Clinical trials: SLE - Systemic Lupus Erythematosus
Systemic Lupus Erythematosus (SLE), Lupus Nephritis (LN)
A Phase IIa Study of ICG318 CAR-T in Refractory Systemic Lupus Erythematosus With or Without Lupus Nephritis
This Phase IIa, open-label, single-arm study includes an initial Safety Run-In followed by dose expansion to evaluate the safety, tolerability, cellular kinetics, pharmacodynamics, and preliminary clinical activity of a single…
- Trial name
- NCT07328581
- Testing
- ICG318, BCMA-CD19-IL-15/IL-15 sushi Compound CAR T following lymphodepletion
- Where
- 4 sites in United States
- Volunteers
- 20 people
- Sponsor
- iCell Gene Therapeutics
Systemic Lupus Erythematosus, Lupus Nephritis
A Study of CNTY-101 in Participants With Refractory B Cell-mediated Autoimmune Diseases
CALiPSO-1 is a Phase 1, multi-centre, dose-confirmation study to evaluate the safety and efficacy of CNTY-101 in participants with refractory B cell-mediated autoimmune diseases including those with moderate to severe systemic…
- Conditions
- Systemic Lupus Erythematosus, Lupus Nephritis, Idiopathic Inflammatory Myopathies, Diffuse Cutaneous Systemic Sclerosis
- Trial name
- CALiPSO-1 (NCT06255028)
- Testing
- CNTY-101, IL-2, Lymphodepleting Chemotherapy
- Where
- 6 sites in United States
- Volunteers
- 6 people
- Sponsor
- Century Therapeutics, Inc.
Systemic Lupus Erythematosus
REACT-01: Reversing Autoimmunity Through Cell Therapy
This is a phase 1, open-label, non-randomized study enrolling pediatric and young adult research participants with treatment-refractory Systemic Lupus Erythematosus (SLE), to examine the safety, feasibility, and efficacy of…
- Trial name
- NCT06465147
- Testing
- SCRI-CAR19v3
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Seattle Children's Hospital
CAR T Cell Therapy, Systemic Lupus Erythematosus
Study of BCMA/CD70 CAR-T Therapy for Refractory cSLE
This is an investigator-initiated trial aimed at assessing the safety and efficacy of anti-BCMA/CD70 CAR-T cells in the treatment of refractory systemic lupus erythematosus.
- Conditions
- CAR T Cell Therapy, Systemic Lupus Erythematosus, BCMA
- Trial name
- NCT06934447
- Testing
- anti-BCMA/CD70-CAR-T cells
- Where
- China
- Volunteers
- 18 people
- Sponsor
- The Children's Hospital of Zhejiang University School of Medicine
Systemic Lupus Erythematosus
Comparison Between Early-onset and Late-onset Patients With Systemic Lupus Erythematosus.
The present study aims to: Compare clinical features, hematological indices and disease activity between the early-onset and late-onset patients with systemic lupus erythematosus.
- Trial name
- NCT06294483
- Testing
- CBC, Antinuclear Antibody tests (ANA), Rest of ANA profile
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Sohag University
Systemic Lupus
Chemokine (CXCL13) as Anew Marker in Diagnosis of SLE
Systemic lupus erythematosus (SLE) is systemic autoimmune disease characterized by various immunological abnormalities, including dysregulated activation of both T and B lymphocytes with overt production of autoreactive…
- Trial name
- NCT03752983
- Testing
- blood samples
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Assiut University
Systemic Lupus Erythematosus, Idiopathic Juvenile Arthritis
Human Papilloma Virus Vaccination and Chronic Inflammatory Rheumatic Diseases.
Patients with chronic inflammatory rheumatic disease (CIR) are at increased risk for infections. Vaccination is a powerful tool to prevent infections, even in immunocompromised patients.
- Conditions
- Systemic Lupus Erythematosus, Idiopathic Juvenile Arthritis, Human Papilloma Virus
- Trial name
- HPV-CIR (NCT04180228)
- Testing
- self-administred questionnaire
- Where
- 3 sites in France
- Volunteers
- 76 people
- Sponsor
- Hospices Civils de Lyon
Systemic Lupus Erythematosus
Anti KU Antibodies and Its Relationship With Systemic Lupus Erythematosus
systemic lupus Erythematosus (SLE) is a multi system autoimmune disorder abroad spectrum of clinical presentations. Diagnosis of SLE depending on Systemic Lupus International Collaborating Clinics (SLICC) Criteria.
- Trial name
- NCT05900232
- Testing
- Anti _KU antibodies
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Sohag University
Systemic Lupus Erythematosus, Sjögren's Disease
Continued Access to Deucravacitinib for Adult SLE/SjD and Pediatric PsO/PsA Study Completers
This study is designed to provide treatment with deucravacitinib for participants with SLE/SjD (Systemic Lupus Erythematosus/Sjögren's Disease) and pediatric participants with PsO/PsA (Psoriasis/Psoriatic Arthritis) who have…
- Conditions
- Systemic Lupus Erythematosus, Sjögren's Disease, Psoriasis, Psoriatic Arthritis
- Trial name
- NCT07791199
- Testing
- Deucravacitinib
- Volunteers
- 2,300 people
- Sponsor
- Bristol-Myers Squibb
Peripheral Neuropathy, System; Lupus Erythematosus
Neuromuscular Ultrasonography Utility for Detection of Peripheral Neuropathy in Systemic Lupus Erythematosus
This study aims to evaluate the rule of NMUS in detection of peripheral neuropathy in SLE patient and to correlate it to traditional neurophysiological studies, clinical signs and activity of SLE.
- Trial name
- NCT04527172
- Testing
- neuromuscular ultrasound
- Where
- Egypt
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Assiut University
Rheumatoid Arthritis, Psoriatic Arthritis
Integration of Remote Monitoring in the Management of Chronic Immunosuppressive Therapy
Systemic autoimmune and chronic inflammatory diseases are a group of chronic illnesses whose treatment is usually very prolonged, often lifelong, and is essential to keep the disease under control, thus reducing the risk of…
- Conditions
- Rheumatoid Arthritis, Psoriatic Arthritis, Systemic Lupus Erythematosus, Systemic Sclerosis
- Trial name
- TEMPLATE (NCT06544343)
- Testing
- Remote Monitoring, On site monitoring
- Where
- Italy
- Volunteers
- 190 people
- Sponsor
- University Of Perugia
Systemic Lupus Erythematosus (SLE), Lupus Nephritis (LN)
The Efficacy and Safety of Biologics (Belimumab/ Telitacicept) Induction Therapy in Proliferative Lupus Nephritis Patients for 6 Months Compared With Mycophenolate Mofetil Treatment
1. Study Design This is a single-center, prospective, randomized, controlled, exploratory clinical trial. The study is designed to evaluate and compare the efficacy and safety of two biologic-based induction regimens against…
- Trial name
- NCT07340463
- Testing
- Glucocorticoids, belimumab, Telitacicept
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Nanjing University School of Medicine
Childhood-onset Systemic Lupus Erythematosus
Immune Profiling of Refractory cSLE Exposed to CD3×CD19 BiTE
This prospective observational study aims to characterize the peripheral immune landscape of pediatric patients with childhood-onset systemic lupus erythematosus ( cSLE) who are receiving CD3×CD19 bispecific T-cell engager (BiTE)…
- Trial name
- BiTE-cSLE-IP (NCT07352332)
- Where
- China
- Volunteers
- 6 people
- Sponsor
- The Children's Hospital of Zhejiang University School of Medicine
Lupus Erythematosus, Systemic
Achievement of LLDAS5 in Patients With Systemic Lupus Erythematosus Treated With Anifrolumab.
This is an observational, multicenter, prospective study on patients with systemic lupus erythematosus treated with anifrolumab in Italy aimed at evaluating the achievement of LLDAS5
- Trial name
- DAHLIA (NCT07330245)
- Testing
- Anifrolumab
- Where
- 22 sites in Italy
- Volunteers
- 218 people
- Sponsor
- AstraZeneca
Systemic Lupus Erythematosus
Web-based Genetic Research on Lupus
The goal of this new lupus research study is two-fold: first, to understand the genetic associations found between people's DNA and this disease, and second, to apply this understanding to drug development efforts with the…
- Trial name
- NCT02530944
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- 23andMe, Inc.
Systemic Lupus Erythematosus, Autoimmune Diseases
A Study of CD19/BCMA Chimeric Antigen Receptor T Cells Therapy for Patients With Refractory Systemic Lupus Erythematosus
A Study of CD19/BCMA Chimeric Antigen Receptor T Cells Therapy for Patients With Refractory Systemic Lupus Erythematosus
- Trial name
- NCT05030779
- Testing
- Assigned Interventions CD19/BCMA CAR T-cells
- Where
- China
- Volunteers
- 9 people
- Sponsor
- Zhejiang University
Nephrotic Syndrome, Systemic Lupus Erythematosus
Drug Therapy in Lupus Nephropathy
Studies have shown that up to 26% of patients with systemic lupus erythematoses nephritis may suffer from membranous lupus nephropathy.
- Trial name
- NCT00001212
- Testing
- prednisone, cyclophosphamide, cyclosporin A
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Lupus Erythematosus, Systemic
Study to Evaluate the Natural History of Osteoporosis in Children and Adolescents With Systemic Lupus Erythematosus
This is a study to determine if people with Lupus have weak bones. Test which is a better method for detecting bone changes: Dual energy X-ray absorptiometry (DXA) Single energy quantitative computed tomography (SEQCT) Evaluate…
- Trial name
- BMD (NCT00582465)
- Where
- United States
- Volunteers
- 243 people
- Sponsor
- University of California, San Francisco
Rheumatic Diseases, Arthritis
Pain-Sleep in Rheumatic Disease
Overall, our understanding of how pain and sleep are experienced and how they can be treated in teenagers with rheumatic diseases is limited.
- Conditions
- Rheumatic Diseases, Arthritis, Lupus, Lupus Arthritis, Systemic Lupus Erythematosus
- Trial name
- NCT07775612
- Testing
- Better Nights, Better Days for Youth
- Volunteers
- 43 people
- Sponsor
- The Hospital for Sick Children
Systemic Lupus Erythematosus
Neuropsycatric Disorders Among Children With Systemic Lupus Erythematosus in Sohag University Hospital
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease involving multiple organs, characterized by the production of autoantibodies and the development of tissue injury.
- Trial name
- NCT06449794
- Testing
- Anti Phospholipid antibodies, EEG
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Sohag University