Clinical trials: ST-segment Elevation Myocardial Infarction
STEMI
Follow up of Clinical Outcome of Deferred vs Immediate Stenting in High Thrombus Stemi Patients
To compare the effect of immediate stenting versus deferred stenting - with use of glycoproteinIIbIIIa inhibitor \& low molecular weight heparin - on the clinical outcome -3 and 6 months after stenting \& also infarct size using…
- Trial name
- NCT05793671
- Testing
- PPCI in heavy thrombus burden STEMI patients
- Volunteers
- 440 people
- Sponsor
- Assiut University
Stable Angina, Unstable Angina
International Collaboration of Comprehensive Physiologic Assessment
The current study evaluated prognostic implication of comprehensive physiologic assessment using fractional flow reserve, coronary flow reserve (CFR) and index of microcirculatory resistance (IMR).
- Conditions
- Stable Angina, Unstable Angina, Non-ST Elevation Myocardial Infarction, ST-segment Elevation Myocardial Infarction
- Trial name
- NCT03690713
- Testing
- Fractional flow reserve, coronary flow reserve, and index of microcirculatory resistance
- Where
- 4 sites in Japan, South Korea and 1 more
- Volunteers
- 1,397 people
- Sponsor
- Seoul National University Hospital
ST Elevation Myocardial Infarction
Impact of Glycemic State on Patients ST Elevation Myocardial Infarction With Primary Percutaneous Coronary Angioplasty
ST-elevation myocardial infarction is a major cause of morbidity and mortality worldwide. ST-elevation myocardial infarction damages the regional myocardium that undergoes ischemia and necrosis, resulting in impairment of both…
- Trial name
- NCT03266978
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Assiut University
ST Segment Elevation Myocardial Infarction
ST Segment Resolution After Primary Percutaneous Coronary Intervention.
To compare the ST segment resolution after primary percutaneous coronary intervention (PPCI) with and without thrombus aspiration in patients with ST segment elevation myocardial infarction as ST segment resolution is the best…
- Trial name
- STresolution (NCT03895983)
- Testing
- Percutaneous primary coronary intervention
- Volunteers
- 270 people
- Sponsor
- Assiut University
Myocardial Infarction
Early Percutaneous Coronary Intervention (PCI) After Fibrinolysis Versus Standard Therapy in ST Segment Elevation Myocardial Infarction (STEMI) Patients
Several recent trials (1,2) suggest that all STEMI patients receiving fibrinolysis in non-PCI centres should be routinely transferred for elective early PCI within 24 hours from hospitalization, with no additive risk of major…
- Trial name
- NCT01014182
- Where
- United Kingdom
- Volunteers
- 3,000 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
MINOCA, STEMI
Retinal OCTA for Microvascular Dysfunction Evaluation and Outcome Prediction in MINOCA Patients
The aim of this study is to evaluate microvascular dysfunction through OCTA in MINOCA patients. In order to better understand the condition, OCTA will also be performed in two matched patient groups: healthy controls and ACS…
- Conditions
- MINOCA, STEMI, Normal
- Trial name
- REVEAL (NCT07055152)
- Where
- Italy
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Pisa
Myocardial Infarction
A Clinical Evaluation of Everolimus Eluting Coronary Stents in the Treatment of Patients With ST-segment Elevation Myocardial Infarction: EXAMINATION Study
This study is a prospective, randomized controlled, single blind, two-arm, multi center clinical evaluation. A total of 1500 patients will be enrolled in the study.
- Trial name
- NCT00828087
- Testing
- Everolimus Eluting Coronary Stent System, cobalt chromium balloon expandable stent ( non drug eluting stent Arm)
- Where
- 11 sites in Italy, Netherlands and 1 more
- Volunteers
- 1,504 people
- Sponsor
- Spanish Society of Cardiology
Stable Angina, Unstable Angina
Harmonizing Optimal Strategy for Treatment of Coronary Artery Stenosis - Coronary Intervention With Next Generation Drug-Eluting Stent Platforms and Abbreviated Dual Antiplatelet Therapy (HOST-IDEA) Trial
We had little experience in coronary intervention with recently introduced newer drug-eluting stent (DES) platforms, despite great anticipation, and optimal duration of dual antiplatelet therapy (DAPT) for these stent systems…
- Conditions
- Stable Angina, Unstable Angina, Non-ST Segment Elevation Myocardial Infarction
- Trial name
- HOST-IDEA (NCT02601157)
- Testing
- 3-months DAPT, 1-year DAPT
- Where
- 12 sites in South Korea
- Volunteers
- 2,173 people
- Sponsor
- Seoul National University Hospital
ST Segment Elevation Myocardial Infarction
DANish Study of Optimal Acute Treatment of Patients With ST-elevation Myocardial Infarction
This study focuses on Cardioprotective strategies.
- Trial name
- DANAMI-3 (NCT01435408)
- Testing
- Conventional primary PCI, Ischemic postconditioning., Deferred stenting in primary PCI.
- Where
- 5 sites in Denmark
- Volunteers
- 2,000 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
ST Elevated Myocardial Infarction Undergoing Mechanical Reperfusion
Primary Angioplasty for STEMI During COVID-19 Pandemic (ISACS-STEMI COVID-19) Registry
The ISACS STEMI COVID-19 has been established in response to the emerging outbreak of COVID-19 to provide a European overview to estimate the real impact of COVID-19 pandemic on treatment and outcome of STEMI by primary…
- Trial name
- ISACS-STEMI (NCT04412655)
- Testing
- Percutaneous Coronary Revascularization for STEMI
- Where
- Italy
- Volunteers
- 6,609 people
- Sponsor
- Università degli Studi del Piemonte Orientale Amedeo Avogadro
Myocardial Infarction
Diagnostic and Prognostic Utility of Pentraxin 3 in Patients With Acute STEMI Undergoing Primary PCI
A number of inflammatory markers have been recognized, among which the acute phase reactant C-reactive protein showed a positive correlation with the risk of coronary artery disease in both healthy individuals and those at high…
- Trial name
- NCT03476252
- Testing
- pentraxin 3
- Volunteers
- 100 people
- Sponsor
- Assiut University
Myocardial Infarction, No Reflow Phenomenon
Validation of New Biomarkers for Predicting No-Reflow in STEMI Patients Undergoing Primary PCI
To evaluate the diagnostic value of the selected emerging biomarkers in predicting the no-reflow phenomenon among patients presenting with STEMI undergoing primary PCI.
- Trial name
- VaBiNoR (NCT07132489)
- Testing
- HbA1c/C-peptide ratio Albumin-bilirubin (ALBI) score. Neutrophil/HDL ratio
- Volunteers
- 114 people
- Sponsor
- Assiut University
STEMI - ST Elevation Myocardial Infarction, Glucagon-like Peptide-1
Plasma Glucagon-like Peptide-1 Levels and In-hospital Complications in ST-segment Elevation Myocardial Infarction
Glucagon-like peptide-1 (GLP-1), produced mainly in enteroendocrine cells, participates in energy homeostasis and glucose metabolism by regulating islet hormone secretion, gastrointestinal motility, and food intake, making GLP-1…
- Conditions
- STEMI - ST Elevation Myocardial Infarction, Glucagon-like Peptide-1, Bleeding, Complications
- Trial name
- NCT03314844
- Volunteers
- 564 people
- Sponsor
- Chinese PLA General Hospital
Familial Hypercholesterolemia
Familial Hypercolerstremia as Risk Factor in Stemi Patient Who Underwent Ppci
Famulial hypercolerstremia as risk factor
- Trial name
- NCT03900169
- Testing
- Genetic
- Where
- Egypt
- Volunteers
- 2 people
- Sponsor
- Assiut University
ST Segment Elevation Myocardial Infarction
China STEMI-PCI Program
1. Registration 2. Performing in three stages 3. Major aim: Much more and standard reperfusion therapy in STEMI patients
- Trial name
- NCT01716884
- Where
- China
- Volunteers
- 4,000 people
- Sponsor
- Peking University First Hospital
STEMI - ST Elevation Myocardial Infarction, Reperfusion Injury, Myocardial
Combination With Treg Levels and CMR to Assess the Severity and Prognosis of Reperfusion Injury After PPCI in STEMI Patients
This study aims to determine whether combination with regulatory T cell (Treg) levels and cardiac magnetic resonance imaging (CMR) are predictive of the severity of reperfusion injury following myocardial infarction and the…
- Trial name
- TregCMRRS (NCT03939338)
- Testing
- Treg levels and CMR results
- Where
- China
- Volunteers
- 250 people
- Sponsor
- Beijing Friendship Hospital
Myocardial Infarction
A Structuralised Sick-leave Program Compared to Usual Care Sick Leave Management in Patients After an Acute Myocardial Infarction
In this study the investigators aim at comparing the effect on quality of life and the cost-effectiveness of a structuralised sick-leave program compared to usual care sick leave management in patients after an acute non ST…
- Trial name
- NCT01108653
- Testing
- Usual care sick-leave management, Structuralised sick-leave program
- Where
- Norway
- Volunteers
- 120 people
- Sponsor
- Oslo University Hospital
Coronary Thrombosis
In-hospital Clinical Outcome of Deferred Stenting Versus Immediate Stenting in the Management of Acute STEMI Presenting With High Thrombus Burden.
To compare the in hospital clinical outcomes in terms of efficacy and safety of deferred stenting versus non-deferred stenting in STEMI patients with high thrombus burden undergoing primary percutaneous intervention.
- Trial name
- NCT05647018
- Testing
- Primary Percutaneous coronary angiography
- Volunteers
- 440 people
- Sponsor
- Assiut University
Non ST Elevation Acute Coronary Syndromes, Stable Coronary Syndromes
Appropriateness of Coronary Angioplasty in PAtients With isCHEmic Heart Disease
An observational, retrospective, multicenter, blinded adjudication study to evaluate the clinical appropriateness of Percutaneous Coronary Intervention (PCI) indication and execution in patients with stable Coronary Artery…
- Conditions
- Non ST Elevation Acute Coronary Syndromes, Stable Coronary Syndromes, NSTEMI, Unstable Angina
- Trial name
- APACHE (NCT02748603)
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- Italian Society of Invasive Cardiology
Acute Myocardial Infarction
Efficacy and Safety of Prehospital Administration of Bivalirudin in STEMI Patients
The purpose of this study is to describe the efficacy and safety of prehospital administration of bivalirudin, as a substitute for heparin, in patients with acute myocardial infarction redirected for primary angioplasty bypassing…
- Trial name
- NCT00391326
- Where
- 2 sites in Denmark
- Volunteers
- 102 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet