Clinical trials: SLE
Systemic Lupus Erythematosus
Autoimmunity in Sisters of Lupus Patients
This study enrolled over 400 unaffected sisters of young women diagnosed with SLE. These unaffected sisters are being followed with an annual health questionnaire (CSQ) and blood sample.
- Trial name
- SisSLE (NCT01076101)
- Where
- United States
- Volunteers
- 817 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Lupus Nephritis
Obe-cel in Severe, Refractory Systemic Lupus Erythematosus (SLE) With Active Lupus Nephritis (LN)
The purpose of this trial is to evaluate the efficacy and safety of obecabtagene autoleucel (obe-cel) administered once following lymphodepletion in participants with severe, refractory systemic lupus erythematosus (SLE) and…
- Trial name
- LUMINA (NCT07053800)
- Testing
- Obecabtagene autoleucel
- Where
- 16 sites in United States, Brazil and 3 more
- Volunteers
- 35 people
- Sponsor
- Autolus Limited
Lupus Nephritis, Systemic Lupus Erythematosus (SLE)
Induction Therapy for Lupus Nephritis With no Added Oral Steroids: A Trial Comparing Oral Corticosteroids Plus Mycophenolate Mofetil (MMF) Versus Obinutuzumab and MMF
This is a randomised, open label, controlled non-inferiority phase III multicentre trial. As primary objective, the study aims to demonstrate that a regimen free of additional oral corticosteroids but with obinutuzumab (and MMF)…
- Trial name
- OBILUP (NCT04702256)
- Testing
- Obinutuzumab administration, Administration of Methylprednisolone + Prednisone + Mycophenolate mofetil, Administration of methylprednisolone, paracetamol and dexchlorpheniramine
- Where
- France
- Volunteers
- 196 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Anxiety Disorders, Anxiety State
Intergenerational Study of War-Affected Youth
War-related violence is a leading driver of mental disorders and illness affecting children in low- and middle-income countries (LMICs).
- Conditions
- Anxiety Disorders, Anxiety State, Depressive Disorder, Mood Disorders
- Trial name
- ISWAY (NCT06440460)
- Where
- Sierra Leone
- Volunteers
- 804 people
- Sponsor
- Boston College
Refractory Lupus Nephritis, Systemic Sclerosis
Umbilical Cord Blood CD19-BCMA CART Cell Therapy for SLE-LN, SSc, andpSS PAH.
This is a single-center, open-label, non-randomized, single-arm clinical trial. Patients with refractory lupus neritis (SLE-LN), systemic sclerosis (SSc), and primary Sjogren syndrome combined with pulmonary artery hypertension…
- Conditions
- Refractory Lupus Nephritis, Systemic Sclerosis, Primary Sjogren's Syndrome Combined With Pulmonary Hypertension
- Trial name
- NCT06947473
- Testing
- umbilical cord blood CD19-BCMA CAR-T cells infusion
- Where
- China
- Volunteers
- 45 people
- Sponsor
- Beijing GoBroad Hospital
Depression, Anxiety
Web-based CBT for Symptoms of Mild-to-Moderate Anxiety and Depression in Youth With Chronic Illness
Symptoms of anxiety and depression are common in adolescents and young adults with chronic illnesses and are associated with decreased adherence to medical regimens.
- Conditions
- Depression, Anxiety, Inflammatory Bowel Disease, Systemic Lupus Erythematosus
- Trial name
- NCT02453880
- Testing
- Web-based Cognitive Behavioral Therapy
- Volunteers
- 14 people
- Sponsor
- Stanford University
Systemic Lupus Erythematosus, Autoimmune Diseases
A Study of CD19/BCMA Chimeric Antigen Receptor T Cells Therapy for Patients With Refractory Systemic Lupus Erythematosus
A Study of CD19/BCMA Chimeric Antigen Receptor T Cells Therapy for Patients With Refractory Systemic Lupus Erythematosus
- Trial name
- NCT05030779
- Testing
- Assigned Interventions CD19/BCMA CAR T-cells
- Where
- China
- Volunteers
- 9 people
- Sponsor
- Zhejiang University
Ebola Disease
A Clinical Trial to Evaluate the Recombinant Human Type5 Adenovirus Vector Based Ebola Virus Disease Vaccine
A Single-Center, Randomized, Blind, Phase II Clinical Trial to Evaluate the Safety and Immunogenicity of the Adenovirus Type 5 Vector Based Ebola Virus Disease Vaccine (Ad5-EBOV) in Healthy Adults Aged Between 18 and 50 years in…
- Trial name
- NCT02575456
- Testing
- Ebola Vaccine
- Where
- Sierra Leone
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Jiangsu Province Centers for Disease Control and Prevention
Systemic Lupus Erythematosus
Evaluation of Janus Kinase_3 in Juvenile Onset Systemic Lupus Erythematosus
One of the best understood mechanisms by which cytokines activate signals, thus eliciting specific responses in target cells, involves enzymes such as Janus kinases (JAKs) and transcriptional factors such as signal transducers…
- Trial name
- NCT04293510
- Testing
- renal biopsy and blood sampling
- Volunteers
- 67 people
- Sponsor
- Assiut University
Antineutrophilic Cytoplasmic Antibody (ANCA)- Associated Vasculitis (AAV), Idiopathic Inflammatory Myositis (IIM)
A Phase 1 Study of FT819 in B-cell Mediated Autoimmune Disease
This is a phase 1 study designed to evaluate the safety, pharmacokinetics (PK), and anti-B-cell activity of FT819 following treatment with or without auxiliary medicinal product (AMP) in participants with moderate-to-severe…
- Conditions
- Antineutrophilic Cytoplasmic Antibody (ANCA)- Associated Vasculitis (AAV), Idiopathic Inflammatory Myositis (IIM), Systemic Sclerosis (SSc), Systemic Lupus Erythematosus (SLE)
- Trial name
- NCT06308978
- Testing
- FT819, Fludarabine, Cyclophosphamide
- Where
- 21 sites in United States, France and 2 more
- Volunteers
- 244 people
- Sponsor
- Fate Therapeutics
Systemic Lupus Erythematosus, Lupus Nephritis
Systemic Immune Inflammatory Index in Systemic Lupus Erythematosus
This study aims to investigate the association between the systemic immune-inflammation index and disease activity, as well as lupus nephritis in patients with systemic lupus erythematosus
- Trial name
- NCT06796569
- Testing
- systemic immune inflammatory index
- Where
- Egypt
- Volunteers
- 149 people, healthy volunteers welcome
- Sponsor
- Sohag University
Systemic Lupus Erythematosus
Phase I Study of Immune Ablation and CD34+ Peripheral Blood Stem Cell Support in Patients With Systemic Lupus Erythematosus
OBJECTIVES: I. Determine the safety of immune ablation with high-dose cyclophosphamide and anti-thymocyte globulin followed by peripheral blood stem cell support in patients with systemic lupus erythematosus.
- Trial name
- NCT00017641
- Testing
- anti-thymocyte globulin, cyclophosphamide, filgrastim
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Northwestern Memorial Hospital
Juvenile Systemic Lupus Erythematosus, Juvenile Dermatomyositis
Creatine Supplementation in Pediatric Rheumatology
Creatine supplementation may improve strength, muscle mass, bone mass and muscle function in healthy and elderly people. The investigators speculate that creatine supplementation could have therapeutic effects in pediatric…
- Trial name
- NCT01217320
- Testing
- creatine
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- University of Sao Paulo
Anxiety Disorder, Depressive Disorder
Sub-Trial of the Youth Readiness Intervention (YRI): Treatment of Control Group and Addition of Stress Biomarkers
This research is a continuation of the Youth Readiness Intervention (YRI) randomized clinical trial by adding additional pre and post intervention data collection upon treatment of the control group (N=222) with the intervention…
- Conditions
- Anxiety Disorder, Depressive Disorder, Social Problems, Stress, Psychological
- Trial name
- NCT02128568
- Testing
- Youth Readiness Intervention
- Where
- Sierra Leone
- Sponsor
- Harvard School of Public Health (HSPH)
Lupus Erythematosus, Systemic
Chinese Rheumatism Biobank(CRB)
Early prediction of major organ damage in SLE needs to dynamically track the evolution of SLE patients before and after the onset of major organ damage, and analyze the microscopic molecular evolution patterns synchronized with…
- Trial name
- NCT06887517
- Testing
- Antimalarial with or without oral glucocorticosteroid
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Chinese SLE Treatment And Research Group
Systemic Lupus Erythematosus
Efficacy and Safety of CD19 UCAR T Cells in Refractory Systemic Lupus Erythematosus
This is an investigator-initiated trial to evaluate the safety and efficacy of CD19 Universal CAR-T cells in the treatment of refractory systemic lupus erythematosus.
- Trial name
- SLE (NCT06691152)
- Testing
- CD19 Universal CAR-T cells
- Where
- China
- Volunteers
- 18 people
- Sponsor
- The Children's Hospital of Zhejiang University School of Medicine
Systemic Lupus Erythematosus
Genetic Study of Lupus Patients and Their Families
The purpose of this study is to perform genetic testing in and to collect information from families affected by lupus in order to identify the genetic factors associated with systemic lupus erythematosus (SLE).
- Trial name
- NCT00235378
- Where
- United States
- Volunteers
- 2,356 people, healthy volunteers welcome
- Sponsor
- Oklahoma Medical Research Foundation
Systemic Lupus Erythematosus
Biomarkers of Lupus Disease: Serial Biomarker Sampling in Patients With Active Systemic Lupus Erythematosus (SLE)
Hypothesis: A reason for repeated disappointing outcomes of clinical trials testing targeted immune biologics for lupus may be the heterogeneity of the disease, exacerbated by the variable effects on immune homeostasis of the…
- Trial name
- BOLD (NCT00987831)
- Testing
- Group B SLE one blood donation, Blood drawing only Group C, Group A SLE prospective study
- Where
- 2 sites in United States
- Volunteers
- 158 people, healthy volunteers welcome
- Sponsor
- Oklahoma Medical Research Foundation
Sickle Cell Disease, Chronic Kidney Diseases
Peer i-Coaching for Activated Self-Management Optimization in Adolescents and Young Adults With Chronic Conditions
The purpose of this study is to test the efficacy of a peer support coaching intervention to improve activated chronic illness self-management versus an attention control group in 225 adolescents and young adults with childhood…
- Conditions
- Sickle Cell Disease, Chronic Kidney Diseases, Systemic Lupus Erythematosus, Childhood Cancer
- Trial name
- PiCASO (NCT03938324)
- Testing
- PiCASO Intervention Group
- Where
- United States
- Volunteers
- 222 people
- Sponsor
- Duke University
Anxiety Disorder/Anxiety State, Depressive Disorder/Psychology
Adapting Mental Health Interventions for War-Affected Youth Through Employment Programs
The research will first examine data obtained from YRI participants to investigate effects of the group sessions on psychosocial functioning outcomes in youth aged 15 - 24.
- Conditions
- Anxiety Disorder/Anxiety State, Depressive Disorder/Psychology, Social Problems/Psychology, Violence, Non-accidental
- Trial name
- NCT02561949
- Testing
- YRI, Income generating activity program
- Where
- Sierra Leone
- Volunteers
- 80 people
- Sponsor
- Boston College