Clinical trials: Saline
Cystic Fibrosis
Effect of Hypertonic Saline on Mucus Clearance in Children Ages 5-12 With Cystic Fibrosis
Previous work demonstrated that inhaled hypertonic saline (HS) reduces exacerbation frequency and improves lung function in adults with cystic fibrosis (CF).
- Trial name
- NCT01031706
- Testing
- Hypertonic Saline
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of North Carolina, Chapel Hill
Trauma
Trial Of Normal Saline Versus Ringer's Lactate In Paediatric Trauma Patients
Background: Trauma is a major cause of death in children and teenagers. When young patients have suffered major traumatic injuries, they require intravenous (iv) fluids to keep their blood vessels full and ensure blood flow to…
- Trial name
- NCT01692769
- Testing
- Normal Saline, Ringer's Lactate
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Wound Heal
The Efficacy of Hyaluronic Acid and Honey in Healing of Multiple Extraction Sockets of Primary Teeth Compared to Saline
This study aims to evaluate the effect of hyaluronic acid and honey compared to saline in healing of multiple extraction sockets of primary teeth in a group of children aging from Two to Seven years old.
- Trial name
- NCT05161403
- Testing
- Hyaluronic acid, honey
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Cairo University
Acute Bronchiolitis Due to Respiratory Syncytial Virus
Comparative Efficacy of Hypertonic Saline vs Adrenaline Nebulization in Acute Bronchiolitis
The goal of this clinical trial is to compare the efficacy of hypertonic saline nebulization with adrenaline nebulization in the treatment of acute bronchiolitis in children.
- Trial name
- children (NCT06267118)
- Testing
- Hypertonic Saline Solution, 1 Ml, Adrenaline
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Combined Military Hospital, Pakistan
Labor Pain
Combined Spinal/Epidural (CSE) Saline Duration/Spread
An attempt is being made to see if by injecting a set volume of sterile saline into the epidural space during the treatment of labor pain with a combined spinal/epidural (CSE) increases the amount of pain relief obtained and…
- Trial name
- NCT01062893
- Testing
- Sterile normal saline 0 mls, 15 mls sterile normal saline
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- Wake Forest University Health Sciences
Bronchiolitis
Nasal Irrigation in Infants With Bronchiolitis.
Bronchiolitis is a leading cause of acute illness and hospitalization in the first year of life. Most children with bronchiolitis have mild disease and are managed at home with support from primary care providers, while children…
- Trial name
- NCT02162745
- Testing
- Isotonic solution (NaCl 0.9%), Hypertonic solution (NaCl 3%)
- Where
- 2 sites in Italy
- Volunteers
- 133 people
- Sponsor
- IRCCS Burlo Garofolo
Asthma
Nebulized Magnesium Sulfate in Children With Moderate to Severe Asthma Exacerbation
The purpose of this study is to evaluate the effectiveness of nebulized magnesium sulfate as a vehicle for albuterol in children with moderate to severe asthma exacerbation.
- Trial name
- NCT01515995
- Testing
- Nebulized magnesium sulfate
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Texas Southwestern Medical Center
Acute Bronchiolitis
7% Hypertonic Saline for Acute Bronchiolitis
Research suggests that hypertonic saline may improve mucous flow in infants with acute bronchiolitis. Data suggest a trend favoring reduced length of hospital stay and improved pulmonary scores with increasing concentration of…
- Trial name
- HS (NCT01871857)
- Testing
- Hypertonic saline and epinephrine, Normal saline and epinephrine
- Where
- United States
- Volunteers
- 101 people
- Sponsor
- Le Bonheur Children's Hospital
Post-operative Pain, Vital Pulp Therapy
Compare the Impact of Sodium Hypochlorite and Saline Irrigation Protocols With and Without Cryotherapy on Post-operative Pain Following Pulpotomy in Permanent Mandibular Molar Teeth.
The aim of the present study will compare the impact of sodium hypochlorite and saline irrigation protocols with and without cryotherapy on post-operative pain following pulpotomy in permanent mandibular molar teeth.Will the use…
- Trial name
- NaOCl/VPT/MTA (NCT07764666)
- Testing
- VPT /pulpotomy, VPT/complete pulpotomy, vital pulp therapy /complete pulpotomy
- Where
- Egypt
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Abdelrahman Refaat Khalaf Ahmed
Bronchiolitis
Effectiveness of Nebulized Hypertonic Saline and Epinephrine in Hospitalized Infants With Bronchiolitis
Acute bronchiolitis is the main cause for respiratory illness that requires hospitalization in children younger than 2 years. In the United States it has been shown that the burden of the disease is considerable, having an annual…
- Trial name
- NCT01300325
- Testing
- 3% hypertonic saline solution
- Where
- Italy
- Volunteers
- 136 people
- Sponsor
- Federico II University
Scoliosis Idiopathic, Scoliosis;Congenital
Hypertonic Saline in Posterior Spinal Fusion
This is a prospective, randomized study in patients greater than or equal to 10 years of age scheduled for an posterior spinal fusion that requires invasive monitoring of arterial blood pressure.
- Trial name
- NCT06822374
- Testing
- Normosol-R, buffered 2% hypertonic saline
- Where
- United States
- Sponsor
- Joseph D. Tobias
Neonatal Respiratory Failure
Normal Saline Nebulization on Prevention of Extubation Failure in Neonates
this study is about evaluating the effect of using normal saline nebulization in preventing re-intubation in extubated neonates , provided that the cause of intubation is mainly due to respiratory cause
- Trial name
- NCT05194761
- Testing
- Normal saline
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Cirrhosis, Ascites
Acute Hemodynamics of Albumin Versus Normal Saline in Cirrhosis
Cirrhosis is frequently complicated by derangement of body fluid homeostasis resulting in accumulation of large amounts of extracellular fluid in the peritoneal cavity (ascites) and interstitial tissue (edema).
- Trial name
- NCT00511394
- Testing
- 20% Human Albumin, Normal Saline
- Where
- India
- Volunteers
- 16 people
- Sponsor
- Govind Ballabh Pant Hospital
Acute Viral Bronchiolitis
Efficacy of 3% Hypertonic Saline in Acute Viral Bronchiolitis
The purpose of this study is to determine whether nebulized hypertonic saline solution reduces the admission rate 48 hours after initial treatment in the emergency department, when compared to normal saline solution (control).
- Trial name
- GUERANDE (NCT01777347)
- Testing
- 3% Saline, 0.9% Normal Saline
- Where
- 21 sites in France
- Volunteers
- 778 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Gastroenteritis Acute, Dehydration
Balanced Crystalloid vs Normal Saline in Pediatric Acute Gastroenteritis
Acute gastroenteritis (AGE) is among the most common reasons for paediatric emergency visits. Children with significant dehydration often require intravenous (IV) fluid therapy.
- Conditions
- Gastroenteritis Acute, Dehydration, Acidosis, Metabolic, Diarrhea
- Trial name
- NCT07610382
- Where
- Turkey (Türkiye)
- Volunteers
- 180 people
- Sponsor
- Aydin Adnan Menderes University
Coronary Artery Disease
Hypertonic Solution in Off Pump Coronary Artery Bypass Graft Surgery
This is a comparison between Hypertonic versus isotonic solution in a double blind randomized trial for off pump Coronary Artery Bypass Graft (CABG) surgery targeting the left marginal branch.
- Trial name
- NCT01463917
- Testing
- Hypertonic solution, Isotonic
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- Hospital Pitangueiras
Sinusitis
Effect of Squeezable Bottle Nasal Irrigation Device in Children With Sinusitis
The purpose of this study is to the effect of squeezable bottle nasal irrigation device with syringe in children with sinusitis in symptom score and satisfaction to nasal irrigation
- Trial name
- NCT02191046
- Testing
- squeezable bottle, syringe 20 ml
- Where
- Thailand
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Thammasat University
Normal Anion Gap Metabolic Acidosis
Ringer's Lactate Versus Normal Saline in Caesarean Section
The objective of this study is to compare the effect on mean maternal and neonatal pH, and 24-hour postoperative morbidity, following intraoperative infusion of Ringer's Lactated versus normal saline in caesarean section at…
- Trial name
- NCT01585740
- Testing
- 0.9% Normal Saline, Ringer's Lactate
- Where
- Uganda
- Volunteers
- 500 people
- Sponsor
- Makerere University
Nasal Congestion, Common Cold
Post-market Clinical Follow-up Study of an Isotonic Saline Solution for the Relief of Nasal Congestion in Infants and Toddlers
The goal of this observational post-market clinical follow-up study is to evaluate the safety and performance of the CE-marked nasal spray for the relief of nasal congestion in infants and toddlers aged 6 to 48 months at day 5…
- Conditions
- Nasal Congestion, Common Cold, Allergic Rhinitis, Rhinosinusitis
- Trial name
- NASBY (NCT07257224)
- Testing
- Quinton Medical Nasal Health Baby®
- Where
- 2 sites in Spain
- Volunteers
- 83 people
- Sponsor
- Laboratoires Quinton International S.L.
Bronchiolitis
Epinephrine, Dexamethasone, and Hypertonic Saline in Bronchiolitis, Randomised Clinical Trial of Efficacy and Safety
In infancy, bronchiolitis is the most common acute infection of the lower respiratory Tract. The current treatment of bronchiolitis is controversial.
- Trial name
- NCT01834820
- Testing
- Epinephrine and Dexamethasone, Hypertonic Saline, Normal Saline
- Where
- Mexico
- Volunteers
- 120 people
- Sponsor
- Hospital General Naval de Alta Especialidad - Escuela Medico Naval