of Invasive Spinal Cord Stimulation and Evaluation of Its Physiological Effects Using the Electroencephalography
The aim of the study is to identify the specific characteristics of brain network dysfunctions and assess the recovery of their functionality through the recording of resting-state electroencephalography (EEG) during…
- Trial name
- NCT06725836
- Testing
- Implantation of electrodes into the epidural space for spinal cord stimulation, Selection of the optimal spinal cord stimulation program for spastic syndrome suppression, Selection of the optimal spinal cord stimulation program for volitional motor control
- Where
- 3 sites in Russia
- Volunteers
- 35 people
- Sponsor
- Artur Biktimirov
Spinal Cord Injury Cervical, Spinal Cord Injury, Acute
Upper Limb Rehabilitation Using Non-invasive Spinal Cord Stimulation
The goal of this RCT study is to evaluate if combining activity-based therapy (ABT) with transcutaneous spinal cord stimulation (tSCS) can improve recovery of arm and hand movement in people with cervical spinal cord injury…
- Conditions
- Spinal Cord Injury Cervical, Spinal Cord Injury, Acute, Spinal Cord Injury (Quadraplegia)
- Trial name
- CIME_upperlimb (NCT07361627)
- Testing
- Protocol 2: Combination of activity-based therapy and facilitatory transcutaneous spinal cord stimulation
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Centre for Interdisciplinary Research in Rehabilitation of Greater Montreal
Sialorrhea, Spastic Cerebral Palsy (sCP)
Effect of SCS Technique on Oromotor Skills in Children With CP
This study evaluates the clinical efficacy of the Strain Counter-Strain (SCS) technique on improving oromotor functions in children with spastic cerebral palsy.
- Conditions
- Sialorrhea, Spastic Cerebral Palsy (sCP), Strain Counterstrain Technique, Oral Motor Functions
- Trial name
- NCT07516860
- Testing
- Strain Counter-Strain (SCS), Designed Oral Motor Program
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Cairo University
Spinal Cord Injuries (SCI), Spinal Cord Injury
Guttmann NeuroRecovery - Viability, Safety, and Efficacy of Intrathecal Wharton's Jelly Mesenchymal Stem Cells and Transcutaneous Spinal Cord Stimulation in Chronic Spinal Cord Injury Rehabilitation
This clinical trial primarily aims to evaluate the safety and feasibility of a combined therapeutic approach for chronic spinal cord injury (SCI).
- Conditions
- Spinal Cord Injuries (SCI), Spinal Cord Injury, Traumatic Spinal Cord Injuries, Spinal Cord Disease
- Trial name
- GNR-SCI-01 (NCT06981338)
- Testing
- Allogeneic Wharton's jelly mesenchymal stem cells (WJ-MSCs)
- Where
- Spain
- Volunteers
- 10 people
- Sponsor
- Institut Guttmann
Craniosynostosis Repair, Untethering of Cord
The Effect of Gender on the Consumption of Pain Medication in Infants Undergoing Craniosynostosis Repair or Untethering of Cord in ITU
Postoperative pain is a major concern in routine management of children admitted to pediatric intensive care treatment. There are significant negative physiological and psychological ramifications of postoperative pain such as…
- Trial name
- NCT01996163
- Volunteers
- 40 people
- Sponsor
- Tel-Aviv Sourasky Medical Center